Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Derek Wong, Kohl Lounsbury, Amy Lum, Jungeun Song, Susanna Chan, Veronique LeBlanc, Suganthi Chittaranjan, Marco Marra, Stephen Yip

ABSTRACT

Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through activation of the MAPK signalling cascade and derepression of oncogenic ETS transcription factors. The Ataxin-family protein ATXN1L has previously been reported to interact with CIC in developmental and disease contexts to facilitate the repression of CIC target genes. To further investigate this relationship, we performed functional in vitro studies utilizing ATXN1LKO and CICKO human cell lines and characterized a reciprocal functional relationship between CIC and ATXN1L. Transcriptomic interrogation of the CIC-ATXN1-ATXN1L axis in low-grade glioma, prostate adenocarcinoma and stomach adenocarcinoma TCGA cohorts revealed context-dependent convergence of gene sets and pathways related to mitotic cell cycle and division. This study highlights the CIC-ATXN1-ATXN1L axis as a more potent regulator of the cell cycle than previously appreciated. More... »

PAGES

273-290

References to SciGraph publications

  • 2015-05. Mutational landscape and clonal architecture in grade II and III gliomas in NATURE GENETICS
  • 2011-12. Single-cell dissection of transcriptional heterogeneity in human colon tumors in NATURE BIOTECHNOLOGY
  • 2015-10. E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution in CELL DEATH & DIFFERENTIATION
  • 2012-12. Fold change and p-value cutoffs significantly alter microarray interpretations in BMC BIOINFORMATICS
  • 2012-03. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype in NATURE
  • 2014-03. Loss of CIC and FUBP1 expressions are potential markers of shorter time to recurrence in oligodendroglial tumors in MODERN PATHOLOGY
  • 2017-04. Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans in NATURE GENETICS
  • 2014-12. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2014-07-23. Comprehensive molecular characterization of gastric adenocarcinoma in NATURE
  • 2017-01. Inactivation of Capicua drives cancer metastasis in NATURE GENETICS
  • 2012-06. CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas in ACTA NEUROPATHOLOGICA
  • 1992-06. Characterization of a cell line derived from a human oligodendroglioma in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2016-06. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary in ACTA NEUROPATHOLOGICA
  • 2007-03. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes in NATURE GENETICS
  • 2015-07. Deficiency of Capicua disrupts bile acid homeostasis in SCIENTIFIC REPORTS
  • 2009-11. Emerging roles of E2Fs in cancer: an exit from cell cycle control in NATURE REVIEWS CANCER
  • 2016-09. Targeting the RB-E2F pathway in breast cancer in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41388-018-0427-5

    DOI

    http://dx.doi.org/10.1038/s41388-018-0427-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106052555

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30093628


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ataxin-1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Repressor Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada", 
                "Molecular Oncology, BC Cancer, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wong", 
            "givenName": "Derek", 
            "id": "sg:person.014545435370.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014545435370.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lounsbury", 
            "givenName": "Kohl", 
            "id": "sg:person.016140376370.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016140376370.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Molecular Oncology, BC Cancer, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lum", 
            "givenName": "Amy", 
            "id": "sg:person.01316034776.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316034776.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
              "id": "https://www.grid.ac/institutes/grid.434706.2", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "Jungeun", 
            "id": "sg:person.01345045334.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345045334.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
              "id": "https://www.grid.ac/institutes/grid.434706.2", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chan", 
            "givenName": "Susanna", 
            "id": "sg:person.0720115374.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720115374.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
              "id": "https://www.grid.ac/institutes/grid.434706.2", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "LeBlanc", 
            "givenName": "Veronique", 
            "id": "sg:person.01206651124.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206651124.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
              "id": "https://www.grid.ac/institutes/grid.434706.2", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chittaranjan", 
            "givenName": "Suganthi", 
            "id": "sg:person.0672143104.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672143104.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada", 
                "Medical Genetics, University of British Columbia, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marra", 
            "givenName": "Marco", 
            "id": "sg:person.01150455763.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada", 
                "Molecular Oncology, BC Cancer, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yip", 
            "givenName": "Stephen", 
            "id": "sg:person.0745471507.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745471507.67"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.scr.2016.02.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002247769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biophys.27.1.133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005816601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006109556", 
              "https://doi.org/10.1038/nrc2696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007363870", 
              "https://doi.org/10.1038/ng.3273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0703945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008864975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(03)00818-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009068479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009199541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009199541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2011.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009501135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1210557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009784017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010733927", 
              "https://doi.org/10.1038/nature10866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0076623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010748475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010828271", 
              "https://doi.org/10.1038/ng.3728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2011.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011537418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011831914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011894036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2013.165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012176186", 
              "https://doi.org/10.1038/modpathol.2013.165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7601532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013497405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1005634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014384763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2008.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016416561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1231143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019873131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020052263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.22172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020984609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-016-1545-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021788062", 
              "https://doi.org/10.1007/s00401-016-1545-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1232033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022072971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2016.32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024091241", 
              "https://doi.org/10.1038/onc.2016.32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.11.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025764671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1609417113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026928098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.24443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027703789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-13-s2-s11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028272461", 
              "https://doi.org/10.1186/1471-2105-13-s2-s11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.22283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029055688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.212068.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029517858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029818016", 
              "https://doi.org/10.1038/nbt.2038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029818016", 
              "https://doi.org/10.1038/nbt.2038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031140100", 
              "https://doi.org/10.1038/ng1977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.4372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033116261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03159976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033251781", 
              "https://doi.org/10.1007/bf03159976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03159976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033251781", 
              "https://doi.org/10.1007/bf03159976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03159976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033251781", 
              "https://doi.org/10.1007/bf03159976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2004088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033807182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1402121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034690235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2015.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034823430", 
              "https://doi.org/10.1038/cdd.2015.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddl136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035229396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035707124", 
              "https://doi.org/10.1038/nature13480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-012-0993-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037252294", 
              "https://doi.org/10.1007/s00401-012-0993-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1001021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038979103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038993520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(02)00439-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039343802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(02)00439-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039343802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.2401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047901400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.381706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048643612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2007.03.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048968872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.092965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051951040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep08272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053515309", 
              "https://doi.org/10.1038/srep08272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.3.12.1494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072293309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.3.4.773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072297881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074582952", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074841691", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075003322", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.291948.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083687466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.291948.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083687466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2017.01.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083699278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084015437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129148", 
              "https://doi.org/10.1038/ng.3808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.117.039909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084864365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.117.039909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084864365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2017.06.105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086117209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.300244.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091296416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2017.7460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092887362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.29738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099710068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101385026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101385026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101385026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2018.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101385026"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-01", 
        "datePublishedReg": "2019-01-01", 
        "description": "Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through activation of the MAPK signalling cascade and derepression of oncogenic ETS transcription factors. The Ataxin-family protein ATXN1L has previously been reported to interact with CIC in developmental and disease contexts to facilitate the repression of CIC target genes. To further investigate this relationship, we performed functional in vitro studies utilizing ATXN1LKO and CICKO human cell lines and characterized a reciprocal functional relationship between CIC and ATXN1L. Transcriptomic interrogation of the CIC-ATXN1-ATXN1L axis in low-grade glioma, prostate adenocarcinoma and stomach adenocarcinoma TCGA cohorts revealed context-dependent convergence of gene sets and pathways related to mitotic cell cycle and division. This study highlights the CIC-ATXN1-ATXN1L axis as a more potent regulator of the cell cycle than previously appreciated.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41388-018-0427-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "38"
          }
        ], 
        "name": "Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer", 
        "pagination": "273-290", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "00f62933e993791cd86285506136deeb24b2df916564b5f7953cab17f726392f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30093628"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41388-018-0427-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1106052555"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41388-018-0427-5", 
          "https://app.dimensions.ai/details/publication/pub.1106052555"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113667_00000005.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41388-018-0427-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0427-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0427-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0427-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0427-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    371 TRIPLES      21 PREDICATES      101 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41388-018-0427-5 schema:about N02b4d0d674624b23998aa0ff5d8d6b5a
    2 N394a11d0d8df4c41849d547a32119102
    3 N414a0e114f114cb2bec0f0bac44a29bf
    4 N9b576c063955439083be121cc08c698e
    5 Na729496f3bea477ead3c0a848b793084
    6 Nd0ccaf8a68aa43a0a8717c3978205030
    7 Ne11c5a270ffc4466a182af0db645370d
    8 anzsrc-for:06
    9 anzsrc-for:0601
    10 schema:author Neb80d9f695e14ee4816edd517202fe20
    11 schema:citation sg:pub.10.1007/bf03159976
    12 sg:pub.10.1007/s00401-012-0993-5
    13 sg:pub.10.1007/s00401-016-1545-1
    14 sg:pub.10.1038/cdd.2015.4
    15 sg:pub.10.1038/modpathol.2013.165
    16 sg:pub.10.1038/nature10866
    17 sg:pub.10.1038/nature13480
    18 sg:pub.10.1038/nbt.2038
    19 sg:pub.10.1038/ng.3273
    20 sg:pub.10.1038/ng.3728
    21 sg:pub.10.1038/ng.3808
    22 sg:pub.10.1038/ng1977
    23 sg:pub.10.1038/nrc2696
    24 sg:pub.10.1038/onc.2016.32
    25 sg:pub.10.1038/srep08272
    26 sg:pub.10.1186/1471-2105-13-s2-s11
    27 sg:pub.10.1186/s13059-014-0550-8
    28 https://app.dimensions.ai/details/publication/pub.1074582952
    29 https://app.dimensions.ai/details/publication/pub.1074841691
    30 https://app.dimensions.ai/details/publication/pub.1075003322
    31 https://doi.org/10.1002/ana.24443
    32 https://doi.org/10.1002/gcc.22172
    33 https://doi.org/10.1002/gcc.22283
    34 https://doi.org/10.1002/hep.29738
    35 https://doi.org/10.1002/path.2995
    36 https://doi.org/10.1002/path.4894
    37 https://doi.org/10.1016/j.bbrc.2017.06.105
    38 https://doi.org/10.1016/j.canlet.2008.02.001
    39 https://doi.org/10.1016/j.cell.2004.08.005
    40 https://doi.org/10.1016/j.cell.2006.11.038
    41 https://doi.org/10.1016/j.celrep.2017.01.031
    42 https://doi.org/10.1016/j.cub.2007.03.023
    43 https://doi.org/10.1016/j.devcel.2011.08.017
    44 https://doi.org/10.1016/j.neuron.2018.02.013
    45 https://doi.org/10.1016/j.scr.2016.02.005
    46 https://doi.org/10.1016/s0014-5793(03)00818-4
    47 https://doi.org/10.1016/s0169-328x(02)00439-4
    48 https://doi.org/10.1038/embor.2011.49
    49 https://doi.org/10.1038/sj.bjp.0703945
    50 https://doi.org/10.1038/sj.emboj.7600785
    51 https://doi.org/10.1038/sj.emboj.7601532
    52 https://doi.org/10.1056/nejmoa1402121
    53 https://doi.org/10.1073/pnas.1609417113
    54 https://doi.org/10.1093/hmg/ddl136
    55 https://doi.org/10.1101/gad.212068.112
    56 https://doi.org/10.1101/gad.291948.116
    57 https://doi.org/10.1101/gad.300244.117
    58 https://doi.org/10.1101/gad.381706
    59 https://doi.org/10.1126/science.1210557
    60 https://doi.org/10.1126/science.1231143
    61 https://doi.org/10.1126/science.1232033
    62 https://doi.org/10.1126/scisignal.2004088
    63 https://doi.org/10.1146/annurev.biophys.27.1.133
    64 https://doi.org/10.1158/2159-8290.cd-12-0095
    65 https://doi.org/10.1242/jcs.092965
    66 https://doi.org/10.1371/journal.pgen.1001021
    67 https://doi.org/10.1371/journal.pgen.1003359
    68 https://doi.org/10.1371/journal.pgen.1005634
    69 https://doi.org/10.1371/journal.pone.0076623
    70 https://doi.org/10.1534/g3.117.039909
    71 https://doi.org/10.18632/oncotarget.2401
    72 https://doi.org/10.18632/oncotarget.4372
    73 https://doi.org/10.3892/ol.2017.7460
    74 https://doi.org/10.4161/cbt.3.12.1494
    75 https://doi.org/10.4161/cc.3.4.773
    76 schema:datePublished 2019-01
    77 schema:datePublishedReg 2019-01-01
    78 schema:description Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through activation of the MAPK signalling cascade and derepression of oncogenic ETS transcription factors. The Ataxin-family protein ATXN1L has previously been reported to interact with CIC in developmental and disease contexts to facilitate the repression of CIC target genes. To further investigate this relationship, we performed functional in vitro studies utilizing ATXN1L<sup>KO</sup> and CIC<sup>KO</sup> human cell lines and characterized a reciprocal functional relationship between CIC and ATXN1L. Transcriptomic interrogation of the CIC-ATXN1-ATXN1L axis in low-grade glioma, prostate adenocarcinoma and stomach adenocarcinoma TCGA cohorts revealed context-dependent convergence of gene sets and pathways related to mitotic cell cycle and division. This study highlights the CIC-ATXN1-ATXN1L axis as a more potent regulator of the cell cycle than previously appreciated.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree false
    82 schema:isPartOf N6ef775f093c4422a803d96056e828f66
    83 Nd6fd3435a8d04232bf4a27b98b598b3c
    84 sg:journal.1097543
    85 schema:name Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer
    86 schema:pagination 273-290
    87 schema:productId N106017c912cb4367961db37b6ec2b912
    88 N1eea3cf8b49949aeb1031ed31fcae6e0
    89 N2e992479acde45af91bfbb1fcaed1b7c
    90 Nc786302d8ba04f9693d759827c9b899a
    91 Nfa9a879bc50f4518a92c69747b0742ca
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106052555
    93 https://doi.org/10.1038/s41388-018-0427-5
    94 schema:sdDatePublished 2019-04-11T10:35
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher Nb16345288a39461fbf08374ace921076
    97 schema:url https://www.nature.com/articles/s41388-018-0427-5
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N02b4d0d674624b23998aa0ff5d8d6b5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Repressor Proteins
    103 rdf:type schema:DefinedTerm
    104 N106017c912cb4367961db37b6ec2b912 schema:name nlm_unique_id
    105 schema:value 8711562
    106 rdf:type schema:PropertyValue
    107 N1eea3cf8b49949aeb1031ed31fcae6e0 schema:name readcube_id
    108 schema:value 00f62933e993791cd86285506136deeb24b2df916564b5f7953cab17f726392f
    109 rdf:type schema:PropertyValue
    110 N1f99811716234ceba11fe510af85ecfd rdf:first sg:person.01150455763.02
    111 rdf:rest N3c07571c323f4756b541da23486dcece
    112 N21a12e6308ef418398cec8fd592b400d rdf:first sg:person.01206651124.42
    113 rdf:rest Ne5f23e8743484ade951d2c8d689970fb
    114 N2e992479acde45af91bfbb1fcaed1b7c schema:name pubmed_id
    115 schema:value 30093628
    116 rdf:type schema:PropertyValue
    117 N31c0839ea5ca4e969b7b755f1550415a rdf:first sg:person.0720115374.37
    118 rdf:rest N21a12e6308ef418398cec8fd592b400d
    119 N394a11d0d8df4c41849d547a32119102 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Neoplasms
    121 rdf:type schema:DefinedTerm
    122 N3c07571c323f4756b541da23486dcece rdf:first sg:person.0745471507.67
    123 rdf:rest rdf:nil
    124 N414a0e114f114cb2bec0f0bac44a29bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Cell Line, Tumor
    126 rdf:type schema:DefinedTerm
    127 N6ef775f093c4422a803d96056e828f66 schema:issueNumber 2
    128 rdf:type schema:PublicationIssue
    129 N7a99180aa0874b6e862ff3d1f26e4602 rdf:first sg:person.016140376370.97
    130 rdf:rest N8d78fc831df54da3a3c2b9e0c4b0f7a2
    131 N8d78fc831df54da3a3c2b9e0c4b0f7a2 rdf:first sg:person.01316034776.15
    132 rdf:rest N9970b010c925418d8b9d3aaa73d02d81
    133 N9970b010c925418d8b9d3aaa73d02d81 rdf:first sg:person.01345045334.55
    134 rdf:rest N31c0839ea5ca4e969b7b755f1550415a
    135 N9b576c063955439083be121cc08c698e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Humans
    137 rdf:type schema:DefinedTerm
    138 Na729496f3bea477ead3c0a848b793084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Gene Expression Profiling
    140 rdf:type schema:DefinedTerm
    141 Nb16345288a39461fbf08374ace921076 schema:name Springer Nature - SN SciGraph project
    142 rdf:type schema:Organization
    143 Nc786302d8ba04f9693d759827c9b899a schema:name doi
    144 schema:value 10.1038/s41388-018-0427-5
    145 rdf:type schema:PropertyValue
    146 Nd0ccaf8a68aa43a0a8717c3978205030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Cell Cycle
    148 rdf:type schema:DefinedTerm
    149 Nd6fd3435a8d04232bf4a27b98b598b3c schema:volumeNumber 38
    150 rdf:type schema:PublicationVolume
    151 Ne11c5a270ffc4466a182af0db645370d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Ataxin-1
    153 rdf:type schema:DefinedTerm
    154 Ne5f23e8743484ade951d2c8d689970fb rdf:first sg:person.0672143104.98
    155 rdf:rest N1f99811716234ceba11fe510af85ecfd
    156 Neb80d9f695e14ee4816edd517202fe20 rdf:first sg:person.014545435370.01
    157 rdf:rest N7a99180aa0874b6e862ff3d1f26e4602
    158 Nfa9a879bc50f4518a92c69747b0742ca schema:name dimensions_id
    159 schema:value pub.1106052555
    160 rdf:type schema:PropertyValue
    161 Nfe17ef246f0a43a190cc9f5de219b309 schema:name Molecular Oncology, BC Cancer, Vancouver, Canada
    162 rdf:type schema:Organization
    163 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Biological Sciences
    165 rdf:type schema:DefinedTerm
    166 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Biochemistry and Cell Biology
    168 rdf:type schema:DefinedTerm
    169 sg:journal.1097543 schema:issn 0950-9232
    170 1476-5594
    171 schema:name Oncogene
    172 rdf:type schema:Periodical
    173 sg:person.01150455763.02 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    174 schema:familyName Marra
    175 schema:givenName Marco
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02
    177 rdf:type schema:Person
    178 sg:person.01206651124.42 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
    179 schema:familyName LeBlanc
    180 schema:givenName Veronique
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206651124.42
    182 rdf:type schema:Person
    183 sg:person.01316034776.15 schema:affiliation Nfe17ef246f0a43a190cc9f5de219b309
    184 schema:familyName Lum
    185 schema:givenName Amy
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316034776.15
    187 rdf:type schema:Person
    188 sg:person.01345045334.55 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
    189 schema:familyName Song
    190 schema:givenName Jungeun
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345045334.55
    192 rdf:type schema:Person
    193 sg:person.014545435370.01 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    194 schema:familyName Wong
    195 schema:givenName Derek
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014545435370.01
    197 rdf:type schema:Person
    198 sg:person.016140376370.97 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    199 schema:familyName Lounsbury
    200 schema:givenName Kohl
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016140376370.97
    202 rdf:type schema:Person
    203 sg:person.0672143104.98 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
    204 schema:familyName Chittaranjan
    205 schema:givenName Suganthi
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672143104.98
    207 rdf:type schema:Person
    208 sg:person.0720115374.37 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
    209 schema:familyName Chan
    210 schema:givenName Susanna
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720115374.37
    212 rdf:type schema:Person
    213 sg:person.0745471507.67 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    214 schema:familyName Yip
    215 schema:givenName Stephen
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745471507.67
    217 rdf:type schema:Person
    218 sg:pub.10.1007/bf03159976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033251781
    219 https://doi.org/10.1007/bf03159976
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00401-012-0993-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037252294
    222 https://doi.org/10.1007/s00401-012-0993-5
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00401-016-1545-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021788062
    225 https://doi.org/10.1007/s00401-016-1545-1
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/cdd.2015.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034823430
    228 https://doi.org/10.1038/cdd.2015.4
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/modpathol.2013.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012176186
    231 https://doi.org/10.1038/modpathol.2013.165
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature10866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010733927
    234 https://doi.org/10.1038/nature10866
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature13480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035707124
    237 https://doi.org/10.1038/nature13480
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nbt.2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029818016
    240 https://doi.org/10.1038/nbt.2038
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/ng.3273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007363870
    243 https://doi.org/10.1038/ng.3273
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/ng.3728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010828271
    246 https://doi.org/10.1038/ng.3728
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ng.3808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129148
    249 https://doi.org/10.1038/ng.3808
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ng1977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031140100
    252 https://doi.org/10.1038/ng1977
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nrc2696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006109556
    255 https://doi.org/10.1038/nrc2696
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/onc.2016.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024091241
    258 https://doi.org/10.1038/onc.2016.32
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/srep08272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053515309
    261 https://doi.org/10.1038/srep08272
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/1471-2105-13-s2-s11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028272461
    264 https://doi.org/10.1186/1471-2105-13-s2-s11
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    267 https://doi.org/10.1186/s13059-014-0550-8
    268 rdf:type schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1074582952 schema:CreativeWork
    270 https://app.dimensions.ai/details/publication/pub.1074841691 schema:CreativeWork
    271 https://app.dimensions.ai/details/publication/pub.1075003322 schema:CreativeWork
    272 https://doi.org/10.1002/ana.24443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027703789
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1002/gcc.22172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020984609
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1002/gcc.22283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029055688
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1002/hep.29738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099710068
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1002/path.2995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038993520
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1002/path.4894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084015437
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.bbrc.2017.06.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086117209
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.canlet.2008.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016416561
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.cell.2004.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011894036
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.cell.2006.11.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025764671
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.celrep.2017.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083699278
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.cub.2007.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048968872
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.devcel.2011.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009501135
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.neuron.2018.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101385026
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.scr.2016.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002247769
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/s0014-5793(03)00818-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009068479
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/s0169-328x(02)00439-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039343802
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1038/embor.2011.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011537418
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1038/sj.bjp.0703945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008864975
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1038/sj.emboj.7600785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009199541
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1038/sj.emboj.7601532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013497405
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1056/nejmoa1402121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034690235
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1073/pnas.1609417113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026928098
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1093/hmg/ddl136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035229396
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1101/gad.212068.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029517858
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1101/gad.291948.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083687466
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1101/gad.300244.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091296416
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1101/gad.381706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048643612
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1126/science.1210557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009784017
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1126/science.1231143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019873131
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1126/science.1232033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022072971
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1146/annurev.biophys.27.1.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005816601
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1242/jcs.092965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051951040
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1371/journal.pgen.1001021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038979103
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1371/journal.pgen.1003359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020052263
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1371/journal.pgen.1005634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014384763
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1371/journal.pone.0076623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010748475
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1534/g3.117.039909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084864365
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.18632/oncotarget.2401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047901400
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.18632/oncotarget.4372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033116261
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.3892/ol.2017.7460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092887362
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.4161/cbt.3.12.1494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293309
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.4161/cc.3.4.773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297881
    361 rdf:type schema:CreativeWork
    362 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    363 schema:name Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada
    364 Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada
    365 Medical Genetics, University of British Columbia, Vancouver, Canada
    366 Molecular Oncology, BC Cancer, Vancouver, Canada
    367 Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    368 rdf:type schema:Organization
    369 https://www.grid.ac/institutes/grid.434706.2 schema:alternateName Canada's Michael Smith Genome Sciences Centre
    370 schema:name Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada
    371 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...