Ontology type: schema:ScholarlyArticle
2019-12
AUTHORSChang Li, Lihong Huang, Wei Sun, Ying Chen, Ming-Liang He, Jianbo Yue, Heather Ballard
ABSTRACTThe dysregulation of autophagy, an evolutionarily conserved lysosomal degradation process, has been implicated in a wide variety of human diseases, and thus, small chemicals that modulate autophagy have therapeutic potential. Here, we assessed the ability of active components isolated from Bupleurum falcatum, a popular Chinese herb, to modulate autophagy. We found that saikosaponin D (SsD) and A (SsA) but not C (SsC) potently and reversibly inhibited the fusion of autophagosomes and lysosomes, resulting in the accumulation of autophagosomes, an increased lysosomal pH, and TFEB nuclear translocation. RAB5A knockdown or the expression of a dominant-negative RAB5 mutant significantly reduced the ability of SsD or SsA to block autophagy. Enterovirus A71 (EV-A71), the cause of hand-foot-mouth disease, has been shown to induce autophagy. We found that SsD potently inhibited EV-A71 RNA replication and subsequent viral protein synthesis, thereby preventing EV-A71-induced cell death. ATG5 knockdown inhibited EV-A71 viral protein synthesis, whereas autophagy induction by rapamycin promoted synthesis. Taken together, our data indicate that SsD and SsA are potent late-stage autophagy inhibitors that can be used to prevent EV-A71 infection. More... »
PAGES4
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"type": "PropertyValue",
"value": [
"101676423"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41392-019-0037-x"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112285927"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41392-019-0037-x",
"https://app.dimensions.ai/details/publication/pub.1112285927"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:22",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11734_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41392-019-0037-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41392-019-0037-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41392-019-0037-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41392-019-0037-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41392-019-0037-x'
This table displays all metadata directly associated to this object as RDF triples.
312 TRIPLES
21 PREDICATES
90 URIs
21 LITERALS
9 BLANK NODES