Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-30

AUTHORS

Joan Cao, Zhou Zhu, Hui Wang, Timothy C. Nichols, Goldie Y. L. Lui, Shibing Deng, Paul A. Rejto, Todd VanArsdale, James S. Hardwick, Scott L. Weinrich, Ping Wei

ABSTRACT

The CDK4/6 inhibitor palbociclib reduces tumor growth by decreasing retinoblastoma (RB) protein phosphorylation and inducing cell cycle arrest at the G1/S phase transition. Palbociclib in combination with anti-hormonal therapy brings significant benefit to breast cancer patients. In this study, novel combination approaches and underlying molecular/cellular mechanisms for palbociclib were explored in squamous cell lung cancer (SqCLC), the second most common subtype of non-small cell lung cancer. While approximate 20% lung patients benefit from immunotherapy, most SqCLC patients who receive platinum-doublet chemotherapy as first-line treatment, which often includes a taxane, are still in need of more effective combination therapies. Our results demonstrated enhanced cytotoxicity and anti-tumor effect with palbociclib plus taxanes at clinically achievable doses in multiple SqCLC models with diverse cancer genetic backgrounds. Comprehensive gene expression analysis revealed a sustained disruption of pRB-E2F signaling by combination that was accompanied with enhanced regulation of pleiotropic biological effects. These included several novel mechanisms such as abrogation of G2/M and mitotic spindle assembly checkpoints, as well as impaired induction of hypoxia-inducible factor 1 alpha (HIF-1α). The decrease in HIF-1α modulated a couple key angiogenic and anti-angiogenic factors, resulting in an enhanced anti-angiogenic effect. This preclinical work suggests a new therapeutic opportunity for palbociclib in lung and other cancers currently treated with taxane based chemotherapy as standard of care. More... »

PAGES

1-17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-019-0708-7

DOI

http://dx.doi.org/10.1038/s41388-019-0708-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111776890

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30700828


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Oncology Translational Research, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Joan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Oncology Translational Research, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Zhou", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Hui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Drug Safety Research and Development, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nichols", 
        "givenName": "Timothy C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fred Hutchinson Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Fred Hutchinson Cancer Research Center, 98109, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lui", 
        "givenName": "Goldie Y. L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Biostatistics, La Jolla Laboratories, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "Shibing", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Oncology Translational Research, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rejto", 
        "givenName": "Paul A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Tumor Cell Biology, Oncology Research and Development, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "VanArsdale", 
        "givenName": "Todd", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Oncology Translational Research, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hardwick", 
        "givenName": "James S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Oncology Translational Research, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weinrich", 
        "givenName": "Scott L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Oncology Translational Research, Pfizer Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Ping", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1208369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003573347", 
          "https://doi.org/10.1038/sj.onc.1208369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003573347", 
          "https://doi.org/10.1038/sj.onc.1208369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-06-0166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004420604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006014163", 
          "https://doi.org/10.1038/nature11404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006014163", 
          "https://doi.org/10.1038/nature11404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006541515", 
          "https://doi.org/10.1038/nmeth.1923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-013-9334-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007921818", 
          "https://doi.org/10.1007/s10456-013-9334-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-013-9334-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007921818", 
          "https://doi.org/10.1007/s10456-013-9334-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14656566.2016.1157581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008379171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2005.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011129923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/trns.23680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012008293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.949802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012307300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81813-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012641956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.365494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014575863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2941", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014975189", 
          "https://doi.org/10.1038/nm.2941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci28803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016268643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.25.14863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020882317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-12-323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021902674", 
          "https://doi.org/10.1186/1471-2105-12-323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-12-0102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022147976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023247882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-800249-0.00004-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023739956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2016.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024091241", 
          "https://doi.org/10.1038/onc.2016.32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4914(01)02090-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026165981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026262643", 
          "https://doi.org/10.1038/sj.onc.1209631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026262643", 
          "https://doi.org/10.1038/sj.onc.1209631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3747/co.21.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026832574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep27382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029211550", 
          "https://doi.org/10.1038/srep27382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2016.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031060512", 
          "https://doi.org/10.1038/nrclinonc.2016.26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728222.2010.522328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033905368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.20.7751-7763.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034238233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-0903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034245850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-2793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038203026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.9.20.13454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038689991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2012.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039165155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039584714", 
          "https://doi.org/10.1038/nrc3216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040741355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-4095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041116145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2014.05.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041312538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911423654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042073119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911423654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042073119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-015-0379-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043117739", 
          "https://doi.org/10.1007/s40265-015-0379-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043378487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-14-0816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043466683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00077-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046874357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m304930200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047007748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2015.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049525245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050917004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052152545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2011.197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053322918", 
          "https://doi.org/10.1038/cdd.2011.197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-16-1164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063225513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/s1152851704000997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064420652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.24592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072292945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.24592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072292945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076965945", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-017-0742-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084859902", 
          "https://doi.org/10.1007/s40265-017-0742-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-017-0742-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084859902", 
          "https://doi.org/10.1007/s40265-017-0742-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/emmm.201607084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085735300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2017.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099650432"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-30", 
    "datePublishedReg": "2019-01-30", 
    "description": "The CDK4/6 inhibitor palbociclib reduces tumor growth by decreasing retinoblastoma (RB) protein phosphorylation and inducing cell cycle arrest at the G1/S phase transition. Palbociclib in combination with anti-hormonal therapy brings significant benefit to breast cancer patients. In this study, novel combination approaches and underlying molecular/cellular mechanisms for palbociclib were explored in squamous cell lung cancer (SqCLC), the second most common subtype of non-small cell lung cancer. While approximate 20% lung patients benefit from immunotherapy, most SqCLC patients who receive platinum-doublet chemotherapy as first-line treatment, which often includes a taxane, are still in need of more effective combination therapies. Our results demonstrated enhanced cytotoxicity and anti-tumor effect with palbociclib plus taxanes at clinically achievable doses in multiple SqCLC models with diverse cancer genetic backgrounds. Comprehensive gene expression analysis revealed a sustained disruption of pRB-E2F signaling by combination that was accompanied with enhanced regulation of pleiotropic biological effects. These included several novel mechanisms such as abrogation of G2/M and mitotic spindle assembly checkpoints, as well as impaired induction of hypoxia-inducible factor 1 alpha (HIF-1\u03b1). The decrease in HIF-1\u03b1 modulated a couple key angiogenic and anti-angiogenic factors, resulting in an enhanced anti-angiogenic effect. This preclinical work suggests a new therapeutic opportunity for palbociclib in lung and other cancers currently treated with taxane based chemotherapy as standard of care.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41388-019-0708-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }
    ], 
    "name": "Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer", 
    "pagination": "1-17", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a66fd2ed76351ec6bbae50a4afac4cff3e7f2a6ac5aae58c8c6a12461f1d2bcb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30700828"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41388-019-0708-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111776890"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41388-019-0708-7", 
      "https://app.dimensions.ai/details/publication/pub.1111776890"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68471_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41388-019-0708-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0708-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0708-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0708-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-019-0708-7'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      78 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41388-019-0708-7 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nc80b2b47ba134b00bfd70f92e661d6d5
4 schema:citation sg:pub.10.1007/s10456-013-9334-0
5 sg:pub.10.1007/s40265-015-0379-9
6 sg:pub.10.1007/s40265-017-0742-0
7 sg:pub.10.1038/cdd.2011.197
8 sg:pub.10.1038/nature11404
9 sg:pub.10.1038/nm.2941
10 sg:pub.10.1038/nmeth.1923
11 sg:pub.10.1038/nrc3216
12 sg:pub.10.1038/nrclinonc.2016.26
13 sg:pub.10.1038/onc.2016.32
14 sg:pub.10.1038/sj.onc.1208369
15 sg:pub.10.1038/sj.onc.1209631
16 sg:pub.10.1038/srep27382
17 sg:pub.10.1186/1471-2105-12-323
18 https://app.dimensions.ai/details/publication/pub.1076965945
19 https://doi.org/10.1016/b978-0-12-800249-0.00004-4
20 https://doi.org/10.1016/j.ccell.2017.11.006
21 https://doi.org/10.1016/j.ccr.2011.10.001
22 https://doi.org/10.1016/j.ccr.2014.05.020
23 https://doi.org/10.1016/j.celrep.2016.04.036
24 https://doi.org/10.1016/j.molcel.2015.11.006
25 https://doi.org/10.1016/j.molmed.2005.01.007
26 https://doi.org/10.1016/s0092-8674(00)81813-9
27 https://doi.org/10.1016/s1471-4914(01)02090-1
28 https://doi.org/10.1016/s1535-6108(03)00077-1
29 https://doi.org/10.1038/emboj.2012.231
30 https://doi.org/10.1073/pnas.0506580102
31 https://doi.org/10.1073/pnas.95.25.14863
32 https://doi.org/10.1074/jbc.m112.365494
33 https://doi.org/10.1074/jbc.m304930200
34 https://doi.org/10.1093/bioinformatics/btp616
35 https://doi.org/10.1101/gad.949802
36 https://doi.org/10.1128/mcb.20.20.7751-7763.2000
37 https://doi.org/10.1158/0008-5472.can-04-3995
38 https://doi.org/10.1158/0008-5472.can-04-4095
39 https://doi.org/10.1158/1078-0432.ccr-06-2793
40 https://doi.org/10.1158/1078-0432.ccr-11-0509
41 https://doi.org/10.1158/1078-0432.ccr-12-0903
42 https://doi.org/10.1158/1078-0432.ccr-14-0816
43 https://doi.org/10.1158/1078-0432.ccr-16-1164
44 https://doi.org/10.1158/1535-7163.mct-06-0166
45 https://doi.org/10.1158/1535-7163.mct-12-0102
46 https://doi.org/10.1172/jci28803
47 https://doi.org/10.1177/1947601911423654
48 https://doi.org/10.1215/s1152851704000997
49 https://doi.org/10.1517/14656566.2016.1157581
50 https://doi.org/10.1517/14728222.2010.522328
51 https://doi.org/10.15252/emmm.201607084
52 https://doi.org/10.3747/co.21.1997
53 https://doi.org/10.4161/cbt.24592
54 https://doi.org/10.4161/cc.9.20.13454
55 https://doi.org/10.4161/trns.23680
56 schema:datePublished 2019-01-30
57 schema:datePublishedReg 2019-01-30
58 schema:description The CDK4/6 inhibitor palbociclib reduces tumor growth by decreasing retinoblastoma (RB) protein phosphorylation and inducing cell cycle arrest at the G1/S phase transition. Palbociclib in combination with anti-hormonal therapy brings significant benefit to breast cancer patients. In this study, novel combination approaches and underlying molecular/cellular mechanisms for palbociclib were explored in squamous cell lung cancer (SqCLC), the second most common subtype of non-small cell lung cancer. While approximate 20% lung patients benefit from immunotherapy, most SqCLC patients who receive platinum-doublet chemotherapy as first-line treatment, which often includes a taxane, are still in need of more effective combination therapies. Our results demonstrated enhanced cytotoxicity and anti-tumor effect with palbociclib plus taxanes at clinically achievable doses in multiple SqCLC models with diverse cancer genetic backgrounds. Comprehensive gene expression analysis revealed a sustained disruption of pRB-E2F signaling by combination that was accompanied with enhanced regulation of pleiotropic biological effects. These included several novel mechanisms such as abrogation of G2/M and mitotic spindle assembly checkpoints, as well as impaired induction of hypoxia-inducible factor 1 alpha (HIF-1α). The decrease in HIF-1α modulated a couple key angiogenic and anti-angiogenic factors, resulting in an enhanced anti-angiogenic effect. This preclinical work suggests a new therapeutic opportunity for palbociclib in lung and other cancers currently treated with taxane based chemotherapy as standard of care.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf sg:journal.1097543
63 schema:name Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer
64 schema:pagination 1-17
65 schema:productId N17b56d96c0e042579eb72052b97af95c
66 N2cac438ca09d417f8cf1cb11d3b9aa1f
67 N538f776c780d4df09d5e6a23f360142c
68 Ne974b913bb174f31b45d39711985b9ec
69 Nefd419227d8d45e5ac8c5821ab817a88
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111776890
71 https://doi.org/10.1038/s41388-019-0708-7
72 schema:sdDatePublished 2019-04-11T08:58
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nd6e11ea1866741d68c1cd953f67a4d45
75 schema:url https://www.nature.com/articles/s41388-019-0708-7
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N06e2584b8acd42df86c340dc3a8006fe schema:affiliation https://www.grid.ac/institutes/grid.410513.2
80 schema:familyName Cao
81 schema:givenName Joan
82 rdf:type schema:Person
83 N16261687eb4541ecbae15c46c673773d schema:affiliation https://www.grid.ac/institutes/grid.410513.2
84 schema:familyName Weinrich
85 schema:givenName Scott L.
86 rdf:type schema:Person
87 N17b56d96c0e042579eb72052b97af95c schema:name doi
88 schema:value 10.1038/s41388-019-0708-7
89 rdf:type schema:PropertyValue
90 N1a56a4271f6046a481ae0cb38ccd0a7e schema:affiliation https://www.grid.ac/institutes/grid.418185.1
91 schema:familyName Wang
92 schema:givenName Hui
93 rdf:type schema:Person
94 N1d7ed024c3ad421f88abf572277e8b44 rdf:first N95aa616f068940ddaa93dda9b556b760
95 rdf:rest N61e85070bebc4985950e4d246ffa1bf7
96 N22cd2c320ae94a6d8f36a21c6def9b40 rdf:first Ncc65f97abc024c91854a53f73ad2e916
97 rdf:rest Nf94b82c8ece74f89a9fdaa3dbb72467b
98 N2cac438ca09d417f8cf1cb11d3b9aa1f schema:name dimensions_id
99 schema:value pub.1111776890
100 rdf:type schema:PropertyValue
101 N30bb89ca28714e94a057a5779a620a4f schema:affiliation https://www.grid.ac/institutes/grid.410513.2
102 schema:familyName VanArsdale
103 schema:givenName Todd
104 rdf:type schema:Person
105 N3bc6f207d2fc4ba6a1c3527c0b9ca4a5 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
106 schema:familyName Rejto
107 schema:givenName Paul A.
108 rdf:type schema:Person
109 N44a4809a554146c88ad78b45cae26f31 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
110 schema:familyName Hardwick
111 schema:givenName James S.
112 rdf:type schema:Person
113 N46a926301da04a24989298e620210f96 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
114 schema:familyName Wei
115 schema:givenName Ping
116 rdf:type schema:Person
117 N538f776c780d4df09d5e6a23f360142c schema:name nlm_unique_id
118 schema:value 8711562
119 rdf:type schema:PropertyValue
120 N5a7f43f752994314a1a86d525cae79b6 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
121 schema:familyName Deng
122 schema:givenName Shibing
123 rdf:type schema:Person
124 N61e85070bebc4985950e4d246ffa1bf7 rdf:first Ne9e46bbe3f7b4b72b94ed7afd85ea041
125 rdf:rest N9db91f0b1e36471684c4b731e6dfd2e1
126 N6795127cfd98464c8d9c9d3601f95915 rdf:first N44a4809a554146c88ad78b45cae26f31
127 rdf:rest N93aafea0f5c849579d6321370189afb2
128 N7746571c869c4f179ec2942c525bbebc rdf:first N30bb89ca28714e94a057a5779a620a4f
129 rdf:rest N6795127cfd98464c8d9c9d3601f95915
130 N93aafea0f5c849579d6321370189afb2 rdf:first N16261687eb4541ecbae15c46c673773d
131 rdf:rest Nebbe9f59ac4e43a78c073bbd01cecd45
132 N95aa616f068940ddaa93dda9b556b760 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
133 schema:familyName Nichols
134 schema:givenName Timothy C.
135 rdf:type schema:Person
136 N9db91f0b1e36471684c4b731e6dfd2e1 rdf:first N5a7f43f752994314a1a86d525cae79b6
137 rdf:rest Na298f5dcb56a4267ab3ee43f18151c14
138 Na298f5dcb56a4267ab3ee43f18151c14 rdf:first N3bc6f207d2fc4ba6a1c3527c0b9ca4a5
139 rdf:rest N7746571c869c4f179ec2942c525bbebc
140 Nc80b2b47ba134b00bfd70f92e661d6d5 rdf:first N06e2584b8acd42df86c340dc3a8006fe
141 rdf:rest N22cd2c320ae94a6d8f36a21c6def9b40
142 Ncc65f97abc024c91854a53f73ad2e916 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
143 schema:familyName Zhu
144 schema:givenName Zhou
145 rdf:type schema:Person
146 Nd6e11ea1866741d68c1cd953f67a4d45 schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 Ne974b913bb174f31b45d39711985b9ec schema:name readcube_id
149 schema:value a66fd2ed76351ec6bbae50a4afac4cff3e7f2a6ac5aae58c8c6a12461f1d2bcb
150 rdf:type schema:PropertyValue
151 Ne9e46bbe3f7b4b72b94ed7afd85ea041 schema:affiliation https://www.grid.ac/institutes/grid.270240.3
152 schema:familyName Lui
153 schema:givenName Goldie Y. L.
154 rdf:type schema:Person
155 Nebbe9f59ac4e43a78c073bbd01cecd45 rdf:first N46a926301da04a24989298e620210f96
156 rdf:rest rdf:nil
157 Nefd419227d8d45e5ac8c5821ab817a88 schema:name pubmed_id
158 schema:value 30700828
159 rdf:type schema:PropertyValue
160 Nf94b82c8ece74f89a9fdaa3dbb72467b rdf:first N1a56a4271f6046a481ae0cb38ccd0a7e
161 rdf:rest N1d7ed024c3ad421f88abf572277e8b44
162 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
163 schema:name Medical and Health Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
166 schema:name Oncology and Carcinogenesis
167 rdf:type schema:DefinedTerm
168 sg:journal.1097543 schema:issn 0950-9232
169 1476-5594
170 schema:name Oncogene
171 rdf:type schema:Periodical
172 sg:pub.10.1007/s10456-013-9334-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007921818
173 https://doi.org/10.1007/s10456-013-9334-0
174 rdf:type schema:CreativeWork
175 sg:pub.10.1007/s40265-015-0379-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043117739
176 https://doi.org/10.1007/s40265-015-0379-9
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/s40265-017-0742-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084859902
179 https://doi.org/10.1007/s40265-017-0742-0
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/cdd.2011.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053322918
182 https://doi.org/10.1038/cdd.2011.197
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nature11404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006014163
185 https://doi.org/10.1038/nature11404
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nm.2941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014975189
188 https://doi.org/10.1038/nm.2941
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nmeth.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541515
191 https://doi.org/10.1038/nmeth.1923
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/nrc3216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039584714
194 https://doi.org/10.1038/nrc3216
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/nrclinonc.2016.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031060512
197 https://doi.org/10.1038/nrclinonc.2016.26
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/onc.2016.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024091241
200 https://doi.org/10.1038/onc.2016.32
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/sj.onc.1208369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003573347
203 https://doi.org/10.1038/sj.onc.1208369
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/sj.onc.1209631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026262643
206 https://doi.org/10.1038/sj.onc.1209631
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/srep27382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029211550
209 https://doi.org/10.1038/srep27382
210 rdf:type schema:CreativeWork
211 sg:pub.10.1186/1471-2105-12-323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021902674
212 https://doi.org/10.1186/1471-2105-12-323
213 rdf:type schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1076965945 schema:CreativeWork
215 https://doi.org/10.1016/b978-0-12-800249-0.00004-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023739956
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.ccell.2017.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099650432
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ccr.2011.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052152545
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ccr.2014.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041312538
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.celrep.2016.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040741355
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.molcel.2015.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049525245
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.molmed.2005.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011129923
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0092-8674(00)81813-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012641956
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s1471-4914(01)02090-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026165981
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s1535-6108(03)00077-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046874357
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1038/emboj.2012.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039165155
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.95.25.14863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882317
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.m112.365494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014575863
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1074/jbc.m304930200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047007748
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/bioinformatics/btp616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023247882
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1101/gad.949802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012307300
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1128/mcb.20.20.7751-7763.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034238233
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1158/0008-5472.can-04-3995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043378487
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1158/0008-5472.can-04-4095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041116145
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1158/1078-0432.ccr-06-2793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038203026
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1158/1078-0432.ccr-11-0509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050917004
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1158/1078-0432.ccr-12-0903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034245850
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1158/1078-0432.ccr-14-0816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043466683
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1158/1078-0432.ccr-16-1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063225513
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1158/1535-7163.mct-06-0166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004420604
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1158/1535-7163.mct-12-0102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022147976
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1172/jci28803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016268643
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1177/1947601911423654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042073119
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1215/s1152851704000997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064420652
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1517/14656566.2016.1157581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008379171
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1517/14728222.2010.522328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033905368
278 rdf:type schema:CreativeWork
279 https://doi.org/10.15252/emmm.201607084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085735300
280 rdf:type schema:CreativeWork
281 https://doi.org/10.3747/co.21.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026832574
282 rdf:type schema:CreativeWork
283 https://doi.org/10.4161/cbt.24592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072292945
284 rdf:type schema:CreativeWork
285 https://doi.org/10.4161/cc.9.20.13454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038689991
286 rdf:type schema:CreativeWork
287 https://doi.org/10.4161/trns.23680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012008293
288 rdf:type schema:CreativeWork
289 https://www.grid.ac/institutes/grid.270240.3 schema:alternateName Fred Hutchinson Cancer Research Center
290 schema:name Fred Hutchinson Cancer Research Center, 98109, Seattle, WA, USA
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.410513.2 schema:alternateName Pfizer (United States)
293 schema:name Biostatistics, La Jolla Laboratories, Pfizer Inc., 92121, San Diego, CA, USA
294 Drug Safety Research and Development, Pfizer Inc., 92121, San Diego, CA, USA
295 Oncology Translational Research, Pfizer Inc., 92121, San Diego, CA, USA
296 Tumor Cell Biology, Oncology Research and Development, Pfizer Inc., 92121, San Diego, CA, USA
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.418185.1 schema:alternateName Genomics Institute of the Novartis Research Foundation
299 schema:name Genomics Institute of the Novartis Research Foundation, 92121, San Diego, CA, USA
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...