JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bierbaumer", 
        "givenName": "Lisa", 
        "id": "sg:person.014105011363.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014105011363.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katschnig", 
        "givenName": "Anna M.", 
        "id": "sg:person.012415411625.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012415411625.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Radic-Sarikas", 
        "givenName": "Branka", 
        "id": "sg:person.016127003365.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016127003365.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kauer", 
        "givenName": "Maximilian O.", 
        "id": "sg:person.012126736467.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012126736467.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, USA", 
          "id": "http://www.grid.ac/institutes/grid.213910.8", 
          "name": [
            "Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petro", 
        "givenName": "Jeffrey A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pathology, Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Veterin\u00e4rplatz 1, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.6583.8", 
          "name": [
            "Institute of Pathology, Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Veterin\u00e4rplatz 1, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6gler", 
        "givenName": "Sandra", 
        "id": "sg:person.01110563475.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110563475.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Medical University of Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Pathology, Medical University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gurnhofer", 
        "givenName": "Elisabeth", 
        "id": "sg:person.01317634731.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317634731.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology and Children\u2019s Research Center, University Children\u2019s Hospital, Zurich, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.412341.1", 
          "name": [
            "Department of Oncology and Children\u2019s Research Center, University Children\u2019s Hospital, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedot", 
        "givenName": "Gloria", 
        "id": "sg:person.014025602467.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014025602467.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology and Children\u2019s Research Center, University Children\u2019s Hospital, Zurich, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.412341.1", 
          "name": [
            "Department of Oncology and Children\u2019s Research Center, University Children\u2019s Hospital, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00e4fer", 
        "givenName": "Beat W.", 
        "id": "sg:person.01365327353.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365327353.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwentner", 
        "givenName": "Raphaela", 
        "id": "sg:person.01120340475.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120340475.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fchlbacher", 
        "givenName": "Karin", 
        "id": "sg:person.01251743570.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251743570.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.416346.2", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kromp", 
        "givenName": "Florian", 
        "id": "sg:person.01343476057.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343476057.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Paediatrics, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
            "Department of Paediatrics, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aryee", 
        "givenName": "Dave N. T.", 
        "id": "sg:person.015406057707.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015406057707.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CBmed Vienna, Corelab 2, W\u00e4hringerg\u00fcrtel 18-20, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Institute of Pathology, Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Veterin\u00e4rplatz 1, Vienna, Austria", 
            "Department of Pathology, Medical University of Vienna, Vienna, Austria", 
            "Christian Doppler Laboratory for Applied Metabolomics (CDL-AM), W\u00e4hringerg\u00fcrtel 18-20, Medical University Vienna, Vienna, Austria", 
            "CBmed Vienna, Corelab 2, W\u00e4hringerg\u00fcrtel 18-20, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kenner", 
        "givenName": "Lukas", 
        "id": "sg:person.01051120405.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051120405.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, USA", 
          "id": "http://www.grid.ac/institutes/grid.213910.8", 
          "name": [
            "Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uren", 
        "givenName": "Aykut", 
        "id": "sg:person.0620216134.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620216134.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Paediatrics, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Children\u2019s Cancer Research Institute, Zimmermannplatz 10, 1090, Vienna, Austria", 
            "Department of Paediatrics, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kovar", 
        "givenName": "Heinrich", 
        "id": "sg:person.0741362200.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741362200.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrc3458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013461220", 
          "https://doi.org/10.1038/nrc3458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2016.498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074247760", 
          "https://doi.org/10.1038/onc.2016.498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41419-019-1989-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1121477900", 
          "https://doi.org/10.1038/s41419-019-1989-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1478-811x-8-23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019258854", 
          "https://doi.org/10.1186/1478-811x-8-23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048896478", 
          "https://doi.org/10.1038/nrc3876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028063527", 
          "https://doi.org/10.1038/nature10137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2017.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129932", 
          "https://doi.org/10.1038/onc.2017.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-01556-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092714916", 
          "https://doi.org/10.1038/s41467-017-01556-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007487744", 
          "https://doi.org/10.1038/onc.2010.571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006822728", 
          "https://doi.org/10.1038/nrm3416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-013-1511-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038834638", 
          "https://doi.org/10.1007/s13277-013-1511-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050872467", 
          "https://doi.org/10.1038/onc.2010.205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2017.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090330897", 
          "https://doi.org/10.1038/onc.2017.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006047977", 
          "https://doi.org/10.1038/nrd4161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41572-018-0003-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105307431", 
          "https://doi.org/10.1038/s41572-018-0003-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-015-9729-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000099771", 
          "https://doi.org/10.1007/s10585-015-9729-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.1085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025499740", 
          "https://doi.org/10.1038/ng.1085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000488571", 
          "https://doi.org/10.1038/onc.2013.361"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-01-08", 
    "datePublishedReg": "2021-01-08", 
    "description": "Ewing sarcoma (EwS) is a highly metastatic bone cancer characterized by the ETS fusion oncoprotein EWS-FLI1. EwS cells are phenotypically highly plastic and switch between functionally distinct cell states dependent on EWS-FLI1 fluctuations. Whereas EWS-FLI1high cells proliferate, EWS-FLI1low cells are migratory and invasive. Recently, we reported activation of MRTFB and TEAD, effectors of RhoA and Hippo signalling, upon low EWS-FLI1, orchestrating key steps of the EwS migratory gene expression program. TEAD and its co-activators YAP and TAZ are commonly overexpressed in cancer, providing attractive therapeutic targets. We find TAZ levels to increase in the migratory EWS-FLI1low state and to associate with adverse prognosis in EwS patients. We tested the effects of the potent YAP/TAZ/TEAD complex inhibitor verteporfin on EwS cell migration in vitro and on metastasis in vivo. Verteporfin suppressed expression of EWS-FLI1 regulated cytoskeletal genes involved in actin signalling to the extracellular matrix, effectively blocked F-actin and focal-adhesion assembly and inhibited EwS cell migration at submicromolar concentrations. In a mouse EwS xenograft model, verteporfin treatment reduced relapses at the surgical site and delayed lung metastasis. These data suggest that YAP/TAZ pathway inhibition may prevent EwS cell dissemination and metastasis, justifying further preclinical development of YAP/TAZ inhibitors for EwS treatment.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41389-020-00294-8", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3794224", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6805041", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7579400", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1046557", 
        "issn": [
          "2157-9024"
        ], 
        "name": "Oncogenesis", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "EWS-FLI1", 
      "co-activator YAP", 
      "cell migration", 
      "gene expression programs", 
      "focal adhesion assembly", 
      "distinct cell states", 
      "YAP/TAZ inhibition", 
      "effector of RhoA", 
      "expression programs", 
      "cytoskeletal genes", 
      "Hippo signaling", 
      "cell states", 
      "YAP/TAZ inhibitor", 
      "TAZ inhibition", 
      "F-actin", 
      "attractive therapeutic target", 
      "ETS fusions", 
      "extracellular matrix", 
      "TEAD", 
      "TAZ levels", 
      "verteporfin treatment", 
      "metastatic bone cancer", 
      "metastatic potential", 
      "pathway inhibition", 
      "EwS cells", 
      "therapeutic target", 
      "sarcoma cells", 
      "cell dissemination", 
      "cells", 
      "further preclinical development", 
      "submicromolar concentrations", 
      "EwS patients", 
      "xenograft model", 
      "MRTFB", 
      "adverse prognosis", 
      "lung metastases", 
      "surgical site", 
      "bone cancer", 
      "preclinical development", 
      "TAZ", 
      "RhoA", 
      "metastasis", 
      "genes", 
      "EW treatment", 
      "signaling", 
      "YAP", 
      "effectors", 
      "inhibition", 
      "actin", 
      "migration", 
      "key step", 
      "verteporfin", 
      "cancer", 
      "expression", 
      "assembly", 
      "treatment", 
      "activation", 
      "vivo", 
      "inhibitors", 
      "target", 
      "fusion", 
      "relapse", 
      "prognosis", 
      "patients", 
      "sarcoma", 
      "sites", 
      "development", 
      "levels", 
      "dissemination", 
      "potential", 
      "step", 
      "effect", 
      "concentration", 
      "program", 
      "fluctuations", 
      "data", 
      "matrix", 
      "state", 
      "model"
    ], 
    "name": "YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells", 
    "pagination": "2", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1134416510"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41389-020-00294-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33419969"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41389-020-00294-8", 
      "https://app.dimensions.ai/details/publication/pub.1134416510"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_892.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41389-020-00294-8"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

352 TRIPLES      21 PREDICATES      125 URIs      96 LITERALS      7 BLANK NODES