Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-21

AUTHORS

Samira Laouirem, Aurélie Sannier, Emma Norkowski, François Cauchy, Sabrina Doblas, Pierre Emmanuel Rautou, Miguel Albuquerque, Philippe Garteiser, Laura Sognigbé, Jerôme Raffenne, Bernard E. van Beers, Olivier Soubrane, Pierre Bedossa, Jerôme Cros, Valérie Paradis

ABSTRACT

Metabolic syndrome (MS) is becoming the leading risk factor for hepatocellular carcinoma (HCC). HCC development related to MS may occur in advanced or non-advanced liver fibrosis, suggesting specific molecular pathways. Among these pathways, basal inflammatory state and adipokines production are involved. The aim of this study was to evaluate the role of fatty acid-binding protein 4 (FABP4). In this study, we demonstrate the specific overexpression of FABP4 in human HCC samples from patients with MS compared to other risk factors for chronic liver disease with FABP4 expression restricted to peritumoral endothelial cells. In vitro, glucose, insulin, VEGFA and hypoxia upregulated endothelial FABP4, which was reversed by metformin through mTOR pathway inhibition. FABP4 exerts oncogenic effects on hepatoma cell lines by upregulating the angiogenesis gene signature and pathways involved in the cell cycle, leading to increased cell proliferation and migration, and downregulating HIF1 pathway; effects were reversed in the presence of a specific FABP4 inhibitor (BMS309403). We showed the role of microvesicles as FABP4 vectors between endothelial and tumor cells. In vivo, BMS309403 significantly reduces tumor growth in heterotopic and orthotopic xenografted mice model. In conclusion, this study demonstrates the emerging oncogenic role of liver endothelial cells through FABP4 in HCC related to MS, and highlights new anti-neoplastic mechanism of metformin. More... »

PAGES

1-14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-018-0597-1

DOI

http://dx.doi.org/10.1038/s41388-018-0597-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110821016

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30575815


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