Persistent organic pollutants in pregnant women potentially affect child development and thyroid hormone status View Full Text


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Article Info

DATE

2021-04-06

AUTHORS

Anna A. Krönke, Anne Jurkutat, Maike Schlingmann, Tanja Poulain, Matthias Nüchter, Anja Hilbert, Hannu Kiviranta, Antje Körner, Mandy Vogel, Olle Söder, Carl G. Bornehag, Wieland Kiess

ABSTRACT

BackgroundPotentially harmful effects of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) on prenatal development and the endocrine system have been controversially discussed.MethodsWorking with a German cohort of 324 pregnant women, we assessed POP levels and used robust linear regression models to determine potential associations between maternal POP concentrations and pre- and postnatal development in the children, as well as the thyroid hormone status of the mother and child.ResultsMaternal p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) and most measured PCBs positively correlated with postnatal weight gain. We detected no correlation between newborn birth weight and head circumference, respectively, and maternal PCB and p,p′-DDE serum levels, while body length at birth was negatively associated with the maternal serum concentration of PCB 183. Maternal p,p′-DDE and nearly all PCB serum levels showed a negative correlation with maternal free triiodothyronine (FT3). p,p′-DDE and PCB 74 and 118 were negatively associated with maternal thyroid-stimulating hormone levels. In addition, we identified significant associations between maternal POP levels and thyroid hormone parameters of the child.ConclusionsThese results indicate that POP exposure likely affects different aspects of pre- and postnatal development and impacts the thyroid hormone status of both mother and child.ImpactPregnant women in a German cohort display a substantial accumulation of POPs.Body mass index and age influence maternal serum POP levels.Maternal POP levels show correlations with the child’s length at birth and weight gain, and FT3 levels in the mother and child.Our data provide additional evidence for the potentially harmful influence of POPs.Our data indicate that POPs influence pre- and postnatal development. More... »

PAGES

690-698

References to SciGraph publications

  • 2017-03-30. Cytophysiological Changes in the Follicular Epithelium of the Thyroid Gland after Long-Term Exposure to Low Doses of Dichlorodiphenyltrichloroethane (DDT) in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • 2018-03-27. Life cycle of PCBs and contamination of the environment and of food products from animal origin in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2009-05-12. Environmental Fate and Global Distribution of Polychlorinated Biphenyls in REVIEWS OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY VOL 201
  • 2017-04-21. Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013 in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2017-04-26. Endokrine Modulatoren in BUNDESGESUNDHEITSBLATT - GESUNDHEITSFORSCHUNG - GESUNDHEITSSCHUTZ
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41390-021-01488-5

    DOI

    http://dx.doi.org/10.1038/s41390-021-01488-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1136952770

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33824444


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    27 schema:description BackgroundPotentially harmful effects of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) on prenatal development and the endocrine system have been controversially discussed.MethodsWorking with a German cohort of 324 pregnant women, we assessed POP levels and used robust linear regression models to determine potential associations between maternal POP concentrations and pre- and postnatal development in the children, as well as the thyroid hormone status of the mother and child.ResultsMaternal p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) and most measured PCBs positively correlated with postnatal weight gain. We detected no correlation between newborn birth weight and head circumference, respectively, and maternal PCB and p,p′-DDE serum levels, while body length at birth was negatively associated with the maternal serum concentration of PCB 183. Maternal p,p′-DDE and nearly all PCB serum levels showed a negative correlation with maternal free triiodothyronine (FT3). p,p′-DDE and PCB 74 and 118 were negatively associated with maternal thyroid-stimulating hormone levels. In addition, we identified significant associations between maternal POP levels and thyroid hormone parameters of the child.ConclusionsThese results indicate that POP exposure likely affects different aspects of pre- and postnatal development and impacts the thyroid hormone status of both mother and child.ImpactPregnant women in a German cohort display a substantial accumulation of POPs.Body mass index and age influence maternal serum POP levels.Maternal POP levels show correlations with the child’s length at birth and weight gain, and FT3 levels in the mother and child.Our data provide additional evidence for the potentially harmful influence of POPs.Our data indicate that POPs influence pre- and postnatal development.
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    35 FT3 levels
    36 German cohort
    37 PCB 74
    38 PCB serum levels
    39 PCB-183
    40 PCBs
    41 POP concentrations
    42 POP exposure
    43 POP levels
    44 accumulation
    45 addition
    46 additional evidence
    47 aspects
    48 association
    49 biphenyls
    50 birth
    51 birth weight
    52 body length
    53 body mass index
    54 child development
    55 child length
    56 children
    57 circumference
    58 cohort
    59 concentration
    60 correlation
    61 data
    62 development
    63 dichlorodiphenyltrichloroethane
    64 different aspects
    65 effect
    66 endocrine system
    67 evidence
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    69 free triiodothyronine
    70 gain
    71 harmful effects
    72 harmful influence
    73 head circumference
    74 hormone levels
    75 hormone parameters
    76 hormone status
    77 index
    78 influence
    79 length
    80 levels
    81 linear regression models
    82 mass index
    83 maternal PCB
    84 maternal serum concentrations
    85 model
    86 mothers
    87 negative correlation
    88 newborn birth weight
    89 organic pollutants
    90 p'-DDE
    91 p'-DDE serum levels
    92 p'-dichlorodiphenyldichloroethylene
    93 parameters
    94 persistent organic pollutants
    95 pollutants
    96 postnatal development
    97 postnatal weight gain
    98 potential association
    99 pregnant women
    100 prenatal development
    101 regression models
    102 results
    103 robust linear regression models
    104 serum POP levels
    105 serum concentrations
    106 serum levels
    107 significant association
    108 status
    109 substantial accumulation
    110 system
    111 thyroid hormone parameters
    112 thyroid hormone status
    113 thyroid-stimulating hormone levels
    114 triiodothyronine
    115 weight
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    117 women
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