MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-25

AUTHORS

Nicholas G. Nickols, Ramin Nazarian, Shuang G. Zhao, Victor Tan, Vladislav Uzunangelov, Zheng Xia, Robert Baertsch, Elad Neeman, Allen C. Gao, George V. Thomas, Lauren Howard, Amanda M. De Hoedt, Josh Stuart, Theodore Goldstein, Kim Chi, Martin E. Gleave, Julie N. Graff, Tomasz M. Beer, Justin M. Drake, Christopher P. Evans, Rahul Aggarwal, Adam Foye, Felix Y. Feng, Eric J. Small, William J. Aronson, Stephen J. Freedland, Owen N. Witte, Jiaoti Huang, Joshi J. Alumkal, Robert E. Reiter, Matthew B. Rettig

ABSTRACT

BACKGROUND: Metastatic castration resistant prostate cancer (mCRPC) is incurable and progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there is an urgent need to develop more effective treatments beyond hormonal manipulation. We sought to identify activated kinases in mCRPC as therapeutic targets for existing, approved agents, with the goal of identifying candidate drugs for rapid translation into proof of concept Phase II trials in mCRPC. METHODS: To identify evidence of activation of druggable kinases in these patients, we compared mRNA expression from metastatic biopsies of patients with mCRPC (n = 101) to mRNA expression in localized prostate from TCGA and used this analysis to infer differential kinase activity. In addition, we assessed the differential phosphorylation levels for key MAPK pathway kinases between mCRPC and localized prostate cancers. RESULTS: Transcriptomic profiling of 101 patients with mCRPC as compared to patients with localized prostate cancer identified evidence of hyperactive ERK1, and whole genome sequencing revealed frequent amplifications of members of the MAPK pathway in 32% of this cohort. Next, we confirmed elevated levels of phosphorylated ERK1/2 in castration resistant prostate cancer as compared to untreated primary prostate cancer. We observed that the presence of detectable phosphorylated ERK1/2 in the primary tumor is associated with biochemical failure after radical prostatectomy independent of clinicopathologic features. ERK1 is the immediate downstream target of MEK1/2, which is druggable with trametinib, an approved therapeutic for melanoma. Trametinib elicited a profound biochemical and clinical response in a patient who had failed multiple prior treatments for mCRPC. CONCLUSIONS: We conclude that pharmacologic targeting of the MEK/ERK pathway may be a viable treatment strategy for patients with refractory metastatic prostate cancer. An ongoing Phase II trial tests this hypothesis. More... »

PAGES

1-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41391-019-0134-5

DOI

http://dx.doi.org/10.1038/s41391-019-0134-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112364872

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30804427


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Radiation Oncology, VA Greater Los Angeles Healthcare System, 90073, Los Angeles, CA, USA", 
            "Department of Radiation Oncology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA", 
            "Department of Urology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nickols", 
        "givenName": "Nicholas G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Division of Dermatology/Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nazarian", 
        "givenName": "Ramin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Shuang G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutgers University", 
          "id": "https://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Department of Medicine, Division of Medical Oncology, Rutgers Robert Wood Johnson Medical School, 08854, Piscatway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "Victor", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Santa Cruz", 
          "id": "https://www.grid.ac/institutes/grid.205975.c", 
          "name": [
            "Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, 95064, Santa Cruz, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uzunangelov", 
        "givenName": "Vladislav", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Molecular Microbiology & Immunology, Computational Biology Program, Oregon Health and Science University, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xia", 
        "givenName": "Zheng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Santa Cruz", 
          "id": "https://www.grid.ac/institutes/grid.205975.c", 
          "name": [
            "Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, 95064, Santa Cruz, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baertsch", 
        "givenName": "Robert", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Division of Hematology-Oncology/Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neeman", 
        "givenName": "Elad", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Department of Urology, School of Medicine, University of California Davis, 95817, Sacramento, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Allen C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Oregon Health and Science University, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "George V.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Biostatistics and Bioinformatics, Duke University School of Medicine, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Howard", 
        "givenName": "Lauren", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Durham VA Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410332.7", 
          "name": [
            "Division of Urology, Durham Veterans Affairs Medical Center, 27705, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Hoedt", 
        "givenName": "Amanda M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Santa Cruz", 
          "id": "https://www.grid.ac/institutes/grid.205975.c", 
          "name": [
            "Department of Biomolecular Engineering, University of California Santa Cruz, 95064, Santa Cruz, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stuart", 
        "givenName": "Josh", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldstein", 
        "givenName": "Theodore", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, BC V6T 1Z3, Vancouver, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chi", 
        "givenName": "Kim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, BC V6T 1Z3, Vancouver, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gleave", 
        "givenName": "Martin E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "VA Portland Health Care System, Portland and Knight Cancer Institute, Oregon Health and Science University, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graff", 
        "givenName": "Julie N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Medicine, Oregon Health and Science University, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beer", 
        "givenName": "Tomasz M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutgers University", 
          "id": "https://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Department of Medicine, Division of Medical Oncology, Rutgers Robert Wood Johnson Medical School, 08854, Piscatway, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drake", 
        "givenName": "Justin M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Department of Urology, School of Medicine, University of California Davis, 95817, Sacramento, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evans", 
        "givenName": "Christopher P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aggarwal", 
        "givenName": "Rahul", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foye", 
        "givenName": "Adam", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Radiation Oncology, University of California San Francisco, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Felix Y.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Small", 
        "givenName": "Eric J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA Greater Los Angeles Healthcare System", 
          "id": "https://www.grid.ac/institutes/grid.417119.b", 
          "name": [
            "Department of Urology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA", 
            "Division of Urology, VA Greater Los Angeles Healthcare System, 90073, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aronson", 
        "givenName": "William J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cedars-Sinai Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.50956.3f", 
          "name": [
            "Division of Urology, Durham Veterans Affairs Medical Center, 27705, Durham, NC, USA", 
            "Division of Urology, Cedars-Sinai Medical Center, 90048, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Freedland", 
        "givenName": "Stephen J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Witte", 
        "givenName": "Owen N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Pathology, School of Medicine, Duke University, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Jiaoti", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Medicine, Oregon Health and Science University, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alumkal", 
        "givenName": "Joshi J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Urology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reiter", 
        "givenName": "Robert E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA Greater Los Angeles Healthcare System", 
          "id": "https://www.grid.ac/institutes/grid.417119.b", 
          "name": [
            "Department of Urology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA", 
            "Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA", 
            "Department of Medicine, VA Greater Los Angeles Healthcare System, 90073, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rettig", 
        "givenName": "Matthew B.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2015.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001625886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001625886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328361feb0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002136202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e328361feb0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002136202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002569885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.14049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002671346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2008.08327.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006573530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006916541", 
          "https://doi.org/10.1038/nature08902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006916541", 
          "https://doi.org/10.1038/nature08902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2011.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007622253", 
          "https://doi.org/10.1038/bjc.2011.163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci76094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010679452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012432963", 
          "https://doi.org/10.1038/nrd4281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013706518", 
          "https://doi.org/10.1038/sj.onc.1210422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70479-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027103739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70479-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027103739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2010.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028349062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1521674112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033465046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-011-9722-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034871441", 
          "https://doi.org/10.1007/s10637-011-9722-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.17546311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037473452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.65.5597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043319884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2011.367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044043489", 
          "https://doi.org/10.1038/bjc.2011.367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fcell.2016.00053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046671172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1120985109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047743019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048415365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048541781", 
          "https://doi.org/10.1038/ng.3593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052183344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052183344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.11.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187152009789735080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069218318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083382559", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2017.02.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085398516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2017.02.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085398516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2017.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092181091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2017.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092181091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-17-0580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092479210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-018-0578-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101350382", 
          "https://doi.org/10.1007/s10637-018-0578-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-018-0578-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101350382", 
          "https://doi.org/10.1007/s10637-018-0578-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-018-0578-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101350382", 
          "https://doi.org/10.1007/s10637-018-0578-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-018-0578-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101350382", 
          "https://doi.org/10.1007/s10637-018-0578-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-018-0578-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101350382", 
          "https://doi.org/10.1007/s10637-018-0578-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-018-0578-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101350382", 
          "https://doi.org/10.1007/s10637-018-0578-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.77.6880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105496598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105710388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105710388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105710388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105710388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105710388"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-25", 
    "datePublishedReg": "2019-02-25", 
    "description": "BACKGROUND: Metastatic castration resistant prostate cancer (mCRPC) is incurable and progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there is an urgent need to develop more effective treatments beyond hormonal manipulation. We sought to identify activated kinases in mCRPC as therapeutic targets for existing, approved agents, with the goal of identifying candidate drugs for rapid translation into proof of concept Phase II trials in mCRPC.\nMETHODS: To identify evidence of activation of druggable kinases in these patients, we compared mRNA expression from metastatic biopsies of patients with mCRPC (n\u2009=\u2009101) to mRNA expression in localized prostate from TCGA and used this analysis to infer differential kinase activity. In addition, we assessed the differential phosphorylation levels for key MAPK pathway kinases between mCRPC and localized prostate cancers.\nRESULTS: Transcriptomic profiling of 101 patients with mCRPC as compared to patients with localized prostate cancer identified evidence of hyperactive ERK1, and whole genome sequencing revealed frequent amplifications of members of the MAPK pathway in 32% of this cohort. Next, we confirmed elevated levels of phosphorylated ERK1/2 in castration resistant prostate cancer as compared to untreated primary prostate cancer. We observed that the presence of detectable phosphorylated ERK1/2 in the primary tumor is associated with biochemical failure after radical prostatectomy independent of clinicopathologic features. ERK1 is the immediate downstream target of MEK1/2, which is druggable with trametinib, an approved therapeutic for melanoma. Trametinib elicited a profound biochemical and clinical response in a patient who had failed multiple prior treatments for mCRPC.\nCONCLUSIONS: We conclude that pharmacologic targeting of the MEK/ERK pathway may be a viable treatment strategy for patients with refractory metastatic prostate cancer. An ongoing Phase II trial tests this hypothesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41391-019-0134-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7570212", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1119336", 
        "issn": [
          "1365-7852", 
          "1476-5608"
        ], 
        "name": "Prostate Cancer and Prostatic Diseases", 
        "type": "Periodical"
      }
    ], 
    "name": "MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer", 
    "pagination": "1-8", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41391-019-0134-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112364872"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8e24b962cc92e28c2e58352d00828557f79de57c2154e0fb3f9e8a7da8c864e5"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9815755"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30804427"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41391-019-0134-5", 
      "https://app.dimensions.ai/details/publication/pub.1112364872"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106813_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41391-019-0134-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41391-019-0134-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41391-019-0134-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41391-019-0134-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41391-019-0134-5'


 

This table displays all metadata directly associated to this object as RDF triples.

392 TRIPLES      21 PREDICATES      57 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41391-019-0134-5 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N1fa47ec7042f478c83de8db8fd8fe600
4 schema:citation sg:pub.10.1007/s10637-011-9722-5
5 sg:pub.10.1007/s10637-018-0578-9
6 sg:pub.10.1038/bjc.2011.163
7 sg:pub.10.1038/bjc.2011.367
8 sg:pub.10.1038/nature08902
9 sg:pub.10.1038/ng.3593
10 sg:pub.10.1038/nrd4281
11 sg:pub.10.1038/sj.onc.1210422
12 https://app.dimensions.ai/details/publication/pub.1083382559
13 https://doi.org/10.1016/j.ccell.2017.09.003
14 https://doi.org/10.1016/j.ccr.2010.05.026
15 https://doi.org/10.1016/j.ccr.2011.04.008
16 https://doi.org/10.1016/j.cell.2015.05.001
17 https://doi.org/10.1016/j.cell.2016.07.007
18 https://doi.org/10.1016/j.cell.2018.06.039
19 https://doi.org/10.1016/j.ejca.2017.02.030
20 https://doi.org/10.1016/s1470-2045(13)70479-0
21 https://doi.org/10.1073/pnas.1120985109
22 https://doi.org/10.1073/pnas.1521674112
23 https://doi.org/10.1097/cad.0b013e328361feb0
24 https://doi.org/10.1101/gad.17546311
25 https://doi.org/10.1111/j.1464-410x.2008.08327.x
26 https://doi.org/10.1158/0008-5472.can-11-3132
27 https://doi.org/10.1158/0008-5472.can-17-0580
28 https://doi.org/10.1172/jci76094
29 https://doi.org/10.1200/jco.2003.11.069
30 https://doi.org/10.1200/jco.2015.65.5597
31 https://doi.org/10.1200/jco.2017.77.6880
32 https://doi.org/10.18632/oncotarget.14049
33 https://doi.org/10.2174/187152009789735080
34 https://doi.org/10.3389/fcell.2016.00053
35 schema:datePublished 2019-02-25
36 schema:datePublishedReg 2019-02-25
37 schema:description BACKGROUND: Metastatic castration resistant prostate cancer (mCRPC) is incurable and progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there is an urgent need to develop more effective treatments beyond hormonal manipulation. We sought to identify activated kinases in mCRPC as therapeutic targets for existing, approved agents, with the goal of identifying candidate drugs for rapid translation into proof of concept Phase II trials in mCRPC. METHODS: To identify evidence of activation of druggable kinases in these patients, we compared mRNA expression from metastatic biopsies of patients with mCRPC (n = 101) to mRNA expression in localized prostate from TCGA and used this analysis to infer differential kinase activity. In addition, we assessed the differential phosphorylation levels for key MAPK pathway kinases between mCRPC and localized prostate cancers. RESULTS: Transcriptomic profiling of 101 patients with mCRPC as compared to patients with localized prostate cancer identified evidence of hyperactive ERK1, and whole genome sequencing revealed frequent amplifications of members of the MAPK pathway in 32% of this cohort. Next, we confirmed elevated levels of phosphorylated ERK1/2 in castration resistant prostate cancer as compared to untreated primary prostate cancer. We observed that the presence of detectable phosphorylated ERK1/2 in the primary tumor is associated with biochemical failure after radical prostatectomy independent of clinicopathologic features. ERK1 is the immediate downstream target of MEK1/2, which is druggable with trametinib, an approved therapeutic for melanoma. Trametinib elicited a profound biochemical and clinical response in a patient who had failed multiple prior treatments for mCRPC. CONCLUSIONS: We conclude that pharmacologic targeting of the MEK/ERK pathway may be a viable treatment strategy for patients with refractory metastatic prostate cancer. An ongoing Phase II trial tests this hypothesis.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree false
41 schema:isPartOf sg:journal.1119336
42 schema:name MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer
43 schema:pagination 1-8
44 schema:productId N573b3094bb504bbab70a11542f292fc5
45 N782448e4572e46468fbef40436b4af0e
46 Na071ef306f5a42e8bc7c9e3adad01755
47 Nadb3bc6f812d481f8eac7492c071e6cd
48 Nbac9b37af5c54bfd93006f7cce81d8ca
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112364872
50 https://doi.org/10.1038/s41391-019-0134-5
51 schema:sdDatePublished 2019-04-16T06:22
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N80bd0b3dc4a3444d8788372b6f4b09f3
54 schema:url https://www.nature.com/articles/s41391-019-0134-5
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N0967eba6014e4ba79b14add1678e9d2d schema:affiliation https://www.grid.ac/institutes/grid.266102.1
59 schema:familyName Foye
60 schema:givenName Adam
61 rdf:type schema:Person
62 N0d0c91038dc24bd79be346117b5ab964 rdf:first N7a185465d255421188e221815ee7d0d4
63 rdf:rest N54f5e6c5ac1346e9adfc534668e855df
64 N14b42ecbd43a4877832f810f080d6429 schema:affiliation https://www.grid.ac/institutes/grid.205975.c
65 schema:familyName Stuart
66 schema:givenName Josh
67 rdf:type schema:Person
68 N15f130606ce941f68c7cfc65d9109216 schema:affiliation https://www.grid.ac/institutes/grid.205975.c
69 schema:familyName Baertsch
70 schema:givenName Robert
71 rdf:type schema:Person
72 N1da0756893bc42368b1d185bbe419717 rdf:first N89814807843c48c8b70f461e97ad1fd4
73 rdf:rest Nfb01a53c6df5486b9e7a23eb6d058218
74 N1f3bbaea3816467ea2ffd79c06d7d562 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
75 schema:familyName Small
76 schema:givenName Eric J.
77 rdf:type schema:Person
78 N1fa47ec7042f478c83de8db8fd8fe600 rdf:first N4d08ce491d164104ae1f9e564a212761
79 rdf:rest N55debaeda7254a108de8d304c4a01e88
80 N21cfadcd8ea341d2a1c5604017e35939 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
81 schema:familyName Drake
82 schema:givenName Justin M.
83 rdf:type schema:Person
84 N23c53fb47a2c43bb93643fe2aea5089f schema:affiliation https://www.grid.ac/institutes/grid.5288.7
85 schema:familyName Alumkal
86 schema:givenName Joshi J.
87 rdf:type schema:Person
88 N26e532a01f5a40349418ab6140a994f2 rdf:first N417591af268246d38b3868b1c04b8c18
89 rdf:rest Nebedff96ef594f98a86e1f09188a240f
90 N38d87394a0fb4c0c86b5d9cd5ca752c4 rdf:first Nc6fabfd08a194194bee0af54fb186f55
91 rdf:rest Na220d2ad842f4389b2d21ffbbb04aa2c
92 N3948bfb6f87f4ba7a2e864d89a8c839e schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
93 schema:familyName Gao
94 schema:givenName Allen C.
95 rdf:type schema:Person
96 N3a4a8233b5514605b05735f758b5e28a rdf:first Nf14def0e4467499da284743bedaa601e
97 rdf:rest N6963f1d71e7045089c216b42a38644e7
98 N400c27332675414a988a84f78dda56f2 rdf:first N0967eba6014e4ba79b14add1678e9d2d
99 rdf:rest N5dcb85bb84a649d38a843bab5ef3306c
100 N417591af268246d38b3868b1c04b8c18 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
101 schema:familyName Beer
102 schema:givenName Tomasz M.
103 rdf:type schema:Person
104 N41b9dd71b8f14dd0967acee94340cb95 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
105 schema:familyName Feng
106 schema:givenName Felix Y.
107 rdf:type schema:Person
108 N4d08ce491d164104ae1f9e564a212761 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
109 schema:familyName Nickols
110 schema:givenName Nicholas G.
111 rdf:type schema:Person
112 N54f5e6c5ac1346e9adfc534668e855df rdf:first N801476856c924042b465735292f0b309
113 rdf:rest N3a4a8233b5514605b05735f758b5e28a
114 N55debaeda7254a108de8d304c4a01e88 rdf:first N56b42b7aaf454f1094f9b60c8896cc5b
115 rdf:rest N1da0756893bc42368b1d185bbe419717
116 N56b42b7aaf454f1094f9b60c8896cc5b schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
117 schema:familyName Nazarian
118 schema:givenName Ramin
119 rdf:type schema:Person
120 N573b3094bb504bbab70a11542f292fc5 schema:name dimensions_id
121 schema:value pub.1112364872
122 rdf:type schema:PropertyValue
123 N5dcb85bb84a649d38a843bab5ef3306c rdf:first N41b9dd71b8f14dd0967acee94340cb95
124 rdf:rest N858aabc3ab574bc6a683e56987a64104
125 N630c308dea7f46369e18731ff0b94265 rdf:first Nc1f5e81a71e94f52814bb67b4c25a640
126 rdf:rest Nd4674db64cb94282b892af31a4efa995
127 N6963f1d71e7045089c216b42a38644e7 rdf:first N7172e88619734e6fb26eb0bcf8e6f306
128 rdf:rest N26e532a01f5a40349418ab6140a994f2
129 N697d624c637d4fa3b9d7b4e24b539bc3 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
130 schema:familyName Witte
131 schema:givenName Owen N.
132 rdf:type schema:Person
133 N6e162b89cb21453bbe6bb00fc526686e schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
134 schema:familyName Neeman
135 schema:givenName Elad
136 rdf:type schema:Person
137 N6f9b0c7af62f4116bd500720b43f4992 schema:affiliation https://www.grid.ac/institutes/grid.410332.7
138 schema:familyName De Hoedt
139 schema:givenName Amanda M.
140 rdf:type schema:Person
141 N7172e88619734e6fb26eb0bcf8e6f306 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
142 schema:familyName Graff
143 schema:givenName Julie N.
144 rdf:type schema:Person
145 N7282022f708840f39c31bc71372bb49f schema:affiliation https://www.grid.ac/institutes/grid.50956.3f
146 schema:familyName Freedland
147 schema:givenName Stephen J.
148 rdf:type schema:Person
149 N782448e4572e46468fbef40436b4af0e schema:name doi
150 schema:value 10.1038/s41391-019-0134-5
151 rdf:type schema:PropertyValue
152 N7a185465d255421188e221815ee7d0d4 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
153 schema:familyName Goldstein
154 schema:givenName Theodore
155 rdf:type schema:Person
156 N7bc7621fe6204e3fab02fd2ddace13a6 schema:affiliation https://www.grid.ac/institutes/grid.417119.b
157 schema:familyName Aronson
158 schema:givenName William J.
159 rdf:type schema:Person
160 N7cce7be4702d4e0d813789ff8205fbde schema:affiliation https://www.grid.ac/institutes/grid.430387.b
161 schema:familyName Tan
162 schema:givenName Victor
163 rdf:type schema:Person
164 N801476856c924042b465735292f0b309 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
165 schema:familyName Chi
166 schema:givenName Kim
167 rdf:type schema:Person
168 N80bd0b3dc4a3444d8788372b6f4b09f3 schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 N858aabc3ab574bc6a683e56987a64104 rdf:first N1f3bbaea3816467ea2ffd79c06d7d562
171 rdf:rest Ncd3f442a498646be837fd9a7448a8e93
172 N88bdbd70f315407b8f33441ec216356e schema:affiliation https://www.grid.ac/institutes/grid.205975.c
173 schema:familyName Uzunangelov
174 schema:givenName Vladislav
175 rdf:type schema:Person
176 N89814807843c48c8b70f461e97ad1fd4 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
177 schema:familyName Zhao
178 schema:givenName Shuang G.
179 rdf:type schema:Person
180 N937e8c61657741059ece3420c59fd41f rdf:first N7282022f708840f39c31bc71372bb49f
181 rdf:rest Ned766646c7a747c6b9265ca1b1720918
182 N950389451a384846a22603496c161aae schema:affiliation https://www.grid.ac/institutes/grid.417119.b
183 schema:familyName Rettig
184 schema:givenName Matthew B.
185 rdf:type schema:Person
186 Na071ef306f5a42e8bc7c9e3adad01755 schema:name readcube_id
187 schema:value 8e24b962cc92e28c2e58352d00828557f79de57c2154e0fb3f9e8a7da8c864e5
188 rdf:type schema:PropertyValue
189 Na220d2ad842f4389b2d21ffbbb04aa2c rdf:first N15f130606ce941f68c7cfc65d9109216
190 rdf:rest Nf8c7b642ad4e4a2bbf4b48fb3bc03433
191 Na45f6d7162fb47198c7b88cc25e0f85a rdf:first Naec4723c21e94683bdf7c425d37b271d
192 rdf:rest N400c27332675414a988a84f78dda56f2
193 Na6f1ef4a1f22454c9b54a4c9adc73191 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
194 schema:familyName Evans
195 schema:givenName Christopher P.
196 rdf:type schema:Person
197 Na7c51acf80be44c2a39a97ceca6f2cd6 rdf:first N950389451a384846a22603496c161aae
198 rdf:rest rdf:nil
199 Nac86d1e9344045b09ec60f5bcd493f6a rdf:first N6f9b0c7af62f4116bd500720b43f4992
200 rdf:rest Nf6118676bc7a4c45ab8955cdc42d1a57
201 Nadb3bc6f812d481f8eac7492c071e6cd schema:name pubmed_id
202 schema:value 30804427
203 rdf:type schema:PropertyValue
204 Naec4723c21e94683bdf7c425d37b271d schema:affiliation https://www.grid.ac/institutes/grid.266102.1
205 schema:familyName Aggarwal
206 schema:givenName Rahul
207 rdf:type schema:Person
208 Nb5ed468aaab543d694ed5cd867e4902c schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
209 schema:familyName Reiter
210 schema:givenName Robert E.
211 rdf:type schema:Person
212 Nbac9b37af5c54bfd93006f7cce81d8ca schema:name nlm_unique_id
213 schema:value 9815755
214 rdf:type schema:PropertyValue
215 Nbe47eaf5144c4825bf9b7a98e7753cf5 rdf:first N88bdbd70f315407b8f33441ec216356e
216 rdf:rest N38d87394a0fb4c0c86b5d9cd5ca752c4
217 Nc1f5e81a71e94f52814bb67b4c25a640 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
218 schema:familyName Huang
219 schema:givenName Jiaoti
220 rdf:type schema:Person
221 Nc6fabfd08a194194bee0af54fb186f55 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
222 schema:familyName Xia
223 schema:givenName Zheng
224 rdf:type schema:Person
225 Nc925e69980d7442da8f3c6e90ac62e05 rdf:first N3948bfb6f87f4ba7a2e864d89a8c839e
226 rdf:rest Nd8755ff15ad6418684124742ef480943
227 Ncd3f442a498646be837fd9a7448a8e93 rdf:first N7bc7621fe6204e3fab02fd2ddace13a6
228 rdf:rest N937e8c61657741059ece3420c59fd41f
229 Nd18d315e878d473ab4db3e31031e8e83 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
230 schema:familyName Howard
231 schema:givenName Lauren
232 rdf:type schema:Person
233 Nd4674db64cb94282b892af31a4efa995 rdf:first N23c53fb47a2c43bb93643fe2aea5089f
234 rdf:rest Neee0959691c649b68557a6e38a823519
235 Nd5a81336bda34b499d78c6941ad83998 rdf:first Nd18d315e878d473ab4db3e31031e8e83
236 rdf:rest Nac86d1e9344045b09ec60f5bcd493f6a
237 Nd8755ff15ad6418684124742ef480943 rdf:first Nf2b5b82cb57b437cbfc8b6ce7b53e626
238 rdf:rest Nd5a81336bda34b499d78c6941ad83998
239 Nebedff96ef594f98a86e1f09188a240f rdf:first N21cfadcd8ea341d2a1c5604017e35939
240 rdf:rest Nf37f604bd78347cf94151c754e2f0f0d
241 Ned766646c7a747c6b9265ca1b1720918 rdf:first N697d624c637d4fa3b9d7b4e24b539bc3
242 rdf:rest N630c308dea7f46369e18731ff0b94265
243 Neee0959691c649b68557a6e38a823519 rdf:first Nb5ed468aaab543d694ed5cd867e4902c
244 rdf:rest Na7c51acf80be44c2a39a97ceca6f2cd6
245 Nf14def0e4467499da284743bedaa601e schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
246 schema:familyName Gleave
247 schema:givenName Martin E.
248 rdf:type schema:Person
249 Nf2b5b82cb57b437cbfc8b6ce7b53e626 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
250 schema:familyName Thomas
251 schema:givenName George V.
252 rdf:type schema:Person
253 Nf37f604bd78347cf94151c754e2f0f0d rdf:first Na6f1ef4a1f22454c9b54a4c9adc73191
254 rdf:rest Na45f6d7162fb47198c7b88cc25e0f85a
255 Nf6118676bc7a4c45ab8955cdc42d1a57 rdf:first N14b42ecbd43a4877832f810f080d6429
256 rdf:rest N0d0c91038dc24bd79be346117b5ab964
257 Nf8c7b642ad4e4a2bbf4b48fb3bc03433 rdf:first N6e162b89cb21453bbe6bb00fc526686e
258 rdf:rest Nc925e69980d7442da8f3c6e90ac62e05
259 Nfb01a53c6df5486b9e7a23eb6d058218 rdf:first N7cce7be4702d4e0d813789ff8205fbde
260 rdf:rest Nbe47eaf5144c4825bf9b7a98e7753cf5
261 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
262 schema:name Medical and Health Sciences
263 rdf:type schema:DefinedTerm
264 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
265 schema:name Oncology and Carcinogenesis
266 rdf:type schema:DefinedTerm
267 sg:grant.7570212 http://pending.schema.org/fundedItem sg:pub.10.1038/s41391-019-0134-5
268 rdf:type schema:MonetaryGrant
269 sg:journal.1119336 schema:issn 1365-7852
270 1476-5608
271 schema:name Prostate Cancer and Prostatic Diseases
272 rdf:type schema:Periodical
273 sg:pub.10.1007/s10637-011-9722-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034871441
274 https://doi.org/10.1007/s10637-011-9722-5
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s10637-018-0578-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101350382
277 https://doi.org/10.1007/s10637-018-0578-9
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/bjc.2011.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007622253
280 https://doi.org/10.1038/bjc.2011.163
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/bjc.2011.367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044043489
283 https://doi.org/10.1038/bjc.2011.367
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nature08902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006916541
286 https://doi.org/10.1038/nature08902
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/ng.3593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048541781
289 https://doi.org/10.1038/ng.3593
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nrd4281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012432963
292 https://doi.org/10.1038/nrd4281
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/sj.onc.1210422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013706518
295 https://doi.org/10.1038/sj.onc.1210422
296 rdf:type schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1083382559 schema:CreativeWork
298 https://doi.org/10.1016/j.ccell.2017.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092181091
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.ccr.2010.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028349062
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.ccr.2011.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002569885
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.cell.2015.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001625886
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.cell.2016.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052183344
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.cell.2018.06.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105710388
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ejca.2017.02.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085398516
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s1470-2045(13)70479-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027103739
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1073/pnas.1120985109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047743019
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1073/pnas.1521674112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033465046
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1097/cad.0b013e328361feb0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002136202
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1101/gad.17546311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037473452
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1111/j.1464-410x.2008.08327.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006573530
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1158/0008-5472.can-11-3132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048415365
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/0008-5472.can-17-0580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092479210
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1172/jci76094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010679452
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1200/jco.2003.11.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203957
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1200/jco.2015.65.5597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043319884
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1200/jco.2017.77.6880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105496598
335 rdf:type schema:CreativeWork
336 https://doi.org/10.18632/oncotarget.14049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002671346
337 rdf:type schema:CreativeWork
338 https://doi.org/10.2174/187152009789735080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069218318
339 rdf:type schema:CreativeWork
340 https://doi.org/10.3389/fcell.2016.00053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046671172
341 rdf:type schema:CreativeWork
342 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
343 schema:name Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, BC V6T 1Z3, Vancouver, Canada
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
346 schema:name Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA
347 Department of Radiation Oncology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA
348 Department of Radiation Oncology, VA Greater Los Angeles Healthcare System, 90073, Los Angeles, CA, USA
349 Department of Urology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA
350 Division of Dermatology/Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA
351 Division of Hematology-Oncology/Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA
352 rdf:type schema:Organization
353 https://www.grid.ac/institutes/grid.205975.c schema:alternateName University of California, Santa Cruz
354 schema:name Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, 95064, Santa Cruz, CA, USA
355 Department of Biomolecular Engineering, University of California Santa Cruz, 95064, Santa Cruz, CA, USA
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
358 schema:name Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
361 schema:name Department of Biostatistics and Bioinformatics, Duke University School of Medicine, 27710, Durham, NC, USA
362 Department of Pathology, School of Medicine, Duke University, 27710, Durham, NC, USA
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
365 schema:name Department of Radiation Oncology, University of California San Francisco, 94143, San Francisco, CA, USA
366 Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, 94143, San Francisco, CA, USA
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
369 schema:name Department of Urology, School of Medicine, University of California Davis, 95817, Sacramento, CA, USA
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.410332.7 schema:alternateName Durham VA Medical Center
372 schema:name Division of Urology, Durham Veterans Affairs Medical Center, 27705, Durham, NC, USA
373 rdf:type schema:Organization
374 https://www.grid.ac/institutes/grid.417119.b schema:alternateName VA Greater Los Angeles Healthcare System
375 schema:name Department of Medicine, VA Greater Los Angeles Healthcare System, 90073, Los Angeles, CA, USA
376 Department of Urology, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA
377 Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, Los Angeles, CA, USA
378 Division of Urology, VA Greater Los Angeles Healthcare System, 90073, Los Angeles, CA, USA
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.430387.b schema:alternateName Rutgers University
381 schema:name Department of Medicine, Division of Medical Oncology, Rutgers Robert Wood Johnson Medical School, 08854, Piscatway, NJ, USA
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.50956.3f schema:alternateName Cedars-Sinai Medical Center
384 schema:name Division of Urology, Cedars-Sinai Medical Center, 90048, Los Angeles, CA, USA
385 Division of Urology, Durham Veterans Affairs Medical Center, 27705, Durham, NC, USA
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.5288.7 schema:alternateName Oregon Health & Science University
388 schema:name Department of Medicine, Oregon Health and Science University, 97239, Portland, OR, USA
389 Department of Molecular Microbiology & Immunology, Computational Biology Program, Oregon Health and Science University, 97239, Portland, OR, USA
390 Department of Pathology and Laboratory Medicine, Oregon Health and Science University, 97239, Portland, OR, USA
391 VA Portland Health Care System, Portland and Knight Cancer Institute, Oregon Health and Science University, 97239, Portland, OR, USA
392 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...