Genetic associations with suicide attempt severity and genetic overlap with major depression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01

AUTHORS

Daniel F. Levey, Renato Polimanti, Zhongshan Cheng, Hang Zhou, Yaira Z. Nuñez, Sonia Jain, Feng He, Xiaoying Sun, Robert J. Ursano, Ronald C. Kessler, Jordan W. Smoller, Murray B. Stein, Henry R. Kranzler, Joel Gelernter

ABSTRACT

In 2015, ~800,000 people died by suicide worldwide. For every death by suicide there are as many as 25 suicide attempts, which can result in serious injury even when not fatal. Despite this large impact on morbidity and mortality, the genetic influences on suicide attempt are poorly understood. We performed a genome-wide association study (GWAS) of severity of suicide attempts to investigate genetic influences. A discovery GWAS was performed in Yale-Penn sample cohorts of European Americans (EAs, n = 2,439) and African Americans (AAs, n = 3,881). We found one genome-wide significant (GWS) signal in EAs near the gene LDHB (rs1677091, p = 1.07 × 10-8) and three GWS associations in AAs: ARNTL2 on chromosome 12 (rs683813, p = 2.07 × 10-8), FAH on chromosome 15 (rs72740082, p = 2.36 × 10-8), and on chromosome 18 (rs11876255, p = 4.61 × 10-8) in the Yale-Penn discovery sample. We conducted a limited replication analysis in the completely independent Army-STARRS cohorts. rs1677091 replicated in Latinos (LAT, p = 6.52 × 10-3). A variant in LD with FAH rs72740082 (rs72740088; r2 = 0.68) was replicated in AAs (STARRS AA p = 5.23 × 10-3; AA meta, 1.51 × 10-9). When combined for a trans-population meta-analysis, the final sample size included n = 20,153 individuals. Finally, we found significant genetic overlap with major depressive disorder (MDD) using polygenic risk scores from a large GWAS (r2 = 0.007, p = 6.42 × 10-5). To our knowledge, this is the first GWAS of suicide attempt severity. We identified GWS associations near genes involved in anaerobic energy production (LDHB), circadian clock regulation (ARNTL2), and catabolism of tyrosine (FAH). These findings provide evidence of genetic risk factors for suicide attempt severity, providing new information regarding the molecular mechanisms involved. More... »

PAGES

22

References to SciGraph publications

  • 2014-01. Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci in MOLECULAR PSYCHIATRY
  • 2012-07. Genome-wide efficient mixed-model analysis for association studies in NATURE GENETICS
  • 2016-07. Histone Modifications in a Mouse Model of Early Adversities and Panic Disorder: Role for Asic1 and Neurodevelopmental Genes in SCIENTIFIC REPORTS
  • 2017-09. Precision medicine for suicidality: from universality to subtypes and personalization in MOLECULAR PSYCHIATRY
  • 2015-12. Second-generation PLINK: rising to the challenge of larger and richer datasets in GIGASCIENCE
  • 2017-08. Toward fine-grained phenotyping of suicidal behavior: the role of suicidal subtypes in MOLECULAR PSYCHIATRY
  • 2011-08. Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients in MOLECULAR PSYCHIATRY
  • 2018-08-16. Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study in MOLECULAR PSYCHIATRY
  • 2017-12. Functional mapping and annotation of genetic associations with FUMA in NATURE COMMUNICATIONS
  • 2015-11. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach in MOLECULAR PSYCHIATRY
  • 2012-04. A genome-wide association study of attempted suicide in MOLECULAR PSYCHIATRY
  • 2013-12. Discovery and validation of blood biomarkers for suicidality in MOLECULAR PSYCHIATRY
  • 2016-06. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment in MOLECULAR PSYCHIATRY
  • 2014-06. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene in MOLECULAR PSYCHIATRY
  • 2018-05. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression in NATURE GENETICS
  • 2013-01. Power in GWAS: lifting the curse of the clinical cut-off in MOLECULAR PSYCHIATRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41398-018-0340-2

    DOI

    http://dx.doi.org/10.1038/s41398-018-0340-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111494092

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30655502


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