Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Derek Wong, Kohl Lounsbury, Amy Lum, Jungeun Song, Susanna Chan, Veronique LeBlanc, Suganthi Chittaranjan, Marco Marra, Stephen Yip

ABSTRACT

Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through activation of the MAPK signalling cascade and derepression of oncogenic ETS transcription factors. The Ataxin-family protein ATXN1L has previously been reported to interact with CIC in developmental and disease contexts to facilitate the repression of CIC target genes. To further investigate this relationship, we performed functional in vitro studies utilizing ATXN1LKO and CICKO human cell lines and characterized a reciprocal functional relationship between CIC and ATXN1L. Transcriptomic interrogation of the CIC-ATXN1-ATXN1L axis in low-grade glioma, prostate adenocarcinoma and stomach adenocarcinoma TCGA cohorts revealed context-dependent convergence of gene sets and pathways related to mitotic cell cycle and division. This study highlights the CIC-ATXN1-ATXN1L axis as a more potent regulator of the cell cycle than previously appreciated. More... »

PAGES

273-290

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41388-018-0427-5

    DOI

    http://dx.doi.org/10.1038/s41388-018-0427-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106052555

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30093628


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