ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

G. Vargas, M. Bouchet, L. Bouazza, P. Reboul, C. Boyault, M. Gervais, C. Kan, C. Benetollo, M. Brevet, M. Croset, M. Mazel, L. Cayrefourcq, S. Geraci, S. Vacher, F. Pantano, M. Filipits, K. Driouch, I. Bieche, M. Gnant, W. Jacot, J. E. Aubin, M. Duterque-Coquillaud, C. Alix-Panabières, P. Clézardin, E. Bonnelye

ABSTRACT

Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. Here, we established that ERRα promotes spontaneous metastatic dissemination of breast cancer cells from primary mammary tumors to the skeleton. We carried out cohort studies, pharmacological inhibition, gain-of-function analyses in vivo and cellular and molecular studies in vitro to identify new biomarkers in breast cancer metastases. Meta-analysis of human primary breast tumors revealed that high ERRα expression levels were associated with bone but not lung metastases. ERRα expression was also detected in circulating tumor cells from metastatic breast cancer patients. ERRα overexpression in murine 4T1 breast cancer cells promoted spontaneous bone micro-metastases formation when tumor cells were inoculated orthotopically, whereas lung metastases occurred irrespective of ERRα expression level. In vivo, Rank was identified as a target for ERRα. That was confirmed in vitro in Rankl stimulated tumor cell invasion, in mTOR/pS6K phosphorylation, by transactivation assay, ChIP and bioinformatics analyses. Moreover, pharmacological inhibition of ERRα reduced primary tumor growth, bone micro-metastases formation and Rank expression in vitro and in vivo. Transcriptomic studies and meta-analysis confirmed a positive association between metastases and ERRα/RANK in breast cancer patients and also revealed a positive correlation between ERRα and BRCA1mut carriers. Taken together, our results reveal a novel ERRα/RANK axis by which ERRα in primary breast cancer promotes early dissemination of cancer cells to bone. These findings suggest that ERRα may be a useful therapeutic target to prevent bone metastases. More... »

PAGES

950-964

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-018-0579-3

DOI

http://dx.doi.org/10.1038/s41388-018-0579-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110196780

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30478447


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Neoplasms, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor Activator of Nuclear Factor-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vargas", 
        "givenName": "G.", 
        "id": "sg:person.011333357055.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011333357055.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de G\u00e9nomique Fonctionnelle de Lyon", 
          "id": "https://www.grid.ac/institutes/grid.462143.6", 
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France", 
            "IGFL, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouchet", 
        "givenName": "M.", 
        "id": "sg:person.013462124645.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013462124645.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouazza", 
        "givenName": "L.", 
        "id": "sg:person.0734324640.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734324640.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lorraine", 
          "id": "https://www.grid.ac/institutes/grid.29172.3f", 
          "name": [
            "UMR7365-CNRS-Universit\u00e9 de Lorraine, Nancy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reboul", 
        "givenName": "P.", 
        "id": "sg:person.01216372477.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216372477.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute for Advanced Biosciences, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boyault", 
        "givenName": "C.", 
        "id": "sg:person.01303372600.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303372600.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gervais", 
        "givenName": "M.", 
        "id": "sg:person.015055065645.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015055065645.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sydney", 
          "id": "https://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France", 
            "Center for Cancer Research, University of Sydney, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kan", 
        "givenName": "C.", 
        "id": "sg:person.01215272714.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215272714.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lyon Neuroscience Research Center", 
          "id": "https://www.grid.ac/institutes/grid.461862.f", 
          "name": [
            "University of Lyon1, Lyon, France", 
            "INSERM-U1028-CNRS-UMR5292, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benetollo", 
        "givenName": "C.", 
        "id": "sg:person.0765171236.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765171236.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "Centre de Biologie et de Pathologie Est, Bron, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brevet", 
        "givenName": "M.", 
        "id": "sg:person.01244651352.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244651352.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Croset", 
        "givenName": "M.", 
        "id": "sg:person.01216656070.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216656070.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Universitaire de Recherche Clinique", 
          "id": "https://www.grid.ac/institutes/grid.411720.1", 
          "name": [
            "EA2415-Institut Universitaire de Recherche Clinique, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazel", 
        "givenName": "M.", 
        "id": "sg:person.0631446651.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631446651.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Universitaire de Recherche Clinique", 
          "id": "https://www.grid.ac/institutes/grid.411720.1", 
          "name": [
            "EA2415-Institut Universitaire de Recherche Clinique, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cayrefourcq", 
        "givenName": "L.", 
        "id": "sg:person.0746105614.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746105614.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geraci", 
        "givenName": "S.", 
        "id": "sg:person.01306177447.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306177447.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Department of Genetics, Institut-Curie, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vacher", 
        "givenName": "S.", 
        "id": "sg:person.01206061107.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206061107.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "University-Campus-Bio-Medico, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pantano", 
        "givenName": "F.", 
        "id": "sg:person.01202320751.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202320751.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery and Comprehensive Cancer Center, Medical-University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Filipits", 
        "givenName": "M.", 
        "id": "sg:person.0655171554.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655171554.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Department of Genetics, Institut-Curie, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Driouch", 
        "givenName": "K.", 
        "id": "sg:person.01260617123.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260617123.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Department of Genetics, Institut-Curie, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bieche", 
        "givenName": "I.", 
        "id": "sg:person.01315226364.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315226364.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Surgery and Comprehensive Cancer Center, Medical-University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gnant", 
        "givenName": "M.", 
        "id": "sg:person.01112754113.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112754113.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Montpellier Cancer Institute, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacot", 
        "givenName": "W.", 
        "id": "sg:person.01213577351.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213577351.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "University of Toronto, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aubin", 
        "givenName": "J. E.", 
        "id": "sg:person.01326167126.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326167126.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Biologie de Lille", 
          "id": "https://www.grid.ac/institutes/grid.418183.7", 
          "name": [
            "UMR8161/CNRS-Institut de Biologie de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duterque-Coquillaud", 
        "givenName": "M.", 
        "id": "sg:person.01326701035.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326701035.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Universitaire de Recherche Clinique", 
          "id": "https://www.grid.ac/institutes/grid.411720.1", 
          "name": [
            "EA2415-Institut Universitaire de Recherche Clinique, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alix-Panabi\u00e8res", 
        "givenName": "C.", 
        "id": "sg:person.01070760060.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070760060.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cl\u00e9zardin", 
        "givenName": "P.", 
        "id": "sg:person.01127467004.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127467004.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM-UMR1033, Lyon, France", 
            "University of Lyon1, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonnelye", 
        "givenName": "E.", 
        "id": "sg:person.01073215653.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073215653.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1315319110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000415024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000685998", 
          "https://doi.org/10.1038/nature04524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000685998", 
          "https://doi.org/10.1038/nature04524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000685998", 
          "https://doi.org/10.1038/nature04524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003855200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2010.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006081439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2016.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006087467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2016.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006087467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2016.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006087467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0401420101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006829866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/jme-10-0024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007655529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkj109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007734343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008910903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/aps.2014.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010941247", 
          "https://doi.org/10.1038/aps.2014.121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010946448", 
          "https://doi.org/10.1038/nature08021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010946448", 
          "https://doi.org/10.1038/nature08021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkw951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014351455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014607335", 
          "https://doi.org/10.1038/nature10983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-013-9624-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017179526", 
          "https://doi.org/10.1007/s10585-013-9624-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019910253", 
          "https://doi.org/10.1038/nature01658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019910253", 
          "https://doi.org/10.1038/nature01658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019964423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2004.12.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020284663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2011-200312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021422142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/331091a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021607757", 
          "https://doi.org/10.1038/331091a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsbmb.2015.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024059735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024724091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.15.5986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024790064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2016.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024896153", 
          "https://doi.org/10.1038/cr.2016.69"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025264215", 
          "https://doi.org/10.1038/nm.4118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms12156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026658462", 
          "https://doi.org/10.1038/ncomms12156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.12787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027491002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms17101674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029704178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030207920", 
          "https://doi.org/10.1038/nature03799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031306051", 
          "https://doi.org/10.1038/nrc3396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.58.4.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032695522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsbmb.2009.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036055409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036060000", 
          "https://doi.org/10.1038/nature11003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-1431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036104104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa021967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038600096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2013.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040519864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.2584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044246023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046574763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)17947-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047788005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2011.1309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048115801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2016-1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050092926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051041408", 
          "https://doi.org/10.1038/nrd3705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.1239303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052744398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm101063h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm101063h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/87.15.1162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059819418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-3728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063215760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.01.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2009-0121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064249926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2002-021353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2005-0227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064327532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074782136", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075192374", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076911265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.11.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083758210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1614664114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084152768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci89935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085554963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbo.2017.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091521338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbo.2017.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091521338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00159.2017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092155463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00159.2017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092155463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2017.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092271137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci97794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100986386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2018.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106856990"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERR\u03b1) has been implicated in cancer cell invasiveness. Here, we established that ERR\u03b1 promotes spontaneous metastatic dissemination of breast cancer cells from primary mammary tumors to the skeleton. We carried out cohort studies, pharmacological inhibition, gain-of-function analyses in vivo and cellular and molecular studies in vitro to identify new biomarkers in breast cancer metastases. Meta-analysis of human primary breast tumors revealed that high ERR\u03b1 expression levels were associated with bone but not lung metastases. ERR\u03b1 expression was also detected in circulating tumor cells from metastatic breast cancer patients. ERR\u03b1 overexpression in murine 4T1 breast cancer cells promoted spontaneous bone micro-metastases formation when tumor cells were inoculated orthotopically, whereas lung metastases occurred irrespective of ERR\u03b1 expression level. In vivo, Rank was identified as a target for ERR\u03b1. That was confirmed in vitro in Rankl stimulated tumor cell invasion, in mTOR/pS6K phosphorylation, by transactivation assay, ChIP and bioinformatics analyses. Moreover, pharmacological inhibition of ERR\u03b1 reduced primary tumor growth, bone micro-metastases formation and Rank expression in vitro and in vivo. Transcriptomic studies and meta-analysis confirmed a positive association between metastases and ERR\u03b1/RANK in breast cancer patients and also revealed a positive correlation between ERR\u03b1 and BRCA1mut carriers. Taken together, our results reveal a novel ERR\u03b1/RANK axis by which ERR\u03b1 in primary breast cancer promotes early dissemination of cancer cells to bone. These findings suggest that ERR\u03b1 may be a useful therapeutic target to prevent bone metastases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41388-018-0579-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "ERR\u03b1 promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors", 
    "pagination": "950-964", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1a0da8d490ae0b98b3b18a55f12a9cd5bec452f0953cc44b357054e64ef6836d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30478447"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41388-018-0579-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110196780"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41388-018-0579-3", 
      "https://app.dimensions.ai/details/publication/pub.1110196780"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89801_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41388-018-0579-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0579-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0579-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0579-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0579-3'


 

This table displays all metadata directly associated to this object as RDF triples.

536 TRIPLES      21 PREDICATES      101 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41388-018-0579-3 schema:about N0dfa5a17812d47e4bc00c6a53304f31d
2 N1f9860017c14429c8385ad1d0683950e
3 N300bdf4b98874cdb9ba95d906d851984
4 N3e1c2a475c8c47dfaa942e6eef6704db
5 N4d123a9607524a9cb3719ed7ea0decf8
6 N517816cb88704d71b2f233b2f26d7ad2
7 N6139f0736900470ca35ee274769ac8df
8 N6edc237467f045c89dffebdbb31a102c
9 N783f0e7803c443d8934108b1039d82d9
10 Nd3de26a5ad6748a2842bfc7e8a315028
11 Nd952c20d8e1d4e239bdce4c7118f96e0
12 Ne613732e8d7a443da42de1b9a788111e
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author Nf0b01333534e4f03a79c106070216971
16 schema:citation sg:pub.10.1007/s10585-013-9624-3
17 sg:pub.10.1038/331091a0
18 sg:pub.10.1038/aps.2014.121
19 sg:pub.10.1038/cr.2016.69
20 sg:pub.10.1038/nature01658
21 sg:pub.10.1038/nature03799
22 sg:pub.10.1038/nature04524
23 sg:pub.10.1038/nature08021
24 sg:pub.10.1038/nature10983
25 sg:pub.10.1038/nature11003
26 sg:pub.10.1038/ncomms12156
27 sg:pub.10.1038/nm.4118
28 sg:pub.10.1038/nrc3396
29 sg:pub.10.1038/nrd3705
30 https://app.dimensions.ai/details/publication/pub.1074782136
31 https://app.dimensions.ai/details/publication/pub.1075192374
32 https://app.dimensions.ai/details/publication/pub.1076911265
33 https://doi.org/10.1002/jbmr.1836
34 https://doi.org/10.1002/jbmr.2584
35 https://doi.org/10.1016/j.bbcan.2016.06.001
36 https://doi.org/10.1016/j.bbrc.2004.12.165
37 https://doi.org/10.1016/j.canlet.2018.08.027
38 https://doi.org/10.1016/j.ccr.2009.05.017
39 https://doi.org/10.1016/j.cell.2016.11.037
40 https://doi.org/10.1016/j.cmet.2010.04.015
41 https://doi.org/10.1016/j.cmet.2013.03.003
42 https://doi.org/10.1016/j.ctrv.2017.09.008
43 https://doi.org/10.1016/j.jbo.2017.09.001
44 https://doi.org/10.1016/j.jsbmb.2009.02.010
45 https://doi.org/10.1016/j.jsbmb.2015.06.009
46 https://doi.org/10.1016/s0140-6736(05)17947-1
47 https://doi.org/10.1021/jm101063h
48 https://doi.org/10.1056/nejmoa021967
49 https://doi.org/10.1073/pnas.0401420101
50 https://doi.org/10.1073/pnas.1315319110
51 https://doi.org/10.1073/pnas.1614664114
52 https://doi.org/10.1093/jnci/87.15.1162
53 https://doi.org/10.1093/nar/gkj109
54 https://doi.org/10.1093/nar/gkw951
55 https://doi.org/10.1101/gr.1239303
56 https://doi.org/10.1124/pr.58.4.10
57 https://doi.org/10.1136/jclinpath-2011-200312
58 https://doi.org/10.1152/ajpendo.00159.2017
59 https://doi.org/10.1158/0008-5472.can-10-0226
60 https://doi.org/10.1158/0008-5472.can-11-1431
61 https://doi.org/10.1158/0008-5472.can-14-3728
62 https://doi.org/10.1172/jci89935
63 https://doi.org/10.1172/jci97794
64 https://doi.org/10.1200/jco.2003.01.138
65 https://doi.org/10.1200/jco.2007.15.5986
66 https://doi.org/10.1210/en.2009-0121
67 https://doi.org/10.1210/jc.2002-021353
68 https://doi.org/10.1210/me.2005-0227
69 https://doi.org/10.1210/me.2016-1036
70 https://doi.org/10.1371/journal.pbio.1001363
71 https://doi.org/10.1371/journal.pone.0019234
72 https://doi.org/10.1677/jme-10-0024
73 https://doi.org/10.18632/oncotarget.12787
74 https://doi.org/10.3390/ijms17101674
75 https://doi.org/10.3892/ijo.2011.1309
76 schema:datePublished 2019-02
77 schema:datePublishedReg 2019-02-01
78 schema:description Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. Here, we established that ERRα promotes spontaneous metastatic dissemination of breast cancer cells from primary mammary tumors to the skeleton. We carried out cohort studies, pharmacological inhibition, gain-of-function analyses in vivo and cellular and molecular studies in vitro to identify new biomarkers in breast cancer metastases. Meta-analysis of human primary breast tumors revealed that high ERRα expression levels were associated with bone but not lung metastases. ERRα expression was also detected in circulating tumor cells from metastatic breast cancer patients. ERRα overexpression in murine 4T1 breast cancer cells promoted spontaneous bone micro-metastases formation when tumor cells were inoculated orthotopically, whereas lung metastases occurred irrespective of ERRα expression level. In vivo, Rank was identified as a target for ERRα. That was confirmed in vitro in Rankl stimulated tumor cell invasion, in mTOR/pS6K phosphorylation, by transactivation assay, ChIP and bioinformatics analyses. Moreover, pharmacological inhibition of ERRα reduced primary tumor growth, bone micro-metastases formation and Rank expression in vitro and in vivo. Transcriptomic studies and meta-analysis confirmed a positive association between metastases and ERRα/RANK in breast cancer patients and also revealed a positive correlation between ERRα and BRCA1<sup>mut</sup> carriers. Taken together, our results reveal a novel ERRα/RANK axis by which ERRα in primary breast cancer promotes early dissemination of cancer cells to bone. These findings suggest that ERRα may be a useful therapeutic target to prevent bone metastases.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree false
82 schema:isPartOf N4dc440b9b23347bc9b8e7de3b6e897cb
83 Nb76cc45cd6a345818934c3de8ee17d2c
84 sg:journal.1097543
85 schema:name ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors
86 schema:pagination 950-964
87 schema:productId N03a7963564e349a2a08060fd2a5b7502
88 N4d72f8f5ba9b49e2a068ec0b7d6dacf9
89 N91ce2b7a70124286952157e065cbe784
90 N95687201ee074ef6be809ac2ff2dbccf
91 Nd3dcf7c4d5a24b20be1fb9fb70ac800c
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110196780
93 https://doi.org/10.1038/s41388-018-0579-3
94 schema:sdDatePublished 2019-04-11T09:55
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher Nd45f6253a14b436c945a7fa3d7b45868
97 schema:url https://www.nature.com/articles/s41388-018-0579-3
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N01c17d91a6254ddf805ff569ee59f3a4 rdf:first sg:person.0631446651.42
102 rdf:rest N38b00ef7ad0d46d78d5d0c03e11fe799
103 N03a7963564e349a2a08060fd2a5b7502 schema:name readcube_id
104 schema:value 1a0da8d490ae0b98b3b18a55f12a9cd5bec452f0953cc44b357054e64ef6836d
105 rdf:type schema:PropertyValue
106 N0dfa5a17812d47e4bc00c6a53304f31d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Bone Neoplasms
108 rdf:type schema:DefinedTerm
109 N142061bd468f45c0b0b2f5c6706f8005 schema:name INSERM-UMR1033, Lyon, France
110 University of Lyon1, Lyon, France
111 rdf:type schema:Organization
112 N1f9860017c14429c8385ad1d0683950e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Receptors, Estrogen
114 rdf:type schema:DefinedTerm
115 N2f1beb3a6bc246aeb5e31847fcd21188 schema:name INSERM-UMR1033, Lyon, France
116 University of Lyon1, Lyon, France
117 rdf:type schema:Organization
118 N300bdf4b98874cdb9ba95d906d851984 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Neoplasm Proteins
120 rdf:type schema:DefinedTerm
121 N30c9b2bd106b4a3fa97f670b1c2effb6 rdf:first sg:person.01326167126.28
122 rdf:rest Nf133ecece0444f8c8ec88953b8fd984b
123 N35ede9f8662b4dfd81e3481f308da09d rdf:first sg:person.0765171236.32
124 rdf:rest N8fc5d7e678c0462b903e317e4307dfef
125 N38676ba41b05421792fedc7b8fc8f617 rdf:first sg:person.013462124645.98
126 rdf:rest N742f200971104cd1b703913c604a40db
127 N38b00ef7ad0d46d78d5d0c03e11fe799 rdf:first sg:person.0746105614.96
128 rdf:rest N5290ff1c07ee449f814c3691305106ff
129 N3aa7a4fca7d548328b7583121a47520b rdf:first sg:person.01202320751.28
130 rdf:rest Nff787e6e0f364b6db393b6998608d56b
131 N3e1c2a475c8c47dfaa942e6eef6704db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mammary Neoplasms, Animal
133 rdf:type schema:DefinedTerm
134 N404e2917ef5546a9980b0fae3629cad2 rdf:first sg:person.01073215653.61
135 rdf:rest rdf:nil
136 N46ce960d8e634b32ac2f0002ce6577a1 rdf:first sg:person.01127467004.71
137 rdf:rest N404e2917ef5546a9980b0fae3629cad2
138 N4b97e986776b4fb29386a9d6f376371b rdf:first sg:person.01315226364.92
139 rdf:rest N6a7bca16cea040beb913e5d63ffca7dd
140 N4d123a9607524a9cb3719ed7ea0decf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Receptor Activator of Nuclear Factor-kappa B
142 rdf:type schema:DefinedTerm
143 N4d72f8f5ba9b49e2a068ec0b7d6dacf9 schema:name dimensions_id
144 schema:value pub.1110196780
145 rdf:type schema:PropertyValue
146 N4dc440b9b23347bc9b8e7de3b6e897cb schema:volumeNumber 38
147 rdf:type schema:PublicationVolume
148 N4ed919b3feea4cf3b4d30c15730f3de7 rdf:first sg:person.01216656070.21
149 rdf:rest N01c17d91a6254ddf805ff569ee59f3a4
150 N517816cb88704d71b2f233b2f26d7ad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Female
152 rdf:type schema:DefinedTerm
153 N5290ff1c07ee449f814c3691305106ff rdf:first sg:person.01306177447.00
154 rdf:rest N94cc017c39954c59b7f8389c2b9c79c9
155 N6139f0736900470ca35ee274769ac8df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Humans
157 rdf:type schema:DefinedTerm
158 N6217c2e26f4c47c3ba14219505def95e rdf:first sg:person.01213577351.80
159 rdf:rest N30c9b2bd106b4a3fa97f670b1c2effb6
160 N62816091895a40cf95654134d02c602d rdf:first sg:person.01260617123.41
161 rdf:rest N4b97e986776b4fb29386a9d6f376371b
162 N646a5715d29942a78405115575688d8a schema:name Centre de Biologie et de Pathologie Est, Bron, France
163 INSERM-UMR1033, Lyon, France
164 rdf:type schema:Organization
165 N6a7bca16cea040beb913e5d63ffca7dd rdf:first sg:person.01112754113.07
166 rdf:rest N6217c2e26f4c47c3ba14219505def95e
167 N6edc237467f045c89dffebdbb31a102c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Gene Expression Regulation, Neoplastic
169 rdf:type schema:DefinedTerm
170 N6f45569a4ccf4d3182c9e8820a22dd43 rdf:first sg:person.01070760060.55
171 rdf:rest N46ce960d8e634b32ac2f0002ce6577a1
172 N73a54277a2a243ed80d321ee11d673fd rdf:first sg:person.01216372477.81
173 rdf:rest Neb85d3a1084d401aa9fa0b649142e698
174 N742f200971104cd1b703913c604a40db rdf:first sg:person.0734324640.25
175 rdf:rest N73a54277a2a243ed80d321ee11d673fd
176 N783f0e7803c443d8934108b1039d82d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Mice, Inbred BALB C
178 rdf:type schema:DefinedTerm
179 N8fc5d7e678c0462b903e317e4307dfef rdf:first sg:person.01244651352.52
180 rdf:rest N4ed919b3feea4cf3b4d30c15730f3de7
181 N91ce2b7a70124286952157e065cbe784 schema:name nlm_unique_id
182 schema:value 8711562
183 rdf:type schema:PropertyValue
184 N94cc017c39954c59b7f8389c2b9c79c9 rdf:first sg:person.01206061107.59
185 rdf:rest N3aa7a4fca7d548328b7583121a47520b
186 N95687201ee074ef6be809ac2ff2dbccf schema:name doi
187 schema:value 10.1038/s41388-018-0579-3
188 rdf:type schema:PropertyValue
189 N986f8832ad244049a943758b7612f365 rdf:first sg:person.015055065645.47
190 rdf:rest Nfaba71c5b12f41889ef6c814f4051f38
191 N9e78a35bfbd141ff8fc5c74247645eb8 schema:name INSERM-UMR1033, Lyon, France
192 University of Lyon1, Lyon, France
193 rdf:type schema:Organization
194 N9f99f8d783f14078abea6f2e29a0a8e3 schema:name INSERM-UMR1033, Lyon, France
195 University of Lyon1, Lyon, France
196 rdf:type schema:Organization
197 Na023c04e1074476cbc2a6df1dfd71cfe schema:name INSERM-UMR1033, Lyon, France
198 University of Lyon1, Lyon, France
199 rdf:type schema:Organization
200 Nad79b74dfb504c6bb71feaad3b67f3da schema:name INSERM-UMR1033, Lyon, France
201 University of Lyon1, Lyon, France
202 rdf:type schema:Organization
203 Nb76cc45cd6a345818934c3de8ee17d2c schema:issueNumber 7
204 rdf:type schema:PublicationIssue
205 Ncb460c26df4c456888be627be6421fe5 schema:name INSERM-UMR1033, Lyon, France
206 University of Lyon1, Lyon, France
207 rdf:type schema:Organization
208 Nce73de53a2a341729cd6464bb048dec2 schema:name Institute for Advanced Biosciences, Grenoble, France
209 rdf:type schema:Organization
210 Nd3dcf7c4d5a24b20be1fb9fb70ac800c schema:name pubmed_id
211 schema:value 30478447
212 rdf:type schema:PropertyValue
213 Nd3de26a5ad6748a2842bfc7e8a315028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Animals
215 rdf:type schema:DefinedTerm
216 Nd45f6253a14b436c945a7fa3d7b45868 schema:name Springer Nature - SN SciGraph project
217 rdf:type schema:Organization
218 Nd952c20d8e1d4e239bdce4c7118f96e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Breast Neoplasms
220 rdf:type schema:DefinedTerm
221 Ne0563f6d5c284d5ebaaeb9d439bc4363 schema:name Montpellier Cancer Institute, Montpellier, France
222 rdf:type schema:Organization
223 Ne613732e8d7a443da42de1b9a788111e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Mice
225 rdf:type schema:DefinedTerm
226 Neb85d3a1084d401aa9fa0b649142e698 rdf:first sg:person.01303372600.06
227 rdf:rest N986f8832ad244049a943758b7612f365
228 Nf0b01333534e4f03a79c106070216971 rdf:first sg:person.011333357055.64
229 rdf:rest N38676ba41b05421792fedc7b8fc8f617
230 Nf133ecece0444f8c8ec88953b8fd984b rdf:first sg:person.01326701035.49
231 rdf:rest N6f45569a4ccf4d3182c9e8820a22dd43
232 Nfaba71c5b12f41889ef6c814f4051f38 rdf:first sg:person.01215272714.49
233 rdf:rest N35ede9f8662b4dfd81e3481f308da09d
234 Nff787e6e0f364b6db393b6998608d56b rdf:first sg:person.0655171554.11
235 rdf:rest N62816091895a40cf95654134d02c602d
236 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
237 schema:name Medical and Health Sciences
238 rdf:type schema:DefinedTerm
239 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
240 schema:name Oncology and Carcinogenesis
241 rdf:type schema:DefinedTerm
242 sg:journal.1097543 schema:issn 0950-9232
243 1476-5594
244 schema:name Oncogene
245 rdf:type schema:Periodical
246 sg:person.01070760060.55 schema:affiliation https://www.grid.ac/institutes/grid.411720.1
247 schema:familyName Alix-Panabières
248 schema:givenName C.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070760060.55
250 rdf:type schema:Person
251 sg:person.01073215653.61 schema:affiliation N9e78a35bfbd141ff8fc5c74247645eb8
252 schema:familyName Bonnelye
253 schema:givenName E.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073215653.61
255 rdf:type schema:Person
256 sg:person.01112754113.07 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
257 schema:familyName Gnant
258 schema:givenName M.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112754113.07
260 rdf:type schema:Person
261 sg:person.01127467004.71 schema:affiliation Nad79b74dfb504c6bb71feaad3b67f3da
262 schema:familyName Clézardin
263 schema:givenName P.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127467004.71
265 rdf:type schema:Person
266 sg:person.011333357055.64 schema:affiliation N142061bd468f45c0b0b2f5c6706f8005
267 schema:familyName Vargas
268 schema:givenName G.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011333357055.64
270 rdf:type schema:Person
271 sg:person.01202320751.28 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
272 schema:familyName Pantano
273 schema:givenName F.
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202320751.28
275 rdf:type schema:Person
276 sg:person.01206061107.59 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
277 schema:familyName Vacher
278 schema:givenName S.
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206061107.59
280 rdf:type schema:Person
281 sg:person.01213577351.80 schema:affiliation Ne0563f6d5c284d5ebaaeb9d439bc4363
282 schema:familyName Jacot
283 schema:givenName W.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213577351.80
285 rdf:type schema:Person
286 sg:person.01215272714.49 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
287 schema:familyName Kan
288 schema:givenName C.
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215272714.49
290 rdf:type schema:Person
291 sg:person.01216372477.81 schema:affiliation https://www.grid.ac/institutes/grid.29172.3f
292 schema:familyName Reboul
293 schema:givenName P.
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216372477.81
295 rdf:type schema:Person
296 sg:person.01216656070.21 schema:affiliation N2f1beb3a6bc246aeb5e31847fcd21188
297 schema:familyName Croset
298 schema:givenName M.
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216656070.21
300 rdf:type schema:Person
301 sg:person.01244651352.52 schema:affiliation N646a5715d29942a78405115575688d8a
302 schema:familyName Brevet
303 schema:givenName M.
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244651352.52
305 rdf:type schema:Person
306 sg:person.01260617123.41 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
307 schema:familyName Driouch
308 schema:givenName K.
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260617123.41
310 rdf:type schema:Person
311 sg:person.01303372600.06 schema:affiliation Nce73de53a2a341729cd6464bb048dec2
312 schema:familyName Boyault
313 schema:givenName C.
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303372600.06
315 rdf:type schema:Person
316 sg:person.01306177447.00 schema:affiliation N9f99f8d783f14078abea6f2e29a0a8e3
317 schema:familyName Geraci
318 schema:givenName S.
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306177447.00
320 rdf:type schema:Person
321 sg:person.01315226364.92 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
322 schema:familyName Bieche
323 schema:givenName I.
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315226364.92
325 rdf:type schema:Person
326 sg:person.01326167126.28 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
327 schema:familyName Aubin
328 schema:givenName J. E.
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326167126.28
330 rdf:type schema:Person
331 sg:person.01326701035.49 schema:affiliation https://www.grid.ac/institutes/grid.418183.7
332 schema:familyName Duterque-Coquillaud
333 schema:givenName M.
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326701035.49
335 rdf:type schema:Person
336 sg:person.013462124645.98 schema:affiliation https://www.grid.ac/institutes/grid.462143.6
337 schema:familyName Bouchet
338 schema:givenName M.
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013462124645.98
340 rdf:type schema:Person
341 sg:person.015055065645.47 schema:affiliation Ncb460c26df4c456888be627be6421fe5
342 schema:familyName Gervais
343 schema:givenName M.
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015055065645.47
345 rdf:type schema:Person
346 sg:person.0631446651.42 schema:affiliation https://www.grid.ac/institutes/grid.411720.1
347 schema:familyName Mazel
348 schema:givenName M.
349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631446651.42
350 rdf:type schema:Person
351 sg:person.0655171554.11 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
352 schema:familyName Filipits
353 schema:givenName M.
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655171554.11
355 rdf:type schema:Person
356 sg:person.0734324640.25 schema:affiliation Na023c04e1074476cbc2a6df1dfd71cfe
357 schema:familyName Bouazza
358 schema:givenName L.
359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734324640.25
360 rdf:type schema:Person
361 sg:person.0746105614.96 schema:affiliation https://www.grid.ac/institutes/grid.411720.1
362 schema:familyName Cayrefourcq
363 schema:givenName L.
364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746105614.96
365 rdf:type schema:Person
366 sg:person.0765171236.32 schema:affiliation https://www.grid.ac/institutes/grid.461862.f
367 schema:familyName Benetollo
368 schema:givenName C.
369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765171236.32
370 rdf:type schema:Person
371 sg:pub.10.1007/s10585-013-9624-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017179526
372 https://doi.org/10.1007/s10585-013-9624-3
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/331091a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021607757
375 https://doi.org/10.1038/331091a0
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/aps.2014.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010941247
378 https://doi.org/10.1038/aps.2014.121
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/cr.2016.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024896153
381 https://doi.org/10.1038/cr.2016.69
382 rdf:type schema:CreativeWork
383 sg:pub.10.1038/nature01658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019910253
384 https://doi.org/10.1038/nature01658
385 rdf:type schema:CreativeWork
386 sg:pub.10.1038/nature03799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030207920
387 https://doi.org/10.1038/nature03799
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/nature04524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000685998
390 https://doi.org/10.1038/nature04524
391 rdf:type schema:CreativeWork
392 sg:pub.10.1038/nature08021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010946448
393 https://doi.org/10.1038/nature08021
394 rdf:type schema:CreativeWork
395 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
396 https://doi.org/10.1038/nature10983
397 rdf:type schema:CreativeWork
398 sg:pub.10.1038/nature11003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060000
399 https://doi.org/10.1038/nature11003
400 rdf:type schema:CreativeWork
401 sg:pub.10.1038/ncomms12156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026658462
402 https://doi.org/10.1038/ncomms12156
403 rdf:type schema:CreativeWork
404 sg:pub.10.1038/nm.4118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025264215
405 https://doi.org/10.1038/nm.4118
406 rdf:type schema:CreativeWork
407 sg:pub.10.1038/nrc3396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031306051
408 https://doi.org/10.1038/nrc3396
409 rdf:type schema:CreativeWork
410 sg:pub.10.1038/nrd3705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051041408
411 https://doi.org/10.1038/nrd3705
412 rdf:type schema:CreativeWork
413 https://app.dimensions.ai/details/publication/pub.1074782136 schema:CreativeWork
414 https://app.dimensions.ai/details/publication/pub.1075192374 schema:CreativeWork
415 https://app.dimensions.ai/details/publication/pub.1076911265 schema:CreativeWork
416 https://doi.org/10.1002/jbmr.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008910903
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1002/jbmr.2584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044246023
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1016/j.bbcan.2016.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006087467
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1016/j.bbrc.2004.12.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020284663
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1016/j.canlet.2018.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106856990
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1016/j.ccr.2009.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003855200
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1016/j.cell.2016.11.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083758210
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1016/j.cmet.2010.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006081439
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1016/j.cmet.2013.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040519864
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1016/j.ctrv.2017.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092271137
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1016/j.jbo.2017.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091521338
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1016/j.jsbmb.2009.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036055409
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1016/j.jsbmb.2015.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024059735
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1016/s0140-6736(05)17947-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047788005
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1021/jm101063h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055951901
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1056/nejmoa021967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038600096
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1073/pnas.0401420101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006829866
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1073/pnas.1315319110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000415024
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1073/pnas.1614664114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084152768
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1093/jnci/87.15.1162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819418
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1093/nar/gkj109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007734343
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1093/nar/gkw951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014351455
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1101/gr.1239303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052744398
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1124/pr.58.4.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032695522
463 rdf:type schema:CreativeWork
464 https://doi.org/10.1136/jclinpath-2011-200312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021422142
465 rdf:type schema:CreativeWork
466 https://doi.org/10.1152/ajpendo.00159.2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092155463
467 rdf:type schema:CreativeWork
468 https://doi.org/10.1158/0008-5472.can-10-0226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019964423
469 rdf:type schema:CreativeWork
470 https://doi.org/10.1158/0008-5472.can-11-1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036104104
471 rdf:type schema:CreativeWork
472 https://doi.org/10.1158/0008-5472.can-14-3728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215760
473 rdf:type schema:CreativeWork
474 https://doi.org/10.1172/jci89935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085554963
475 rdf:type schema:CreativeWork
476 https://doi.org/10.1172/jci97794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100986386
477 rdf:type schema:CreativeWork
478 https://doi.org/10.1200/jco.2003.01.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203299
479 rdf:type schema:CreativeWork
480 https://doi.org/10.1200/jco.2007.15.5986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024790064
481 rdf:type schema:CreativeWork
482 https://doi.org/10.1210/en.2009-0121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249926
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1210/jc.2002-021353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286365
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1210/me.2005-0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064327532
487 rdf:type schema:CreativeWork
488 https://doi.org/10.1210/me.2016-1036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050092926
489 rdf:type schema:CreativeWork
490 https://doi.org/10.1371/journal.pbio.1001363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024724091
491 rdf:type schema:CreativeWork
492 https://doi.org/10.1371/journal.pone.0019234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046574763
493 rdf:type schema:CreativeWork
494 https://doi.org/10.1677/jme-10-0024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007655529
495 rdf:type schema:CreativeWork
496 https://doi.org/10.18632/oncotarget.12787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027491002
497 rdf:type schema:CreativeWork
498 https://doi.org/10.3390/ijms17101674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029704178
499 rdf:type schema:CreativeWork
500 https://doi.org/10.3892/ijo.2011.1309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048115801
501 rdf:type schema:CreativeWork
502 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
503 schema:name Center for Cancer Research, University of Sydney, Sydney, Australia
504 INSERM-UMR1033, Lyon, France
505 University of Lyon1, Lyon, France
506 rdf:type schema:Organization
507 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
508 schema:name University of Toronto, Toronto, Canada
509 rdf:type schema:Organization
510 https://www.grid.ac/institutes/grid.22937.3d schema:alternateName Medical University of Vienna
511 schema:name Department of Surgery and Comprehensive Cancer Center, Medical-University of Vienna, Vienna, Austria
512 rdf:type schema:Organization
513 https://www.grid.ac/institutes/grid.29172.3f schema:alternateName University of Lorraine
514 schema:name UMR7365-CNRS-Université de Lorraine, Nancy, France
515 rdf:type schema:Organization
516 https://www.grid.ac/institutes/grid.411720.1 schema:alternateName Institut Universitaire de Recherche Clinique
517 schema:name EA2415-Institut Universitaire de Recherche Clinique, Montpellier, France
518 rdf:type schema:Organization
519 https://www.grid.ac/institutes/grid.418183.7 schema:alternateName Institut de Biologie de Lille
520 schema:name UMR8161/CNRS-Institut de Biologie de Lille, Lille, France
521 rdf:type schema:Organization
522 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
523 schema:name Department of Genetics, Institut-Curie, Paris, France
524 rdf:type schema:Organization
525 https://www.grid.ac/institutes/grid.461862.f schema:alternateName Lyon Neuroscience Research Center
526 schema:name INSERM-U1028-CNRS-UMR5292, Lyon, France
527 University of Lyon1, Lyon, France
528 rdf:type schema:Organization
529 https://www.grid.ac/institutes/grid.462143.6 schema:alternateName Institut de Génomique Fonctionnelle de Lyon
530 schema:name IGFL, Lyon, France
531 INSERM-UMR1033, Lyon, France
532 University of Lyon1, Lyon, France
533 rdf:type schema:Organization
534 https://www.grid.ac/institutes/grid.9657.d schema:alternateName Università Campus Bio-Medico
535 schema:name University-Campus-Bio-Medico, 00128, Rome, Italy
536 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...