RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKα2-mediated autophagy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-09-21

AUTHORS

Lan-Ya Li, Xi-Sha Chen, Kuan-Song Wang, Yi-Di Guan, Xing-Cong Ren, Dong-Sheng Cao, Xin-Yuan Sun, Ao-Xue Li, Yong-Guang Tao, Yi Zhang, Ming-Zhu Yin, Xin-Luan Wang, Ming-Hua Wu, Jin-Ming Yang, Yan Cheng

ABSTRACT

Autophagy can protect stressed cancer cell by degradation of damaged proteins and organelles. However, the regulatory mechanisms behind this cellular process remain incompletely understood. Here, we demonstrate that RSK2 (p90 ribosomal S6 kinase 2) plays a critical role in ER stress-induced autophagy in breast cancer cells. We demonstrated that the promotive effect of RSK2 on autophagy resulted from directly binding of AMPKα2 in nucleus and phosphorylating it at Thr172 residue. IRE1α, an ER membrane-associated protein mediating unfolded protein response (UPR), is required for transducing the signal for activation of ERK1/2-RSK2 under ER stress. Suppression of autophagy by knockdown of RSK2 enhanced the sensitivity of breast cancer cells to ER stress both in vitro and in vivo. Furthermore, we demonstrated that inhibition of RSK2-mediated autophagy rendered breast cancer cells more sensitive to paclitaxel, a chemotherapeutic agent that induces ER stress-mediated cell death. This study identifies RSK2 as a novel controller of autophagy in tumor cells and suggests that targeting RSK2 can be exploited as an approach to reinforce the efficacy of ER stress-inducing agents against cancer. More... »

PAGES

6704-6718

References to SciGraph publications

  • 2014-02-17. Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis in ONCOGENE
  • 2019-06-21. Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling in CELL DEATH & DISEASE
  • 2013-09-22. PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium in ARCHIVES OF TOXICOLOGY
  • 2014-08-22. The impact of the endoplasmic reticulum protein-folding environment on cancer development in NATURE REVIEWS CANCER
  • 2008-10. The RSK family of kinases: emerging roles in cellular signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-02-01. Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis in BREAST CANCER RESEARCH AND TREATMENT
  • 2016-06-15. AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy in NATURE
  • 2017-12-15. DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells in ONCOGENE
  • 2013-12-17. Autophagy regulation by nutrient signaling in CELL RESEARCH
  • 2017-07-28. Targeting autophagy in cancer in NATURE REVIEWS CANCER
  • 2019-07-01. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression in NATURE CELL BIOLOGY
  • 2017-07-27. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response in CELL DEATH & DISEASE
  • 2012-05-14. Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death in ONCOGENE
  • 2017-09-15. RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia in LEUKEMIA
  • 2017-01-21. Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells in BMC CANCER
  • 2012-06-11. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer in ONCOGENE
  • 2017-09-14. Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer in CELL DEATH & DISEASE
  • Journal

    TITLE

    Oncogene

    ISSUE

    43

    VOLUME

    39

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41388-020-01447-0

    DOI

    http://dx.doi.org/10.1038/s41388-020-01447-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131004394

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32958832


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