Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Marta Gordillo-Salas, Fuencisla Pilar-Cuéllar, Yves P. Auberson, Albert Adell

ABSTRACT

In a previous study we found that the preferring GluN2A receptor antagonist, NVP-AAM077, elicited rapid antidepressant-like effects in the forced swim test that was related to the release of glutamate and serotonin in the medial prefrontal cortex. In the present work we sought to examine the duration of this behavioral effect as well as the molecular readouts involved. Our results showed that NVP-AAM077 reduced the immobility in the forced swim test 30 min and 24 h after its administration. However, this effect waned 7 days later. The rapid antidepressant-like response seems to be associated with increases in the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, mammalian target of rapamycin (mTOR) signaling, glia markers such as glial fibrillary acidic protein (GFAP) and excitatory amino acid transporter 1 (EAAT1), and a rapid mobilization of intracellular stores of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex. More... »

PAGES

84

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41398-018-0131-9

    DOI

    http://dx.doi.org/10.1038/s41398-018-0131-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103416911

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29666360


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