Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-09

AUTHORS

Julia Ramírez-Moya, León Wert-Lamas, Garcilaso Riesco-Eizaguirre, Pilar Santisteban

ABSTRACT

The global downregulation of microRNAs (miRNAs) is emerging as a common hallmark of cancer. However, the mechanisms underlying this phenomenon are not well known. We identified that the oncogenic miR-146b-5p attenuates miRNA biosynthesis by targeting DICER1 and reducing its expression. DICER1 overexpression inhibited all the miR-146b-induced aggressive phenotypes in thyroid cells. Systemic injection of an anti-miR-146b in mice with orthotopic thyroid tumors suppressed tumor growth and recovered DICER1 levels. Notably, DICER1 downregulation promoted proliferation, migration, invasion, and epithelial-mesenchymal transition through miRNA downregulation. Our analysis of The Cancer Genome Atlas revealed a general decrease in DICER1 expression in thyroid cancer that was associated with a worse clinical outcome. Administration of the small-molecule enoxacin to promote DICER1 complex activity reduced tumor aggressiveness both in vitro and in vivo. Overall, our data confirm DICER1 as a tumor suppressor and show that oncogenic miR-146b contributes to its downregulation. Moreover, our results highlight a potential therapeutic application of RNA-based therapies including miRNA inhibitors and restoration of the biogenesis machinery, which may provide treatments for thyroid and other cancers. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-019-0804-8

DOI

http://dx.doi.org/10.1038/s41388-019-0804-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113327849

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30967628


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto de Salud Carlos III", 
          "id": "https://www.grid.ac/institutes/grid.413448.e", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\"; Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), Madrid, Spain.", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ram\u00edrez-Moya", 
        "givenName": "Julia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario de M\u00f3stoles", 
          "id": "https://www.grid.ac/institutes/grid.440814.d", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\"; Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), Madrid, Spain.", 
            "Departamento de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Universitario de M\u00f3stoles, Madrid, Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wert-Lamas", 
        "givenName": "Le\u00f3n", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\"; Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), Madrid, Spain.", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.", 
            "Departamento de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Universitario de M\u00f3stoles, Madrid, Spain.", 
            "Universidad Francisco de Vitoria, Madrid, Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riesco-Eizaguirre", 
        "givenName": "Garcilaso", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Salud Carlos III", 
          "id": "https://www.grid.ac/institutes/grid.413448.e", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \"Alberto Sols\"; Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), Madrid, Spain. psantisteban@iib.uam.es.", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. psantisteban@iib.uam.es."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santisteban", 
        "givenName": "Pilar", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1014720108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001498014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.10356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002682465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0029929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003897835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2016.12.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004587870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004880322", 
          "https://doi.org/10.1038/nature09459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004880322", 
          "https://doi.org/10.1038/nature09459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.9655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004990517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2013.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006814246", 
          "https://doi.org/10.1038/nrendo.2013.223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.09.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006907054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.09.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006907054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009089021", 
          "https://doi.org/10.1038/nrc3431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010610829", 
          "https://doi.org/10.1038/nbt.1481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.21431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012388380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012737365", 
          "https://doi.org/10.1038/nrc3932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12253-011-9450-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013903508", 
          "https://doi.org/10.1007/s12253-011-9450-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12253-011-9450-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013903508", 
          "https://doi.org/10.1007/s12253-011-9450-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2014.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014414006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2014.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014414006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014646805", 
          "https://doi.org/10.1038/ng1253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014646805", 
          "https://doi.org/10.1038/ng1253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00541-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019720069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021715986", 
          "https://doi.org/10.1038/sj.onc.1210809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.21265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022166801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-3547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022951354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/embj.201490493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024801971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024825726", 
          "https://doi.org/10.1038/nature03702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024825726", 
          "https://doi.org/10.1038/nature03702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2013-4206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025238812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1444406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025405827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025957515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2005.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029296398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.7.9.3365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033379336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035246723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035246723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036221931", 
          "https://doi.org/10.1038/ng2003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036221931", 
          "https://doi.org/10.1038/ng2003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038480751", 
          "https://doi.org/10.1038/onc.2010.169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038480751", 
          "https://doi.org/10.1038/onc.2010.169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0027648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039052408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042196381", 
          "https://doi.org/10.1038/nature03868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042196381", 
          "https://doi.org/10.1038/nature03868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-2304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042211822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043438836", 
          "https://doi.org/10.1038/onc.2011.381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044680330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0103871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045279503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0103871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045279503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2009.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050555244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-16-0202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051192428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2015-2169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052254112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2015-2169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052254112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2012-1038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-2666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2017.2719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084005759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2017.2719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084005759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2017.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084095410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci84424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084239206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2016-2954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084505116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15384101.2017.1380127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091931291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41388-017-0088-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100512166", 
          "https://doi.org/10.1038/s41388-017-0088-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41388-017-0088-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100512166", 
          "https://doi.org/10.1038/s41388-017-0088-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-09", 
    "datePublishedReg": "2019-04-09", 
    "description": "The global downregulation of microRNAs (miRNAs) is emerging as a common hallmark of cancer. However, the mechanisms underlying this phenomenon are not well known. We identified that the oncogenic miR-146b-5p attenuates miRNA biosynthesis by targeting DICER1 and reducing its expression. DICER1 overexpression inhibited all the miR-146b-induced aggressive phenotypes in thyroid cells. Systemic injection of an anti-miR-146b in mice with orthotopic thyroid tumors suppressed tumor growth and recovered DICER1 levels. Notably, DICER1 downregulation promoted proliferation, migration, invasion, and epithelial-mesenchymal transition through miRNA downregulation. Our analysis of The Cancer Genome Atlas revealed a general decrease in DICER1 expression in thyroid cancer that was associated with a worse clinical outcome. Administration of the small-molecule enoxacin to promote DICER1 complex activity reduced tumor aggressiveness both in vitro and in vivo. Overall, our data confirm DICER1 as a tumor suppressor and show that oncogenic miR-146b contributes to its downregulation. Moreover, our results highlight a potential therapeutic application of RNA-based therapies including miRNA inhibitors and restoration of the biogenesis machinery, which may provide treatments for thyroid and other cancers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41388-019-0804-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }
    ], 
    "name": "Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness.", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41388-019-0804-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113327849"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30967628"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41388-019-0804-8", 
      "https://app.dimensions.ai/details/publication/pub.1113327849"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91469_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/s41388-019-0804-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0804-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0804-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0804-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0804-8'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      20 PREDICATES      70 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41388-019-0804-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N3b9b33ef92114de0bfcbfffda46a1298
4 schema:citation sg:pub.10.1007/s12253-011-9450-3
5 sg:pub.10.1038/nature03702
6 sg:pub.10.1038/nature03868
7 sg:pub.10.1038/nature09459
8 sg:pub.10.1038/nbt.1481
9 sg:pub.10.1038/ng1253
10 sg:pub.10.1038/ng2003
11 sg:pub.10.1038/nrc3431
12 sg:pub.10.1038/nrc3932
13 sg:pub.10.1038/nrendo.2013.223
14 sg:pub.10.1038/onc.2010.169
15 sg:pub.10.1038/onc.2011.381
16 sg:pub.10.1038/s41388-017-0088-9
17 sg:pub.10.1038/sj.onc.1210809
18 https://doi.org/10.1001/jama.2017.2719
19 https://doi.org/10.1002/pbc.21265
20 https://doi.org/10.1002/pbc.21431
21 https://doi.org/10.1016/j.cell.2009.06.016
22 https://doi.org/10.1016/j.cell.2010.05.017
23 https://doi.org/10.1016/j.cell.2014.09.050
24 https://doi.org/10.1016/j.gde.2005.12.005
25 https://doi.org/10.1016/j.mce.2009.10.010
26 https://doi.org/10.1016/j.mce.2016.12.017
27 https://doi.org/10.1016/j.mce.2017.03.015
28 https://doi.org/10.1016/j.surg.2014.08.007
29 https://doi.org/10.1016/s1097-2765(02)00541-5
30 https://doi.org/10.1073/pnas.1014720108
31 https://doi.org/10.1080/15384101.2017.1380127
32 https://doi.org/10.1101/gad.1444406
33 https://doi.org/10.1128/mcb.7.9.3365
34 https://doi.org/10.1158/0008-5472.can-05-0298
35 https://doi.org/10.1158/0008-5472.can-14-2304
36 https://doi.org/10.1158/0008-5472.can-14-3547
37 https://doi.org/10.1172/jci84424
38 https://doi.org/10.1210/er.2012-1038
39 https://doi.org/10.1210/jc.2012-2666
40 https://doi.org/10.1210/jc.2013-4206
41 https://doi.org/10.1210/jc.2015-2169
42 https://doi.org/10.1210/jc.2016-2954
43 https://doi.org/10.1371/journal.pone.0027648
44 https://doi.org/10.1371/journal.pone.0029929
45 https://doi.org/10.1371/journal.pone.0103871
46 https://doi.org/10.15252/embj.201490493
47 https://doi.org/10.1530/eje-16-0202
48 https://doi.org/10.18632/oncotarget.10356
49 https://doi.org/10.18632/oncotarget.9655
50 schema:datePublished 2019-04-09
51 schema:datePublishedReg 2019-04-09
52 schema:description The global downregulation of microRNAs (miRNAs) is emerging as a common hallmark of cancer. However, the mechanisms underlying this phenomenon are not well known. We identified that the oncogenic miR-146b-5p attenuates miRNA biosynthesis by targeting DICER1 and reducing its expression. DICER1 overexpression inhibited all the miR-146b-induced aggressive phenotypes in thyroid cells. Systemic injection of an anti-miR-146b in mice with orthotopic thyroid tumors suppressed tumor growth and recovered DICER1 levels. Notably, DICER1 downregulation promoted proliferation, migration, invasion, and epithelial-mesenchymal transition through miRNA downregulation. Our analysis of The Cancer Genome Atlas revealed a general decrease in DICER1 expression in thyroid cancer that was associated with a worse clinical outcome. Administration of the small-molecule enoxacin to promote DICER1 complex activity reduced tumor aggressiveness both in vitro and in vivo. Overall, our data confirm DICER1 as a tumor suppressor and show that oncogenic miR-146b contributes to its downregulation. Moreover, our results highlight a potential therapeutic application of RNA-based therapies including miRNA inhibitors and restoration of the biogenesis machinery, which may provide treatments for thyroid and other cancers.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf sg:journal.1097543
57 schema:name Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness.
58 schema:productId N1aad00e61cdb47f0bf4f47096e5f1d45
59 N57277b5f377a42d0ada0ec4f9763d09c
60 N67f8ae44207b4e1ba91b31af97ae316d
61 Nf21925de9f554478a199ddbc6049971a
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113327849
63 https://doi.org/10.1038/s41388-019-0804-8
64 schema:sdDatePublished 2019-04-15T09:04
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N4a7c070d88644c6fa75b0ff838c68871
67 schema:url http://www.nature.com/articles/s41388-019-0804-8
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N1aad00e61cdb47f0bf4f47096e5f1d45 schema:name doi
72 schema:value 10.1038/s41388-019-0804-8
73 rdf:type schema:PropertyValue
74 N2e37cacf60144c039546e5e975a9fb06 rdf:first N8fdec825b4364eb7801cbe553c10b9b3
75 rdf:rest rdf:nil
76 N2e7486bbf47e485d90739e50f280c27c schema:affiliation https://www.grid.ac/institutes/grid.413448.e
77 schema:familyName Ramírez-Moya
78 schema:givenName Julia
79 rdf:type schema:Person
80 N3b9b33ef92114de0bfcbfffda46a1298 rdf:first N2e7486bbf47e485d90739e50f280c27c
81 rdf:rest N8f4ea274419447dd94a05a109c980bb2
82 N489c26fff09743e48d97689a74a84781 schema:affiliation https://www.grid.ac/institutes/grid.440814.d
83 schema:familyName Wert-Lamas
84 schema:givenName León
85 rdf:type schema:Person
86 N4a7c070d88644c6fa75b0ff838c68871 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N57277b5f377a42d0ada0ec4f9763d09c schema:name pubmed_id
89 schema:value 30967628
90 rdf:type schema:PropertyValue
91 N67f8ae44207b4e1ba91b31af97ae316d schema:name dimensions_id
92 schema:value pub.1113327849
93 rdf:type schema:PropertyValue
94 N8f4ea274419447dd94a05a109c980bb2 rdf:first N489c26fff09743e48d97689a74a84781
95 rdf:rest Nf591fe5c0339450692be067dd4f6f978
96 N8fdec825b4364eb7801cbe553c10b9b3 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
97 schema:familyName Santisteban
98 schema:givenName Pilar
99 rdf:type schema:Person
100 Nec44fa7dd7f44c46b34e9f5015e554e8 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
101 schema:familyName Riesco-Eizaguirre
102 schema:givenName Garcilaso
103 rdf:type schema:Person
104 Nf21925de9f554478a199ddbc6049971a schema:name nlm_unique_id
105 schema:value 8711562
106 rdf:type schema:PropertyValue
107 Nf591fe5c0339450692be067dd4f6f978 rdf:first Nec44fa7dd7f44c46b34e9f5015e554e8
108 rdf:rest N2e37cacf60144c039546e5e975a9fb06
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
113 schema:name Oncology and Carcinogenesis
114 rdf:type schema:DefinedTerm
115 sg:journal.1097543 schema:issn 0950-9232
116 1476-5594
117 schema:name Oncogene
118 rdf:type schema:Periodical
119 sg:pub.10.1007/s12253-011-9450-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013903508
120 https://doi.org/10.1007/s12253-011-9450-3
121 rdf:type schema:CreativeWork
122 sg:pub.10.1038/nature03702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024825726
123 https://doi.org/10.1038/nature03702
124 rdf:type schema:CreativeWork
125 sg:pub.10.1038/nature03868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042196381
126 https://doi.org/10.1038/nature03868
127 rdf:type schema:CreativeWork
128 sg:pub.10.1038/nature09459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004880322
129 https://doi.org/10.1038/nature09459
130 rdf:type schema:CreativeWork
131 sg:pub.10.1038/nbt.1481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010610829
132 https://doi.org/10.1038/nbt.1481
133 rdf:type schema:CreativeWork
134 sg:pub.10.1038/ng1253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014646805
135 https://doi.org/10.1038/ng1253
136 rdf:type schema:CreativeWork
137 sg:pub.10.1038/ng2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036221931
138 https://doi.org/10.1038/ng2003
139 rdf:type schema:CreativeWork
140 sg:pub.10.1038/nrc3431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009089021
141 https://doi.org/10.1038/nrc3431
142 rdf:type schema:CreativeWork
143 sg:pub.10.1038/nrc3932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012737365
144 https://doi.org/10.1038/nrc3932
145 rdf:type schema:CreativeWork
146 sg:pub.10.1038/nrendo.2013.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006814246
147 https://doi.org/10.1038/nrendo.2013.223
148 rdf:type schema:CreativeWork
149 sg:pub.10.1038/onc.2010.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038480751
150 https://doi.org/10.1038/onc.2010.169
151 rdf:type schema:CreativeWork
152 sg:pub.10.1038/onc.2011.381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043438836
153 https://doi.org/10.1038/onc.2011.381
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/s41388-017-0088-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100512166
156 https://doi.org/10.1038/s41388-017-0088-9
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/sj.onc.1210809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021715986
159 https://doi.org/10.1038/sj.onc.1210809
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1001/jama.2017.2719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084005759
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1002/pbc.21265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022166801
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1002/pbc.21431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012388380
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.cell.2009.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025957515
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.cell.2010.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035246723
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.cell.2014.09.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006907054
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.gde.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029296398
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.mce.2009.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050555244
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.mce.2016.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004587870
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.mce.2017.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084095410
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.surg.2014.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014414006
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/s1097-2765(02)00541-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019720069
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1073/pnas.1014720108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001498014
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1080/15384101.2017.1380127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091931291
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1101/gad.1444406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025405827
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1128/mcb.7.9.3365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033379336
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1158/0008-5472.can-05-0298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044680330
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1158/0008-5472.can-14-2304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042211822
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1158/0008-5472.can-14-3547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022951354
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1172/jci84424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084239206
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1210/er.2012-1038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286033
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1210/jc.2012-2666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293766
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1210/jc.2013-4206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025238812
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1210/jc.2015-2169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052254112
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1210/jc.2016-2954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084505116
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1371/journal.pone.0027648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039052408
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1371/journal.pone.0029929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003897835
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1371/journal.pone.0103871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045279503
216 rdf:type schema:CreativeWork
217 https://doi.org/10.15252/embj.201490493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024801971
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1530/eje-16-0202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051192428
220 rdf:type schema:CreativeWork
221 https://doi.org/10.18632/oncotarget.10356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002682465
222 rdf:type schema:CreativeWork
223 https://doi.org/10.18632/oncotarget.9655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004990517
224 rdf:type schema:CreativeWork
225 https://www.grid.ac/institutes/grid.413448.e schema:alternateName Instituto de Salud Carlos III
226 schema:name Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
227 Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. psantisteban@iib.uam.es.
228 Instituto de Investigaciones Biomédicas "Alberto Sols"; Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
229 Instituto de Investigaciones Biomédicas "Alberto Sols"; Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain. psantisteban@iib.uam.es.
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.440814.d schema:alternateName Hospital Universitario de Móstoles
232 schema:name Departamento de Endocrinología y Nutrición, Hospital Universitario de Móstoles, Madrid, Spain.
233 Instituto de Investigaciones Biomédicas "Alberto Sols"; Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.449795.2 schema:alternateName Universidad Francisco de Vitoria
236 schema:name Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
237 Departamento de Endocrinología y Nutrición, Hospital Universitario de Móstoles, Madrid, Spain.
238 Instituto de Investigaciones Biomédicas "Alberto Sols"; Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
239 Universidad Francisco de Vitoria, Madrid, Spain.
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...