Ontology type: schema:ScholarlyArticle
2019-03
AUTHORSTim M. Govers, Daphne Hessels, Virginie Vlaeminck-Guillem, Bernd J. Schmitz-Dräger, Christian G. Stief, Claudio Martinez-Ballesteros, Matteo Ferro, Angel Borque-Fernando, Jose Rubio-Briones, J. P. Michiel Sedelaar, Wim van Criekinge, Jack A. Schalken
ABSTRACTBACKGROUND: Low specificity of prostate-specific antigen results in a considerable number of unnecessary prostate biopsies in current practice. SelectMDx® predicts significant prostate cancer upon biopsy and is used to reduce the number of unnecessary initial prostate biopsies. Furthermore, potential overtreatment of insignificant prostate cancer can be reduced. Besides the diagnostic accuracy of the test, also the context in a specific country determines the potential health benefit and cost-effectiveness. Therefore, the health benefit and cost-effectiveness of SelectMDx were assessed in France, Germany, Italy, and Spain. SUBJECT AND METHODS: A decision model was used to compare the current standard of care in which men undergo initial prostate biopsy in case of an elevated prostate-specific antigen, to a strategy in which SelectMDx was used to select men for biopsy. Model inputs most relevant to each of the four countries were obtained. With use of the model long-term quality-adjusted life years (QALYs) and healthcare costs were calculated for both strategies. RESULTS: In all four countries, the SelectMDx resulted in QALY gain and cost savings compared with the current standard of care. In France, SelectMDx resulted in 0.022 QALYs gained and cost savings of €1217 per patient. For Germany, the model showed a QALY gain of 0.016 and a cost saving of €442. In Italy, the QALY gain and cost savings were 0.031 and €762. In Spain 0.020 QALYs were gained and €250 costs were saved. CONCLUSIONS: The results of the model showed that with SelectMDx, QALYs could be gained while saving healthcare costs in the initial diagnosis of prostate cancer. The significant presence of overtreatment in the current standard of care in all four countries was the main factor that resulted in the beneficial outcomes with SelectMDx. More... »
PAGES101-109
http://scigraph.springernature.com/pub.10.1038/s41391-018-0076-3
DOIhttp://dx.doi.org/10.1038/s41391-018-0076-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1106250560
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30127462
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biopsy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Clinical Decision-Making",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cost-Benefit Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Decision Trees",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Europe",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "France",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Germany",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Italy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Statistical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prostatic Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Public Health Surveillance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quality of Life",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quality-Adjusted Life Years",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sensitivity and Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spain",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"MedValue, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Govers",
"givenName": "Tim M.",
"id": "sg:person.01012410703.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012410703.40"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"MDxHealth BV, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Hessels",
"givenName": "Daphne",
"id": "sg:person.01136456165.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136456165.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospices Civils de Lyon",
"id": "https://www.grid.ac/institutes/grid.413852.9",
"name": [
"Medical Unit of Molecular Oncology and Transfer, Department of Biochemistry and Molecular Biology, University Hospital of Lyon-Sud, Hospices Civils of Lyon, Lyon, France",
"Cancer Research Centre of Lyon, U1052 INSERM, CNRS 5286, L\u00e9on B\u00e9rard Centre, Lyon I University, Lyon, France"
],
"type": "Organization"
},
"familyName": "Vlaeminck-Guillem",
"givenName": "Virginie",
"id": "sg:person.0642635567.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642635567.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Erlangen-Nuremberg",
"id": "https://www.grid.ac/institutes/grid.5330.5",
"name": [
"BSD: Urologie24, Nuremberg and Dept. of Urology, Friedrich-Alexander University, Erlangen, Germany"
],
"type": "Organization"
},
"familyName": "Schmitz-Dr\u00e4ger",
"givenName": "Bernd J.",
"id": "sg:person.0761212356.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761212356.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Maximilian University of Munich",
"id": "https://www.grid.ac/institutes/grid.5252.0",
"name": [
"Department of Urology, Ludwig Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"
],
"type": "Organization"
},
"familyName": "Stief",
"givenName": "Christian G.",
"id": "sg:person.010164650137.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010164650137.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital Universitario Puerta de Hierro Majadahonda",
"id": "https://www.grid.ac/institutes/grid.73221.35",
"name": [
"Urology department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Martinez-Ballesteros",
"givenName": "Claudio",
"id": "sg:person.0614364161.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614364161.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "European Institute of Oncology",
"id": "https://www.grid.ac/institutes/grid.15667.33",
"name": [
"Division of Urology, European Institute of Oncology, Milan, Italy"
],
"type": "Organization"
},
"familyName": "Ferro",
"givenName": "Matteo",
"id": "sg:person.01145773223.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145773223.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital Universitario Miguel Servet",
"id": "https://www.grid.ac/institutes/grid.411106.3",
"name": [
"Department of Urology, Hospital Universitatio Miguel Servet, IIS-Arag\u00f3n, Zaragoza, Spain"
],
"type": "Organization"
},
"familyName": "Borque-Fernando",
"givenName": "Angel",
"id": "sg:person.01372404637.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372404637.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fundaci\u00f3n Instituto Valenciano de Oncolog\u00eda",
"id": "https://www.grid.ac/institutes/grid.418082.7",
"name": [
"Department of Urology, Fundaci\u00f3n instituto Valenciano, de oncolog\u00eda, Valencia, Spain"
],
"type": "Organization"
},
"familyName": "Rubio-Briones",
"givenName": "Jose",
"id": "sg:person.01062032457.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062032457.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Urology, Radboudumc, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Sedelaar",
"givenName": "J. P. Michiel",
"id": "sg:person.01305232241.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305232241.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ghent University",
"id": "https://www.grid.ac/institutes/grid.5342.0",
"name": [
"Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium"
],
"type": "Organization"
},
"familyName": "van Criekinge",
"givenName": "Wim",
"id": "sg:person.01035674133.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035674133.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Urology, Radboudumc, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Schalken",
"givenName": "Jack A.",
"id": "sg:person.0703572542.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703572542.91"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1136/bmjopen-2014-006674",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002537462"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1201637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005348698"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2016.04.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007969242"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrurol.2016.45",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012770436",
"https://doi.org/10.1038/nrurol.2016.45"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1606220",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020137376"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.pcan.4500963",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020290983",
"https://doi.org/10.1038/sj.pcan.4500963"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.pcan.4500963",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020290983",
"https://doi.org/10.1038/sj.pcan.4500963"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1311593",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020594922"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djp001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031887748"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1541-0420.2007.00825.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034224306"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2005.08.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035855791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2005.08.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035855791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199104253241702",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045536165"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2014.10.028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049428267"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2016.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050492283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.juro.2012.11.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052564063"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.juro.2012.11.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052564063"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/009286150103500122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063722894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/009286150103500122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063722894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/bju.13861",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084210827"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-03",
"datePublishedReg": "2019-03-01",
"description": "BACKGROUND: Low specificity of prostate-specific antigen results in a considerable number of unnecessary prostate biopsies in current practice. SelectMDx\u00ae predicts significant prostate cancer upon biopsy and is used to reduce the number of unnecessary initial prostate biopsies. Furthermore, potential overtreatment of insignificant prostate cancer can be reduced. Besides the diagnostic accuracy of the test, also the context in a specific country determines the potential health benefit and cost-effectiveness. Therefore, the health benefit and cost-effectiveness of SelectMDx were assessed in France, Germany, Italy, and Spain.\nSUBJECT AND METHODS: A decision model was used to compare the current standard of care in which men undergo initial prostate biopsy in case of an elevated prostate-specific antigen, to a strategy in which SelectMDx was used to select men for biopsy. Model inputs most relevant to each of the four countries were obtained. With use of the model long-term quality-adjusted life years (QALYs) and healthcare costs were calculated for both strategies.\nRESULTS: In all four countries, the SelectMDx resulted in QALY gain and cost savings compared with the current standard of care. In France, SelectMDx resulted in 0.022 QALYs gained and cost savings of \u20ac1217 per patient. For Germany, the model showed a QALY gain of 0.016 and a cost saving of \u20ac442. In Italy, the QALY gain and cost savings were 0.031 and \u20ac762. In Spain 0.020 QALYs were gained and \u20ac250 costs were saved.\nCONCLUSIONS: The results of the model showed that with SelectMDx, QALYs could be gained while saving healthcare costs in the initial diagnosis of prostate cancer. The significant presence of overtreatment in the current standard of care in all four countries was the main factor that resulted in the beneficial outcomes with SelectMDx.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41391-018-0076-3",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1119336",
"issn": [
"1365-7852",
"1476-5608"
],
"name": "Prostate Cancer and Prostatic Diseases",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "22"
}
],
"name": "Cost-effectiveness of SelectMDx for prostate cancer in four European countries: a comparative modeling study",
"pagination": "101-109",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"339e05e32d9a6fddd176c903b3bc0b428eb29225615be5f3c7c25b08d790a823"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30127462"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9815755"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41391-018-0076-3"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1106250560"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41391-018-0076-3",
"https://app.dimensions.ai/details/publication/pub.1106250560"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29204_00000003.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41391-018-0076-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41391-018-0076-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41391-018-0076-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41391-018-0076-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41391-018-0076-3'
This table displays all metadata directly associated to this object as RDF triples.
297 TRIPLES
21 PREDICATES
63 URIs
39 LITERALS
27 BLANK NODES