Ontology type: schema:ScholarlyArticle
2019-01
AUTHORSFeng He, Zhi Song, Huacui Chen, Zhuanpeng Chen, Ping Yang, Wanglin Li, Zhi Yang, Tong Zhang, Fei Wang, Jianchang Wei, Fang Wei, Qiang Wang, Jie Cao
ABSTRACTLong noncoding RNAs (lncRNAs) are implicated in human cancer, but their mechanisms of action are largely unknown. In this study, we investigated lncRNA alterations that contribute to colorectal cancer (CRC) through microarray expression profiling in CRC patient samples. Here, we report that the CRC-associated lncRNA PVT1-214 is a key regulator of CRC development and progression; patients with high PVT1-214 expression had a shorter survival and poorer prognosis. In vitro and in vivo investigation of the role of PVT1-214 revealed a complex integrated phenotype affecting cell growth, stem-like properties, migration, and invasion. Furthermore, using RNA pull-down and mass spectrometry, we found that Lin28 (also known as Lin28A), a highly conserved RNA-binding protein, is associated with PVT1-214. Strikingly, we found that PVT1-214 not only upregulated Lin28 protein expression in CRC cells by stabilizing Lin28, but also participated in crosstalk with Lin28 mRNA through competition for miR-128 binding, imposing an additional level of post-transcriptional regulation. In addition, we further show that PVT1-214 repressed expression of let-7 family miRNAs, which was abrogated by Lin28 knockdown. Taken together, our findings support a model in which the PVT1-214/Lin28/let-7 axis serves as a critical regulator of CRC pathogenesis, which may simulate a new direction for CRC therapeutic development. More... »
PAGES164-179
http://scigraph.springernature.com/pub.10.1038/s41388-018-0432-8
DOIhttp://dx.doi.org/10.1038/s41388-018-0432-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105977934
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30076414
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Proliferation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Heterografts",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred BALB C",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Nude",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "MicroRNAs",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Invasiveness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Long Noncoding",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA-Binding Proteins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Yale University",
"id": "https://www.grid.ac/institutes/grid.47100.32",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China",
"Department of Nephrology, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China",
"Department of Pathology, Yale University School of Medicine, 06520, New Haven, CT, USA"
],
"type": "Organization"
},
"familyName": "He",
"givenName": "Feng",
"id": "sg:person.01042010167.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042010167.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sun Yat-sen University",
"id": "https://www.grid.ac/institutes/grid.12981.33",
"name": [
"Department of Pathology, Yale University School of Medicine, 06520, New Haven, CT, USA",
"Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, 510055, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Song",
"givenName": "Zhi",
"id": "sg:person.0774451731.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774451731.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou Medical University",
"id": "https://www.grid.ac/institutes/grid.410737.6",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China",
"Department of Pathology, Yale University School of Medicine, 06520, New Haven, CT, USA",
"Department of General Surgery, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Huacui",
"id": "sg:person.015246041521.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015246041521.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Zhuanpeng",
"id": "sg:person.012326252721.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012326252721.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Yang",
"givenName": "Ping",
"id": "sg:person.01226635365.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226635365.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Wanglin",
"id": "sg:person.01222667546.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222667546.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Yang",
"givenName": "Zhi",
"id": "sg:person.016333076047.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016333076047.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Zhang",
"givenName": "Tong",
"id": "sg:person.01256515775.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256515775.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Fei",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Wei",
"givenName": "Jianchang",
"id": "sg:person.01026040775.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026040775.61"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Wei",
"givenName": "Fang",
"id": "sg:person.0730111612.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730111612.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou First People's Hospital",
"id": "https://www.grid.ac/institutes/grid.413432.3",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Qiang",
"id": "sg:person.0665573065.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665573065.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Guangzhou Medical University",
"id": "https://www.grid.ac/institutes/grid.410737.6",
"name": [
"Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People\u2019s Hospital, The Second Affiliated Hospital of South China University of Technology, 510180, Guangzhou, China",
"Department of General Surgery, Guangzhou First People\u2019s Hospital, Guangzhou Medical University, 510180, Guangzhou, China"
],
"type": "Organization"
},
"familyName": "Cao",
"givenName": "Jie",
"id": "sg:person.01071013341.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071013341.94"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature13311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001968824",
"https://doi.org/10.1038/nature13311"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2013.698",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002352686",
"https://doi.org/10.1038/bjc.2013.698"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gks915",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002477416"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11233",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003047559",
"https://doi.org/10.1038/nature11233"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/embor.2012.91",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007766550"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4137/ebo.s20772",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009609848"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2013.02.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011697893"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.30039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014238789"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.humpath.2010.09.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018457765"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature18632",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019621143",
"https://doi.org/10.1038/nature18632"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.13012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023508043"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12986",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025529308",
"https://doi.org/10.1038/nature12986"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddl046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030570965"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.27239",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033240173"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-014-3282-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034108908",
"https://doi.org/10.1007/s00125-014-3282-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-014-3282-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034108908",
"https://doi.org/10.1007/s00125-014-3282-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.13215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034605714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2009.01.045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037337105"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.11709",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038789965"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2016.278",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039316214",
"https://doi.org/10.1038/onc.2016.278"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.392",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039771504",
"https://doi.org/10.1038/ng.392"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-15-3047",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044807948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2008.09.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047698038"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12943-015-0355-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048196313",
"https://doi.org/10.1186/s12943-015-0355-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12943-015-0355-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048196313",
"https://doi.org/10.1186/s12943-015-0355-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1261/rna.1155108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048224171"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2290",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048988578",
"https://doi.org/10.1038/nrg2290"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.12869",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050406349"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.07.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053021425"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms9584",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056451336",
"https://doi.org/10.1038/ncomms9584"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-15-1824",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063215911"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-16-0742",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063225440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-15-0707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063226397"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.14839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074245507"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd.2016.246",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083845449",
"https://doi.org/10.1038/nrd.2016.246"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.15878",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084372996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.15878",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084372996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1010428317699122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084611725"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1010428317699122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084611725"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-017-00304-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091148241",
"https://doi.org/10.1038/s41467-017-00304-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2017.09.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091490586"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2018.03.068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103793726"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2018.03.068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103793726"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2018.03.068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103793726"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-01",
"datePublishedReg": "2019-01-01",
"description": "Long noncoding RNAs (lncRNAs) are implicated in human cancer, but their mechanisms of action are largely unknown. In this study, we investigated lncRNA alterations that contribute to colorectal cancer (CRC) through microarray expression profiling in CRC patient samples. Here, we report that the CRC-associated lncRNA PVT1-214 is a key regulator of CRC development and progression; patients with high PVT1-214 expression had a shorter survival and poorer prognosis. In vitro and in vivo investigation of the role of PVT1-214 revealed a complex integrated phenotype affecting cell growth, stem-like properties, migration, and invasion. Furthermore, using RNA pull-down and mass spectrometry, we found that Lin28 (also known as Lin28A), a highly conserved RNA-binding protein, is associated with PVT1-214. Strikingly, we found that PVT1-214 not only upregulated Lin28 protein expression in CRC cells by stabilizing Lin28, but also participated in crosstalk with Lin28 mRNA through competition for miR-128 binding, imposing an additional level of post-transcriptional regulation. In addition, we further show that PVT1-214 repressed expression of let-7 family miRNAs, which was abrogated by Lin28 knockdown. Taken together, our findings support a model in which the PVT1-214/Lin28/let-7 axis serves as a critical regulator of CRC pathogenesis, which may simulate a new direction for CRC therapeutic development.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41388-018-0432-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.6616624",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1097543",
"issn": [
"0950-9232",
"1476-5594"
],
"name": "Oncogene",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "38"
}
],
"name": "Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128",
"pagination": "164-179",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9156969df0ad15bcae6dbcda60ffb2b212cf4f208fe70b45a925b9607757b834"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30076414"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8711562"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41388-018-0432-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1105977934"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41388-018-0432-8",
"https://app.dimensions.ai/details/publication/pub.1105977934"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T10:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113655_00000004.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41388-018-0432-8"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0432-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0432-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0432-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0432-8'
This table displays all metadata directly associated to this object as RDF triples.
347 TRIPLES
21 PREDICATES
80 URIs
34 LITERALS
22 BLANK NODES