Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-13

AUTHORS

Sean M. Kearney, Sean M. Gibbons, Mathilde Poyet, Thomas Gurry, Kevin Bullock, Jessica R. Allegretti, Clary B. Clish, Eric J. Alm

ABSTRACT

Endospore-formers in the human microbiota are well adapted for host-to-host transmission, and an emerging consensus points to their role in determining health and disease states in the gut. The human gut, more than any other environment, encourages the maintenance of endospore formation, with recent culture-based work suggesting that over 50% of genera in the microbiome carry genes attributed to this trait. However, there has been limited work on the ecological role of endospores and other stress-resistant cellular states in the human gut. In fact, there is no data to indicate whether organisms with the genetic potential to form endospores actually form endospores in situ and how sporulation varies across individuals and over time. Here we applied a culture-independent protocol to enrich for endospores and other stress-resistant cells in human feces to identify variation in these states across people and within an individual over time. We see that cells with resistant states are more likely than those without to be shared among multiple individuals, which suggests that these resistant states are particularly adapted for cross-host dissemination. Furthermore, we use untargeted fecal metabolomics in 24 individuals and within a person over time to show that these organisms respond to shared environmental signals, and in particular, dietary fatty acids, that likely mediate colonization of recently disturbed human guts. More... »

PAGES

2403-2416

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41396-018-0192-z

DOI

http://dx.doi.org/10.1038/s41396-018-0192-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104552949

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29899513


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/05", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Environmental Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biodiversity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Microbiome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spores, Bacterial", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA", 
            "The Broad Institute, Cambridge, MA, USA", 
            "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kearney", 
        "givenName": "Sean M.", 
        "id": "sg:person.01135434547.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135434547.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA", 
            "The Broad Institute, Cambridge, MA, USA", 
            "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gibbons", 
        "givenName": "Sean M.", 
        "id": "sg:person.0773016300.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773016300.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA", 
            "The Broad Institute, Cambridge, MA, USA", 
            "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poyet", 
        "givenName": "Mathilde", 
        "id": "sg:person.010365221306.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010365221306.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA", 
            "The Broad Institute, Cambridge, MA, USA", 
            "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gurry", 
        "givenName": "Thomas", 
        "id": "sg:person.0773322652.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773322652.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Broad Institute, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "The Broad Institute, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bullock", 
        "givenName": "Kevin", 
        "id": "sg:person.01250315201.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250315201.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard Medical School, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Gastroenterology, Brigham and Women\u2019s Hospital, Boston, MA, USA", 
            "Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allegretti", 
        "givenName": "Jessica R.", 
        "id": "sg:person.01306337515.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306337515.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Broad Institute, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "The Broad Institute, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clish", 
        "givenName": "Clary B.", 
        "id": "sg:person.0764632420.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA", 
            "The Broad Institute, Cambridge, MA, USA", 
            "The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alm", 
        "givenName": "Eric J.", 
        "id": "sg:person.0622302463.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622302463.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ismej.2012.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053664960", 
          "https://doi.org/10.1038/ismej.2012.158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016631324", 
          "https://doi.org/10.1038/nmeth.3869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021135023", 
          "https://doi.org/10.1038/nature12721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051734110", 
          "https://doi.org/10.1038/ajg.2010.281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021980193", 
          "https://doi.org/10.1038/nature12331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature17645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009705339", 
          "https://doi.org/10.1038/nature17645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6150-4-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025245856", 
          "https://doi.org/10.1186/1745-6150-4-19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2014-15-7-r89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022685985", 
          "https://doi.org/10.1186/gb-2014-15-7-r89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021876780", 
          "https://doi.org/10.1038/nature11225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002139060", 
          "https://doi.org/10.1038/nmeth.2658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/204076a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032553374", 
          "https://doi.org/10.1038/204076a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-06-13", 
    "datePublishedReg": "2018-06-13", 
    "description": "Endospore-formers in the human microbiota are well adapted for host-to-host transmission, and an emerging consensus points to their role in determining health and disease states in the gut. The human gut, more than any other environment, encourages the maintenance of endospore formation, with recent culture-based work suggesting that over 50% of genera in the microbiome carry genes attributed to this trait. However, there has been limited work on the ecological role of endospores and other stress-resistant cellular states in the human gut. In fact, there is no data to indicate whether organisms with the genetic potential to form endospores actually form endospores in situ and how sporulation varies across individuals and over time. Here we applied a culture-independent protocol to enrich for endospores and other stress-resistant cells in human feces to identify variation in these states across people and within an individual over time. We see that cells with resistant states are more likely than those without to be shared among multiple individuals, which suggests that these resistant states are particularly adapted for cross-host dissemination. Furthermore, we use untargeted fecal metabolomics in 24 individuals and within a person over time to show that these organisms respond to shared environmental signals, and in particular, dietary fatty acids, that likely mediate colonization of recently disturbed human guts.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41396-018-0192-z", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438997", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439002", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1038436", 
        "issn": [
          "1751-7362", 
          "1751-7370"
        ], 
        "name": "The ISME Journal: Multidisciplinary Journal of Microbial Ecology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "human gut", 
      "human microbiota", 
      "stress-resistant cells", 
      "carry genes", 
      "ecological role", 
      "endospore formation", 
      "environmental signals", 
      "cellular states", 
      "untargeted fecal metabolomics", 
      "core community", 
      "genetic potential", 
      "host transmission", 
      "endospores", 
      "resistant state", 
      "multiple individuals", 
      "dietary fatty acids", 
      "organisms", 
      "fatty acids", 
      "gut", 
      "disease states", 
      "human feces", 
      "microbiota", 
      "cells", 
      "sporulation", 
      "genus", 
      "genes", 
      "traits", 
      "bacteria", 
      "colonization", 
      "host", 
      "role", 
      "metabolomics", 
      "fecal metabolomics", 
      "maintenance", 
      "individuals", 
      "acid", 
      "community", 
      "variation", 
      "formation", 
      "feces", 
      "signals", 
      "environment", 
      "potential", 
      "consensus points", 
      "situ", 
      "health", 
      "state", 
      "transmission", 
      "time", 
      "persons", 
      "data", 
      "dissemination", 
      "protocol", 
      "work", 
      "fact", 
      "people", 
      "point"
    ], 
    "name": "Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota", 
    "pagination": "2403-2416", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104552949"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41396-018-0192-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29899513"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41396-018-0192-z", 
      "https://app.dimensions.ai/details/publication/pub.1104552949"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_793.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41396-018-0192-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41396-018-0192-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41396-018-0192-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41396-018-0192-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41396-018-0192-z'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      100 URIs      80 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41396-018-0192-z schema:about N02aee4a2baa447b68355d17f6b4a9e44
2 N2db9137eee564fffa3658eb825f06a75
3 N73d9cf702b764e1c8207051097ee375f
4 N746fd359725b4acc9f5988024e56f728
5 N9bed23d1f031457ab100a6fee598cae7
6 Nfffcb80830e442f69636c5e8f2451ed3
7 anzsrc-for:05
8 anzsrc-for:06
9 anzsrc-for:10
10 schema:author N58cb4d1d705f419ab05e944032344afe
11 schema:citation sg:pub.10.1038/204076a0
12 sg:pub.10.1038/ajg.2010.281
13 sg:pub.10.1038/ismej.2012.158
14 sg:pub.10.1038/nature11225
15 sg:pub.10.1038/nature12331
16 sg:pub.10.1038/nature12721
17 sg:pub.10.1038/nature17645
18 sg:pub.10.1038/nmeth.2658
19 sg:pub.10.1038/nmeth.3869
20 sg:pub.10.1186/1745-6150-4-19
21 sg:pub.10.1186/gb-2014-15-7-r89
22 schema:datePublished 2018-06-13
23 schema:datePublishedReg 2018-06-13
24 schema:description Endospore-formers in the human microbiota are well adapted for host-to-host transmission, and an emerging consensus points to their role in determining health and disease states in the gut. The human gut, more than any other environment, encourages the maintenance of endospore formation, with recent culture-based work suggesting that over 50% of genera in the microbiome carry genes attributed to this trait. However, there has been limited work on the ecological role of endospores and other stress-resistant cellular states in the human gut. In fact, there is no data to indicate whether organisms with the genetic potential to form endospores actually form endospores in situ and how sporulation varies across individuals and over time. Here we applied a culture-independent protocol to enrich for endospores and other stress-resistant cells in human feces to identify variation in these states across people and within an individual over time. We see that cells with resistant states are more likely than those without to be shared among multiple individuals, which suggests that these resistant states are particularly adapted for cross-host dissemination. Furthermore, we use untargeted fecal metabolomics in 24 individuals and within a person over time to show that these organisms respond to shared environmental signals, and in particular, dietary fatty acids, that likely mediate colonization of recently disturbed human guts.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N2247317fb1844ac084e9d6d316063205
28 Nf7522f36a68a44b59ab7287b2712b7b6
29 sg:journal.1038436
30 schema:keywords acid
31 bacteria
32 carry genes
33 cells
34 cellular states
35 colonization
36 community
37 consensus points
38 core community
39 data
40 dietary fatty acids
41 disease states
42 dissemination
43 ecological role
44 endospore formation
45 endospores
46 environment
47 environmental signals
48 fact
49 fatty acids
50 fecal metabolomics
51 feces
52 formation
53 genes
54 genetic potential
55 genus
56 gut
57 health
58 host
59 host transmission
60 human feces
61 human gut
62 human microbiota
63 individuals
64 maintenance
65 metabolomics
66 microbiota
67 multiple individuals
68 organisms
69 people
70 persons
71 point
72 potential
73 protocol
74 resistant state
75 role
76 signals
77 situ
78 sporulation
79 state
80 stress-resistant cells
81 time
82 traits
83 transmission
84 untargeted fecal metabolomics
85 variation
86 work
87 schema:name Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota
88 schema:pagination 2403-2416
89 schema:productId N48b0ec2ea2b94eb28301e01c09116e06
90 N9d8631bb903e4b00aef16a7cab99a96e
91 Ndc59e1991b3a416a83263b75dabc1a7f
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104552949
93 https://doi.org/10.1038/s41396-018-0192-z
94 schema:sdDatePublished 2022-10-01T06:45
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N4ccf72012b5a487e88c281fe02cea509
97 schema:url https://doi.org/10.1038/s41396-018-0192-z
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N02aee4a2baa447b68355d17f6b4a9e44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Feces
103 rdf:type schema:DefinedTerm
104 N15329188be8148a987ee2a45591796f4 rdf:first sg:person.0764632420.16
105 rdf:rest N9e005d9f7e0f4036a624e04098b582cb
106 N163b273e78df44b6ac91e7d13ab22409 rdf:first sg:person.0773322652.36
107 rdf:rest Ndb87d39e7afe4f189bbd16bc9c28f91b
108 N2247317fb1844ac084e9d6d316063205 schema:volumeNumber 12
109 rdf:type schema:PublicationVolume
110 N2db9137eee564fffa3658eb825f06a75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Biodiversity
112 rdf:type schema:DefinedTerm
113 N37aaf09edc5842abb4950b448e8047d6 rdf:first sg:person.0773016300.66
114 rdf:rest Nf30bc2198e4b4f3b8ffa36cb046ccbec
115 N48b0ec2ea2b94eb28301e01c09116e06 schema:name pubmed_id
116 schema:value 29899513
117 rdf:type schema:PropertyValue
118 N4ccf72012b5a487e88c281fe02cea509 schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N58cb4d1d705f419ab05e944032344afe rdf:first sg:person.01135434547.66
121 rdf:rest N37aaf09edc5842abb4950b448e8047d6
122 N73d9cf702b764e1c8207051097ee375f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Humans
124 rdf:type schema:DefinedTerm
125 N746fd359725b4acc9f5988024e56f728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Gastrointestinal Microbiome
127 rdf:type schema:DefinedTerm
128 N9af6713332694cf5b78c77135caf5efb rdf:first sg:person.01306337515.02
129 rdf:rest N15329188be8148a987ee2a45591796f4
130 N9bed23d1f031457ab100a6fee598cae7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Spores, Bacterial
132 rdf:type schema:DefinedTerm
133 N9d8631bb903e4b00aef16a7cab99a96e schema:name dimensions_id
134 schema:value pub.1104552949
135 rdf:type schema:PropertyValue
136 N9e005d9f7e0f4036a624e04098b582cb rdf:first sg:person.0622302463.69
137 rdf:rest rdf:nil
138 Ndb87d39e7afe4f189bbd16bc9c28f91b rdf:first sg:person.01250315201.08
139 rdf:rest N9af6713332694cf5b78c77135caf5efb
140 Ndc59e1991b3a416a83263b75dabc1a7f schema:name doi
141 schema:value 10.1038/s41396-018-0192-z
142 rdf:type schema:PropertyValue
143 Nf30bc2198e4b4f3b8ffa36cb046ccbec rdf:first sg:person.010365221306.10
144 rdf:rest N163b273e78df44b6ac91e7d13ab22409
145 Nf7522f36a68a44b59ab7287b2712b7b6 schema:issueNumber 10
146 rdf:type schema:PublicationIssue
147 Nfffcb80830e442f69636c5e8f2451ed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Bacteria
149 rdf:type schema:DefinedTerm
150 anzsrc-for:05 schema:inDefinedTermSet anzsrc-for:
151 schema:name Environmental Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biological Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
157 schema:name Technology
158 rdf:type schema:DefinedTerm
159 sg:grant.2438997 http://pending.schema.org/fundedItem sg:pub.10.1038/s41396-018-0192-z
160 rdf:type schema:MonetaryGrant
161 sg:grant.2439002 http://pending.schema.org/fundedItem sg:pub.10.1038/s41396-018-0192-z
162 rdf:type schema:MonetaryGrant
163 sg:journal.1038436 schema:issn 1751-7362
164 1751-7370
165 schema:name The ISME Journal: Multidisciplinary Journal of Microbial Ecology
166 schema:publisher Springer Nature
167 rdf:type schema:Periodical
168 sg:person.010365221306.10 schema:affiliation grid-institutes:None
169 schema:familyName Poyet
170 schema:givenName Mathilde
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010365221306.10
172 rdf:type schema:Person
173 sg:person.01135434547.66 schema:affiliation grid-institutes:None
174 schema:familyName Kearney
175 schema:givenName Sean M.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135434547.66
177 rdf:type schema:Person
178 sg:person.01250315201.08 schema:affiliation grid-institutes:grid.66859.34
179 schema:familyName Bullock
180 schema:givenName Kevin
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250315201.08
182 rdf:type schema:Person
183 sg:person.01306337515.02 schema:affiliation grid-institutes:grid.38142.3c
184 schema:familyName Allegretti
185 schema:givenName Jessica R.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306337515.02
187 rdf:type schema:Person
188 sg:person.0622302463.69 schema:affiliation grid-institutes:None
189 schema:familyName Alm
190 schema:givenName Eric J.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622302463.69
192 rdf:type schema:Person
193 sg:person.0764632420.16 schema:affiliation grid-institutes:grid.66859.34
194 schema:familyName Clish
195 schema:givenName Clary B.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16
197 rdf:type schema:Person
198 sg:person.0773016300.66 schema:affiliation grid-institutes:None
199 schema:familyName Gibbons
200 schema:givenName Sean M.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773016300.66
202 rdf:type schema:Person
203 sg:person.0773322652.36 schema:affiliation grid-institutes:None
204 schema:familyName Gurry
205 schema:givenName Thomas
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773322652.36
207 rdf:type schema:Person
208 sg:pub.10.1038/204076a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032553374
209 https://doi.org/10.1038/204076a0
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/ajg.2010.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051734110
212 https://doi.org/10.1038/ajg.2010.281
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/ismej.2012.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053664960
215 https://doi.org/10.1038/ismej.2012.158
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/nature11225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021876780
218 https://doi.org/10.1038/nature11225
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/nature12331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021980193
221 https://doi.org/10.1038/nature12331
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nature12721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021135023
224 https://doi.org/10.1038/nature12721
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/nature17645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009705339
227 https://doi.org/10.1038/nature17645
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/nmeth.2658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002139060
230 https://doi.org/10.1038/nmeth.2658
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nmeth.3869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016631324
233 https://doi.org/10.1038/nmeth.3869
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/1745-6150-4-19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025245856
236 https://doi.org/10.1186/1745-6150-4-19
237 rdf:type schema:CreativeWork
238 sg:pub.10.1186/gb-2014-15-7-r89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022685985
239 https://doi.org/10.1186/gb-2014-15-7-r89
240 rdf:type schema:CreativeWork
241 grid-institutes:None schema:alternateName The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA
242 schema:name Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
243 The Broad Institute, Cambridge, MA, USA
244 The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, USA
245 rdf:type schema:Organization
246 grid-institutes:grid.38142.3c schema:alternateName Harvard Medical School, Boston, MA, USA
247 schema:name Division of Gastroenterology, Brigham and Women’s Hospital, Boston, MA, USA
248 Harvard Medical School, Boston, MA, USA
249 rdf:type schema:Organization
250 grid-institutes:grid.66859.34 schema:alternateName The Broad Institute, Cambridge, MA, USA
251 schema:name The Broad Institute, Cambridge, MA, USA
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...