Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04

AUTHORS

Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Ahmed Alnatsha, Eduardo Villar, Javier Valdivia-Bautista, María José Faus-Dáder, Miguel Ángel Calleja-Hernández

ABSTRACT

Chemotherapy based on platinum compounds is the standard treatment for NSCLC patients with EGFR wild type, and is also used as second line in mutated EGFR patients. Nevertheless, this therapy presents poor clinical outcomes. ERCC1, ERCC2, XRCC1, MDM2, MTHFR, MTR, and SLC19A1 gene polymorphisms may contribute to individual variation in response and survival to platinum-based chemotherapy. The aim of this study was to investigate the influence of these polymorphisms on response and survival of NSCLC patients treated with platinum-based chemotherapy. A retrospective-prospective cohorts study was conducted, including 141 NSCLC patients. Polymorphisms were analyzed by PCR real-time with Taqman® probes. Patients with ERCC1 rs3212986-GG (p = 0.0268; OR = 2.50; CI95% = 1.12-5.69) and XRCC1 rs25487-GG (p = 0.0161; OR = 2.99; CI95% = 1.26-7.62) genotype showed significantly better ORR. Cox survival analysis revealed that patients carrying the MDM2 rs1690924-GG genotype (p = 0.0345; HR = 1.99; CI95% = 1.05-3.80) presented higher risk of death. Furthermore, carriers of MTR rs1805087-A alleles (p = 0.0060; HR = 8.91; CI95% = 1.87-42.42) and SLC19A1 rs1051266-AA genotype (p = 0.0130; HR = 1.74; CI95% = 1.12-2.68) showed greater risk of progression. No influence of ERCC1 rs11615, ERCC2 rs13181, ERCC2 rs1799793, XRCC1 rs1799782, MDM2 rs1470383, MTHFR rs1801131, and MTHFR rs1801133 on platinum-based chemotherapy clinical outcomes was found. In conclusion, our results suggest that ERCC1 rs3212986, XRCC1 rs25487, MDM2 rs1690924, MTR rs1805087, and SLC19A1 rs1051266 gene polymorphisms may significantly act as predictive factors in NSCLC patients treated with platinum-based chemotherapy. More... »

PAGES

164-177

References to SciGraph publications

  • 2014-08. Genetic polymorphism of GSTP1 and ERCC1 correlated with response to platinum-based chemotherapy in non-small cell lung cancer in MEDICAL ONCOLOGY
  • 2013-04. ERCC1/BRCA1 expression and gene polymorphisms as prognostic and predictive factors in advanced NSCLC treated with or without cisplatin in BRITISH JOURNAL OF CANCER
  • 2014-08. Polymorphisms in ERCC1 gene could predict clinical outcome of platinum-based chemotherapy for non-small cell lung cancer patients in TUMOR BIOLOGY
  • 2011-03. Predictive value of ERCC1 and XPD polymorphism in patients with advanced non-small cell lung cancer receiving platinum-based chemotherapy: a systematic review and meta-analysis in MEDICAL ONCOLOGY
  • 2000-08. Molecular mechanisms involved in cisplatin cytotoxicity in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007-07. Prognostic significance of folate metabolism polymorphisms for lung cancer in BRITISH JOURNAL OF CANCER
  • 2012-02. A C118T polymorphism of ERCC1 and response to cisplatin chemotherapy in patients with late-stage non-small cell lung cancer in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2014-11. Heterozygote advantage of methylenetetrahydrofolate reductase polymorphisms on clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy in TUMOR BIOLOGY
  • 2014-04. The association between the ERCC1/2 polymorphisms and the clinical outcomes of the platinum-based chemotherapy in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis in TUMOR BIOLOGY
  • 2006-09. A multicenter phase II study of carboplatin and paclitaxel with a biweekly schedule in patients with advanced non-small-cell lung cancer: Kyushu thoracic oncology group trial in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2016-02. The relationship between polymorphisms of genes regulating DNA repair or cell division and the toxicity of platinum and vinorelbine chemotherapy in advanced NSCLC patients in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2014-06. Safety and efficacy of gemcitabine or pemetrexed in combination with a platinum in patients with non-small-cell lung cancer and prior interstitial lung disease in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2015-03. A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-05. Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2006-12. Effect of ERCC1 polymorphisms and the modification by smoking on the survival of non-small cell lung cancer patients in MEDICAL ONCOLOGY
  • 2014-10. Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations in THE PHARMACOGENOMICS JOURNAL
  • 2014-05. Role of ERCC1 variants in response to chemotherapy and clinical outcome of advanced non-small cell lung cancer in TUMOR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41397-018-0014-8

    DOI

    http://dx.doi.org/10.1038/s41397-018-0014-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103269102

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29662106


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Granada", 
              "id": "https://www.grid.ac/institutes/grid.4489.1", 
              "name": [
                "Pharmacogenetics Unit, UGC Provincial de Farmacia de Granada, Instituto de Investigaci\u00f3n Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, Granada, Spain", 
                "Department of Biochemistry, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071, Granada, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "P\u00e9rez-Ram\u00edrez", 
            "givenName": "Cristina", 
            "id": "sg:person.01051633365.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051633365.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Queen's University Belfast", 
              "id": "https://www.grid.ac/institutes/grid.4777.3", 
              "name": [
                "Centre for Public Health, Nephrology Research Group, Queen\u2019s University Belfast, c/o Regional Genetics Centre, Level A Tower Block Belfast City Hospital Lisburn Road, BT9 7AB, Belfast, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ca\u00f1adas-Garre", 
            "givenName": "Marisa", 
            "id": "sg:person.0755220161.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755220161.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Molecular Medicine, Faculty of Medicine, University of T\u00fcbingen, Geissweg 5, 72076, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alnatsha", 
            "givenName": "Ahmed", 
            "id": "sg:person.011752533651.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011752533651.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Pathology Service, UGC Anatom\u00eda Patol\u00f3gica, Instituto de Investigaci\u00f3n Biosanitaria de Granada Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, 18014, Granada, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Villar", 
            "givenName": "Eduardo", 
            "id": "sg:person.012550114251.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012550114251.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario Universitario de Granada", 
              "id": "https://www.grid.ac/institutes/grid.459499.c", 
              "name": [
                "Medical Oncology Service, UGC Oncolog\u00eda M\u00e9dica Instituto de Investigaci\u00f3n Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, 18014, Granada, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Valdivia-Bautista", 
            "givenName": "Javier", 
            "id": "sg:person.01275006034.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275006034.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Granada", 
              "id": "https://www.grid.ac/institutes/grid.4489.1", 
              "name": [
                "Department of Biochemistry, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071, Granada, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Faus-D\u00e1der", 
            "givenName": "Mar\u00eda Jos\u00e9", 
            "id": "sg:person.01234175165.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234175165.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Granada", 
              "id": "https://www.grid.ac/institutes/grid.4489.1", 
              "name": [
                "Pharmacogenetics Unit, UGC Provincial de Farmacia de Granada, Instituto de Investigaci\u00f3n Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, Granada, Spain", 
                "Department of Pharmacology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071, Granada, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Calleja-Hern\u00e1ndez", 
            "givenName": "Miguel \u00c1ngel", 
            "id": "sg:person.015234424727.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015234424727.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.4065/83.5.584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000454522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00195-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001250823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0802714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002128638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0058466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003240881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0089518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005080939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.30.5334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005654090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jjco/hyq071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005800147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jjco/hyq071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005800147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14656566.6.12.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007155231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14656566.6.12.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007155231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2003.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008992006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cllc.2015.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009232032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0069553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009902669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0033200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011582528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-010-9443-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011676331", 
              "https://doi.org/10.1007/s12032-010-9443-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.23.5622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012862395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1044-579x(02)00099-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014137348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1044-579x(02)00099-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014137348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2008.11.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016389985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cllc.2012.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017484322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cllc.2011.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017649567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-014-2427-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017855062", 
              "https://doi.org/10.1007/s13277-014-2427-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mc.20819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019269603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2011.05.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020877509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021806605", 
              "https://doi.org/10.1038/sj.bjc.6603830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000362222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021830983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/jto.0b013e31824fe98c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022007048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/coc.0b013e3181b9cedc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022222660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/coc.0b013e3181b9cedc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022222660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/coc.0b013e3181b9cedc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022222660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cllc.2016.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022390312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3349/ymj.2013.54.6.1384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022846787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2006.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024829864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024886715", 
              "https://doi.org/10.1038/bjc.2013.127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0027-5107(01)00142-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025058614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2009.06.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025319083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/mo:23:4:489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025333082", 
              "https://doi.org/10.1385/mo:23:4:489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.19.1650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025473968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-014-2673-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025954301", 
              "https://doi.org/10.1007/s00280-014-2673-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0099843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026059905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2013.1175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026304480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2013.1175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026304480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026558254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2016.04.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028480503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jss.2009.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029550510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-013-1526-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030160132", 
              "https://doi.org/10.1007/s13277-013-1526-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-013-1526-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030160132", 
              "https://doi.org/10.1007/s13277-013-1526-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-014-2458-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030799105", 
              "https://doi.org/10.1007/s00280-014-2458-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/jto.0b013e3181ec18c4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030933806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2014.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031643166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2012.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031733728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032745321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-2543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033315392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2009.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033439641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phrs.2016.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034060514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.11.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034654616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3816/clc.2009.n.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035214133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-013-1493-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035289119", 
              "https://doi.org/10.1007/s13277-013-1493-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2014.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037405778", 
              "https://doi.org/10.1038/tpj.2014.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2014.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037405778", 
              "https://doi.org/10.1038/tpj.2014.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07357907.2014.1001897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037633589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-013-2127-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038689876", 
              "https://doi.org/10.1007/s00280-013-2127-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12094-015-1343-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038981786", 
              "https://doi.org/10.1007/s12094-015-1343-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00230-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040191614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-014-0086-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041031257", 
              "https://doi.org/10.1007/s12032-014-0086-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.arcmed.2011.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041250241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/etm.2012.714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041362992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2009.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041476280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-014-2033-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041920148", 
              "https://doi.org/10.1007/s13277-014-2033-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-011-1090-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042393806", 
              "https://doi.org/10.1007/s00432-011-1090-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-011-1090-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042393806", 
              "https://doi.org/10.1007/s00432-011-1090-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00000762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043478916", 
              "https://doi.org/10.1007/pl00000762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-005-0168-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043959759", 
              "https://doi.org/10.1007/s00280-005-0168-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-005-0168-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043959759", 
              "https://doi.org/10.1007/s00280-005-0168-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/jto.0b013e3181e7fe2a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045811947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0909530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047104724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.59.0489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048114647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.ge.29.120195.000441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048462298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2013.01.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048648441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7314/apjcp.2012.13.9.4413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048865040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.26562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049178979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/thg.2014.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049430749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050271265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050271265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdh319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050592997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-0247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052294490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-03-0097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052340744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.45.3753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052635973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2004.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052780384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0025-6196(11)60735-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054591557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1023/a:1008342116536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056303305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1160/th13-11-0941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063293598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.21037/tlcr.2016.07.01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068835158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/br.2014.282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071502317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4149/neo_2011_04_348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072262357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/2014.april.17.6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072391995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/2014.april.29.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072392024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/2014.january.14.2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072392394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/2014.may.16.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072392783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/2014.october.31.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072392985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/2015.august.28.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072393379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5603/fhc.2012.0011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073037988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5732/cjc.009.10139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073088516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.1.12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074511203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074962570", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074988284", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075097685", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076876507", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077276010", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3779/j.issn.1009-3419.2010.04.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078195736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3779/j.issn.1009-3419.2011.12.03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078486064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079099174", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079106910", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079106910", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2016.0031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079239151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2016.0031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079239151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3978/j.issn.2218-6751.2016.01.06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079239474"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04", 
        "datePublishedReg": "2019-04-01", 
        "description": "Chemotherapy based on platinum compounds is the standard treatment for NSCLC patients with EGFR wild type, and is also used as second line in mutated EGFR patients. Nevertheless, this therapy presents poor clinical outcomes. ERCC1, ERCC2, XRCC1, MDM2, MTHFR, MTR, and SLC19A1 gene polymorphisms may contribute to individual variation in response and survival to platinum-based chemotherapy. The aim of this study was to investigate the influence of these polymorphisms on response and survival of NSCLC patients treated with platinum-based chemotherapy. A retrospective-prospective cohorts study was conducted, including 141 NSCLC patients. Polymorphisms were analyzed by PCR real-time with Taqman\u00ae probes. Patients with ERCC1 rs3212986-GG (p\u2009=\u20090.0268; OR\u2009=\u20092.50; CI95%\u2009=\u20091.12-5.69) and XRCC1 rs25487-GG (p\u2009=\u20090.0161; OR\u2009=\u20092.99; CI95%\u2009=\u20091.26-7.62) genotype showed significantly better ORR. Cox survival analysis revealed that patients carrying the MDM2 rs1690924-GG genotype (p\u2009=\u20090.0345; HR\u2009=\u20091.99; CI95%\u2009=\u20091.05-3.80) presented higher risk of death. Furthermore, carriers of MTR rs1805087-A alleles (p\u2009=\u20090.0060; HR\u2009=\u20098.91; CI95%\u2009=\u20091.87-42.42) and SLC19A1 rs1051266-AA genotype (p\u2009=\u20090.0130; HR\u2009=\u20091.74; CI95%\u2009=\u20091.12-2.68) showed greater risk of progression. No influence of ERCC1 rs11615, ERCC2 rs13181, ERCC2 rs1799793, XRCC1 rs1799782, MDM2 rs1470383, MTHFR rs1801131, and MTHFR rs1801133 on platinum-based chemotherapy clinical outcomes was found. In conclusion, our results suggest that ERCC1 rs3212986, XRCC1 rs25487, MDM2 rs1690924, MTR rs1805087, and SLC19A1 rs1051266 gene polymorphisms may significantly act as predictive factors in NSCLC patients treated with platinum-based chemotherapy.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41397-018-0014-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1027238", 
            "issn": [
              "1470-269X", 
              "1473-1150"
            ], 
            "name": "The Pharmacogenomics Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer patients", 
        "pagination": "164-177", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "60113e03bb55f81cb740d2c58120ba043ede565374b0dd77c2cc069a8dfb0131"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29662106"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101083949"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41397-018-0014-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1103269102"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41397-018-0014-8", 
          "https://app.dimensions.ai/details/publication/pub.1103269102"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T14:33", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13102_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41397-018-0014-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41397-018-0014-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41397-018-0014-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41397-018-0014-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41397-018-0014-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    449 TRIPLES      21 PREDICATES      134 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41397-018-0014-8 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author Nc1633f3ba2b14b03b4cfdba8dbd20fd9
    4 schema:citation sg:pub.10.1007/pl00000762
    5 sg:pub.10.1007/s00280-005-0168-3
    6 sg:pub.10.1007/s00280-013-2127-8
    7 sg:pub.10.1007/s00280-014-2458-0
    8 sg:pub.10.1007/s00280-014-2673-8
    9 sg:pub.10.1007/s00432-011-1090-1
    10 sg:pub.10.1007/s12032-010-9443-1
    11 sg:pub.10.1007/s12032-014-0086-5
    12 sg:pub.10.1007/s12094-015-1343-6
    13 sg:pub.10.1007/s13277-013-1493-5
    14 sg:pub.10.1007/s13277-013-1526-0
    15 sg:pub.10.1007/s13277-014-2033-7
    16 sg:pub.10.1007/s13277-014-2427-6
    17 sg:pub.10.1038/bjc.2013.127
    18 sg:pub.10.1038/sj.bjc.6603830
    19 sg:pub.10.1038/tpj.2014.13
    20 sg:pub.10.1385/mo:23:4:489
    21 https://app.dimensions.ai/details/publication/pub.1074962570
    22 https://app.dimensions.ai/details/publication/pub.1074988284
    23 https://app.dimensions.ai/details/publication/pub.1075097685
    24 https://app.dimensions.ai/details/publication/pub.1076876507
    25 https://app.dimensions.ai/details/publication/pub.1077276010
    26 https://app.dimensions.ai/details/publication/pub.1079099174
    27 https://app.dimensions.ai/details/publication/pub.1079106910
    28 https://doi.org/10.1002/cncr.26562
    29 https://doi.org/10.1002/mc.20819
    30 https://doi.org/10.1016/j.arcmed.2011.07.008
    31 https://doi.org/10.1016/j.canlet.2009.05.005
    32 https://doi.org/10.1016/j.canlet.2014.07.023
    33 https://doi.org/10.1016/j.cllc.2011.11.007
    34 https://doi.org/10.1016/j.cllc.2012.10.001
    35 https://doi.org/10.1016/j.cllc.2015.02.001
    36 https://doi.org/10.1016/j.cllc.2016.05.009
    37 https://doi.org/10.1016/j.ejca.2008.10.026
    38 https://doi.org/10.1016/j.jss.2009.09.006
    39 https://doi.org/10.1016/j.lungcan.2003.11.019
    40 https://doi.org/10.1016/j.lungcan.2006.12.002
    41 https://doi.org/10.1016/j.lungcan.2008.11.014
    42 https://doi.org/10.1016/j.lungcan.2009.03.007
    43 https://doi.org/10.1016/j.lungcan.2009.06.026
    44 https://doi.org/10.1016/j.lungcan.2011.05.023
    45 https://doi.org/10.1016/j.lungcan.2012.07.009
    46 https://doi.org/10.1016/j.lungcan.2013.01.008
    47 https://doi.org/10.1016/j.lungcan.2016.04.007
    48 https://doi.org/10.1016/j.phrs.2016.08.002
    49 https://doi.org/10.1016/j.tibs.2004.12.008
    50 https://doi.org/10.1016/s0025-6196(11)60735-0
    51 https://doi.org/10.1016/s0027-5107(01)00142-7
    52 https://doi.org/10.1016/s0092-8674(01)00195-7
    53 https://doi.org/10.1016/s1044-579x(02)00099-8
    54 https://doi.org/10.1017/thg.2014.4
    55 https://doi.org/10.1023/a:1008342116536
    56 https://doi.org/10.1056/nejmoa0909530
    57 https://doi.org/10.1056/nejmra0802714
    58 https://doi.org/10.1086/519795
    59 https://doi.org/10.1093/annonc/mdh319
    60 https://doi.org/10.1093/annonc/mdq207
    61 https://doi.org/10.1093/jjco/hyq071
    62 https://doi.org/10.1097/coc.0b013e3181b9cedc
    63 https://doi.org/10.1097/jto.0b013e3181e7fe2a
    64 https://doi.org/10.1097/jto.0b013e3181ec18c4
    65 https://doi.org/10.1097/jto.0b013e31824fe98c
    66 https://doi.org/10.1128/mcb.00230-06
    67 https://doi.org/10.1146/annurev.ge.29.120195.000441
    68 https://doi.org/10.1158/1055-9965.epi-03-0097
    69 https://doi.org/10.1158/1078-0432.ccr-04-0247
    70 https://doi.org/10.1158/1078-0432.ccr-06-2543
    71 https://doi.org/10.1159/000362222
    72 https://doi.org/10.1160/th13-11-0941
    73 https://doi.org/10.1200/jco.1999.17.1.12
    74 https://doi.org/10.1200/jco.2008.19.1650
    75 https://doi.org/10.1200/jco.2009.23.5622
    76 https://doi.org/10.1200/jco.2010.30.5334
    77 https://doi.org/10.1200/jco.2012.45.3753
    78 https://doi.org/10.1200/jco.2014.59.0489
    79 https://doi.org/10.1371/journal.pone.0033200
    80 https://doi.org/10.1371/journal.pone.0058466
    81 https://doi.org/10.1371/journal.pone.0069553
    82 https://doi.org/10.1371/journal.pone.0089518
    83 https://doi.org/10.1371/journal.pone.0099843
    84 https://doi.org/10.1517/14656566.6.12.2015
    85 https://doi.org/10.21037/tlcr.2016.07.01
    86 https://doi.org/10.2217/pgs.11.27
    87 https://doi.org/10.3109/07357907.2014.1001897
    88 https://doi.org/10.3322/caac.21332
    89 https://doi.org/10.3349/ymj.2013.54.6.1384
    90 https://doi.org/10.3779/j.issn.1009-3419.2010.04.13
    91 https://doi.org/10.3779/j.issn.1009-3419.2011.12.03
    92 https://doi.org/10.3816/clc.2009.n.015
    93 https://doi.org/10.3892/br.2014.282
    94 https://doi.org/10.3892/etm.2012.714
    95 https://doi.org/10.3892/ol.2013.1175
    96 https://doi.org/10.3978/j.issn.2218-6751.2016.01.06
    97 https://doi.org/10.4065/83.5.584
    98 https://doi.org/10.4149/neo_2011_04_348
    99 https://doi.org/10.4238/2014.april.17.6
    100 https://doi.org/10.4238/2014.april.29.9
    101 https://doi.org/10.4238/2014.january.14.2
    102 https://doi.org/10.4238/2014.may.16.1
    103 https://doi.org/10.4238/2014.october.31.14
    104 https://doi.org/10.4238/2015.august.28.19
    105 https://doi.org/10.5603/fhc.2012.0011
    106 https://doi.org/10.5732/cjc.009.10139
    107 https://doi.org/10.6004/jnccn.2016.0031
    108 https://doi.org/10.7314/apjcp.2012.13.9.4413
    109 schema:datePublished 2019-04
    110 schema:datePublishedReg 2019-04-01
    111 schema:description Chemotherapy based on platinum compounds is the standard treatment for NSCLC patients with EGFR wild type, and is also used as second line in mutated EGFR patients. Nevertheless, this therapy presents poor clinical outcomes. ERCC1, ERCC2, XRCC1, MDM2, MTHFR, MTR, and SLC19A1 gene polymorphisms may contribute to individual variation in response and survival to platinum-based chemotherapy. The aim of this study was to investigate the influence of these polymorphisms on response and survival of NSCLC patients treated with platinum-based chemotherapy. A retrospective-prospective cohorts study was conducted, including 141 NSCLC patients. Polymorphisms were analyzed by PCR real-time with Taqman® probes. Patients with ERCC1 rs3212986-GG (p = 0.0268; OR = 2.50; CI<sub>95%</sub> = 1.12-5.69) and XRCC1 rs25487-GG (p = 0.0161; OR = 2.99; CI<sub>95%</sub> = 1.26-7.62) genotype showed significantly better ORR. Cox survival analysis revealed that patients carrying the MDM2 rs1690924-GG genotype (p = 0.0345; HR = 1.99; CI<sub>95%</sub> = 1.05-3.80) presented higher risk of death. Furthermore, carriers of MTR rs1805087-A alleles (p = 0.0060; HR = 8.91; CI<sub>95%</sub> = 1.87-42.42) and SLC19A1 rs1051266-AA genotype (p = 0.0130; HR = 1.74; CI<sub>95%</sub> = 1.12-2.68) showed greater risk of progression. No influence of ERCC1 rs11615, ERCC2 rs13181, ERCC2 rs1799793, XRCC1 rs1799782, MDM2 rs1470383, MTHFR rs1801131, and MTHFR rs1801133 on platinum-based chemotherapy clinical outcomes was found. In conclusion, our results suggest that ERCC1 rs3212986, XRCC1 rs25487, MDM2 rs1690924, MTR rs1805087, and SLC19A1 rs1051266 gene polymorphisms may significantly act as predictive factors in NSCLC patients treated with platinum-based chemotherapy.
    112 schema:genre research_article
    113 schema:inLanguage en
    114 schema:isAccessibleForFree true
    115 schema:isPartOf Nc20a6019a5404d10a122e466aa02c9e5
    116 Nd78de8e0500b48d8ac97bbd6c0a55df4
    117 sg:journal.1027238
    118 schema:name Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer patients
    119 schema:pagination 164-177
    120 schema:productId N037a9a9646b04c0085a57d5be9675dd9
    121 N2ce965e9fb5145ddbfc41636c18dc6a4
    122 N37657247cd2e493fa078127998220f80
    123 N7bde6104f54349e097b8f330c42ab3e3
    124 Nbfae370321604edfb2fcc1f131e228b2
    125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103269102
    126 https://doi.org/10.1038/s41397-018-0014-8
    127 schema:sdDatePublished 2019-04-11T14:33
    128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    129 schema:sdPublisher N4cc3f07c965f43c3892bc5703251414a
    130 schema:url https://www.nature.com/articles/s41397-018-0014-8
    131 sgo:license sg:explorer/license/
    132 sgo:sdDataset articles
    133 rdf:type schema:ScholarlyArticle
    134 N037a9a9646b04c0085a57d5be9675dd9 schema:name nlm_unique_id
    135 schema:value 101083949
    136 rdf:type schema:PropertyValue
    137 N09fae14ac76d4af8aaf159aafb863059 rdf:first sg:person.01234175165.55
    138 rdf:rest N77bcd5fc37954d01866ac4d78c9435ac
    139 N15c8b651a52b46fe89d3839a3f5ae795 rdf:first sg:person.012550114251.16
    140 rdf:rest Na5c91b93b6d64a0aa6693e9894996619
    141 N2ce965e9fb5145ddbfc41636c18dc6a4 schema:name doi
    142 schema:value 10.1038/s41397-018-0014-8
    143 rdf:type schema:PropertyValue
    144 N37657247cd2e493fa078127998220f80 schema:name readcube_id
    145 schema:value 60113e03bb55f81cb740d2c58120ba043ede565374b0dd77c2cc069a8dfb0131
    146 rdf:type schema:PropertyValue
    147 N488ad0ff60c546aab444bdd9259668c8 rdf:first sg:person.011752533651.42
    148 rdf:rest N15c8b651a52b46fe89d3839a3f5ae795
    149 N4cc3f07c965f43c3892bc5703251414a schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 N52b0a18d6e3349afa5785146c5014823 schema:name Pathology Service, UGC Anatomía Patológica, Instituto de Investigación Biosanitaria de Granada Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, 18014, Granada, Spain
    152 rdf:type schema:Organization
    153 N77bcd5fc37954d01866ac4d78c9435ac rdf:first sg:person.015234424727.37
    154 rdf:rest rdf:nil
    155 N7bde6104f54349e097b8f330c42ab3e3 schema:name dimensions_id
    156 schema:value pub.1103269102
    157 rdf:type schema:PropertyValue
    158 Na5c91b93b6d64a0aa6693e9894996619 rdf:first sg:person.01275006034.19
    159 rdf:rest N09fae14ac76d4af8aaf159aafb863059
    160 Nabd74798c6784fdb997788877fcc7c4c rdf:first sg:person.0755220161.35
    161 rdf:rest N488ad0ff60c546aab444bdd9259668c8
    162 Nbfae370321604edfb2fcc1f131e228b2 schema:name pubmed_id
    163 schema:value 29662106
    164 rdf:type schema:PropertyValue
    165 Nc1633f3ba2b14b03b4cfdba8dbd20fd9 rdf:first sg:person.01051633365.85
    166 rdf:rest Nabd74798c6784fdb997788877fcc7c4c
    167 Nc20a6019a5404d10a122e466aa02c9e5 schema:issueNumber 2
    168 rdf:type schema:PublicationIssue
    169 Nd78de8e0500b48d8ac97bbd6c0a55df4 schema:volumeNumber 19
    170 rdf:type schema:PublicationVolume
    171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Medical and Health Sciences
    173 rdf:type schema:DefinedTerm
    174 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    175 schema:name Clinical Sciences
    176 rdf:type schema:DefinedTerm
    177 sg:journal.1027238 schema:issn 1470-269X
    178 1473-1150
    179 schema:name The Pharmacogenomics Journal
    180 rdf:type schema:Periodical
    181 sg:person.01051633365.85 schema:affiliation https://www.grid.ac/institutes/grid.4489.1
    182 schema:familyName Pérez-Ramírez
    183 schema:givenName Cristina
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051633365.85
    185 rdf:type schema:Person
    186 sg:person.011752533651.42 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    187 schema:familyName Alnatsha
    188 schema:givenName Ahmed
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011752533651.42
    190 rdf:type schema:Person
    191 sg:person.01234175165.55 schema:affiliation https://www.grid.ac/institutes/grid.4489.1
    192 schema:familyName Faus-Dáder
    193 schema:givenName María José
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234175165.55
    195 rdf:type schema:Person
    196 sg:person.012550114251.16 schema:affiliation N52b0a18d6e3349afa5785146c5014823
    197 schema:familyName Villar
    198 schema:givenName Eduardo
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012550114251.16
    200 rdf:type schema:Person
    201 sg:person.01275006034.19 schema:affiliation https://www.grid.ac/institutes/grid.459499.c
    202 schema:familyName Valdivia-Bautista
    203 schema:givenName Javier
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275006034.19
    205 rdf:type schema:Person
    206 sg:person.015234424727.37 schema:affiliation https://www.grid.ac/institutes/grid.4489.1
    207 schema:familyName Calleja-Hernández
    208 schema:givenName Miguel Ángel
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015234424727.37
    210 rdf:type schema:Person
    211 sg:person.0755220161.35 schema:affiliation https://www.grid.ac/institutes/grid.4777.3
    212 schema:familyName Cañadas-Garre
    213 schema:givenName Marisa
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755220161.35
    215 rdf:type schema:Person
    216 sg:pub.10.1007/pl00000762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043478916
    217 https://doi.org/10.1007/pl00000762
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/s00280-005-0168-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043959759
    220 https://doi.org/10.1007/s00280-005-0168-3
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/s00280-013-2127-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038689876
    223 https://doi.org/10.1007/s00280-013-2127-8
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/s00280-014-2458-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030799105
    226 https://doi.org/10.1007/s00280-014-2458-0
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/s00280-014-2673-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025954301
    229 https://doi.org/10.1007/s00280-014-2673-8
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s00432-011-1090-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042393806
    232 https://doi.org/10.1007/s00432-011-1090-1
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s12032-010-9443-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011676331
    235 https://doi.org/10.1007/s12032-010-9443-1
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s12032-014-0086-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041031257
    238 https://doi.org/10.1007/s12032-014-0086-5
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s12094-015-1343-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038981786
    241 https://doi.org/10.1007/s12094-015-1343-6
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/s13277-013-1493-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035289119
    244 https://doi.org/10.1007/s13277-013-1493-5
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/s13277-013-1526-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030160132
    247 https://doi.org/10.1007/s13277-013-1526-0
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s13277-014-2033-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041920148
    250 https://doi.org/10.1007/s13277-014-2033-7
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s13277-014-2427-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017855062
    253 https://doi.org/10.1007/s13277-014-2427-6
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/bjc.2013.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024886715
    256 https://doi.org/10.1038/bjc.2013.127
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/sj.bjc.6603830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021806605
    259 https://doi.org/10.1038/sj.bjc.6603830
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/tpj.2014.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037405778
    262 https://doi.org/10.1038/tpj.2014.13
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1385/mo:23:4:489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025333082
    265 https://doi.org/10.1385/mo:23:4:489
    266 rdf:type schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1074962570 schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1074988284 schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1075097685 schema:CreativeWork
    270 https://app.dimensions.ai/details/publication/pub.1076876507 schema:CreativeWork
    271 https://app.dimensions.ai/details/publication/pub.1077276010 schema:CreativeWork
    272 https://app.dimensions.ai/details/publication/pub.1079099174 schema:CreativeWork
    273 https://app.dimensions.ai/details/publication/pub.1079106910 schema:CreativeWork
    274 https://doi.org/10.1002/cncr.26562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049178979
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1002/mc.20819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019269603
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.arcmed.2011.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041250241
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.canlet.2009.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033439641
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.canlet.2014.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031643166
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.cllc.2011.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017649567
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.cllc.2012.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017484322
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.cllc.2015.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009232032
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.cllc.2016.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022390312
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.jss.2009.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029550510
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.lungcan.2003.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008992006
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.lungcan.2006.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024829864
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.lungcan.2008.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016389985
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.lungcan.2009.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041476280
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.lungcan.2009.06.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025319083
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/j.lungcan.2011.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020877509
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/j.lungcan.2012.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031733728
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.lungcan.2013.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048648441
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.lungcan.2016.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028480503
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.phrs.2016.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034060514
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.tibs.2004.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052780384
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s0025-6196(11)60735-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054591557
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/s0027-5107(01)00142-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025058614
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s0092-8674(01)00195-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001250823
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/s1044-579x(02)00099-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014137348
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1017/thg.2014.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049430749
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1023/a:1008342116536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303305
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1056/nejmoa0909530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047104724
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1056/nejmra0802714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002128638
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1093/annonc/mdh319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050592997
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1093/annonc/mdq207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050271265
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1093/jjco/hyq071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005800147
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1097/coc.0b013e3181b9cedc schema:sameAs https://app.dimensions.ai/details/publication/pub.1022222660
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1097/jto.0b013e3181e7fe2a schema:sameAs https://app.dimensions.ai/details/publication/pub.1045811947
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1097/jto.0b013e3181ec18c4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030933806
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1097/jto.0b013e31824fe98c schema:sameAs https://app.dimensions.ai/details/publication/pub.1022007048
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1128/mcb.00230-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040191614
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1146/annurev.ge.29.120195.000441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048462298
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1158/1055-9965.epi-03-0097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052340744
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1158/1078-0432.ccr-04-0247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052294490
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1158/1078-0432.ccr-06-2543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033315392
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1159/000362222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021830983
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1160/th13-11-0941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063293598
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1200/jco.1999.17.1.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074511203
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1200/jco.2008.19.1650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025473968
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1200/jco.2009.23.5622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012862395
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1200/jco.2010.30.5334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005654090
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1200/jco.2012.45.3753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052635973
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1200/jco.2014.59.0489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048114647
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1371/journal.pone.0033200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011582528
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1371/journal.pone.0058466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003240881
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1371/journal.pone.0069553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009902669
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1371/journal.pone.0089518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005080939
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1371/journal.pone.0099843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026059905
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1517/14656566.6.12.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007155231
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.21037/tlcr.2016.07.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068835158
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.2217/pgs.11.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034654616
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.3109/07357907.2014.1001897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037633589
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.3322/caac.21332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032745321
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.3349/ymj.2013.54.6.1384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022846787
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.3779/j.issn.1009-3419.2010.04.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078195736
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.3779/j.issn.1009-3419.2011.12.03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078486064
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.3816/clc.2009.n.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035214133
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.3892/br.2014.282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071502317
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.3892/etm.2012.714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041362992
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.3892/ol.2013.1175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026304480
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.3978/j.issn.2218-6751.2016.01.06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079239474
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.4065/83.5.584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000454522
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.4149/neo_2011_04_348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072262357
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.4238/2014.april.17.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072391995
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.4238/2014.april.29.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072392024
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.4238/2014.january.14.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072392394
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.4238/2014.may.16.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072392783
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.4238/2014.october.31.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072392985
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.4238/2015.august.28.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072393379
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.5603/fhc.2012.0011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073037988
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.5732/cjc.009.10139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073088516
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.6004/jnccn.2016.0031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079239151
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.7314/apjcp.2012.13.9.4413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048865040
    435 rdf:type schema:CreativeWork
    436 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
    437 schema:name Department of Molecular Medicine, Faculty of Medicine, University of Tübingen, Geissweg 5, 72076, Tübingen, Germany
    438 rdf:type schema:Organization
    439 https://www.grid.ac/institutes/grid.4489.1 schema:alternateName University of Granada
    440 schema:name Department of Biochemistry, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071, Granada, Spain
    441 Department of Pharmacology, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071, Granada, Spain
    442 Pharmacogenetics Unit, UGC Provincial de Farmacia de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, Granada, Spain
    443 rdf:type schema:Organization
    444 https://www.grid.ac/institutes/grid.459499.c schema:alternateName Complejo Hospitalario Universitario de Granada
    445 schema:name Medical Oncology Service, UGC Oncología Médica Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, 18014, Granada, Spain
    446 rdf:type schema:Organization
    447 https://www.grid.ac/institutes/grid.4777.3 schema:alternateName Queen's University Belfast
    448 schema:name Centre for Public Health, Nephrology Research Group, Queen’s University Belfast, c/o Regional Genetics Centre, Level A Tower Block Belfast City Hospital Lisburn Road, BT9 7AB, Belfast, UK
    449 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...