Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05-23

AUTHORS

Shambhuprasad K. Togarsimalemath, Ali Si-Mohammed, Mamta Puraswani, Aarti Gupta, Astrid Vabret, Sandrine Liguori, Patricia Mariani-Kurkdjian, Arvind Bagga, Marie-Agnes Dragon-Durey

ABSTRACT

BackgroundProdromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS.MethodsThe presence of 15 gastrointestinal (GI) pathogens was investigated by using xTAG-based multiplex PCR techniques on stools collected at the acute phase in a cohort of Indian HUS children classified according to the presence or absence of anti-FH autoantibodies.ResultsPrevalence of pathogens in patients with anti-FH antibody (62.5%) was twice that in those without (31.5%). Different pathogens were detected, the most frequent being Clostridium difficile, Giardia intestinalis, Salmonella, Shigella, Rotavirus, Norovirus and Entamoeba histolytica. No stool was positive for Shigatoxin.ConclusionThis study reveals a higher prevalence of GI pathogens in anti-FH positive than in negative patients. No single pathogen was implicated exclusively in one form of HUS. These pathogens may play a role in the disease initiation by inducing complement activation or an autoimmune response. More... »

PAGES

118-124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41390-018-0009-9

DOI

http://dx.doi.org/10.1038/s41390-018-0009-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104155443

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29795200


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85 norovirus
86 pathogens
87 patients
88 phase
89 presence
90 prevalence
91 production
92 regulator
93 response
94 role
95 rotavirus
96 single pathogen
97 stool
98 study
99 symptoms
100 syndrome
101 technique
102 triggers
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