Recommendations for the design of therapeutic trials for neonatal seizures View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-24

AUTHORS

Janet S Soul, Ronit Pressler, Marilee Allen, Geraldine Boylan, Heike Rabe, Ron Portman, Pollyanna Hardy, Sarah Zohar, Klaus Romero, Brian Tseng, Varsha Bhatt-Mehta, Cecil Hahn, Scott Denne, Stephane Auvin, Alexander Vinks, John Lantos, Neil Marlow, Jonathan M Davis

ABSTRACT

Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality and neurodevelopmental disability, treatment is largely guided by physician preference and tradition, due to a lack of data from well-designed clinical trials. There is increasing interest in conducting trials of novel drugs to treat neonatal seizures, but the unique characteristics of this disorder and patient population require special consideration with regard to trial design. The Critical Path Institute formed a global working group of experts and key stakeholders from academia, the pharmaceutical industry, regulatory agencies, neonatal nurse associations, and patient advocacy groups to develop consensus recommendations for design of clinical trials to treat neonatal seizures. The broad expertize and perspectives of this group were invaluable in developing recommendations addressing: (1) use of neonate-specific adaptive trial designs, (2) inclusion/exclusion criteria, (3) stratification and randomization, (4) statistical analysis, (5) safety monitoring, and (6) definitions of important outcomes. The guidelines are based on available literature and expert consensus, pharmacokinetic analyses, ethical considerations, and parental concerns. These recommendations will ultimately facilitate development of a Master Protocol and design of efficient and successful drug trials to improve the treatment and outcome for this highly vulnerable population. More... »

PAGES

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41390-018-0242-2

DOI

http://dx.doi.org/10.1038/s41390-018-0242-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110881510

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30584262


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Boston Children's Hospital & Harvard Medical School, Boston, MA, USA. Janet.Soul@childrens.harvard.edu."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soul", 
        "givenName": "Janet S", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "UCL Great Ormond Street Institute of Child Health, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pressler", 
        "givenName": "Ronit", 
        "id": "sg:person.0702164431.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702164431.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "John Hopkins, Baltimore, Maryland, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allen", 
        "givenName": "Marilee", 
        "id": "sg:person.01034026263.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034026263.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Cork", 
          "id": "https://www.grid.ac/institutes/grid.7872.a", 
          "name": [
            "University College Cork, Cork, Ireland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boylan", 
        "givenName": "Geraldine", 
        "id": "sg:person.01142126754.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142126754.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brighton and Sussex Medical School", 
          "id": "https://www.grid.ac/institutes/grid.414601.6", 
          "name": [
            "Brighton and Sussex Medical School, Brighton, England."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rabe", 
        "givenName": "Heike", 
        "id": "sg:person.01150547264.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150547264.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Pharma Corp, Basel, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Portman", 
        "givenName": "Ron", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "University of Birmingham, Birmingham, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hardy", 
        "givenName": "Pollyanna", 
        "id": "sg:person.01142543270.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142543270.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French Institute of Health and Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "INSERM, UMRS1138, University Paris V and University Paris VI, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zohar", 
        "givenName": "Sarah", 
        "id": "sg:person.01207514343.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207514343.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Critical Path Institute", 
          "id": "https://www.grid.ac/institutes/grid.417621.7", 
          "name": [
            "Critical Path Institute, Tucson, Arizona, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero", 
        "givenName": "Klaus", 
        "id": "sg:person.01301125541.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301125541.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Pharma Corp, Basel, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tseng", 
        "givenName": "Brian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "C. S. Mott Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413177.7", 
          "name": [
            "C.S.Mott Children's Hospital, University of Michigan, Ann Arbor, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhatt-Mehta", 
        "givenName": "Varsha", 
        "id": "sg:person.01137007012.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137007012.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Division of Neurology, The Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hahn", 
        "givenName": "Cecil", 
        "id": "sg:person.01125545204.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125545204.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Riley Children's Hospital, Indiana University, Indianapolis, Indiana, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Denne", 
        "givenName": "Scott", 
        "id": "sg:person.0754551230.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754551230.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Robert Debr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.413235.2", 
          "name": [
            "Pediatric neurology department & INSERM U1141, APHP, Robert Debr\u00e9 University Hospital, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auvin", 
        "givenName": "Stephane", 
        "id": "sg:person.01157744314.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157744314.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cincinnati", 
          "id": "https://www.grid.ac/institutes/grid.24827.3b", 
          "name": [
            "College of Medicine & Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vinks", 
        "givenName": "Alexander", 
        "id": "sg:person.01160662243.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160662243.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Mercy Hospital", 
          "id": "https://www.grid.ac/institutes/grid.239559.1", 
          "name": [
            "Children's Mercy Hospital, Kansas City, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lantos", 
        "givenName": "John", 
        "id": "sg:person.014072047055.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014072047055.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "UCL Institute for Women's Health, University College London, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marlow", 
        "givenName": "Neil", 
        "id": "sg:person.0623610604.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623610604.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Floating Hospital for Children", 
          "id": "https://www.grid.ac/institutes/grid.415195.d", 
          "name": [
            "The Floating Hospital for Children at Tufts Medical Center and the Tufts Clinical and Translational Science Institute, Boston, MA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davis", 
        "givenName": "Jonathan M", 
        "id": "sg:person.01312320123.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312320123.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pediatrneurol.2008.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000145683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2013-4060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001590858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2013-4060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001590858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yebeh.2010.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004736216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0165693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006095175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(99)70374-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007085917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2016.05.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010567868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmcps050929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011349386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmcps050929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011349386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnp.0b013e31823e96d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012161948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnp.0b013e31823e96d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012161948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.siny.2013.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012785894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181d4ff4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013165272", 
          "https://doi.org/10.1203/pdr.0b013e3181d4ff4d"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181d4ff4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013165272", 
          "https://doi.org/10.1203/pdr.0b013e3181d4ff4d"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/fn.86.3.f165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014792534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2006.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015134263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annemergmed.2003.09.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016217828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.siny.2013.11.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016252301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jme.2005.013722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016260420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jme.2005.013722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016260420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016438011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(14)70303-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016470168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/archdischild-2014-306191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017034947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199908123410704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018161217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08989620802194392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019167619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pcc.0b013e31825bbbc2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022781352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pcc.0b013e31825bbbc2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022781352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.siny.2013.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024103722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.earlhumdev.2012.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029754078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.222550499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030292720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-200110000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033171697", 
          "https://doi.org/10.1203/00006450-200110000-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pcl.2012.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035706967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/adc.2005.086314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036237243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acn3.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038297313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040541070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2016.221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041063310", 
          "https://doi.org/10.1038/pr.2016.221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jclinepi.2013.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044380287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2009.01659.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044651579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2009.01659.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044651579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13023-016-0464-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045472021", 
          "https://doi.org/10.1186/s13023-016-0464-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13023-016-0464-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045472021", 
          "https://doi.org/10.1186/s13023-016-0464-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jpn-2009-0271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046084241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2014-3777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048192702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2016.03.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050586423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2016.03.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050586423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40262-012-0004-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051637529", 
          "https://doi.org/10.1007/s40262-012-0004-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40262-012-0004-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051637529", 
          "https://doi.org/10.1007/s40262-012-0004-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000430767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053132733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dmcn.12724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053148485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0962280216671348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053886036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0962280216671348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053886036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883073808321056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063854734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883073808321056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063854734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883073810384263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063855044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883073810384263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063855044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883073812470734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063855401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883073812470734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063855401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.31.9.1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064364068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.12.jns111970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.12.jns111970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.12.jns111970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.12.jns111970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.12.jns111970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.12.jns111970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071077480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078179074", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078179257", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5863/1551-6776-17.1.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078642466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14767058.2017.1304536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084166257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1510062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090361612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.siny.2017.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091213537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2017.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092084679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/rssc.12289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104093651"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12-24", 
    "datePublishedReg": "2018-12-24", 
    "description": "Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality and neurodevelopmental disability, treatment is largely guided by physician preference and tradition, due to a lack of data from well-designed clinical trials. There is increasing interest in conducting trials of novel drugs to treat neonatal seizures, but the unique characteristics of this disorder and patient population require special consideration with regard to trial design. The Critical Path Institute formed a global working group of experts and key stakeholders from academia, the pharmaceutical industry, regulatory agencies, neonatal nurse associations, and patient advocacy groups to develop consensus recommendations for design of clinical trials to treat neonatal seizures. The broad expertize and perspectives of this group were invaluable in developing recommendations addressing: (1) use of neonate-specific adaptive trial designs, (2) inclusion/exclusion criteria, (3) stratification and randomization, (4) statistical analysis, (5) safety monitoring, and (6) definitions of important outcomes. The guidelines are based on available literature and expert consensus, pharmacokinetic analyses, ethical considerations, and parental concerns. These recommendations will ultimately facilitate development of a Master Protocol and design of efficient and successful drug trials to improve the treatment and outcome for this highly vulnerable population.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41390-018-0242-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "type": "Periodical"
      }
    ], 
    "name": "Recommendations for the design of therapeutic trials for neonatal seizures", 
    "pagination": "1", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3212acafeab0281921927055b0bbcea9041d11760623290b158e2b10285b4694"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30584262"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0100714"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41390-018-0242-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110881510"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41390-018-0242-2", 
      "https://app.dimensions.ai/details/publication/pub.1110881510"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000309_0000000309/records_106253_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41390-018-0242-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41390-018-0242-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41390-018-0242-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41390-018-0242-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41390-018-0242-2'


 

This table displays all metadata directly associated to this object as RDF triples.

387 TRIPLES      21 PREDICATES      79 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41390-018-0242-2 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nc1b3813c3e90409eb4bd4b61e3d889a5
4 schema:citation sg:pub.10.1007/s40262-012-0004-y
5 sg:pub.10.1038/pr.2016.221
6 sg:pub.10.1186/s13023-016-0464-5
7 sg:pub.10.1203/00006450-200110000-00005
8 sg:pub.10.1203/pdr.0b013e3181d4ff4d
9 https://app.dimensions.ai/details/publication/pub.1078179074
10 https://app.dimensions.ai/details/publication/pub.1078179257
11 https://doi.org/10.1002/acn3.249
12 https://doi.org/10.1016/j.annemergmed.2003.09.016
13 https://doi.org/10.1016/j.brainres.2016.05.040
14 https://doi.org/10.1016/j.clinthera.2006.09.008
15 https://doi.org/10.1016/j.clinthera.2017.09.006
16 https://doi.org/10.1016/j.earlhumdev.2012.12.002
17 https://doi.org/10.1016/j.jclinepi.2013.02.015
18 https://doi.org/10.1016/j.jpeds.2016.03.035
19 https://doi.org/10.1016/j.pcl.2012.07.007
20 https://doi.org/10.1016/j.pediatrneurol.2008.04.008
21 https://doi.org/10.1016/j.siny.2013.01.002
22 https://doi.org/10.1016/j.siny.2013.04.005
23 https://doi.org/10.1016/j.siny.2013.11.015
24 https://doi.org/10.1016/j.siny.2017.07.008
25 https://doi.org/10.1016/j.yebeh.2010.12.011
26 https://doi.org/10.1016/s0022-3476(99)70374-4
27 https://doi.org/10.1016/s1474-4422(14)70303-5
28 https://doi.org/10.1056/nejm199908123410704
29 https://doi.org/10.1056/nejmcps050929
30 https://doi.org/10.1056/nejmra1510062
31 https://doi.org/10.1073/pnas.222550499
32 https://doi.org/10.1080/08989620802194392
33 https://doi.org/10.1080/14767058.2017.1304536
34 https://doi.org/10.1097/pcc.0b013e31825bbbc2
35 https://doi.org/10.1097/wnp.0b013e31823e96d7
36 https://doi.org/10.1111/bcp.12467
37 https://doi.org/10.1111/bcp.12753
38 https://doi.org/10.1111/dmcn.12724
39 https://doi.org/10.1111/j.1651-2227.2009.01659.x
40 https://doi.org/10.1111/rssc.12289
41 https://doi.org/10.1136/adc.2005.086314
42 https://doi.org/10.1136/archdischild-2014-306191
43 https://doi.org/10.1136/fn.86.3.f165
44 https://doi.org/10.1136/jme.2005.013722
45 https://doi.org/10.1159/000430767
46 https://doi.org/10.1177/0883073808321056
47 https://doi.org/10.1177/0883073810384263
48 https://doi.org/10.1177/0883073812470734
49 https://doi.org/10.1177/0962280216671348
50 https://doi.org/10.1212/wnl.31.9.1107
51 https://doi.org/10.1371/journal.pone.0165693
52 https://doi.org/10.1542/peds.2013-4060
53 https://doi.org/10.1542/peds.2014-3777
54 https://doi.org/10.3171/2012.12.jns111970
55 https://doi.org/10.3233/jpn-2009-0271
56 https://doi.org/10.5863/1551-6776-17.1.31
57 schema:datePublished 2018-12-24
58 schema:datePublishedReg 2018-12-24
59 schema:description Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality and neurodevelopmental disability, treatment is largely guided by physician preference and tradition, due to a lack of data from well-designed clinical trials. There is increasing interest in conducting trials of novel drugs to treat neonatal seizures, but the unique characteristics of this disorder and patient population require special consideration with regard to trial design. The Critical Path Institute formed a global working group of experts and key stakeholders from academia, the pharmaceutical industry, regulatory agencies, neonatal nurse associations, and patient advocacy groups to develop consensus recommendations for design of clinical trials to treat neonatal seizures. The broad expertize and perspectives of this group were invaluable in developing recommendations addressing: (1) use of neonate-specific adaptive trial designs, (2) inclusion/exclusion criteria, (3) stratification and randomization, (4) statistical analysis, (5) safety monitoring, and (6) definitions of important outcomes. The guidelines are based on available literature and expert consensus, pharmacokinetic analyses, ethical considerations, and parental concerns. These recommendations will ultimately facilitate development of a Master Protocol and design of efficient and successful drug trials to improve the treatment and outcome for this highly vulnerable population.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf sg:journal.1007352
64 schema:name Recommendations for the design of therapeutic trials for neonatal seizures
65 schema:pagination 1
66 schema:productId N41af87e4488a44d2a2091dbf55837e9a
67 Na1e3e530a1734a9998b2652cd23a58bd
68 Ne627170a3259418abfed3545417a8e9e
69 Nf5e0995893274374a9527d64f66f89a4
70 Nfb7cf299df874f168ae30417b0bca487
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110881510
72 https://doi.org/10.1038/s41390-018-0242-2
73 schema:sdDatePublished 2019-04-11T08:29
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N16b349237034407ea718e7ddef1b31ec
76 schema:url https://www.nature.com/articles/s41390-018-0242-2
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0642e0930ee245efb72553128ce55aae rdf:first sg:person.01034026263.68
81 rdf:rest N3786286257ca4a5f889318ef50495c3a
82 N07eeac81ad14427ea7b1faa4a501783a rdf:first sg:person.0702164431.11
83 rdf:rest N0642e0930ee245efb72553128ce55aae
84 N0a32c11bfe6e455c98063d822ac30dbf rdf:first sg:person.01125545204.13
85 rdf:rest N3ac5092290644357b79fb025a8e49fc6
86 N14877c883d7848fa9ac155d7328dbf9a rdf:first N2bef1d53e4ef4c0c85ec8f3b4d57cc5b
87 rdf:rest N77f63fa811d1447d806de2a8c8fbd66d
88 N16b349237034407ea718e7ddef1b31ec schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N1dcd49455b544da0baa09cf7091a5f3a rdf:first sg:person.014072047055.95
91 rdf:rest N8ed8488e7bc34c1b8a0a460cc1d9b47d
92 N1f010576f1e74e61a4df6317880dd058 rdf:first sg:person.01207514343.96
93 rdf:rest N23e552318b8a4e7999c19c8a6d68e908
94 N23e552318b8a4e7999c19c8a6d68e908 rdf:first sg:person.01301125541.46
95 rdf:rest N3fbb081a03e44416b440eb0fec81ec69
96 N24331d29e574404dbc622126e310f764 rdf:first sg:person.01150547264.44
97 rdf:rest N14877c883d7848fa9ac155d7328dbf9a
98 N2bef1d53e4ef4c0c85ec8f3b4d57cc5b schema:affiliation https://www.grid.ac/institutes/grid.419481.1
99 schema:familyName Portman
100 schema:givenName Ron
101 rdf:type schema:Person
102 N3786286257ca4a5f889318ef50495c3a rdf:first sg:person.01142126754.66
103 rdf:rest N24331d29e574404dbc622126e310f764
104 N3ac5092290644357b79fb025a8e49fc6 rdf:first sg:person.0754551230.67
105 rdf:rest Na8e4f0478c0d4db9a7100eed8c964ca3
106 N3fbb081a03e44416b440eb0fec81ec69 rdf:first N456c74b964c44397a5bf5e6ec7b793b9
107 rdf:rest Nf11d389b73a249828fa132a39aee1926
108 N41af87e4488a44d2a2091dbf55837e9a schema:name pubmed_id
109 schema:value 30584262
110 rdf:type schema:PropertyValue
111 N456c74b964c44397a5bf5e6ec7b793b9 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
112 schema:familyName Tseng
113 schema:givenName Brian
114 rdf:type schema:Person
115 N77f63fa811d1447d806de2a8c8fbd66d rdf:first sg:person.01142543270.75
116 rdf:rest N1f010576f1e74e61a4df6317880dd058
117 N7a948f1c38574bbb944dba0ad1af031d schema:affiliation https://www.grid.ac/institutes/grid.2515.3
118 schema:familyName Soul
119 schema:givenName Janet S
120 rdf:type schema:Person
121 N8eb4445c74fc4f8d8520fe3ad0431485 rdf:first sg:person.01312320123.01
122 rdf:rest rdf:nil
123 N8ed8488e7bc34c1b8a0a460cc1d9b47d rdf:first sg:person.0623610604.17
124 rdf:rest N8eb4445c74fc4f8d8520fe3ad0431485
125 Na1e3e530a1734a9998b2652cd23a58bd schema:name readcube_id
126 schema:value 3212acafeab0281921927055b0bbcea9041d11760623290b158e2b10285b4694
127 rdf:type schema:PropertyValue
128 Na8e4f0478c0d4db9a7100eed8c964ca3 rdf:first sg:person.01157744314.35
129 rdf:rest Nf8a8fd960db54b089535cca35f513912
130 Nc1b3813c3e90409eb4bd4b61e3d889a5 rdf:first N7a948f1c38574bbb944dba0ad1af031d
131 rdf:rest N07eeac81ad14427ea7b1faa4a501783a
132 Ne627170a3259418abfed3545417a8e9e schema:name nlm_unique_id
133 schema:value 0100714
134 rdf:type schema:PropertyValue
135 Nf11d389b73a249828fa132a39aee1926 rdf:first sg:person.01137007012.29
136 rdf:rest N0a32c11bfe6e455c98063d822ac30dbf
137 Nf5e0995893274374a9527d64f66f89a4 schema:name dimensions_id
138 schema:value pub.1110881510
139 rdf:type schema:PropertyValue
140 Nf8a8fd960db54b089535cca35f513912 rdf:first sg:person.01160662243.81
141 rdf:rest N1dcd49455b544da0baa09cf7091a5f3a
142 Nfb7cf299df874f168ae30417b0bca487 schema:name doi
143 schema:value 10.1038/s41390-018-0242-2
144 rdf:type schema:PropertyValue
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
149 schema:name Clinical Sciences
150 rdf:type schema:DefinedTerm
151 sg:journal.1007352 schema:issn 0031-3998
152 1530-0447
153 schema:name Pediatric Research
154 rdf:type schema:Periodical
155 sg:person.01034026263.68 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
156 schema:familyName Allen
157 schema:givenName Marilee
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034026263.68
159 rdf:type schema:Person
160 sg:person.01125545204.13 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
161 schema:familyName Hahn
162 schema:givenName Cecil
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125545204.13
164 rdf:type schema:Person
165 sg:person.01137007012.29 schema:affiliation https://www.grid.ac/institutes/grid.413177.7
166 schema:familyName Bhatt-Mehta
167 schema:givenName Varsha
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137007012.29
169 rdf:type schema:Person
170 sg:person.01142126754.66 schema:affiliation https://www.grid.ac/institutes/grid.7872.a
171 schema:familyName Boylan
172 schema:givenName Geraldine
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142126754.66
174 rdf:type schema:Person
175 sg:person.01142543270.75 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
176 schema:familyName Hardy
177 schema:givenName Pollyanna
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142543270.75
179 rdf:type schema:Person
180 sg:person.01150547264.44 schema:affiliation https://www.grid.ac/institutes/grid.414601.6
181 schema:familyName Rabe
182 schema:givenName Heike
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150547264.44
184 rdf:type schema:Person
185 sg:person.01157744314.35 schema:affiliation https://www.grid.ac/institutes/grid.413235.2
186 schema:familyName Auvin
187 schema:givenName Stephane
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157744314.35
189 rdf:type schema:Person
190 sg:person.01160662243.81 schema:affiliation https://www.grid.ac/institutes/grid.24827.3b
191 schema:familyName Vinks
192 schema:givenName Alexander
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160662243.81
194 rdf:type schema:Person
195 sg:person.01207514343.96 schema:affiliation https://www.grid.ac/institutes/grid.7429.8
196 schema:familyName Zohar
197 schema:givenName Sarah
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207514343.96
199 rdf:type schema:Person
200 sg:person.01301125541.46 schema:affiliation https://www.grid.ac/institutes/grid.417621.7
201 schema:familyName Romero
202 schema:givenName Klaus
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301125541.46
204 rdf:type schema:Person
205 sg:person.01312320123.01 schema:affiliation https://www.grid.ac/institutes/grid.415195.d
206 schema:familyName Davis
207 schema:givenName Jonathan M
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312320123.01
209 rdf:type schema:Person
210 sg:person.014072047055.95 schema:affiliation https://www.grid.ac/institutes/grid.239559.1
211 schema:familyName Lantos
212 schema:givenName John
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014072047055.95
214 rdf:type schema:Person
215 sg:person.0623610604.17 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
216 schema:familyName Marlow
217 schema:givenName Neil
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623610604.17
219 rdf:type schema:Person
220 sg:person.0702164431.11 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
221 schema:familyName Pressler
222 schema:givenName Ronit
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702164431.11
224 rdf:type schema:Person
225 sg:person.0754551230.67 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
226 schema:familyName Denne
227 schema:givenName Scott
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754551230.67
229 rdf:type schema:Person
230 sg:pub.10.1007/s40262-012-0004-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051637529
231 https://doi.org/10.1007/s40262-012-0004-y
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/pr.2016.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041063310
234 https://doi.org/10.1038/pr.2016.221
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/s13023-016-0464-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045472021
237 https://doi.org/10.1186/s13023-016-0464-5
238 rdf:type schema:CreativeWork
239 sg:pub.10.1203/00006450-200110000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033171697
240 https://doi.org/10.1203/00006450-200110000-00005
241 rdf:type schema:CreativeWork
242 sg:pub.10.1203/pdr.0b013e3181d4ff4d schema:sameAs https://app.dimensions.ai/details/publication/pub.1013165272
243 https://doi.org/10.1203/pdr.0b013e3181d4ff4d
244 rdf:type schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1078179074 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1078179257 schema:CreativeWork
247 https://doi.org/10.1002/acn3.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038297313
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.annemergmed.2003.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016217828
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.brainres.2016.05.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010567868
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.clinthera.2006.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015134263
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.clinthera.2017.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092084679
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.earlhumdev.2012.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029754078
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.jclinepi.2013.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044380287
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.jpeds.2016.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050586423
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.pcl.2012.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035706967
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.pediatrneurol.2008.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000145683
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.siny.2013.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024103722
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.siny.2013.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012785894
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.siny.2013.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016252301
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.siny.2017.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091213537
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.yebeh.2010.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004736216
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0022-3476(99)70374-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007085917
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s1474-4422(14)70303-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016470168
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1056/nejm199908123410704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018161217
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1056/nejmcps050929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011349386
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1056/nejmra1510062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090361612
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.222550499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030292720
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1080/08989620802194392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019167619
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1080/14767058.2017.1304536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084166257
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/pcc.0b013e31825bbbc2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022781352
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/wnp.0b013e31823e96d7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012161948
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/bcp.12467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016438011
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1111/bcp.12753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040541070
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1111/dmcn.12724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053148485
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1111/j.1651-2227.2009.01659.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044651579
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1111/rssc.12289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104093651
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1136/adc.2005.086314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036237243
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1136/archdischild-2014-306191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017034947
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1136/fn.86.3.f165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014792534
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1136/jme.2005.013722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016260420
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1159/000430767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053132733
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1177/0883073808321056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063854734
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1177/0883073810384263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063855044
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1177/0883073812470734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063855401
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1177/0962280216671348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053886036
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1212/wnl.31.9.1107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064364068
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1371/journal.pone.0165693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006095175
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1542/peds.2013-4060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001590858
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1542/peds.2014-3777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048192702
332 rdf:type schema:CreativeWork
333 https://doi.org/10.3171/2012.12.jns111970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071077480
334 rdf:type schema:CreativeWork
335 https://doi.org/10.3233/jpn-2009-0271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046084241
336 rdf:type schema:CreativeWork
337 https://doi.org/10.5863/1551-6776-17.1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078642466
338 rdf:type schema:CreativeWork
339 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
340 schema:name Division of Neurology, The Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
343 schema:name John Hopkins, Baltimore, Maryland, USA.
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.239559.1 schema:alternateName Children's Mercy Hospital
346 schema:name Children's Mercy Hospital, Kansas City, Missouri, USA.
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.24827.3b schema:alternateName University of Cincinnati
349 schema:name College of Medicine & Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
350 rdf:type schema:Organization
351 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
352 schema:name Boston Children's Hospital & Harvard Medical School, Boston, MA, USA. Janet.Soul@childrens.harvard.edu.
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.257413.6 schema:alternateName Indiana University – Purdue University Indianapolis
355 schema:name Riley Children's Hospital, Indiana University, Indianapolis, Indiana, USA.
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.413177.7 schema:alternateName C. S. Mott Children's Hospital
358 schema:name C.S.Mott Children's Hospital, University of Michigan, Ann Arbor, USA.
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.413235.2 schema:alternateName Hôpital Robert Debré
361 schema:name Pediatric neurology department & INSERM U1141, APHP, Robert Debré University Hospital, Paris, France.
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.414601.6 schema:alternateName Brighton and Sussex Medical School
364 schema:name Brighton and Sussex Medical School, Brighton, England.
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.415195.d schema:alternateName Floating Hospital for Children
367 schema:name The Floating Hospital for Children at Tufts Medical Center and the Tufts Clinical and Translational Science Institute, Boston, MA, USA.
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.417621.7 schema:alternateName Critical Path Institute
370 schema:name Critical Path Institute, Tucson, Arizona, USA.
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.419481.1 schema:alternateName Novartis (Switzerland)
373 schema:name Novartis Pharma Corp, Basel, Switzerland.
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.6572.6 schema:alternateName University of Birmingham
376 schema:name University of Birmingham, Birmingham, UK.
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.7429.8 schema:alternateName French Institute of Health and Medical Research
379 schema:name INSERM, UMRS1138, University Paris V and University Paris VI, Paris, France.
380 rdf:type schema:Organization
381 https://www.grid.ac/institutes/grid.7872.a schema:alternateName University College Cork
382 schema:name University College Cork, Cork, Ireland.
383 rdf:type schema:Organization
384 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
385 schema:name UCL Great Ormond Street Institute of Child Health, London, UK.
386 UCL Institute for Women's Health, University College London, London, UK.
387 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...