The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-03

AUTHORS

Imène Hamaidi, Catherine Coquard, Sabrina Danilin, Valérian Dormoy, Claire Béraud, Sylvie Rothhut, Mariette Barthelmebs, Nadia Benkirane-Jessel, Véronique Lindner, Hervé Lang, Thierry Massfelder

ABSTRACT

Metastatic clear cell renal cell carcinoma (CCC) remains incurable despite advances in the development of anti-angiogenic targeted therapies and the emergence of immune checkpoint inhibitors. We have previously shown that the sonic hedgehog-Gli signaling pathway is oncogenic in CCC allowing us to identify the developmental Lim1 transcription factor as a Gli target and as a new oncogene in CCC regulating cell proliferation and apoptosis, and promoting tumor growth. In this previous study, preliminary in vitro results also suggested that Lim1 may be implicated in metastatic spread. Here we investigated the potential pro-metastatic role of Lim1 in advanced CCC (1) in vitro using a panel of CCC cell lines expressing or not the von Hippel-Lindau (VHL) tumor suppressor gene either naturally or by gene transfer and (2) ex vivo in 30 CCC metastatic tissues, including lymph nodes, lung, skin, bone, and adrenal metastases, and (3) in vivo, using a metastatic model by intravenous injection of siRNA-transfected cells into Balb/c nude. Our in vitro results reveal that Lim1 knockdown time-dependently decreased CCC cell motility, migration, invasion, and clonogenicity by up to 50% regardless of their VHL status. Investigating the molecular machinery involved in these processes, we identified a large panel of Lim1 targets known to be involved in cell adhesion (paxillin and fibronectin), epithelial-mesenchymal transition (Twist1/2 and snail), invasion (MMP1/2/3/8/9), and metastatic progression (CXCR4, SDF-1, and ANG-1). Importantly, Lim1 was found constitutively expressed in all metastatic tissues. The H-score in metastatic tissues being significantly superior to the score in the corresponding primary tumor tissues (P value = 0.009). Furthermore, we showed that Lim1 silencing decreases pulmonary metastasis development in terms of number and size in the in vivo metastatic model of human CCC. Taken together, these experiments strengthen the potential therapeutic value of Lim1 targeting as a promising novel approach for treating metastatic human CCC. More... »

PAGES

60-72

Journal

TITLE

Oncogene

ISSUE

1

VOLUME

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-018-0413-y

DOI

http://dx.doi.org/10.1038/s41388-018-0413-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105981472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30076415


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial-Mesenchymal Transition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "LIM-Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Targeted Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Von Hippel-Lindau Tumor Suppressor Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamaidi", 
        "givenName": "Im\u00e8ne", 
        "id": "sg:person.015624037465.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015624037465.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coquard", 
        "givenName": "Catherine", 
        "id": "sg:person.01337631722.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337631722.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Firalis, 68330, Huningue, France", 
          "id": "http://www.grid.ac/institutes/grid.450762.2", 
          "name": [
            "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France", 
            "Firalis, 68330, Huningue, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Danilin", 
        "givenName": "Sabrina", 
        "id": "sg:person.01176555406.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176555406.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM UMR_S1250, Universit\u00e9 de Reims Champagne-Ardenne (URCA), CHU Maison Blanche, 45 rue Cognacq-Jay, 51092, Reims, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France", 
            "INSERM UMR_S1250, Universit\u00e9 de Reims Champagne-Ardenne (URCA), CHU Maison Blanche, 45 rue Cognacq-Jay, 51092, Reims, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dormoy", 
        "givenName": "Val\u00e9rian", 
        "id": "sg:person.0576141204.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576141204.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Medicine, UROLEAD SAS, 67085, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "School of Medicine, UROLEAD SAS, 67085, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e9raud", 
        "givenName": "Claire", 
        "id": "sg:person.0644254404.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644254404.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rothhut", 
        "givenName": "Sylvie", 
        "id": "sg:person.01361117206.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361117206.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barthelmebs", 
        "givenName": "Mariette", 
        "id": "sg:person.01250763743.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250763743.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UMR_S1260, Regenerative Nanomedicine laboratory, INSERM and University of Strasbourg, School of Medicine, FMTS, 67085, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "UMR_S1260, Regenerative Nanomedicine laboratory, INSERM and University of Strasbourg, School of Medicine, FMTS, 67085, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benkirane-Jessel", 
        "givenName": "Nadia", 
        "id": "sg:person.0621341370.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621341370.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, H\u00f4pital de Strasbourg-Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67200, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.412220.7", 
          "name": [
            "Department of Pathology, H\u00f4pital de Strasbourg-Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67200, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindner", 
        "givenName": "V\u00e9ronique", 
        "id": "sg:person.01023651541.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023651541.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Urology, Nouvel H\u00f4pital Civil, H\u00f4pitaux Universitaires de Strasbourg, 67091, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.413866.e", 
          "name": [
            "Department of Urology, Nouvel H\u00f4pital Civil, H\u00f4pitaux Universitaires de Strasbourg, 67091, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lang", 
        "givenName": "Herv\u00e9", 
        "id": "sg:person.01350132425.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350132425.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Massfelder", 
        "givenName": "Thierry", 
        "id": "sg:person.01025176262.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025176262.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1476-4598-8-123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009815086", 
          "https://doi.org/10.1186/1476-4598-8-123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012289076", 
          "https://doi.org/10.1038/onc.2010.557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-017-0681-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090289325", 
          "https://doi.org/10.1186/s12943-017-0681-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038965314", 
          "https://doi.org/10.1038/nprot.2006.339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00418-011-0909-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023598201", 
          "https://doi.org/10.1007/s00418-011-0909-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-01084-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084821430", 
          "https://doi.org/10.1038/s41598-017-01084-w"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019270596", 
          "https://doi.org/10.1038/ncb2428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13045-017-0457-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084954698", 
          "https://doi.org/10.1186/s13045-017-0457-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms15724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942916", 
          "https://doi.org/10.1038/ncomms15724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2017.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090576048", 
          "https://doi.org/10.1038/nrneph.2017.82"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-03", 
    "datePublishedReg": "2018-08-03", 
    "description": "Metastatic clear cell renal cell carcinoma (CCC) remains incurable despite advances in the development of anti-angiogenic targeted therapies and the emergence of immune checkpoint inhibitors. We have previously shown that the sonic hedgehog-Gli signaling pathway is oncogenic in CCC allowing us to identify the developmental Lim1 transcription factor as a Gli target and as a new oncogene in CCC regulating cell proliferation and apoptosis, and promoting tumor growth. In this previous study, preliminary in vitro results also suggested that Lim1 may be implicated in metastatic spread. Here we investigated the potential pro-metastatic role of Lim1 in advanced CCC (1) in vitro using a panel of CCC cell lines expressing or not the von Hippel-Lindau (VHL) tumor suppressor gene either naturally or by gene transfer and (2) ex vivo in 30 CCC metastatic tissues, including lymph nodes, lung, skin, bone, and adrenal metastases, and (3) in vivo, using a metastatic model by intravenous injection of siRNA-transfected cells into Balb/c nude. Our in vitro results reveal that Lim1 knockdown time-dependently decreased CCC cell motility, migration, invasion, and clonogenicity by up to 50% regardless of their VHL status. Investigating the molecular machinery involved in these processes, we identified a large panel of Lim1 targets known to be involved in cell adhesion (paxillin and fibronectin), epithelial-mesenchymal transition (Twist1/2 and snail), invasion (MMP1/2/3/8/9), and metastatic progression (CXCR4, SDF-1, and ANG-1). Importantly, Lim1 was found constitutively expressed in all metastatic tissues. The H-score in metastatic tissues being significantly superior to the score in the corresponding primary tumor tissues (P value\u2009=\u20090.009). Furthermore, we showed that Lim1 silencing decreases pulmonary metastasis development in terms of number and size in the in vivo metastatic model of human CCC. Taken together, these experiments strengthen the potential therapeutic value of Lim1 targeting as a promising novel approach for treating metastatic human CCC.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41388-018-0413-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "keywords": [
      "human clear cell renal cell carcinoma", 
      "clear cell renal cell carcinoma", 
      "von Hippel-Lindau (VHL) tumor suppressor gene", 
      "renal cell carcinoma", 
      "sonic hedgehog-Gli", 
      "metastatic tissues", 
      "tumor suppressor gene", 
      "Gli targets", 
      "cell carcinoma", 
      "pro-metastatic role", 
      "metastatic model", 
      "molecular machinery", 
      "siRNA-transfected cells", 
      "corresponding primary tumor tissues", 
      "transcription factors", 
      "advanced clear cell renal cell carcinoma", 
      "metastatic human renal cell carcinoma", 
      "metastatic clear cell renal cell carcinoma", 
      "Balb/c nude", 
      "cell motility", 
      "epithelial-mesenchymal transition", 
      "Hedgehog-Gli", 
      "Lim1", 
      "new oncogene", 
      "VHL status", 
      "vivo metastatic model", 
      "immune checkpoint inhibitors", 
      "suppressor gene", 
      "cell renal cell carcinoma", 
      "human renal cell carcinoma", 
      "cell adhesion", 
      "CCC cell lines", 
      "gene transfer", 
      "primary tumor tissues", 
      "new therapeutic targets", 
      "potential therapeutic value", 
      "cell proliferation", 
      "knockdown time", 
      "cell lines", 
      "metastatic progression", 
      "promising novel approach", 
      "adrenal metastasis", 
      "checkpoint inhibitors", 
      "lymph nodes", 
      "metastatic spread", 
      "intravenous injection", 
      "metastasis development", 
      "oncogene", 
      "therapeutic target", 
      "tumor growth", 
      "tumor tissue", 
      "therapeutic value", 
      "vitro results", 
      "carcinoma", 
      "invasion", 
      "tissue", 
      "large panel", 
      "target", 
      "vivo", 
      "genes", 
      "machinery", 
      "scores", 
      "apoptosis", 
      "pathway", 
      "clonogenicity", 
      "previous studies", 
      "motility", 
      "terms of number", 
      "proliferation", 
      "metastasis", 
      "lung", 
      "therapy", 
      "cells", 
      "vitro", 
      "inhibitors", 
      "progression", 
      "adhesion", 
      "skin", 
      "injection", 
      "growth", 
      "bone", 
      "migration", 
      "development", 
      "role", 
      "status", 
      "panel", 
      "lines", 
      "nudes", 
      "factors", 
      "advances", 
      "emergence", 
      "study", 
      "spread", 
      "novel approach", 
      "results", 
      "number", 
      "size", 
      "transfer", 
      "process", 
      "experiments", 
      "time", 
      "nodes", 
      "model", 
      "transition", 
      "values", 
      "approach", 
      "terms", 
      "developmental Lim1 transcription factor", 
      "Lim1 transcription factor", 
      "potential pro-metastatic role", 
      "Hippel-Lindau (VHL) tumor suppressor gene", 
      "CCC metastatic tissues", 
      "c nude", 
      "Lim1 knockdown time", 
      "CCC cell motility", 
      "Lim1 targets", 
      "pulmonary metastasis development", 
      "metastatic human CCC", 
      "Lim1 oncogene"
    ], 
    "name": "The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma", 
    "pagination": "60-72", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105981472"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41388-018-0413-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30076415"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41388-018-0413-y", 
      "https://app.dimensions.ai/details/publication/pub.1105981472"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_770.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41388-018-0413-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0413-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0413-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0413-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0413-y'


 

This table displays all metadata directly associated to this object as RDF triples.

385 TRIPLES      22 PREDICATES      174 URIs      156 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41388-018-0413-y schema:about N022a1fa3fed341379297a69e74373308
2 N1484e22128d64b15b957722e1bda6028
3 N1f1f3125cb9744c0a3550ccf8167406a
4 N310553fce4d54ecc9f9ca2e26378264e
5 N3501eb018dca4e2687a2813738eb5722
6 N359f8c9dcff04c319579dbb24bc90f1f
7 N4b6fb0d173784034aa8a7404c343c1be
8 N678b38aa5e154fafa5c09c95d60b84e8
9 N6a99b5209da04548a102e0cfb0806c19
10 N7a1c54f121f84d28b602a20c8b813fda
11 N836ceed0466e4bcbba663071e8287d22
12 N8949776019f14e4e884ac263cd6cbe8a
13 N8fe878a724e640148fe6b8abcd0a5ab2
14 N9a2863be957540fd8560436334f1cd86
15 Nb1bf123f41fe423285be016a12e7d1e1
16 Nbf9dd0b1add24f979c4d5606cd08aac6
17 Nc8cd38fb302f49c58c78fb836193d3c5
18 Ndf76000f416445bdb889a5c6c09ca67d
19 Ne455792e582f476cb7e4ffedb3fcca90
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N6fef12b4f91a4fd883461df4d9303ae0
23 schema:citation sg:pub.10.1007/s00418-011-0909-9
24 sg:pub.10.1038/ncb2428
25 sg:pub.10.1038/ncomms15724
26 sg:pub.10.1038/nprot.2006.339
27 sg:pub.10.1038/nrneph.2017.82
28 sg:pub.10.1038/onc.2010.557
29 sg:pub.10.1038/s41598-017-01084-w
30 sg:pub.10.1186/1476-4598-8-123
31 sg:pub.10.1186/s12943-017-0681-0
32 sg:pub.10.1186/s13045-017-0457-4
33 schema:datePublished 2018-08-03
34 schema:datePublishedReg 2018-08-03
35 schema:description Metastatic clear cell renal cell carcinoma (CCC) remains incurable despite advances in the development of anti-angiogenic targeted therapies and the emergence of immune checkpoint inhibitors. We have previously shown that the sonic hedgehog-Gli signaling pathway is oncogenic in CCC allowing us to identify the developmental Lim1 transcription factor as a Gli target and as a new oncogene in CCC regulating cell proliferation and apoptosis, and promoting tumor growth. In this previous study, preliminary in vitro results also suggested that Lim1 may be implicated in metastatic spread. Here we investigated the potential pro-metastatic role of Lim1 in advanced CCC (1) in vitro using a panel of CCC cell lines expressing or not the von Hippel-Lindau (VHL) tumor suppressor gene either naturally or by gene transfer and (2) ex vivo in 30 CCC metastatic tissues, including lymph nodes, lung, skin, bone, and adrenal metastases, and (3) in vivo, using a metastatic model by intravenous injection of siRNA-transfected cells into Balb/c nude. Our in vitro results reveal that Lim1 knockdown time-dependently decreased CCC cell motility, migration, invasion, and clonogenicity by up to 50% regardless of their VHL status. Investigating the molecular machinery involved in these processes, we identified a large panel of Lim1 targets known to be involved in cell adhesion (paxillin and fibronectin), epithelial-mesenchymal transition (Twist1/2 and snail), invasion (MMP1/2/3/8/9), and metastatic progression (CXCR4, SDF-1, and ANG-1). Importantly, Lim1 was found constitutively expressed in all metastatic tissues. The H-score in metastatic tissues being significantly superior to the score in the corresponding primary tumor tissues (P value = 0.009). Furthermore, we showed that Lim1 silencing decreases pulmonary metastasis development in terms of number and size in the in vivo metastatic model of human CCC. Taken together, these experiments strengthen the potential therapeutic value of Lim1 targeting as a promising novel approach for treating metastatic human CCC.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N0e52feab620e46419f28b05ca7e43e21
40 N993a0f8b40084c178b378c6ea9b4d29b
41 sg:journal.1097543
42 schema:keywords Balb/c nude
43 CCC cell lines
44 CCC cell motility
45 CCC metastatic tissues
46 Gli targets
47 Hedgehog-Gli
48 Hippel-Lindau (VHL) tumor suppressor gene
49 Lim1
50 Lim1 knockdown time
51 Lim1 oncogene
52 Lim1 targets
53 Lim1 transcription factor
54 VHL status
55 adhesion
56 adrenal metastasis
57 advanced clear cell renal cell carcinoma
58 advances
59 apoptosis
60 approach
61 bone
62 c nude
63 carcinoma
64 cell adhesion
65 cell carcinoma
66 cell lines
67 cell motility
68 cell proliferation
69 cell renal cell carcinoma
70 cells
71 checkpoint inhibitors
72 clear cell renal cell carcinoma
73 clonogenicity
74 corresponding primary tumor tissues
75 development
76 developmental Lim1 transcription factor
77 emergence
78 epithelial-mesenchymal transition
79 experiments
80 factors
81 gene transfer
82 genes
83 growth
84 human clear cell renal cell carcinoma
85 human renal cell carcinoma
86 immune checkpoint inhibitors
87 inhibitors
88 injection
89 intravenous injection
90 invasion
91 knockdown time
92 large panel
93 lines
94 lung
95 lymph nodes
96 machinery
97 metastasis
98 metastasis development
99 metastatic clear cell renal cell carcinoma
100 metastatic human CCC
101 metastatic human renal cell carcinoma
102 metastatic model
103 metastatic progression
104 metastatic spread
105 metastatic tissues
106 migration
107 model
108 molecular machinery
109 motility
110 new oncogene
111 new therapeutic targets
112 nodes
113 novel approach
114 nudes
115 number
116 oncogene
117 panel
118 pathway
119 potential pro-metastatic role
120 potential therapeutic value
121 previous studies
122 primary tumor tissues
123 pro-metastatic role
124 process
125 progression
126 proliferation
127 promising novel approach
128 pulmonary metastasis development
129 renal cell carcinoma
130 results
131 role
132 scores
133 siRNA-transfected cells
134 size
135 skin
136 sonic hedgehog-Gli
137 spread
138 status
139 study
140 suppressor gene
141 target
142 terms
143 terms of number
144 therapeutic target
145 therapeutic value
146 therapy
147 time
148 tissue
149 transcription factors
150 transfer
151 transition
152 tumor growth
153 tumor suppressor gene
154 tumor tissue
155 values
156 vitro
157 vitro results
158 vivo
159 vivo metastatic model
160 von Hippel-Lindau (VHL) tumor suppressor gene
161 schema:name The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma
162 schema:pagination 60-72
163 schema:productId N144dedbb01fb4b0d97e797a319dbbf1b
164 N341b6e0ac9644680b216359b7785b2d6
165 Neb5c4311c6e145ed98d019724fb3cd95
166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105981472
167 https://doi.org/10.1038/s41388-018-0413-y
168 schema:sdDatePublished 2022-01-01T18:47
169 schema:sdLicense https://scigraph.springernature.com/explorer/license/
170 schema:sdPublisher N73961c3264c64bac872141aa3850ea3c
171 schema:url https://doi.org/10.1038/s41388-018-0413-y
172 sgo:license sg:explorer/license/
173 sgo:sdDataset articles
174 rdf:type schema:ScholarlyArticle
175 N022a1fa3fed341379297a69e74373308 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Transcription Factors
177 rdf:type schema:DefinedTerm
178 N0e52feab620e46419f28b05ca7e43e21 schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 N144dedbb01fb4b0d97e797a319dbbf1b schema:name pubmed_id
181 schema:value 30076415
182 rdf:type schema:PropertyValue
183 N1484e22128d64b15b957722e1bda6028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name RNA, Small Interfering
185 rdf:type schema:DefinedTerm
186 N1f1f3125cb9744c0a3550ccf8167406a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Carcinoma, Renal Cell
188 rdf:type schema:DefinedTerm
189 N25e59b24041642c490cc27f6b491cc2b rdf:first sg:person.01337631722.08
190 rdf:rest N9c919aabdcfe4ba480329631591a6cd5
191 N310553fce4d54ecc9f9ca2e26378264e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Humans
193 rdf:type schema:DefinedTerm
194 N341b6e0ac9644680b216359b7785b2d6 schema:name dimensions_id
195 schema:value pub.1105981472
196 rdf:type schema:PropertyValue
197 N3501eb018dca4e2687a2813738eb5722 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name RNA Interference
199 rdf:type schema:DefinedTerm
200 N359f8c9dcff04c319579dbb24bc90f1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Cell Movement
202 rdf:type schema:DefinedTerm
203 N4b6fb0d173784034aa8a7404c343c1be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Cell Line, Tumor
205 rdf:type schema:DefinedTerm
206 N510628dfe79745daa15c307d85636bcc rdf:first sg:person.01250763743.61
207 rdf:rest Nc8169041a1f2423c82a87531ae54c152
208 N678b38aa5e154fafa5c09c95d60b84e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Gene Expression Regulation, Neoplastic
210 rdf:type schema:DefinedTerm
211 N6a99b5209da04548a102e0cfb0806c19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name LIM-Homeodomain Proteins
213 rdf:type schema:DefinedTerm
214 N6f18848c15584947806ddaca62900024 rdf:first sg:person.01023651541.11
215 rdf:rest Ncb4aca18b30544978e9e17e421b54fd0
216 N6fef12b4f91a4fd883461df4d9303ae0 rdf:first sg:person.015624037465.83
217 rdf:rest N25e59b24041642c490cc27f6b491cc2b
218 N71740025cce04ea2a5549300faaa560d rdf:first sg:person.01025176262.18
219 rdf:rest rdf:nil
220 N73961c3264c64bac872141aa3850ea3c schema:name Springer Nature - SN SciGraph project
221 rdf:type schema:Organization
222 N7a1c54f121f84d28b602a20c8b813fda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Gene Knockdown Techniques
224 rdf:type schema:DefinedTerm
225 N836ceed0466e4bcbba663071e8287d22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Kidney Neoplasms
227 rdf:type schema:DefinedTerm
228 N8949776019f14e4e884ac263cd6cbe8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Epithelial-Mesenchymal Transition
230 rdf:type schema:DefinedTerm
231 N8fe878a724e640148fe6b8abcd0a5ab2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Neoplasm Invasiveness
233 rdf:type schema:DefinedTerm
234 N993a0f8b40084c178b378c6ea9b4d29b schema:volumeNumber 38
235 rdf:type schema:PublicationVolume
236 N9a2863be957540fd8560436334f1cd86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Lung Neoplasms
238 rdf:type schema:DefinedTerm
239 N9c919aabdcfe4ba480329631591a6cd5 rdf:first sg:person.01176555406.71
240 rdf:rest Ndf3e71fd2ac641cc9ad7768f8ff915b9
241 Nb1bf123f41fe423285be016a12e7d1e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
242 schema:name Von Hippel-Lindau Tumor Suppressor Protein
243 rdf:type schema:DefinedTerm
244 Nb591d4a7c82a4a69baf37704673671a4 rdf:first sg:person.01361117206.34
245 rdf:rest N510628dfe79745daa15c307d85636bcc
246 Nbf9dd0b1add24f979c4d5606cd08aac6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
247 schema:name Molecular Targeted Therapy
248 rdf:type schema:DefinedTerm
249 Nc8169041a1f2423c82a87531ae54c152 rdf:first sg:person.0621341370.14
250 rdf:rest N6f18848c15584947806ddaca62900024
251 Nc8cd38fb302f49c58c78fb836193d3c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
252 schema:name Signal Transduction
253 rdf:type schema:DefinedTerm
254 Ncb4aca18b30544978e9e17e421b54fd0 rdf:first sg:person.01350132425.91
255 rdf:rest N71740025cce04ea2a5549300faaa560d
256 Ndf3e71fd2ac641cc9ad7768f8ff915b9 rdf:first sg:person.0576141204.34
257 rdf:rest Nf0a68e411aa1413b8b6f67e1626a4d5c
258 Ndf76000f416445bdb889a5c6c09ca67d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
259 schema:name Oncogenes
260 rdf:type schema:DefinedTerm
261 Ne455792e582f476cb7e4ffedb3fcca90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
262 schema:name Neoplasm Proteins
263 rdf:type schema:DefinedTerm
264 Neb5c4311c6e145ed98d019724fb3cd95 schema:name doi
265 schema:value 10.1038/s41388-018-0413-y
266 rdf:type schema:PropertyValue
267 Nf0a68e411aa1413b8b6f67e1626a4d5c rdf:first sg:person.0644254404.13
268 rdf:rest Nb591d4a7c82a4a69baf37704673671a4
269 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
270 schema:name Medical and Health Sciences
271 rdf:type schema:DefinedTerm
272 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
273 schema:name Oncology and Carcinogenesis
274 rdf:type schema:DefinedTerm
275 sg:journal.1097543 schema:issn 0950-9232
276 1476-5594
277 schema:name Oncogene
278 schema:publisher Springer Nature
279 rdf:type schema:Periodical
280 sg:person.01023651541.11 schema:affiliation grid-institutes:grid.412220.7
281 schema:familyName Lindner
282 schema:givenName Véronique
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023651541.11
284 rdf:type schema:Person
285 sg:person.01025176262.18 schema:affiliation grid-institutes:grid.11843.3f
286 schema:familyName Massfelder
287 schema:givenName Thierry
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025176262.18
289 rdf:type schema:Person
290 sg:person.01176555406.71 schema:affiliation grid-institutes:grid.450762.2
291 schema:familyName Danilin
292 schema:givenName Sabrina
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176555406.71
294 rdf:type schema:Person
295 sg:person.01250763743.61 schema:affiliation grid-institutes:grid.11843.3f
296 schema:familyName Barthelmebs
297 schema:givenName Mariette
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250763743.61
299 rdf:type schema:Person
300 sg:person.01337631722.08 schema:affiliation grid-institutes:grid.11843.3f
301 schema:familyName Coquard
302 schema:givenName Catherine
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337631722.08
304 rdf:type schema:Person
305 sg:person.01350132425.91 schema:affiliation grid-institutes:grid.413866.e
306 schema:familyName Lang
307 schema:givenName Hervé
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350132425.91
309 rdf:type schema:Person
310 sg:person.01361117206.34 schema:affiliation grid-institutes:grid.11843.3f
311 schema:familyName Rothhut
312 schema:givenName Sylvie
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361117206.34
314 rdf:type schema:Person
315 sg:person.015624037465.83 schema:affiliation grid-institutes:grid.11843.3f
316 schema:familyName Hamaidi
317 schema:givenName Imène
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015624037465.83
319 rdf:type schema:Person
320 sg:person.0576141204.34 schema:affiliation grid-institutes:None
321 schema:familyName Dormoy
322 schema:givenName Valérian
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576141204.34
324 rdf:type schema:Person
325 sg:person.0621341370.14 schema:affiliation grid-institutes:grid.11843.3f
326 schema:familyName Benkirane-Jessel
327 schema:givenName Nadia
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621341370.14
329 rdf:type schema:Person
330 sg:person.0644254404.13 schema:affiliation grid-institutes:None
331 schema:familyName Béraud
332 schema:givenName Claire
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644254404.13
334 rdf:type schema:Person
335 sg:pub.10.1007/s00418-011-0909-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023598201
336 https://doi.org/10.1007/s00418-011-0909-9
337 rdf:type schema:CreativeWork
338 sg:pub.10.1038/ncb2428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019270596
339 https://doi.org/10.1038/ncb2428
340 rdf:type schema:CreativeWork
341 sg:pub.10.1038/ncomms15724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085942916
342 https://doi.org/10.1038/ncomms15724
343 rdf:type schema:CreativeWork
344 sg:pub.10.1038/nprot.2006.339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038965314
345 https://doi.org/10.1038/nprot.2006.339
346 rdf:type schema:CreativeWork
347 sg:pub.10.1038/nrneph.2017.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090576048
348 https://doi.org/10.1038/nrneph.2017.82
349 rdf:type schema:CreativeWork
350 sg:pub.10.1038/onc.2010.557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012289076
351 https://doi.org/10.1038/onc.2010.557
352 rdf:type schema:CreativeWork
353 sg:pub.10.1038/s41598-017-01084-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1084821430
354 https://doi.org/10.1038/s41598-017-01084-w
355 rdf:type schema:CreativeWork
356 sg:pub.10.1186/1476-4598-8-123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009815086
357 https://doi.org/10.1186/1476-4598-8-123
358 rdf:type schema:CreativeWork
359 sg:pub.10.1186/s12943-017-0681-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090289325
360 https://doi.org/10.1186/s12943-017-0681-0
361 rdf:type schema:CreativeWork
362 sg:pub.10.1186/s13045-017-0457-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084954698
363 https://doi.org/10.1186/s13045-017-0457-4
364 rdf:type schema:CreativeWork
365 grid-institutes:None schema:alternateName INSERM UMR_S1250, Université de Reims Champagne-Ardenne (URCA), CHU Maison Blanche, 45 rue Cognacq-Jay, 51092, Reims, France
366 School of Medicine, UROLEAD SAS, 67085, Strasbourg, France
367 schema:name INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France
368 INSERM UMR_S1250, Université de Reims Champagne-Ardenne (URCA), CHU Maison Blanche, 45 rue Cognacq-Jay, 51092, Reims, France
369 School of Medicine, UROLEAD SAS, 67085, Strasbourg, France
370 rdf:type schema:Organization
371 grid-institutes:grid.11843.3f schema:alternateName INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France
372 UMR_S1260, Regenerative Nanomedicine laboratory, INSERM and University of Strasbourg, School of Medicine, FMTS, 67085, Strasbourg, France
373 schema:name INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France
374 UMR_S1260, Regenerative Nanomedicine laboratory, INSERM and University of Strasbourg, School of Medicine, FMTS, 67085, Strasbourg, France
375 rdf:type schema:Organization
376 grid-institutes:grid.412220.7 schema:alternateName Department of Pathology, Hôpital de Strasbourg-Hautepierre, Hôpitaux Universitaires de Strasbourg, 67200, Strasbourg, France
377 schema:name Department of Pathology, Hôpital de Strasbourg-Hautepierre, Hôpitaux Universitaires de Strasbourg, 67200, Strasbourg, France
378 rdf:type schema:Organization
379 grid-institutes:grid.413866.e schema:alternateName Department of Urology, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 67091, Strasbourg, France
380 schema:name Department of Urology, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 67091, Strasbourg, France
381 rdf:type schema:Organization
382 grid-institutes:grid.450762.2 schema:alternateName Firalis, 68330, Huningue, France
383 schema:name Firalis, 68330, Huningue, France
384 INSERM UMR_S1113, Section of Cell Signalisation and Communication in Kidney and Prostate Cancer, INSERM and University of Strasbourg, School of Medicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67085, Strasbourg, France
385 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...