Androgen signaling is essential for development of prostate cancer initiated from prostatic basal cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Yongfeng He, Erika Hooker, Eun-Jeong Yu, Gerald R. Cunha, Lan Liao, Jianming Xu, Andrew Earl, Huiqing Wu, Michael L. Gonzalgo, Zijie Sun

ABSTRACT

Emerging evidence has shown that both prostatic basal and luminal cells are able to initiate oncogenic transformation. However, despite the diversity of tumor-initiating cells, most prostate cancer cells express the androgen receptor (AR) and depend on androgens for their growth and expansion, implicating an essential role of androgen signaling in prostate tumorigenesis. Prostatic basal cells express p63 and are able to differentiate into luminal, neuroendocrine, and basal cells. Here, we directly assessed the essential role of androgen signaling in prostatic p63-expressing cell initiated oncogenic transformation and tumor formation. Using novel and relevant mouse models, we demonstrated that, with stabilized β-catenin expression, prostatic p63-expressing cells possess the ability to initiate oncogenic transformation and, in the presence of androgens, they further transdifferentiate into luminal-like tumor cells and develop adenocarcinomas. Castration prior to activating stabilized β-catenin sensitizes p63-expressing cells and increases their sensitivity to androgens, resulting in aggressive and fast growing tumor phenotypes. These findings are consistent with what have been observed in human prostate cancers, demonstrating an essential role for androgen signaling in prostate cancer initiation and progression. This study also provides fresh insight into developing new therapeutic strategies for better treating prostate cancer patients. More... »

PAGES

2337-2350

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-018-0583-7

DOI

http://dx.doi.org/10.1038/s41388-018-0583-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110343350

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30510232


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Cancer Biology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA", 
            "Department of Urology, Stanford University School of Medicine, 94305, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Yongfeng", 
        "id": "sg:person.0651744253.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651744253.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Cancer Biology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA", 
            "Department of Urology, Stanford University School of Medicine, 94305, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hooker", 
        "givenName": "Erika", 
        "id": "sg:person.01202307250.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202307250.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Cancer Biology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA", 
            "Department of Urology, Stanford University School of Medicine, 94305, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Eun-Jeong", 
        "id": "sg:person.01272472725.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272472725.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Urology, School of Medicine, University of California San Francisco, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cunha", 
        "givenName": "Gerald R.", 
        "id": "sg:person.01250420036.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250420036.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Molecular and Cellular Biology, Baylor College of Medicine, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liao", 
        "givenName": "Lan", 
        "id": "sg:person.01357623161.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357623161.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Molecular and Cellular Biology, Baylor College of Medicine, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Jianming", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "Department of Cancer Biology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Earl", 
        "givenName": "Andrew", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "Department of Pathology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Huiqing", 
        "id": "sg:person.0751216534.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751216534.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sylvester Comprehensive Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.419791.3", 
          "name": [
            "Department of Urology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 33136, Miami, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalgo", 
        "givenName": "Michael L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Cancer Biology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA", 
            "Department of Urology, Stanford University School of Medicine, 94305, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Zijie", 
        "id": "sg:person.01050266721.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050266721.67"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000109424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111962200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001088884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006785349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(02)01593-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008226639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008565009", 
          "https://doi.org/10.1038/ncb1988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011660062", 
          "https://doi.org/10.1038/nature08361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011660062", 
          "https://doi.org/10.1038/nature08361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/ijbs.9997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014844661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2013.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015187365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64814-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016219929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.269894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017474268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.269894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017474268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017506378", 
          "https://doi.org/10.1038/nm.2890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017555185", 
          "https://doi.org/10.1038/ncb2697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-0436.2001.680414.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018094524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1734139100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019554565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80275-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024825914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025502773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200135200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027281453", 
          "https://doi.org/10.1038/sj.onc.1206426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027281453", 
          "https://doi.org/10.1038/sj.onc.1206426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1221216110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027285856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81631-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030262329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.2096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030420842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032384183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200202067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033612085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-4213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035607905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.302059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035984185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036085368", 
          "https://doi.org/10.1038/onc.2010.560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1189992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036410278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037279095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038122801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040268601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040688424", 
          "https://doi.org/10.1038/19531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040688424", 
          "https://doi.org/10.1038/19531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040942920", 
          "https://doi.org/10.1038/onc.2010.530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2015.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042365982", 
          "https://doi.org/10.1038/onc.2015.117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0913873107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045679097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00771-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048807157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.21.5931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049664537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod34.5.973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050490134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050700754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.20.010403.113126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051113440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051493123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-122-2-552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064261163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074698410", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrurol.2017.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091567949", 
          "https://doi.org/10.1038/nrurol.2017.144"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03", 
    "datePublishedReg": "2019-03-01", 
    "description": "Emerging evidence has shown that both prostatic basal and luminal cells are able to initiate oncogenic transformation. However, despite the diversity of tumor-initiating cells, most prostate cancer cells express the androgen receptor (AR) and depend on androgens for their growth and expansion, implicating an essential role of androgen signaling in prostate tumorigenesis. Prostatic basal cells express p63 and are able to differentiate into luminal, neuroendocrine, and basal cells. Here, we directly assessed the essential role of androgen signaling in prostatic p63-expressing cell initiated oncogenic transformation and tumor formation. Using novel and relevant mouse models, we demonstrated that, with stabilized \u03b2-catenin expression, prostatic p63-expressing cells possess the ability to initiate oncogenic transformation and, in the presence of androgens, they further transdifferentiate into luminal-like tumor cells and develop adenocarcinomas. Castration prior to activating stabilized \u03b2-catenin sensitizes p63-expressing cells and increases their sensitivity to androgens, resulting in aggressive and fast growing tumor phenotypes. These findings are consistent with what have been observed in human prostate cancers, demonstrating an essential role for androgen signaling in prostate cancer initiation and progression. This study also provides fresh insight into developing new therapeutic strategies for better treating prostate cancer patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41388-018-0583-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2480976", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2477911", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3801811", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4102221", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2472636", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4729170", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4244008", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "13", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Androgen signaling is essential for development of prostate cancer initiated from prostatic basal cells", 
    "pagination": "2337-2350", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cc7fa51c4e631acb97c38636a0b8dd94d53059c9d23f51899ea189b122a32429"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30510232"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41388-018-0583-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110343350"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41388-018-0583-7", 
      "https://app.dimensions.ai/details/publication/pub.1110343350"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130808_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41388-018-0583-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0583-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0583-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0583-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0583-7'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      73 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41388-018-0583-7 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N7b0a65cb70cc4ba7804d9ba0866a0cee
4 schema:citation sg:pub.10.1038/19531
5 sg:pub.10.1038/nature08361
6 sg:pub.10.1038/ncb1988
7 sg:pub.10.1038/ncb2697
8 sg:pub.10.1038/nm.2890
9 sg:pub.10.1038/nrurol.2017.144
10 sg:pub.10.1038/onc.2010.530
11 sg:pub.10.1038/onc.2010.560
12 sg:pub.10.1038/onc.2015.117
13 sg:pub.10.1038/sj.onc.1206426
14 https://app.dimensions.ai/details/publication/pub.1074698410
15 https://doi.org/10.1002/dvg.20335
16 https://doi.org/10.1002/path.1449
17 https://doi.org/10.1002/stem.2096
18 https://doi.org/10.1016/j.canlet.2005.06.004
19 https://doi.org/10.1016/j.ccr.2012.01.005
20 https://doi.org/10.1016/j.ccr.2013.01.002
21 https://doi.org/10.1016/s0002-9440(10)64814-6
22 https://doi.org/10.1016/s0090-4295(02)01593-5
23 https://doi.org/10.1016/s0092-8674(00)81631-1
24 https://doi.org/10.1016/s1097-2765(00)80275-0
25 https://doi.org/10.1046/j.1432-0436.2001.680414.x
26 https://doi.org/10.1073/pnas.0913873107
27 https://doi.org/10.1073/pnas.1221216110
28 https://doi.org/10.1073/pnas.1734139100
29 https://doi.org/10.1074/jbc.m111.269894
30 https://doi.org/10.1074/jbc.m111.302059
31 https://doi.org/10.1074/jbc.m111962200
32 https://doi.org/10.1074/jbc.m200135200
33 https://doi.org/10.1083/jcb.200202067
34 https://doi.org/10.1093/emboj/18.21.5931
35 https://doi.org/10.1095/biolreprod34.5.973
36 https://doi.org/10.1126/science.1189992
37 https://doi.org/10.1128/mcb.00771-07
38 https://doi.org/10.1146/annurev.cellbio.20.010403.113126
39 https://doi.org/10.1158/0008-5472.can-06-3028
40 https://doi.org/10.1158/0008-5472.can-07-5997
41 https://doi.org/10.1158/0008-5472.can-07-6289
42 https://doi.org/10.1158/0008-5472.can-12-4213
43 https://doi.org/10.1172/jci32810
44 https://doi.org/10.1200/jco.2002.10.018
45 https://doi.org/10.1210/endo-122-2-552
46 https://doi.org/10.3322/caac.20121
47 https://doi.org/10.7150/ijbs.9997
48 schema:datePublished 2019-03
49 schema:datePublishedReg 2019-03-01
50 schema:description Emerging evidence has shown that both prostatic basal and luminal cells are able to initiate oncogenic transformation. However, despite the diversity of tumor-initiating cells, most prostate cancer cells express the androgen receptor (AR) and depend on androgens for their growth and expansion, implicating an essential role of androgen signaling in prostate tumorigenesis. Prostatic basal cells express p63 and are able to differentiate into luminal, neuroendocrine, and basal cells. Here, we directly assessed the essential role of androgen signaling in prostatic p63-expressing cell initiated oncogenic transformation and tumor formation. Using novel and relevant mouse models, we demonstrated that, with stabilized β-catenin expression, prostatic p63-expressing cells possess the ability to initiate oncogenic transformation and, in the presence of androgens, they further transdifferentiate into luminal-like tumor cells and develop adenocarcinomas. Castration prior to activating stabilized β-catenin sensitizes p63-expressing cells and increases their sensitivity to androgens, resulting in aggressive and fast growing tumor phenotypes. These findings are consistent with what have been observed in human prostate cancers, demonstrating an essential role for androgen signaling in prostate cancer initiation and progression. This study also provides fresh insight into developing new therapeutic strategies for better treating prostate cancer patients.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N1f72a91e9daf4e8ea1e5325f208b2828
55 Ncbfd91c45c49492bb26f1ec0f3454822
56 sg:journal.1097543
57 schema:name Androgen signaling is essential for development of prostate cancer initiated from prostatic basal cells
58 schema:pagination 2337-2350
59 schema:productId N0e073591473a446da51bd20d1c8b5be4
60 N19942d2a72804ee1bf765555dc607d99
61 N1e4c80a62b34492599eb276b76659cbc
62 N5b7fa659098348b4841c493afb8eca1b
63 Nedda281bee9043499f3fe3d5701b147a
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110343350
65 https://doi.org/10.1038/s41388-018-0583-7
66 schema:sdDatePublished 2019-04-11T13:54
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nfb963958c28f49aea86b0441cb9d4180
69 schema:url https://www.nature.com/articles/s41388-018-0583-7
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N0e073591473a446da51bd20d1c8b5be4 schema:name dimensions_id
74 schema:value pub.1110343350
75 rdf:type schema:PropertyValue
76 N19942d2a72804ee1bf765555dc607d99 schema:name readcube_id
77 schema:value cc7fa51c4e631acb97c38636a0b8dd94d53059c9d23f51899ea189b122a32429
78 rdf:type schema:PropertyValue
79 N1e4c80a62b34492599eb276b76659cbc schema:name pubmed_id
80 schema:value 30510232
81 rdf:type schema:PropertyValue
82 N1f72a91e9daf4e8ea1e5325f208b2828 schema:volumeNumber 38
83 rdf:type schema:PublicationVolume
84 N33234a6d97814135ad7d235ff19fc0cd rdf:first sg:person.01250420036.30
85 rdf:rest N38d5fe822d644b72bbf7243ddd28ee6e
86 N38d5fe822d644b72bbf7243ddd28ee6e rdf:first sg:person.01357623161.42
87 rdf:rest Nf6a6f20dae72400eb2fe8cd10bc0f4e1
88 N4f38edb372004f2fbbadf6d76a0b9e05 rdf:first N524dd629d37d4019b2d4113611475bbd
89 rdf:rest Nd679ddb9cf6046958061c2b97292fb09
90 N524dd629d37d4019b2d4113611475bbd schema:affiliation https://www.grid.ac/institutes/grid.410425.6
91 schema:familyName Earl
92 schema:givenName Andrew
93 rdf:type schema:Person
94 N58333a8ab08243b1b353df8facf63f29 rdf:first sg:person.01202307250.34
95 rdf:rest Nf239e111094f4b0fa2cec1f9ea348d8e
96 N5b7fa659098348b4841c493afb8eca1b schema:name nlm_unique_id
97 schema:value 8711562
98 rdf:type schema:PropertyValue
99 N64eb006439ec4d7ab78f6dd5c917b873 schema:affiliation https://www.grid.ac/institutes/grid.419791.3
100 schema:familyName Gonzalgo
101 schema:givenName Michael L.
102 rdf:type schema:Person
103 N7b0a65cb70cc4ba7804d9ba0866a0cee rdf:first sg:person.0651744253.57
104 rdf:rest N58333a8ab08243b1b353df8facf63f29
105 Nb16f7c15a40d4e7294bc2113b2f256d3 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
106 schema:familyName Xu
107 schema:givenName Jianming
108 rdf:type schema:Person
109 Ncbfd91c45c49492bb26f1ec0f3454822 schema:issueNumber 13
110 rdf:type schema:PublicationIssue
111 Nd679ddb9cf6046958061c2b97292fb09 rdf:first sg:person.0751216534.81
112 rdf:rest Neb6873d2fbb34f5da0701d155326dc13
113 Nd7c84483a4974cee8650a2ee1b79624c rdf:first sg:person.01050266721.67
114 rdf:rest rdf:nil
115 Neb6873d2fbb34f5da0701d155326dc13 rdf:first N64eb006439ec4d7ab78f6dd5c917b873
116 rdf:rest Nd7c84483a4974cee8650a2ee1b79624c
117 Nedda281bee9043499f3fe3d5701b147a schema:name doi
118 schema:value 10.1038/s41388-018-0583-7
119 rdf:type schema:PropertyValue
120 Nf239e111094f4b0fa2cec1f9ea348d8e rdf:first sg:person.01272472725.72
121 rdf:rest N33234a6d97814135ad7d235ff19fc0cd
122 Nf6a6f20dae72400eb2fe8cd10bc0f4e1 rdf:first Nb16f7c15a40d4e7294bc2113b2f256d3
123 rdf:rest N4f38edb372004f2fbbadf6d76a0b9e05
124 Nfb963958c28f49aea86b0441cb9d4180 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
127 schema:name Medical and Health Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
130 schema:name Oncology and Carcinogenesis
131 rdf:type schema:DefinedTerm
132 sg:grant.2472636 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0583-7
133 rdf:type schema:MonetaryGrant
134 sg:grant.2477911 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0583-7
135 rdf:type schema:MonetaryGrant
136 sg:grant.2480976 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0583-7
137 rdf:type schema:MonetaryGrant
138 sg:grant.3801811 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0583-7
139 rdf:type schema:MonetaryGrant
140 sg:grant.4102221 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0583-7
141 rdf:type schema:MonetaryGrant
142 sg:grant.4244008 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0583-7
143 rdf:type schema:MonetaryGrant
144 sg:grant.4729170 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0583-7
145 rdf:type schema:MonetaryGrant
146 sg:journal.1097543 schema:issn 0950-9232
147 1476-5594
148 schema:name Oncogene
149 rdf:type schema:Periodical
150 sg:person.01050266721.67 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
151 schema:familyName Sun
152 schema:givenName Zijie
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050266721.67
154 rdf:type schema:Person
155 sg:person.01202307250.34 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
156 schema:familyName Hooker
157 schema:givenName Erika
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202307250.34
159 rdf:type schema:Person
160 sg:person.01250420036.30 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
161 schema:familyName Cunha
162 schema:givenName Gerald R.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250420036.30
164 rdf:type schema:Person
165 sg:person.01272472725.72 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
166 schema:familyName Yu
167 schema:givenName Eun-Jeong
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272472725.72
169 rdf:type schema:Person
170 sg:person.01357623161.42 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
171 schema:familyName Liao
172 schema:givenName Lan
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357623161.42
174 rdf:type schema:Person
175 sg:person.0651744253.57 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
176 schema:familyName He
177 schema:givenName Yongfeng
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651744253.57
179 rdf:type schema:Person
180 sg:person.0751216534.81 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
181 schema:familyName Wu
182 schema:givenName Huiqing
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751216534.81
184 rdf:type schema:Person
185 sg:pub.10.1038/19531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040688424
186 https://doi.org/10.1038/19531
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/nature08361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011660062
189 https://doi.org/10.1038/nature08361
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/ncb1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008565009
192 https://doi.org/10.1038/ncb1988
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/ncb2697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017555185
195 https://doi.org/10.1038/ncb2697
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/nm.2890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017506378
198 https://doi.org/10.1038/nm.2890
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/nrurol.2017.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091567949
201 https://doi.org/10.1038/nrurol.2017.144
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/onc.2010.530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040942920
204 https://doi.org/10.1038/onc.2010.530
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/onc.2010.560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036085368
207 https://doi.org/10.1038/onc.2010.560
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/onc.2015.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042365982
210 https://doi.org/10.1038/onc.2015.117
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/sj.onc.1206426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027281453
213 https://doi.org/10.1038/sj.onc.1206426
214 rdf:type schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1074698410 schema:CreativeWork
216 https://doi.org/10.1002/dvg.20335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006785349
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/path.1449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040268601
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/stem.2096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030420842
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.canlet.2005.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037279095
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.ccr.2012.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000109424
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.ccr.2013.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015187365
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0002-9440(10)64814-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016219929
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0090-4295(02)01593-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008226639
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0092-8674(00)81631-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030262329
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s1097-2765(00)80275-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024825914
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1046/j.1432-0436.2001.680414.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018094524
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.0913873107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045679097
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1073/pnas.1221216110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027285856
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1073/pnas.1734139100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019554565
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1074/jbc.m111.269894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017474268
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1074/jbc.m111.302059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035984185
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1074/jbc.m111962200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001088884
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1074/jbc.m200135200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706460
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1083/jcb.200202067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033612085
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/emboj/18.21.5931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049664537
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1095/biolreprod34.5.973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050490134
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1126/science.1189992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036410278
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1128/mcb.00771-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048807157
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1146/annurev.cellbio.20.010403.113126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051113440
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1158/0008-5472.can-06-3028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038122801
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1158/0008-5472.can-07-5997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051493123
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1158/0008-5472.can-07-6289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025502773
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1158/0008-5472.can-12-4213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035607905
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1172/jci32810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050700754
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1200/jco.2002.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203142
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1210/endo-122-2-552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064261163
277 rdf:type schema:CreativeWork
278 https://doi.org/10.3322/caac.20121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032384183
279 rdf:type schema:CreativeWork
280 https://doi.org/10.7150/ijbs.9997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014844661
281 rdf:type schema:CreativeWork
282 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
283 schema:name Department of Cancer Biology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA
284 Department of Urology, Stanford University School of Medicine, 94305, Stanford, CA, USA
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
287 schema:name Department of Urology, School of Medicine, University of California San Francisco, 94143, San Francisco, CA, USA
288 rdf:type schema:Organization
289 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
290 schema:name Department of Molecular and Cellular Biology, Baylor College of Medicine, 77030, Houston, TX, USA
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.410425.6 schema:alternateName City Of Hope National Medical Center
293 schema:name Department of Cancer Biology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA
294 Department of Pathology, Beckman Research Institute and Cancer Center, City of Hope, 91010, Duarte, CA, USA
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.419791.3 schema:alternateName Sylvester Comprehensive Cancer Center
297 schema:name Department of Urology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 33136, Miami, FL, USA
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...