Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-09

AUTHORS

Alberto Herrera, Mercedes Herrera, Natalia Guerra-Perez, Cristina Galindo-Pumariño, María Jesús Larriba, Vanesa García-Barberán, Beatriz Gil, Sara Giménez-Moyano, Reyes Ferreiro-Monteagudo, Pilar Veguillas, Antonio Candia, Raúl Peña, Jesús Pinto, Mª Laura García-Bermejo, Alberto Muñoz, Antonio García de Herreros, Félix Bonilla, Alfredo Carrato, Cristina Peña

ABSTRACT

Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mesenchymal Transition, in recent years, many studies have also identified the major role of Snail in the activation of Cancer-Associated Fibroblast (CAF) cells and the remodeling of the extracellular matrix. In CAFs, Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant. High expression of both SNAI1 and PDGF receptors is associated with poor prognosis in cancer patients, but the mechanism(s) that underlie these connections are not understood. In this study, we demonstrate that PDGF-activated fibroblasts stimulate extracellular matrix (ECM) fiber remodeling and deposition. Furthermore, we describe how SNAI1, through the FAK pathway, is a necessary factor for ECM fiber organization. The parallel-oriented fibers are used by endothelial cells as "tracks", facilitating their activation and the creation of tubular structures mimicking in vivo capillary formation. Accordingly, Snail1 expression in fibroblasts was required for the co-adjuvant effect of these cells on matrix remodeling and neoangiogenesis when co-xenografted in nude mice. Finally, in tumor samples from colorectal cancer patients a direct association between stromal SNAI1 expression and the endothelial marker CD34 was observed. In summary, our results advance the understanding of PDGF/SNAI1-activated CAFs in matrix remodeling and angiogenesis stimulation. More... »

PAGES

76

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41389-018-0085-z

DOI

http://dx.doi.org/10.1038/s41389-018-0085-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107209511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30250018


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herrera", 
        "givenName": "Alberto", 
        "id": "sg:person.01274174114.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274174114.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain", 
            "Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herrera", 
        "givenName": "Mercedes", 
        "id": "sg:person.01226060714.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226060714.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria", 
          "id": "https://www.grid.ac/institutes/grid.420232.5", 
          "name": [
            "Medical Oncology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guerra-Perez", 
        "givenName": "Natalia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria", 
          "id": "https://www.grid.ac/institutes/grid.420232.5", 
          "name": [
            "Medical Oncology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galindo-Pumari\u00f1o", 
        "givenName": "Cristina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alberto Sols Biomedical Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.466793.9", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas Alberto Sols, Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, CIBERONC, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larriba", 
        "givenName": "Mar\u00eda Jes\u00fas", 
        "id": "sg:person.0640416275.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640416275.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Investigaciones del Sue\u00f1o", 
          "id": "https://www.grid.ac/institutes/grid.476442.7", 
          "name": [
            "Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain", 
            "Laboratory of Molecular Oncology, IIS Hospital Cl\u00ednico San Carlos, CIBERONC, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Barber\u00e1n", 
        "givenName": "Vanesa", 
        "id": "sg:person.014626005525.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014626005525.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain", 
            "Laboratorio de Oncolog\u00eda Traslacional y Nuevas Terapias. Instituto de Investigaci\u00f3n i+12, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gil", 
        "givenName": "Beatriz", 
        "id": "sg:person.0665252550.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665252550.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria", 
          "id": "https://www.grid.ac/institutes/grid.420232.5", 
          "name": [
            "Biomarkers and Therapeutic Targets Lab, Pathology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gim\u00e9nez-Moyano", 
        "givenName": "Sara", 
        "id": "sg:person.014530411073.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014530411073.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria", 
          "id": "https://www.grid.ac/institutes/grid.420232.5", 
          "name": [
            "Medical Oncology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferreiro-Monteagudo", 
        "givenName": "Reyes", 
        "id": "sg:person.01052301134.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052301134.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario de Guadalajara", 
          "id": "https://www.grid.ac/institutes/grid.411098.5", 
          "name": [
            "Surgery Department, Hospital Universitario de Guadalajara, Guadalajara, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Veguillas", 
        "givenName": "Pilar", 
        "id": "sg:person.0657614241.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657614241.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario de Guadalajara", 
          "id": "https://www.grid.ac/institutes/grid.411098.5", 
          "name": [
            "Pathology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Candia", 
        "givenName": "Antonio", 
        "id": "sg:person.015375201370.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015375201370.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Hospital del Mar d'Investigacions M\u00e8diques", 
          "id": "https://www.grid.ac/institutes/grid.20522.37", 
          "name": [
            "Programa de Recerca en C\u00e0ncer, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pe\u00f1a", 
        "givenName": "Ra\u00fal", 
        "id": "sg:person.01125373546.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125373546.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pathology Department, Virgen de la Concha Hospital, Zamora, Castilla y Le\u00f3n, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinto", 
        "givenName": "Jes\u00fas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratorio de Oncolog\u00eda Traslacional y Nuevas Terapias. Instituto de Investigaci\u00f3n i+12, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Bermejo", 
        "givenName": "M\u00aa Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alberto Sols Biomedical Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.466793.9", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas Alberto Sols, Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid, CIBERONC, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mu\u00f1oz", 
        "givenName": "Alberto", 
        "id": "sg:person.012076006300.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076006300.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Hospital del Mar d'Investigacions M\u00e8diques", 
          "id": "https://www.grid.ac/institutes/grid.20522.37", 
          "name": [
            "Programa de Recerca en C\u00e0ncer, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Herreros", 
        "givenName": "Antonio Garc\u00eda", 
        "id": "sg:person.01205321675.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205321675.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Centro de Estudios Biosanitarios, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonilla", 
        "givenName": "F\u00e9lix", 
        "id": "sg:person.01263153010.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263153010.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Ram\u00f3n y Cajal", 
          "id": "https://www.grid.ac/institutes/grid.411347.4", 
          "name": [
            "Medical Oncology Department, Ramon y Cajal University Hospital, IRYCIS, CIBERONC, Alcala University, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carrato", 
        "givenName": "Alfredo", 
        "id": "sg:person.0602425043.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602425043.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria", 
          "id": "https://www.grid.ac/institutes/grid.420232.5", 
          "name": [
            "Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain", 
            "Medical Oncology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), CIBERONC, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pe\u00f1a", 
        "givenName": "Cristina", 
        "id": "sg:person.01230426741.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230426741.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1242/dmm.004077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000081600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1653708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003496992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009127591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0010747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009941380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011749377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.308940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012988667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci31334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014329144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fon.14.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014686302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.078824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015790497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neo.2014.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016134743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.266803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016227728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.195628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016477682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexmp.2011.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016798307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1005324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016859871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00089-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017597133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.24342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019557746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020517945", 
          "https://doi.org/10.1038/ncb2743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200810113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020673810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021678483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2326-6066.cir-14-0002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022560995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200304105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025850977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13046-015-0218-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026338441", 
          "https://doi.org/10.1186/s13046-015-0218-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026568279", 
          "https://doi.org/10.1038/sj.onc.1209519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026568279", 
          "https://doi.org/10.1038/sj.onc.1209519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12094-015-1474-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027566411", 
          "https://doi.org/10.1007/s12094-015-1474-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m413081200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030175994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2006.060196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031059666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.068023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032600376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-cellbio-092910-154036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033011546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1478-811x-11-97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034089550", 
          "https://doi.org/10.1186/1478-811x-11-97"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2013.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034703779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000191547.64391.e3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034952025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000191547.64391.e3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034952025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12307-010-0040-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035157353", 
          "https://doi.org/10.1007/s12307-010-0040-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12307-010-0040-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035157353", 
          "https://doi.org/10.1007/s12307-010-0040-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036409410", 
          "https://doi.org/10.1186/1471-2407-10-659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215540305100807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037340885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/002215540305100807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037340885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-1903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039014028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2010.01639.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040023224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2010.01639.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040023224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2013.05.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040143966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20061757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041513722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20061757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041513722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0625.2011.01309.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043135317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-0694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045767559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drup.2005.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048627711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048663939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63905-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048730654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.28613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049144286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-0500-2-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053424119", 
          "https://doi.org/10.1186/1756-0500-2-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-0500-2-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053424119", 
          "https://doi.org/10.1186/1756-0500-2-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-015-3230-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053516645", 
          "https://doi.org/10.1007/s13277-015-3230-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-16-0176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063216135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14800/ccm.417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067370576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21769/bioprotoc.1773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069251731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.5.12.3354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293995"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-09", 
    "datePublishedReg": "2018-09-01", 
    "description": "Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mesenchymal Transition, in recent years, many studies have also identified the major role of Snail in the activation of Cancer-Associated Fibroblast (CAF) cells and the remodeling of the extracellular matrix. In CAFs, Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant. High expression of both SNAI1 and PDGF receptors is associated with poor prognosis in cancer patients, but the mechanism(s) that underlie these connections are not understood. In this study, we demonstrate that PDGF-activated fibroblasts stimulate extracellular matrix (ECM) fiber remodeling and deposition. Furthermore, we describe how SNAI1, through the FAK pathway, is a necessary factor for ECM fiber organization. The parallel-oriented fibers are used by endothelial cells as \"tracks\", facilitating their activation and the creation of tubular structures mimicking in vivo capillary formation. Accordingly, Snail1 expression in fibroblasts was required for the co-adjuvant effect of these cells on matrix remodeling and neoangiogenesis when co-xenografted in nude mice. Finally, in tumor samples from colorectal cancer patients a direct association between stromal SNAI1 expression and the endothelial marker CD34 was observed. In summary, our results advance the understanding of PDGF/SNAI1-activated CAFs in matrix remodeling and angiogenesis stimulation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41389-018-0085-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3754109", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3710886", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3719184", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1046557", 
        "issn": [
          "2157-9024"
        ], 
        "name": "Oncogenesis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1", 
    "pagination": "76", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4b39e9874b78c92b5bcbce52a9a72bdb13d378451741e7c38b6eb87fd169acd0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30250018"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101580004"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41389-018-0085-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107209511"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41389-018-0085-z", 
      "https://app.dimensions.ai/details/publication/pub.1107209511"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000548.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41389-018-0085-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41389-018-0085-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41389-018-0085-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41389-018-0085-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41389-018-0085-z'


 

This table displays all metadata directly associated to this object as RDF triples.

389 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41389-018-0085-z schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N334fc70e01f042789d134b29f32b65e0
4 schema:citation sg:pub.10.1007/s12094-015-1474-9
5 sg:pub.10.1007/s12307-010-0040-9
6 sg:pub.10.1007/s13277-015-3230-8
7 sg:pub.10.1038/ncb2743
8 sg:pub.10.1038/sj.onc.1209519
9 sg:pub.10.1186/1471-2407-10-659
10 sg:pub.10.1186/1478-811x-11-97
11 sg:pub.10.1186/1756-0500-2-22
12 sg:pub.10.1186/s13046-015-0218-6
13 https://doi.org/10.1002/ijc.28613
14 https://doi.org/10.1002/jcp.24342
15 https://doi.org/10.1002/stem.1661
16 https://doi.org/10.1016/j.ajpath.2013.02.018
17 https://doi.org/10.1016/j.cell.2009.10.027
18 https://doi.org/10.1016/j.drup.2005.03.004
19 https://doi.org/10.1016/j.molmed.2013.05.004
20 https://doi.org/10.1016/j.neo.2014.05.002
21 https://doi.org/10.1016/j.yexmp.2011.04.007
22 https://doi.org/10.1016/s0002-9440(10)63905-3
23 https://doi.org/10.1016/s1535-6108(03)00089-8
24 https://doi.org/10.1038/sj.emboj.7600289
25 https://doi.org/10.1042/bj20061757
26 https://doi.org/10.1074/jbc.m110.195628
27 https://doi.org/10.1074/jbc.m111.308940
28 https://doi.org/10.1074/jbc.m413081200
29 https://doi.org/10.1083/jcb.200304105
30 https://doi.org/10.1083/jcb.200810113
31 https://doi.org/10.1101/gad.1653708
32 https://doi.org/10.1101/gad.266803
33 https://doi.org/10.1111/j.1349-7006.2010.01639.x
34 https://doi.org/10.1111/j.1600-0625.2011.01309.x
35 https://doi.org/10.1146/annurev-cellbio-092910-154036
36 https://doi.org/10.1158/0008-5472.can-05-1512
37 https://doi.org/10.1158/0008-5472.can-14-1903
38 https://doi.org/10.1158/0008-5472.can-16-0176
39 https://doi.org/10.1158/1078-0432.ccr-13-0694
40 https://doi.org/10.1158/2326-6066.cir-14-0002
41 https://doi.org/10.1161/01.res.0000191547.64391.e3
42 https://doi.org/10.1172/jci31334
43 https://doi.org/10.1177/002215540305100807
44 https://doi.org/10.1242/dev.068023
45 https://doi.org/10.1242/dmm.004077
46 https://doi.org/10.1242/jcs.078824
47 https://doi.org/10.1371/journal.pgen.1005324
48 https://doi.org/10.1371/journal.pone.0010747
49 https://doi.org/10.14800/ccm.417
50 https://doi.org/10.21769/bioprotoc.1773
51 https://doi.org/10.2217/fon.14.83
52 https://doi.org/10.2353/ajpath.2006.060196
53 https://doi.org/10.4161/cbt.5.12.3354
54 schema:datePublished 2018-09
55 schema:datePublishedReg 2018-09-01
56 schema:description Carcinomas, such as colon cancer, initiate their invasion by rescuing the innate plasticity of both epithelial cells and stromal cells. Although Snail is a transcriptional factor involved in the Epithelial-Mesenchymal Transition, in recent years, many studies have also identified the major role of Snail in the activation of Cancer-Associated Fibroblast (CAF) cells and the remodeling of the extracellular matrix. In CAFs, Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant. High expression of both SNAI1 and PDGF receptors is associated with poor prognosis in cancer patients, but the mechanism(s) that underlie these connections are not understood. In this study, we demonstrate that PDGF-activated fibroblasts stimulate extracellular matrix (ECM) fiber remodeling and deposition. Furthermore, we describe how SNAI1, through the FAK pathway, is a necessary factor for ECM fiber organization. The parallel-oriented fibers are used by endothelial cells as "tracks", facilitating their activation and the creation of tubular structures mimicking in vivo capillary formation. Accordingly, Snail1 expression in fibroblasts was required for the co-adjuvant effect of these cells on matrix remodeling and neoangiogenesis when co-xenografted in nude mice. Finally, in tumor samples from colorectal cancer patients a direct association between stromal SNAI1 expression and the endothelial marker CD34 was observed. In summary, our results advance the understanding of PDGF/SNAI1-activated CAFs in matrix remodeling and angiogenesis stimulation.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N20c3b38e1085472681d76838f08748c5
61 N9389670d11f1418e9d498225ffe70903
62 sg:journal.1046557
63 schema:name Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1
64 schema:pagination 76
65 schema:productId N39a3e367e9b643689691800cbe21ac6b
66 N5ce4ed0be4c446d18b166dd0f11a5b11
67 N6ce57aec160f46ff8968485e341f00b8
68 N8426e9cd0a9a4926ad92b42c15dd3714
69 N99f30c0bc0064d3cba3d491898023558
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107209511
71 https://doi.org/10.1038/s41389-018-0085-z
72 schema:sdDatePublished 2019-04-10T19:14
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nc19ef2d55ee344d1be94298aa0b37647
75 schema:url https://www.nature.com/articles/s41389-018-0085-z
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N069221966e2443168ea50d95cfc2a9d0 rdf:first sg:person.0657614241.55
80 rdf:rest N7ad9b9a30b954bd1b7b92f5a45ddb6ec
81 N0bd63cbbbe7d436c9bca7a8f500ad35f rdf:first Na9524b98c3ec4dd782bbeaa04abef608
82 rdf:rest Nd96a671f16d546fcab4a7c9a60b24472
83 N10f30d4ec48b4e69b1607fd3ba14e1e2 schema:affiliation Nbef2d779e70649339c3237809f014561
84 schema:familyName Pinto
85 schema:givenName Jesús
86 rdf:type schema:Person
87 N19c0e0560fd24d77802a5d957f55605a rdf:first sg:person.01263153010.07
88 rdf:rest N23a58a3bb2714a7aaec473bbd1ed696d
89 N20c3b38e1085472681d76838f08748c5 schema:volumeNumber 7
90 rdf:type schema:PublicationVolume
91 N237c1022946440da8dae632974bb1e70 rdf:first sg:person.01052301134.88
92 rdf:rest N069221966e2443168ea50d95cfc2a9d0
93 N23a58a3bb2714a7aaec473bbd1ed696d rdf:first sg:person.0602425043.70
94 rdf:rest N7dbcb68f6a9a4d74973c3f15cb43b816
95 N2e03f9b0936846bebbcb1248fe4f2c5c rdf:first sg:person.014626005525.71
96 rdf:rest N8228505d90914da1bbad7f52d69de993
97 N2fbd7fd42f7a42fe869b95f1cabfa34f rdf:first sg:person.012076006300.84
98 rdf:rest N9abb706f25d3498e959fc43e2aae990d
99 N334fc70e01f042789d134b29f32b65e0 rdf:first sg:person.01274174114.96
100 rdf:rest Ndf37e3e834024e728ed08785ff582b12
101 N370efe5989e142238cf8aa77ab0c5cdf rdf:first Nac7df057d22f46cabf252ac0498ea7f9
102 rdf:rest N2fbd7fd42f7a42fe869b95f1cabfa34f
103 N39a3e367e9b643689691800cbe21ac6b schema:name pubmed_id
104 schema:value 30250018
105 rdf:type schema:PropertyValue
106 N5ce4ed0be4c446d18b166dd0f11a5b11 schema:name dimensions_id
107 schema:value pub.1107209511
108 rdf:type schema:PropertyValue
109 N5f55f0bd1c7041578310dd327ddedb38 schema:name Centro de Estudios Biosanitarios, Madrid, Spain
110 rdf:type schema:Organization
111 N6263b51587264c51810f1fd869533bc2 schema:affiliation https://www.grid.ac/institutes/grid.420232.5
112 schema:familyName Guerra-Perez
113 schema:givenName Natalia
114 rdf:type schema:Person
115 N62bb8ee97d8b476ab5b827e3f2e299f0 rdf:first sg:person.01125373546.12
116 rdf:rest Na4637ef092ec484891c669667af09664
117 N6ce57aec160f46ff8968485e341f00b8 schema:name doi
118 schema:value 10.1038/s41389-018-0085-z
119 rdf:type schema:PropertyValue
120 N7ad9b9a30b954bd1b7b92f5a45ddb6ec rdf:first sg:person.015375201370.16
121 rdf:rest N62bb8ee97d8b476ab5b827e3f2e299f0
122 N7dbcb68f6a9a4d74973c3f15cb43b816 rdf:first sg:person.01230426741.06
123 rdf:rest rdf:nil
124 N8228505d90914da1bbad7f52d69de993 rdf:first sg:person.0665252550.95
125 rdf:rest Na6c9c5ae52a34385834f64f46dd42aeb
126 N8426e9cd0a9a4926ad92b42c15dd3714 schema:name readcube_id
127 schema:value 4b39e9874b78c92b5bcbce52a9a72bdb13d378451741e7c38b6eb87fd169acd0
128 rdf:type schema:PropertyValue
129 N9389670d11f1418e9d498225ffe70903 schema:issueNumber 9
130 rdf:type schema:PublicationIssue
131 N99f30c0bc0064d3cba3d491898023558 schema:name nlm_unique_id
132 schema:value 101580004
133 rdf:type schema:PropertyValue
134 N9abb706f25d3498e959fc43e2aae990d rdf:first sg:person.01205321675.22
135 rdf:rest N19c0e0560fd24d77802a5d957f55605a
136 Na4637ef092ec484891c669667af09664 rdf:first N10f30d4ec48b4e69b1607fd3ba14e1e2
137 rdf:rest N370efe5989e142238cf8aa77ab0c5cdf
138 Na6c9c5ae52a34385834f64f46dd42aeb rdf:first sg:person.014530411073.77
139 rdf:rest N237c1022946440da8dae632974bb1e70
140 Na9524b98c3ec4dd782bbeaa04abef608 schema:affiliation https://www.grid.ac/institutes/grid.420232.5
141 schema:familyName Galindo-Pumariño
142 schema:givenName Cristina
143 rdf:type schema:Person
144 Nac7df057d22f46cabf252ac0498ea7f9 schema:affiliation Nd7dde1afe3d6466ebd481d9388f7d1d9
145 schema:familyName García-Bermejo
146 schema:givenName Mª Laura
147 rdf:type schema:Person
148 Nbef2d779e70649339c3237809f014561 schema:name Pathology Department, Virgen de la Concha Hospital, Zamora, Castilla y León, Spain
149 rdf:type schema:Organization
150 Nc19ef2d55ee344d1be94298aa0b37647 schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 Nc448e476098b4063aba743ea646c97a0 rdf:first N6263b51587264c51810f1fd869533bc2
153 rdf:rest N0bd63cbbbe7d436c9bca7a8f500ad35f
154 Nd7dde1afe3d6466ebd481d9388f7d1d9 schema:name Laboratorio de Oncología Traslacional y Nuevas Terapias. Instituto de Investigación i+12, Madrid, Spain
155 rdf:type schema:Organization
156 Nd96a671f16d546fcab4a7c9a60b24472 rdf:first sg:person.0640416275.76
157 rdf:rest N2e03f9b0936846bebbcb1248fe4f2c5c
158 Ndf37e3e834024e728ed08785ff582b12 rdf:first sg:person.01226060714.29
159 rdf:rest Nc448e476098b4063aba743ea646c97a0
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
164 schema:name Oncology and Carcinogenesis
165 rdf:type schema:DefinedTerm
166 sg:grant.3710886 http://pending.schema.org/fundedItem sg:pub.10.1038/s41389-018-0085-z
167 rdf:type schema:MonetaryGrant
168 sg:grant.3719184 http://pending.schema.org/fundedItem sg:pub.10.1038/s41389-018-0085-z
169 rdf:type schema:MonetaryGrant
170 sg:grant.3754109 http://pending.schema.org/fundedItem sg:pub.10.1038/s41389-018-0085-z
171 rdf:type schema:MonetaryGrant
172 sg:journal.1046557 schema:issn 2157-9024
173 schema:name Oncogenesis
174 rdf:type schema:Periodical
175 sg:person.01052301134.88 schema:affiliation https://www.grid.ac/institutes/grid.420232.5
176 schema:familyName Ferreiro-Monteagudo
177 schema:givenName Reyes
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052301134.88
179 rdf:type schema:Person
180 sg:person.01125373546.12 schema:affiliation https://www.grid.ac/institutes/grid.20522.37
181 schema:familyName Peña
182 schema:givenName Raúl
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125373546.12
184 rdf:type schema:Person
185 sg:person.01205321675.22 schema:affiliation https://www.grid.ac/institutes/grid.20522.37
186 schema:familyName de Herreros
187 schema:givenName Antonio García
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205321675.22
189 rdf:type schema:Person
190 sg:person.012076006300.84 schema:affiliation https://www.grid.ac/institutes/grid.466793.9
191 schema:familyName Muñoz
192 schema:givenName Alberto
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076006300.84
194 rdf:type schema:Person
195 sg:person.01226060714.29 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
196 schema:familyName Herrera
197 schema:givenName Mercedes
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226060714.29
199 rdf:type schema:Person
200 sg:person.01230426741.06 schema:affiliation https://www.grid.ac/institutes/grid.420232.5
201 schema:familyName Peña
202 schema:givenName Cristina
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230426741.06
204 rdf:type schema:Person
205 sg:person.01263153010.07 schema:affiliation N5f55f0bd1c7041578310dd327ddedb38
206 schema:familyName Bonilla
207 schema:givenName Félix
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263153010.07
209 rdf:type schema:Person
210 sg:person.01274174114.96 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
211 schema:familyName Herrera
212 schema:givenName Alberto
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274174114.96
214 rdf:type schema:Person
215 sg:person.014530411073.77 schema:affiliation https://www.grid.ac/institutes/grid.420232.5
216 schema:familyName Giménez-Moyano
217 schema:givenName Sara
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014530411073.77
219 rdf:type schema:Person
220 sg:person.014626005525.71 schema:affiliation https://www.grid.ac/institutes/grid.476442.7
221 schema:familyName García-Barberán
222 schema:givenName Vanesa
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014626005525.71
224 rdf:type schema:Person
225 sg:person.015375201370.16 schema:affiliation https://www.grid.ac/institutes/grid.411098.5
226 schema:familyName Candia
227 schema:givenName Antonio
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015375201370.16
229 rdf:type schema:Person
230 sg:person.0602425043.70 schema:affiliation https://www.grid.ac/institutes/grid.411347.4
231 schema:familyName Carrato
232 schema:givenName Alfredo
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602425043.70
234 rdf:type schema:Person
235 sg:person.0640416275.76 schema:affiliation https://www.grid.ac/institutes/grid.466793.9
236 schema:familyName Larriba
237 schema:givenName María Jesús
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640416275.76
239 rdf:type schema:Person
240 sg:person.0657614241.55 schema:affiliation https://www.grid.ac/institutes/grid.411098.5
241 schema:familyName Veguillas
242 schema:givenName Pilar
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657614241.55
244 rdf:type schema:Person
245 sg:person.0665252550.95 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
246 schema:familyName Gil
247 schema:givenName Beatriz
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665252550.95
249 rdf:type schema:Person
250 sg:pub.10.1007/s12094-015-1474-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027566411
251 https://doi.org/10.1007/s12094-015-1474-9
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s12307-010-0040-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035157353
254 https://doi.org/10.1007/s12307-010-0040-9
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s13277-015-3230-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053516645
257 https://doi.org/10.1007/s13277-015-3230-8
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/ncb2743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020517945
260 https://doi.org/10.1038/ncb2743
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/sj.onc.1209519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026568279
263 https://doi.org/10.1038/sj.onc.1209519
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/1471-2407-10-659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036409410
266 https://doi.org/10.1186/1471-2407-10-659
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1478-811x-11-97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034089550
269 https://doi.org/10.1186/1478-811x-11-97
270 rdf:type schema:CreativeWork
271 sg:pub.10.1186/1756-0500-2-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053424119
272 https://doi.org/10.1186/1756-0500-2-22
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/s13046-015-0218-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026338441
275 https://doi.org/10.1186/s13046-015-0218-6
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/ijc.28613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049144286
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/jcp.24342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019557746
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/stem.1661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021678483
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.ajpath.2013.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034703779
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.cell.2009.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048663939
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.drup.2005.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048627711
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.molmed.2013.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040143966
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.neo.2014.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016134743
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.yexmp.2011.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016798307
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0002-9440(10)63905-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048730654
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s1535-6108(03)00089-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017597133
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1038/sj.emboj.7600289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011749377
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1042/bj20061757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041513722
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1074/jbc.m110.195628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016477682
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m111.308940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012988667
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1074/jbc.m413081200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030175994
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1083/jcb.200304105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025850977
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1083/jcb.200810113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020673810
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1101/gad.1653708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003496992
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1101/gad.266803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016227728
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1111/j.1349-7006.2010.01639.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040023224
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1111/j.1600-0625.2011.01309.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043135317
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1146/annurev-cellbio-092910-154036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033011546
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1158/0008-5472.can-05-1512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009127591
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1158/0008-5472.can-14-1903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039014028
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1158/0008-5472.can-16-0176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063216135
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1158/1078-0432.ccr-13-0694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045767559
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1158/2326-6066.cir-14-0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022560995
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1161/01.res.0000191547.64391.e3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034952025
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1172/jci31334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014329144
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1177/002215540305100807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037340885
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1242/dev.068023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032600376
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1242/dmm.004077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000081600
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1242/jcs.078824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015790497
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1371/journal.pgen.1005324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016859871
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1371/journal.pone.0010747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009941380
348 rdf:type schema:CreativeWork
349 https://doi.org/10.14800/ccm.417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067370576
350 rdf:type schema:CreativeWork
351 https://doi.org/10.21769/bioprotoc.1773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069251731
352 rdf:type schema:CreativeWork
353 https://doi.org/10.2217/fon.14.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014686302
354 rdf:type schema:CreativeWork
355 https://doi.org/10.2353/ajpath.2006.060196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031059666
356 rdf:type schema:CreativeWork
357 https://doi.org/10.4161/cbt.5.12.3354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293995
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.20522.37 schema:alternateName Institut Hospital del Mar d'Investigacions Mèdiques
360 schema:name Programa de Recerca en Càncer, Institut Hospital del Mar d’Investigacions Mèdiques, Barcelona, Spain
361 rdf:type schema:Organization
362 https://www.grid.ac/institutes/grid.411098.5 schema:alternateName Hospital Universitario de Guadalajara
363 schema:name Pathology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain
364 Surgery Department, Hospital Universitario de Guadalajara, Guadalajara, Spain
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.411347.4 schema:alternateName Hospital Universitario Ramón y Cajal
367 schema:name Medical Oncology Department, Ramon y Cajal University Hospital, IRYCIS, CIBERONC, Alcala University, Madrid, Spain
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.420232.5 schema:alternateName Instituto Ramón y Cajal de Investigación Sanitaria
370 schema:name Biomarkers and Therapeutic Targets Lab, Pathology Department, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
371 Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain
372 Medical Oncology Department, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBERONC, Madrid, Spain
373 Medical Oncology Department, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.466793.9 schema:alternateName Alberto Sols Biomedical Research Institute
376 schema:name Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, CIBERONC, Madrid, Spain
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
379 schema:name Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain
380 Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.476442.7 schema:alternateName Instituto de Investigaciones del Sueño
383 schema:name Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain
384 Laboratory of Molecular Oncology, IIS Hospital Clínico San Carlos, CIBERONC, Madrid, Spain
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.73221.35 schema:alternateName Hospital Universitario Puerta de Hierro Majadahonda
387 schema:name Department of Medical Oncology, Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, Madrid, Spain
388 Laboratorio de Oncología Traslacional y Nuevas Terapias. Instituto de Investigación i+12, Madrid, Spain
389 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...