Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-08-13

AUTHORS

Juan Li, Wangqing Chen, Cong Peng, Wu Zhu, Zhaoqian Liu, Wei Zhang, Juan Su, Jie Li, Xiang Chen

ABSTRACT

H1 nonsedating antihistamines, such as desloratadine, are first-line treatment options for chronic spontaneous urticaria (CSU). However, desloratadine induces various degrees of sedation side effect in CSU patients, and no biomarkers currently exist for predicting the severity of such side effect. Herein, we evaluated the association between HRH1 gene rs901865 polymorphism and the severity of sedation side effect following desloratadine therapy in patients with CSU. We found that 20 of the 114 patients (17.50%) showed sedation side effect after desloratadine treatment, and 3 patients (2.63%) experienced serious sleepiness. The frequency of HRH1 rs901865 G allele was significantly higher in patients who experienced sedation than in patients with rs901865 A allele (p = 0.0009). Moreover, patients with the rs901865 G/G genotype suffered a more serious sedation side effect than patients with the rs901865 G/A genotype (p = 0.005). These results provide evidence that the HRH1 rs901865 G/G polymorphism is associated with severe sedation side effect after desloratadine treatment. Thus, the HRH1 rs901865 allele may potentially be used as a biomarker for predicting the severity of sedation side effect in patients suffering from CSU and treated with desloratadine. More... »

PAGES

87-93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41397-019-0094-0

DOI

http://dx.doi.org/10.1038/s41397-019-0094-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120288137

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31406237


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