Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-11

AUTHORS

Jae-Jung Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee Soo Ha, Sejung Sohn, Ryota Ebata, Hiromichi Hamada, Hiroyuki Suzuki, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee

ABSTRACT

Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) treatment effectively attenuates the fever and systemic inflammation. However, 10-20% patients are unresponsive to IVIG. To identify genetic variants influencing IVIG non-response in KD, a genome-wide association study (GWAS) and a replication study were performed using a total of 148 IVIG non-responders and 845 IVIG-responders in a Korean population. rs28662 in the sterile alpha motif domain-containing protein 9-like (SAMD9L) locus showed the most significant result in the joint analysis of GWAS and replication samples (odds ratio (OR) = 3.47, P = 1.39 × 10-5). The same SNP in the SAMD9L locus was tested in the Japanese population, and it revealed a more significant association in a meta-analysis with Japanese data (OR = 4.30, P = 5.30 × 10-6). These results provide new insights into the mechanism of IVIG response in KD. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41397-019-0085-1

DOI

http://dx.doi.org/10.1038/s41397-019-0085-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113356003

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30971808


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jae-Jung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chung-Ang University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411651.6", 
          "name": [
            "Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yun", 
        "givenName": "Sin Weon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Jeong Jin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyung Hee University Hospital at Gangdong", 
          "id": "https://www.grid.ac/institutes/grid.496794.1", 
          "name": [
            "Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Kyung Lim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daejeon St. Mary's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.470171.4", 
          "name": [
            "Department of Pediatrics, The Catholic University of Korea, Daejeon St. Mary's Hospital, Daejeon, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyung-Yil", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungnam National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411665.1", 
          "name": [
            "Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kil", 
        "givenName": "Hong-Ryang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412482.9", 
          "name": [
            "Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Gi Beom", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Pediatrics, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Myung-Ki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University Seoul Paik Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411635.4", 
          "name": [
            "Department of Pediatrics, Inje University Paik Hospital, Busan, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Min Seob", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pusan National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Pediatrics, Pusan National University Hospital, Busan, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyoung Doo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411134.2", 
          "name": [
            "Department of Pediatrics, Korea University Hospital, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ha", 
        "givenName": "Kee Soo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ewha Womans University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411076.5", 
          "name": [
            "Department of Pediatrics, Ewha Womans University Hospital, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sohn", 
        "givenName": "Sejung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ebata", 
        "givenName": "Ryota", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamada", 
        "givenName": "Hiromichi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wakayama Medical University", 
          "id": "https://www.grid.ac/institutes/grid.412857.d", 
          "name": [
            "Department of Pediatrics, Wakayama Medical University, Wakayama, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Hiroyuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Kaoru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.", 
            "Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onouchi", 
        "givenName": "Yoshihiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ewha Womans University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411076.5", 
          "name": [
            "Department of Pediatrics, Ewha Womans University Hospital, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Young Mi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411134.2", 
          "name": [
            "Department of Pediatrics, Korea University Hospital, Seoul, Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Gi Young", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea. cookie_jklee@hotmail.com."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jong-Keuk", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/inf.0000000000000891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000247094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0000000000000891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000247094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0000000000000891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000247094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/ijbs.9143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001156969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-006-0223-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002335791", 
          "https://doi.org/10.1007/s00431-006-0223-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1546-0096-11-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002470753", 
          "https://doi.org/10.1186/1546-0096-11-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(75)80220-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003797871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007473383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000145143.19711.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008681934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.04.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009278958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaad.2013.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011284775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2011.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011905103", 
          "https://doi.org/10.1038/tpj.2011.45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2006.03.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012879472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2013.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014433756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2007.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014936870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2148-13-121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015407054", 
          "https://doi.org/10.1186/1471-2148-13-121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2148-13-121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015407054", 
          "https://doi.org/10.1186/1471-2148-13-121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/519795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019061180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.111.962464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020061053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.111.962464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020061053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.592865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022698508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s100380170047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025024952", 
          "https://doi.org/10.1007/s100380170047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-8-92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036235331", 
          "https://doi.org/10.1186/1471-2164-8-92"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddt248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042364718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2016.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045946146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2016.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045946146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1253/circj.cj-09-0664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049798449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006454-199812000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060266178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006454-199812000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060266178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006454-199812000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060266178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e328363686e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060341146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e328363686e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060341146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e328363686e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060341146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.94.6.1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063337491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.116.001533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.116.001533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077287337", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081543956", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2016-10-743302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083841548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084234999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0000000000000484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084234999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.116.001625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092191774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.116.001625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092191774"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-11", 
    "datePublishedReg": "2019-04-11", 
    "description": "Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) treatment effectively attenuates the fever and systemic inflammation. However, 10-20% patients are unresponsive to IVIG. To identify genetic variants influencing IVIG non-response in KD, a genome-wide association study (GWAS) and a replication study were performed using a total of 148 IVIG non-responders and 845 IVIG-responders in a Korean population. rs28662 in the sterile alpha motif domain-containing protein 9-like (SAMD9L) locus showed the most significant result in the joint analysis of GWAS and replication samples (odds ratio (OR)\u2009=\u20093.47, P\u2009=\u20091.39\u2009\u00d7\u200910-5). The same SNP in the SAMD9L locus was tested in the Japanese population, and it revealed a more significant association in a meta-analysis with Japanese data (OR\u2009=\u20094.30, P\u2009=\u20095.30\u2009\u00d7\u200910-6). These results provide new insights into the mechanism of IVIG response in KD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41397-019-0085-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1027238", 
        "issn": [
          "1470-269X", 
          "1473-1150"
        ], 
        "name": "The Pharmacogenomics Journal", 
        "type": "Periodical"
      }
    ], 
    "name": "Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis.", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41397-019-0085-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113356003"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101083949"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30971808"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41397-019-0085-1", 
      "https://app.dimensions.ai/details/publication/pub.1113356003"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56154_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/s41397-019-0085-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41397-019-0085-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41397-019-0085-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41397-019-0085-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41397-019-0085-1'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      20 PREDICATES      55 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41397-019-0085-1 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N0110f085390f44e3aeb963b66842852f
4 schema:citation sg:pub.10.1007/s00431-006-0223-z
5 sg:pub.10.1007/s100380170047
6 sg:pub.10.1038/tpj.2011.45
7 sg:pub.10.1186/1471-2148-13-121
8 sg:pub.10.1186/1471-2164-8-92
9 sg:pub.10.1186/1546-0096-11-32
10 https://app.dimensions.ai/details/publication/pub.1077287337
11 https://app.dimensions.ai/details/publication/pub.1081543956
12 https://doi.org/10.1016/j.ajhg.2016.04.009
13 https://doi.org/10.1016/j.bbrc.2009.04.004
14 https://doi.org/10.1016/j.ccr.2013.08.011
15 https://doi.org/10.1016/j.jaad.2013.07.002
16 https://doi.org/10.1016/j.jaci.2011.04.027
17 https://doi.org/10.1016/j.jpeds.2006.03.050
18 https://doi.org/10.1016/j.jpeds.2007.12.021
19 https://doi.org/10.1016/s0022-3476(75)80220-4
20 https://doi.org/10.1086/519795
21 https://doi.org/10.1093/hmg/ddt248
22 https://doi.org/10.1097/00006454-199812000-00009
23 https://doi.org/10.1097/fpc.0b013e328363686e
24 https://doi.org/10.1097/inf.0000000000000891
25 https://doi.org/10.1161/01.cir.0000145143.19711.78
26 https://doi.org/10.1161/01.cir.94.6.1379
27 https://doi.org/10.1161/cir.0000000000000484
28 https://doi.org/10.1161/circgenetics.111.962464
29 https://doi.org/10.1161/circgenetics.116.001533
30 https://doi.org/10.1161/circgenetics.116.001625
31 https://doi.org/10.1161/circulationaha.105.592865
32 https://doi.org/10.1182/blood-2016-10-743302
33 https://doi.org/10.1253/circj.cj-09-0664
34 https://doi.org/10.7150/ijbs.9143
35 schema:datePublished 2019-04-11
36 schema:datePublishedReg 2019-04-11
37 schema:description Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) treatment effectively attenuates the fever and systemic inflammation. However, 10-20% patients are unresponsive to IVIG. To identify genetic variants influencing IVIG non-response in KD, a genome-wide association study (GWAS) and a replication study were performed using a total of 148 IVIG non-responders and 845 IVIG-responders in a Korean population. rs28662 in the sterile alpha motif domain-containing protein 9-like (SAMD9L) locus showed the most significant result in the joint analysis of GWAS and replication samples (odds ratio (OR) = 3.47, P = 1.39 × 10<sup>-5</sup>). The same SNP in the SAMD9L locus was tested in the Japanese population, and it revealed a more significant association in a meta-analysis with Japanese data (OR = 4.30, P = 5.30 × 10<sup>-6</sup>). These results provide new insights into the mechanism of IVIG response in KD.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree false
41 schema:isPartOf sg:journal.1027238
42 schema:name Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis.
43 schema:productId N00d84d72fa8549809e352602c41995d6
44 N286ddfc57ff64419ae0b72a44ac7cc57
45 Nc848559fcfce4ad9899b5aed2f9192e7
46 Nd95abc34bbcd4cd2933f07c046923f7e
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113356003
48 https://doi.org/10.1038/s41397-019-0085-1
49 schema:sdDatePublished 2019-04-15T09:09
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Na31ae47aa5df47078a8d8634c9b47d86
52 schema:url http://www.nature.com/articles/s41397-019-0085-1
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N00d84d72fa8549809e352602c41995d6 schema:name dimensions_id
57 schema:value pub.1113356003
58 rdf:type schema:PropertyValue
59 N0110f085390f44e3aeb963b66842852f rdf:first N50cdff7709d745e68fa79bfc2e9c0b79
60 rdf:rest N4a127a07fcc44864ab090391c4983224
61 N1bf128602afd4d0b82eda8662c891e45 rdf:first N1efb82938a55458d83ed28665d3d7e64
62 rdf:rest N58d16807ea744ec6adf6ccd5c4e8bf53
63 N1efb82938a55458d83ed28665d3d7e64 schema:affiliation https://www.grid.ac/institutes/grid.412857.d
64 schema:familyName Suzuki
65 schema:givenName Hiroyuki
66 rdf:type schema:Person
67 N1fe819a1c5b44b7aad3b1105988b30ef rdf:first Nf5a25f5f633e499c93674e18203cfb35
68 rdf:rest rdf:nil
69 N219f64a45716481b8ef544b7e936c319 schema:affiliation https://www.grid.ac/institutes/grid.411134.2
70 schema:familyName Ha
71 schema:givenName Kee Soo
72 rdf:type schema:Person
73 N234f660e1f6f4205848f41d6e8942462 schema:affiliation https://www.grid.ac/institutes/grid.412482.9
74 schema:familyName Kim
75 schema:givenName Gi Beom
76 rdf:type schema:Person
77 N286ddfc57ff64419ae0b72a44ac7cc57 schema:name pubmed_id
78 schema:value 30971808
79 rdf:type schema:PropertyValue
80 N37885fc271724a928c31d2a49bf98df8 rdf:first N4cd44c9ce6874d3db1c2eea43a3f2a36
81 rdf:rest Nb9200ef64b364b83b8b46348b602c676
82 N3de2b3ea16ca4686a2f24779d74ad024 schema:affiliation https://www.grid.ac/institutes/grid.470171.4
83 schema:familyName Lee
84 schema:givenName Kyung-Yil
85 rdf:type schema:Person
86 N3e5025b25ff64886b768fb7ce1573f59 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
87 schema:familyName Ebata
88 schema:givenName Ryota
89 rdf:type schema:Person
90 N4a127a07fcc44864ab090391c4983224 rdf:first Nace138a54a0c407eb2736bc8abb5c62b
91 rdf:rest N50f7723a3e75463983c2ffedb8be14fe
92 N4cd44c9ce6874d3db1c2eea43a3f2a36 schema:affiliation https://www.grid.ac/institutes/grid.411076.5
93 schema:familyName Sohn
94 schema:givenName Sejung
95 rdf:type schema:Person
96 N4dd9666517da4fc3b71cc43cede3dec0 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
97 schema:familyName Onouchi
98 schema:givenName Yoshihiro
99 rdf:type schema:Person
100 N4ea1a0d5e7114ac9b5998d013a62d624 schema:affiliation https://www.grid.ac/institutes/grid.411134.2
101 schema:familyName Jang
102 schema:givenName Gi Young
103 rdf:type schema:Person
104 N50cdff7709d745e68fa79bfc2e9c0b79 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
105 schema:familyName Kim
106 schema:givenName Jae-Jung
107 rdf:type schema:Person
108 N50f7723a3e75463983c2ffedb8be14fe rdf:first Nf4b12da0533a43ec81f49690fd97d256
109 rdf:rest Ncacb57442f684cff9a27badf981ea355
110 N58d16807ea744ec6adf6ccd5c4e8bf53 rdf:first N975a0339ee58422982cae0e7e83c0d16
111 rdf:rest Nb61f12286eff4814ad4dff2ca86c8b15
112 N5d061ffa860d4ccf821c2772d73ca2d1 schema:affiliation https://www.grid.ac/institutes/grid.411076.5
113 schema:familyName Hong
114 schema:givenName Young Mi
115 rdf:type schema:Person
116 N67fb142bb04b465d9ed8276e5f40d67c schema:affiliation https://www.grid.ac/institutes/grid.410818.4
117 schema:familyName Hamada
118 schema:givenName Hiromichi
119 rdf:type schema:Person
120 N6beb4a88f7084ce78cd3a162dc06f364 schema:affiliation https://www.grid.ac/institutes/grid.496794.1
121 schema:familyName Yoon
122 schema:givenName Kyung Lim
123 rdf:type schema:Person
124 N7f3984d8778e4bf8aa4abbbf5a9f7f34 rdf:first N67fb142bb04b465d9ed8276e5f40d67c
125 rdf:rest N1bf128602afd4d0b82eda8662c891e45
126 N81af2c8944c24a3ab9a47046cd252b09 rdf:first N219f64a45716481b8ef544b7e936c319
127 rdf:rest N37885fc271724a928c31d2a49bf98df8
128 N86dcff6cb7f34e63ba560f5c546e38bb rdf:first Nb1205ec02ba846308c1460e35ce7908e
129 rdf:rest N945d32b69d9d4e39beaaeb5ce7196a06
130 N90a5f12223564cc8b93b75778c54e785 rdf:first Na06bafa28e3f47c0b0718b38dc1ca15d
131 rdf:rest N81af2c8944c24a3ab9a47046cd252b09
132 N945d32b69d9d4e39beaaeb5ce7196a06 rdf:first Nb55c7d7333a844a88f1c62ce4f249a55
133 rdf:rest N90a5f12223564cc8b93b75778c54e785
134 N975a0339ee58422982cae0e7e83c0d16 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
135 schema:familyName Ito
136 schema:givenName Kaoru
137 rdf:type schema:Person
138 Na06bafa28e3f47c0b0718b38dc1ca15d schema:affiliation https://www.grid.ac/institutes/grid.412588.2
139 schema:familyName Lee
140 schema:givenName Hyoung Doo
141 rdf:type schema:Person
142 Na31ae47aa5df47078a8d8634c9b47d86 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Nace138a54a0c407eb2736bc8abb5c62b schema:affiliation https://www.grid.ac/institutes/grid.411651.6
145 schema:familyName Yun
146 schema:givenName Sin Weon
147 rdf:type schema:Person
148 Nb1205ec02ba846308c1460e35ce7908e schema:affiliation https://www.grid.ac/institutes/grid.267370.7
149 schema:familyName Han
150 schema:givenName Myung-Ki
151 rdf:type schema:Person
152 Nb220539c776b475cb1ae8d3cf0ab9b59 schema:affiliation https://www.grid.ac/institutes/grid.411665.1
153 schema:familyName Kil
154 schema:givenName Hong-Ryang
155 rdf:type schema:Person
156 Nb55c7d7333a844a88f1c62ce4f249a55 schema:affiliation https://www.grid.ac/institutes/grid.411635.4
157 schema:familyName Song
158 schema:givenName Min Seob
159 rdf:type schema:Person
160 Nb61f12286eff4814ad4dff2ca86c8b15 rdf:first N4dd9666517da4fc3b71cc43cede3dec0
161 rdf:rest Nbdc2cf658aab4d1b8819e67c2a94b0a4
162 Nb9200ef64b364b83b8b46348b602c676 rdf:first N3e5025b25ff64886b768fb7ce1573f59
163 rdf:rest N7f3984d8778e4bf8aa4abbbf5a9f7f34
164 Nbdc2cf658aab4d1b8819e67c2a94b0a4 rdf:first N5d061ffa860d4ccf821c2772d73ca2d1
165 rdf:rest Nd465e435559743b9aa88f447623c5ad6
166 Nc168eee7e94949bca9c18dc8498d9447 rdf:first N234f660e1f6f4205848f41d6e8942462
167 rdf:rest N86dcff6cb7f34e63ba560f5c546e38bb
168 Nc848559fcfce4ad9899b5aed2f9192e7 schema:name doi
169 schema:value 10.1038/s41397-019-0085-1
170 rdf:type schema:PropertyValue
171 Ncacb57442f684cff9a27badf981ea355 rdf:first N6beb4a88f7084ce78cd3a162dc06f364
172 rdf:rest Neb6e81bdc80f463b9ff5f5afa06cd4dc
173 Nd465e435559743b9aa88f447623c5ad6 rdf:first N4ea1a0d5e7114ac9b5998d013a62d624
174 rdf:rest N1fe819a1c5b44b7aad3b1105988b30ef
175 Nd95abc34bbcd4cd2933f07c046923f7e schema:name nlm_unique_id
176 schema:value 101083949
177 rdf:type schema:PropertyValue
178 Ne2d792ba0a8746a49c4cabd69b0eacad rdf:first Nb220539c776b475cb1ae8d3cf0ab9b59
179 rdf:rest Nc168eee7e94949bca9c18dc8498d9447
180 Neb6e81bdc80f463b9ff5f5afa06cd4dc rdf:first N3de2b3ea16ca4686a2f24779d74ad024
181 rdf:rest Ne2d792ba0a8746a49c4cabd69b0eacad
182 Nf4b12da0533a43ec81f49690fd97d256 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
183 schema:familyName Yu
184 schema:givenName Jeong Jin
185 rdf:type schema:Person
186 Nf5a25f5f633e499c93674e18203cfb35 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
187 schema:familyName Lee
188 schema:givenName Jong-Keuk
189 rdf:type schema:Person
190 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biological Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
194 schema:name Genetics
195 rdf:type schema:DefinedTerm
196 sg:journal.1027238 schema:issn 1470-269X
197 1473-1150
198 schema:name The Pharmacogenomics Journal
199 rdf:type schema:Periodical
200 sg:pub.10.1007/s00431-006-0223-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1002335791
201 https://doi.org/10.1007/s00431-006-0223-z
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/s100380170047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025024952
204 https://doi.org/10.1007/s100380170047
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/tpj.2011.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011905103
207 https://doi.org/10.1038/tpj.2011.45
208 rdf:type schema:CreativeWork
209 sg:pub.10.1186/1471-2148-13-121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015407054
210 https://doi.org/10.1186/1471-2148-13-121
211 rdf:type schema:CreativeWork
212 sg:pub.10.1186/1471-2164-8-92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036235331
213 https://doi.org/10.1186/1471-2164-8-92
214 rdf:type schema:CreativeWork
215 sg:pub.10.1186/1546-0096-11-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002470753
216 https://doi.org/10.1186/1546-0096-11-32
217 rdf:type schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1077287337 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1081543956 schema:CreativeWork
220 https://doi.org/10.1016/j.ajhg.2016.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045946146
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.bbrc.2009.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007473383
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.ccr.2013.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014433756
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.jaad.2013.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011284775
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.jaci.2011.04.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009278958
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.jpeds.2006.03.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012879472
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.jpeds.2007.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014936870
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0022-3476(75)80220-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003797871
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/hmg/ddt248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042364718
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1097/00006454-199812000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060266178
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/fpc.0b013e328363686e schema:sameAs https://app.dimensions.ai/details/publication/pub.1060341146
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/inf.0000000000000891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000247094
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1161/01.cir.0000145143.19711.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008681934
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1161/01.cir.94.6.1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337491
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1161/cir.0000000000000484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084234999
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/circgenetics.111.962464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020061053
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1161/circgenetics.116.001533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063343140
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/circgenetics.116.001625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092191774
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1161/circulationaha.105.592865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022698508
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1182/blood-2016-10-743302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083841548
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1253/circj.cj-09-0664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049798449
263 rdf:type schema:CreativeWork
264 https://doi.org/10.7150/ijbs.9143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001156969
265 rdf:type schema:CreativeWork
266 https://www.grid.ac/institutes/grid.136304.3 schema:alternateName Chiba University
267 schema:name Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
268 Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan.
269 Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.267370.7 schema:alternateName University of Ulsan
272 schema:name Department of Pediatrics, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea.
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.410818.4 schema:alternateName Tokyo Women's Medical University
275 schema:name Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.411076.5 schema:alternateName Ewha Womans University Medical Center
278 schema:name Department of Pediatrics, Ewha Womans University Hospital, Seoul, Korea.
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.411134.2 schema:alternateName Korea University Medical Center
281 schema:name Department of Pediatrics, Korea University Hospital, Seoul, Korea.
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.411635.4 schema:alternateName Inje University Seoul Paik Hospital
284 schema:name Department of Pediatrics, Inje University Paik Hospital, Busan, Korea.
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.411651.6 schema:alternateName Chung-Ang University Hospital
287 schema:name Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.
288 rdf:type schema:Organization
289 https://www.grid.ac/institutes/grid.411665.1 schema:alternateName Chungnam National University Hospital
290 schema:name Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.412482.9 schema:alternateName Seoul National University Children's Hospital
293 schema:name Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.412588.2 schema:alternateName Pusan National University Hospital
296 schema:name Department of Pediatrics, Pusan National University Hospital, Busan, Korea.
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.412857.d schema:alternateName Wakayama Medical University
299 schema:name Department of Pediatrics, Wakayama Medical University, Wakayama, Japan.
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.413967.e schema:alternateName Asan Medical Center
302 schema:name Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
303 Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea. cookie_jklee@hotmail.com.
304 Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.470171.4 schema:alternateName Daejeon St. Mary's Hospital
307 schema:name Department of Pediatrics, The Catholic University of Korea, Daejeon St. Mary's Hospital, Daejeon, Korea.
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.496794.1 schema:alternateName Kyung Hee University Hospital at Gangdong
310 schema:name Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.7597.c schema:alternateName RIKEN
313 schema:name Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...