TRAF6 regulates EGF-induced cell transformation and cSCC malignant phenotype through CD147/EGFR View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02-20

AUTHORS

Xu Zhang, Lisha Wu, Ta Xiao, Ling Tang, Xuekun Jia, Yeye Guo, JiangLin Zhang, Jie Li, Yijing He, Juan Su, Shuang Zhao, Juan Tao, Jianda Zhou, Xiang Chen, Cong Peng

ABSTRACT

TRAF6, a well-known adapter molecule, plays pivotal role in TLR/IL-1R associated signaling pathway. Although TRAF6 has been shown to have oncogenic activity in various malignant tumors, the details remain unclear. In this study, we demonstrated that TRAF6 facilitates Ras (G12V) and EGF-induced cellular transformation through EGFR. Silencing of TRAF6 expression significantly downregulated AP-1 activity, as well as MMP-2,9 expression after EGF stimulation. Furthermore, we found that TRAF6 plays an essential role in cutaneous squamous cell carcinoma (cSCC) malignant phenotypes, affecting cell growth and migration. CD147/Basigin, a transmembrane glycoprotein belonging to the immunoglobulin superfamily, is over-expressed in tumors and induces tumorigenesis. Our results showed that CD147 formed complex with EGFR and TRAF6. Knockdown of TRAF6 disrupted the CD147-EGFR complex, thereby inducing EGFR endocytosis. Therefore, TRAF6 might be a novel molecular target for cSCC prevention or therapy. More... »

PAGES

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41389-018-0030-1

DOI

http://dx.doi.org/10.1038/s41389-018-0030-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101123002

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29463844


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24 CD147/basigin
25 EGF stimulation
26 EGF-induced cell transformation
27 EGFR
28 EGFR endocytosis
29 IL-1R
30 Knockdown of TRAF6
31 MMPs
32 RA
33 TLR/IL-1R
34 TRAF6
35 TRAF6 expression
36 activity
37 adapter molecule
38 basigin
39 cSCC prevention
40 cell growth
41 cell transformation
42 cellular transformation
43 complexes
44 detail
45 endocytosis
46 essential role
47 expression
48 glycoprotein
49 growth
50 immunoglobulin
51 knockdown
52 malignant phenotype
53 malignant tumors
54 migration
55 molecular targets
56 molecules
57 novel molecular targets
58 oncogenic activity
59 pathway
60 phenotype
61 pivotal role
62 prevention
63 results
64 role
65 stimulation
66 study
67 target
68 therapy
69 transformation
70 transmembrane glycoprotein
71 tumorigenesis
72 tumors
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