YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10

AUTHORS

Olivia M. Yu, Jorge A. Benitez, Steven W. Plouffe, Daniel Ryback, Andrea Klein, Jeff Smith, Jason Greenbaum, Benjamin Delatte, Anjana Rao, Kun-Liang Guan, Frank B. Furnari, Olga Meiri Chaim, Shigeki Miyamoto, Joan Heller Brown

ABSTRACT

The role of YAP (Yes-associated protein 1) and MRTF-A (myocardin-related transcription factor A), two transcriptional co-activators regulated downstream of GPCRs (G protein-coupled receptors) and RhoA, in the growth of glioblastoma cells and in vivo glioblastoma multiforme (GBM) tumor development was explored using human glioblastoma cell lines and tumor-initiating cells derived from patient-derived xenografts (PDX). Knockdown of these co-activators in GSC-23 PDX cells using short hairpin RNA significantly attenuated in vitro self-renewal capability assessed by limiting dilution, oncogene expression, and neurosphere formation. Orthotopic xenografts of the MRTF-A and YAP knockdown PDX cells formed significantly smaller tumors and were of lower morbidity than wild-type cells. In vitro studies used PDX and 1321N1 glioblastoma cells to examine functional responses to sphingosine 1-phosphate (S1P), a GPCR agonist that activates RhoA signaling, demonstrated that YAP signaling was required for cell migration and invasion, whereas MRTF-A was required for cell adhesion; both YAP and MRTF-A were required for proliferation. Gene expression analysis by RNA-sequencing of S1P-treated MRTF-A or YAP knockout cells identified 44 genes that were induced through RhoA and highly dependent on YAP, MRTF-A, or both. Knockdown of F3 (tissue factor (TF)), a target gene regulated selectively through YAP, blocked cell invasion and migration, whereas knockdown of HBEGF (heparin-binding epidermal growth factor-like growth factor), a gene selectively induced through MRTF-A, prevented cell adhesion in response to S1P. Proliferation was sensitive to knockdown of target genes regulated through either or both YAP and MRTF-A. Expression of TF and HBEGF was also selectively decreased in tumors from PDX cells lacking YAP or MRTF-A, indicating that these transcriptional pathways are regulated in preclinical GBM models and suggesting that their activation through GPCRs and RhoA contributes to growth and maintenance of human GBM. More... »

PAGES

5492-5507

References to SciGraph publications

  • 2002-02. RHO–GTPases and cancer in NATURE REVIEWS CANCER
  • 2017-07. Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells in MOLECULAR NEUROBIOLOGY
  • 2014-08. An EGFR wild type–EGFRvIII–HB-EGF feed-forward loop regulates the activation of EGFRvIII in ONCOGENE
  • 2013-11. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2005-01. A novel CYR61-triggered ‘CYR61-αvβ3 integrin loop’ regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway in ONCOGENE
  • 2014-12. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis in NATURE COMMUNICATIONS
  • 2011-12. Autotaxin and LPA receptor signaling in cancer in CANCER AND METASTASIS REVIEWS
  • 2008-10-23. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 1998-09. Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas in ACTA NEUROPATHOLOGICA
  • 2015-04. Cyr61 promotes growth of glioblastoma in vitro and in vivo in TUMOR BIOLOGY
  • 2015-12. Cyclic stretching of soft substrates induces spreading and growth in NATURE COMMUNICATIONS
  • 2001-04. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways in ONCOGENE
  • 2008-06. Analyzing real-time PCR data by the comparative CT method in NATURE PROTOCOLS
  • 2015-09. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth in NATURE CELL BIOLOGY
  • 2014-01. Discovery and saturation analysis of cancer genes across 21 tumour types in NATURE
  • 2011-06. Role of YAP/TAZ in mechanotransduction in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41388-018-0301-5

    DOI

    http://dx.doi.org/10.1038/s41388-018-0301-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104502359

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29887596


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptor Proteins, Signal Transducing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heterografts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Nude", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphoproteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trans-Activators", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "rhoA GTP-Binding Protein", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA", 
                "Biomedical Sciences Graduate Program, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Olivia M.", 
            "id": "sg:person.01337330044.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337330044.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.1052.6", 
              "name": [
                "Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benitez", 
            "givenName": "Jorge A.", 
            "id": "sg:person.013044464647.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013044464647.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA", 
                "Biomedical Sciences Graduate Program, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plouffe", 
            "givenName": "Steven W.", 
            "id": "sg:person.01066170100.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066170100.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ryback", 
            "givenName": "Daniel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klein", 
            "givenName": "Andrea", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "Jeff", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "La Jolla Institute For Allergy & Immunology", 
              "id": "https://www.grid.ac/institutes/grid.185006.a", 
              "name": [
                "Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Greenbaum", 
            "givenName": "Jason", 
            "id": "sg:person.01147567650.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147567650.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "La Jolla Institute For Allergy & Immunology", 
              "id": "https://www.grid.ac/institutes/grid.185006.a", 
              "name": [
                "Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delatte", 
            "givenName": "Benjamin", 
            "id": "sg:person.013251403237.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013251403237.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA", 
                "Moores Cancer Center, University of California at San Diego, La Jolla, San Diego, CA, USA", 
                "Department of Pathology, School of Medicine, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rao", 
            "givenName": "Anjana", 
            "id": "sg:person.0607343473.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607343473.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA", 
                "Moores Cancer Center, University of California at San Diego, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guan", 
            "givenName": "Kun-Liang", 
            "id": "sg:person.014367272257.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014367272257.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, San Diego, CA, USA", 
                "Moores Cancer Center, University of California at San Diego, La Jolla, San Diego, CA, USA", 
                "Department of Pathology, School of Medicine, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furnari", 
            "givenName": "Frank B.", 
            "id": "sg:person.01220650203.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220650203.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Paran\u00e1", 
              "id": "https://www.grid.ac/institutes/grid.20736.30", 
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA", 
                "Department of Cell Biology, Federal University of Paran\u00e1, Curitiba, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chaim", 
            "givenName": "Olga Meiri", 
            "id": "sg:person.0672775210.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672775210.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyamoto", 
            "givenName": "Shigeki", 
            "id": "sg:person.0776315206.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776315206.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA", 
                "Moores Cancer Center, University of California at San Diego, La Jolla, San Diego, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brown", 
            "givenName": "Joan Heller", 
            "id": "sg:person.01371336651.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371336651.62"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1215/s1152851704000821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000798317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010050901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001327978", 
              "https://doi.org/10.1007/s004010050901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.07.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001535285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.7366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001603536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.08-113266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002480097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005355981", 
              "https://doi.org/10.1038/nprot.2008.73"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2015.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007105952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00772-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008294123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-2526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009990102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010337312", 
              "https://doi.org/10.1038/ncomms5632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2013.00241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012713911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(05)80020-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012846308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.07.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013737934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015784412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534425", 
              "https://doi.org/10.1038/nprot.2013.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m601803200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016974828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016979695", 
              "https://doi.org/10.1038/sj.onc.1204281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016979695", 
              "https://doi.org/10.1038/sj.onc.1204281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.5.1350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017546180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.15.11.6443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019440731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019728507", 
              "https://doi.org/10.1038/sj.onc.1208238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019728507", 
              "https://doi.org/10.1038/sj.onc.1208238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00278-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1314118111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022165361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022417218", 
              "https://doi.org/10.1038/ncb3216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-011-9319-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022594213", 
              "https://doi.org/10.1007/s10555-011-9319-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.239327.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022810043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022902509", 
              "https://doi.org/10.1038/nrc725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022902509", 
              "https://doi.org/10.1038/nrc725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2009.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024208329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-06-0691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024529659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-2997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024678882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.115.097857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025286886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1699-0463.1968.tb03502.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027093163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1699-0463.1968.tb03502.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027093163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.20199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027329243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028063527", 
              "https://doi.org/10.1038/nature10137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-016-0053-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028635046", 
              "https://doi.org/10.1007/s12035-016-0053-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-016-0053-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028635046", 
              "https://doi.org/10.1007/s12035-016-0053-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1877::aid-cncr18>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029725307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m708241200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031049089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2009.00180.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033005708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2009.00180.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033005708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m103565200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033321426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-2510", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033628784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035590916", 
              "https://doi.org/10.1038/onc.2013.400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035590916", 
              "https://doi.org/10.1038/onc.2013.400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(93)80896-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035747393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2013.12.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036281093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1227/01.neu.0000489786.22041.2d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036722646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2014.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036809098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.5219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036913944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038003798", 
              "https://doi.org/10.1038/ncomms7333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039287087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039570773", 
              "https://doi.org/10.1038/nature07385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.17.7819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039577962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1230184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042755313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.261982.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043286434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043554069", 
              "https://doi.org/10.1038/nature12912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2016.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043928907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.09.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044472205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.18.6597-6608.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044479776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1664408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045064078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2007.11.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045412505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2014.10.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046068240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.7.11.1679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046546727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.beha.2008.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046845961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-0659-03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046898806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-014-2915-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047448838", 
              "https://doi.org/10.1007/s13277-014-2915-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-0664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048615053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.14.6741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049326973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0049-3848(16)30369-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050303968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2005.01446.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050451599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2005.01446.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050451599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0003769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050732391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01623-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050905482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.197582.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051369887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2011.04318.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051676577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.25.11781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052510457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2014.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053117511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(00)02224-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053452305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m116.739722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058215248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7652575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082741020", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.201600828r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083717325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2017.04.075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085567554"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-10", 
        "datePublishedReg": "2018-10-01", 
        "description": "The role of YAP (Yes-associated protein 1) and MRTF-A (myocardin-related transcription factor A), two transcriptional co-activators regulated downstream of GPCRs (G protein-coupled receptors) and RhoA, in the growth of glioblastoma cells and in vivo glioblastoma multiforme (GBM) tumor development was explored using human glioblastoma cell lines and tumor-initiating cells derived from patient-derived xenografts (PDX). Knockdown of these co-activators in GSC-23 PDX cells using short hairpin RNA significantly attenuated in vitro self-renewal capability assessed by limiting dilution, oncogene expression, and neurosphere formation. Orthotopic xenografts of the MRTF-A and YAP knockdown PDX cells formed significantly smaller tumors and were of lower morbidity than wild-type cells. In vitro studies used PDX and 1321N1 glioblastoma cells to examine functional responses to sphingosine 1-phosphate (S1P), a GPCR agonist that activates RhoA signaling, demonstrated that YAP signaling was required for cell migration and invasion, whereas MRTF-A was required for cell adhesion; both YAP and MRTF-A were required for proliferation. Gene expression analysis by RNA-sequencing of S1P-treated MRTF-A or YAP knockout cells identified 44 genes that were induced through RhoA and highly dependent on YAP, MRTF-A, or both. Knockdown of F3 (tissue factor (TF)), a target gene regulated selectively through YAP, blocked cell invasion and migration, whereas knockdown of HBEGF (heparin-binding epidermal growth factor-like growth factor), a gene selectively induced through MRTF-A, prevented cell adhesion in response to S1P. Proliferation was sensitive to knockdown of target genes regulated through either or both YAP and MRTF-A. Expression of TF and HBEGF was also selectively decreased in tumors from PDX cells lacking YAP or MRTF-A, indicating that these transcriptional pathways are regulated in preclinical GBM models and suggesting that their activation through GPCRs and RhoA contributes to growth and maintenance of human GBM.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41388-018-0301-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2683814", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2563454", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7439852", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2635652", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2437043", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2511743", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2453543", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3805543", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2542628", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2530405", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "41", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "37"
          }
        ], 
        "name": "YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity", 
        "pagination": "5492-5507", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e07cadbc012534db87097ce8af2059d283bc0b1b94d87f932a24f2ae67d92425"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29887596"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41388-018-0301-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104502359"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41388-018-0301-5", 
          "https://app.dimensions.ai/details/publication/pub.1104502359"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113670_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41388-018-0301-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0301-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0301-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0301-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0301-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    502 TRIPLES      21 PREDICATES      119 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41388-018-0301-5 schema:about N26a6daa55908482c835fc97d508c04f4
    2 N376fa94c78e74345a2a2bf179035ef26
    3 N49a9d0040ad545189157d8ccac34a00a
    4 N58ade2506e8947bcbd053cafd313f6cd
    5 N69063667e05a475db7b4a088f9658bd4
    6 N69af843b3ff34493966229d30a9ede02
    7 N8b72347baf7e40569eab4d02dbc3e47e
    8 N9dd497552698462d9abdb6dd0849d94c
    9 Na3317b7381f44feeae4d727c8447ae08
    10 Nbd87a1e9a80e4ff197dff3b887e7d544
    11 Nee1fad902e1045dc964fbe8a9ffbc32b
    12 Nf3787ce90a50407ab5e43fbe18631d81
    13 anzsrc-for:06
    14 anzsrc-for:0601
    15 schema:author N92465073e6c94af48a692c253d08b9b9
    16 schema:citation sg:pub.10.1007/s004010050901
    17 sg:pub.10.1007/s10555-011-9319-7
    18 sg:pub.10.1007/s12035-016-0053-6
    19 sg:pub.10.1007/s13277-014-2915-8
    20 sg:pub.10.1038/nature07385
    21 sg:pub.10.1038/nature10137
    22 sg:pub.10.1038/nature12912
    23 sg:pub.10.1038/ncb3216
    24 sg:pub.10.1038/ncomms5632
    25 sg:pub.10.1038/ncomms7333
    26 sg:pub.10.1038/nprot.2008.73
    27 sg:pub.10.1038/nprot.2013.143
    28 sg:pub.10.1038/nrc725
    29 sg:pub.10.1038/onc.2013.400
    30 sg:pub.10.1038/sj.onc.1204281
    31 sg:pub.10.1038/sj.onc.1208238
    32 https://app.dimensions.ai/details/publication/pub.1082741020
    33 https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1877::aid-cncr18>3.0.co;2-x
    34 https://doi.org/10.1002/jcb.20199
    35 https://doi.org/10.1016/0014-5793(93)80896-3
    36 https://doi.org/10.1016/j.ajpath.2013.12.017
    37 https://doi.org/10.1016/j.bbrc.2007.11.015
    38 https://doi.org/10.1016/j.bbrc.2014.10.041
    39 https://doi.org/10.1016/j.beha.2008.12.008
    40 https://doi.org/10.1016/j.ccell.2016.05.005
    41 https://doi.org/10.1016/j.ccr.2006.10.002
    42 https://doi.org/10.1016/j.ccr.2014.04.016
    43 https://doi.org/10.1016/j.ccr.2014.04.017
    44 https://doi.org/10.1016/j.cell.2012.06.037
    45 https://doi.org/10.1016/j.cell.2013.07.042
    46 https://doi.org/10.1016/j.cell.2013.09.034
    47 https://doi.org/10.1016/j.cell.2015.07.013
    48 https://doi.org/10.1016/j.cellsig.2009.05.010
    49 https://doi.org/10.1016/j.celrep.2017.04.075
    50 https://doi.org/10.1016/j.molmed.2015.01.003
    51 https://doi.org/10.1016/s0014-5793(00)02224-9
    52 https://doi.org/10.1016/s0049-3848(16)30369-3
    53 https://doi.org/10.1016/s0092-8674(03)00278-2
    54 https://doi.org/10.1016/s0092-8674(05)80020-0
    55 https://doi.org/10.1073/pnas.1314118111
    56 https://doi.org/10.1073/pnas.90.14.6741
    57 https://doi.org/10.1073/pnas.92.17.7819
    58 https://doi.org/10.1073/pnas.92.25.11781
    59 https://doi.org/10.1074/jbc.m103565200
    60 https://doi.org/10.1074/jbc.m116.739722
    61 https://doi.org/10.1074/jbc.m601803200
    62 https://doi.org/10.1074/jbc.m708241200
    63 https://doi.org/10.1091/mbc.7.11.1679
    64 https://doi.org/10.1093/emboj/17.5.1350
    65 https://doi.org/10.1096/fj.08-113266
    66 https://doi.org/10.1096/fj.201600828r
    67 https://doi.org/10.1101/gad.1664408
    68 https://doi.org/10.1101/gad.197582.112
    69 https://doi.org/10.1101/gad.239327.114
    70 https://doi.org/10.1101/gad.261982.115
    71 https://doi.org/10.1111/j.1476-5381.2009.00180.x
    72 https://doi.org/10.1111/j.1538-7836.2005.01446.x
    73 https://doi.org/10.1111/j.1538-7836.2011.04318.x
    74 https://doi.org/10.1111/j.1699-0463.1968.tb03502.x
    75 https://doi.org/10.1124/mol.115.097857
    76 https://doi.org/10.1126/science.1230184
    77 https://doi.org/10.1126/science.7652575
    78 https://doi.org/10.1128/mcb.00772-15
    79 https://doi.org/10.1128/mcb.01623-07
    80 https://doi.org/10.1128/mcb.15.11.6443
    81 https://doi.org/10.1128/mcb.23.18.6597-6608.2003
    82 https://doi.org/10.1158/0008-5472.can-08-2997
    83 https://doi.org/10.1158/0008-5472.can-09-0664
    84 https://doi.org/10.1158/0008-5472.can-11-2526
    85 https://doi.org/10.1158/1078-0432.ccr-05-2510
    86 https://doi.org/10.1158/1078-0432.ccr-0659-03
    87 https://doi.org/10.1158/1535-7163.mct-06-0691
    88 https://doi.org/10.1215/s1152851704000821
    89 https://doi.org/10.1227/01.neu.0000489786.22041.2d
    90 https://doi.org/10.1371/journal.pone.0003769
    91 https://doi.org/10.18632/oncotarget.5219
    92 https://doi.org/10.18632/oncotarget.7366
    93 https://doi.org/10.3389/fonc.2013.00241
    94 schema:datePublished 2018-10
    95 schema:datePublishedReg 2018-10-01
    96 schema:description The role of YAP (Yes-associated protein 1) and MRTF-A (myocardin-related transcription factor A), two transcriptional co-activators regulated downstream of GPCRs (G protein-coupled receptors) and RhoA, in the growth of glioblastoma cells and in vivo glioblastoma multiforme (GBM) tumor development was explored using human glioblastoma cell lines and tumor-initiating cells derived from patient-derived xenografts (PDX). Knockdown of these co-activators in GSC-23 PDX cells using short hairpin RNA significantly attenuated in vitro self-renewal capability assessed by limiting dilution, oncogene expression, and neurosphere formation. Orthotopic xenografts of the MRTF-A and YAP knockdown PDX cells formed significantly smaller tumors and were of lower morbidity than wild-type cells. In vitro studies used PDX and 1321N1 glioblastoma cells to examine functional responses to sphingosine 1-phosphate (S1P), a GPCR agonist that activates RhoA signaling, demonstrated that YAP signaling was required for cell migration and invasion, whereas MRTF-A was required for cell adhesion; both YAP and MRTF-A were required for proliferation. Gene expression analysis by RNA-sequencing of S1P-treated MRTF-A or YAP knockout cells identified 44 genes that were induced through RhoA and highly dependent on YAP, MRTF-A, or both. Knockdown of F3 (tissue factor (TF)), a target gene regulated selectively through YAP, blocked cell invasion and migration, whereas knockdown of HBEGF (heparin-binding epidermal growth factor-like growth factor), a gene selectively induced through MRTF-A, prevented cell adhesion in response to S1P. Proliferation was sensitive to knockdown of target genes regulated through either or both YAP and MRTF-A. Expression of TF and HBEGF was also selectively decreased in tumors from PDX cells lacking YAP or MRTF-A, indicating that these transcriptional pathways are regulated in preclinical GBM models and suggesting that their activation through GPCRs and RhoA contributes to growth and maintenance of human GBM.
    97 schema:genre research_article
    98 schema:inLanguage en
    99 schema:isAccessibleForFree true
    100 schema:isPartOf N20fd4bc3ac8c4b7fb669fc08c8e243c3
    101 Nc5d3ae085c6a4e3f81554eecc5fd6a2d
    102 sg:journal.1097543
    103 schema:name YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity
    104 schema:pagination 5492-5507
    105 schema:productId N47f2a34d6aed4859a245182eb07d91bc
    106 N6a7de66b728d4c259ecf3ca587f3137b
    107 N92e1b66c6f364a8fa1f0aa0744b1f1e3
    108 Nb8f0a4c219b54c83ac6919d45b190eb3
    109 Nfa4bd336517f4a0fb96a8da7445098b0
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104502359
    111 https://doi.org/10.1038/s41388-018-0301-5
    112 schema:sdDatePublished 2019-04-11T10:36
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N9cd1d702542347a78cd25a102e2e8c71
    115 schema:url https://www.nature.com/articles/s41388-018-0301-5
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N074361774a14485b9d885effd9ff7fda schema:affiliation Ncbb9dbcb52884b838e279a857852dd17
    120 schema:familyName Klein
    121 schema:givenName Andrea
    122 rdf:type schema:Person
    123 N195dd35ec87d435e9ac147d7cb77d4e2 rdf:first sg:person.01220650203.57
    124 rdf:rest N98411dbb1911494d9811f8a3f36cf5fd
    125 N20fd4bc3ac8c4b7fb669fc08c8e243c3 schema:volumeNumber 37
    126 rdf:type schema:PublicationVolume
    127 N26a6daa55908482c835fc97d508c04f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Mice
    129 rdf:type schema:DefinedTerm
    130 N313d10fbd61e40a09d35e230733b2772 schema:affiliation N9df69019a43b42219d55962f9dadf5e4
    131 schema:familyName Ryback
    132 schema:givenName Daniel
    133 rdf:type schema:Person
    134 N376fa94c78e74345a2a2bf179035ef26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Humans
    136 rdf:type schema:DefinedTerm
    137 N47f2a34d6aed4859a245182eb07d91bc schema:name dimensions_id
    138 schema:value pub.1104502359
    139 rdf:type schema:PropertyValue
    140 N498a88172fbf447abff42df81aa38dde rdf:first N313d10fbd61e40a09d35e230733b2772
    141 rdf:rest Na78e82a3e5b14d51b894c85a8627b1b6
    142 N49a9d0040ad545189157d8ccac34a00a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name rhoA GTP-Binding Protein
    144 rdf:type schema:DefinedTerm
    145 N58ade2506e8947bcbd053cafd313f6cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Phosphoproteins
    147 rdf:type schema:DefinedTerm
    148 N6161233c295b4391b3f89c6a0af0e4ee rdf:first sg:person.013251403237.77
    149 rdf:rest Nabfc4942e19e496fb45caa8bf2cfcef8
    150 N67dee2940d93415faff38ef66e24b409 rdf:first sg:person.01371336651.62
    151 rdf:rest rdf:nil
    152 N69063667e05a475db7b4a088f9658bd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Trans-Activators
    154 rdf:type schema:DefinedTerm
    155 N69af843b3ff34493966229d30a9ede02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Brain Neoplasms
    157 rdf:type schema:DefinedTerm
    158 N6a7de66b728d4c259ecf3ca587f3137b schema:name doi
    159 schema:value 10.1038/s41388-018-0301-5
    160 rdf:type schema:PropertyValue
    161 N6c8091d0f40b4b55a51d7fd200ee5fa5 rdf:first sg:person.01147567650.98
    162 rdf:rest N6161233c295b4391b3f89c6a0af0e4ee
    163 N863a6df4d2f14ce18c27978afa78906e schema:name Biomedical Sciences Graduate Program, University of California, La Jolla, San Diego, CA, USA
    164 Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    165 rdf:type schema:Organization
    166 N8b72347baf7e40569eab4d02dbc3e47e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Mice, Nude
    168 rdf:type schema:DefinedTerm
    169 N92465073e6c94af48a692c253d08b9b9 rdf:first sg:person.01337330044.67
    170 rdf:rest Nf2733d70a2804744bf3a265b723db702
    171 N92e1b66c6f364a8fa1f0aa0744b1f1e3 schema:name nlm_unique_id
    172 schema:value 8711562
    173 rdf:type schema:PropertyValue
    174 N958a48626fc245069e700350df1dd594 rdf:first Nbd644178d4124f8ca4e1eb6499dc7cf5
    175 rdf:rest N6c8091d0f40b4b55a51d7fd200ee5fa5
    176 N9693ab28f0094498a2a4b22694218d5b rdf:first sg:person.01066170100.97
    177 rdf:rest N498a88172fbf447abff42df81aa38dde
    178 N98411dbb1911494d9811f8a3f36cf5fd rdf:first sg:person.0672775210.67
    179 rdf:rest Ne39f66788de042cd9f8080109fe0f08a
    180 N9cd1d702542347a78cd25a102e2e8c71 schema:name Springer Nature - SN SciGraph project
    181 rdf:type schema:Organization
    182 N9dd497552698462d9abdb6dd0849d94c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Adaptor Proteins, Signal Transducing
    184 rdf:type schema:DefinedTerm
    185 N9df69019a43b42219d55962f9dadf5e4 schema:name Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    186 rdf:type schema:Organization
    187 Na3317b7381f44feeae4d727c8447ae08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Gene Expression Regulation, Neoplastic
    189 rdf:type schema:DefinedTerm
    190 Na78e82a3e5b14d51b894c85a8627b1b6 rdf:first N074361774a14485b9d885effd9ff7fda
    191 rdf:rest N958a48626fc245069e700350df1dd594
    192 Nabfc4942e19e496fb45caa8bf2cfcef8 rdf:first sg:person.0607343473.23
    193 rdf:rest Nc56f174520144f0d90a787656dd66aa6
    194 Nae9548a0518c4ca39dd99c604bb99cfe schema:name Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    195 rdf:type schema:Organization
    196 Nae95ee6af1c54498a2c2c46d4a02e3c0 schema:name Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    197 rdf:type schema:Organization
    198 Nb8f0a4c219b54c83ac6919d45b190eb3 schema:name readcube_id
    199 schema:value e07cadbc012534db87097ce8af2059d283bc0b1b94d87f932a24f2ae67d92425
    200 rdf:type schema:PropertyValue
    201 Nbd644178d4124f8ca4e1eb6499dc7cf5 schema:affiliation Nae95ee6af1c54498a2c2c46d4a02e3c0
    202 schema:familyName Smith
    203 schema:givenName Jeff
    204 rdf:type schema:Person
    205 Nbd87a1e9a80e4ff197dff3b887e7d544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Glioblastoma
    207 rdf:type schema:DefinedTerm
    208 Nc56f174520144f0d90a787656dd66aa6 rdf:first sg:person.014367272257.59
    209 rdf:rest N195dd35ec87d435e9ac147d7cb77d4e2
    210 Nc5d3ae085c6a4e3f81554eecc5fd6a2d schema:issueNumber 41
    211 rdf:type schema:PublicationIssue
    212 Nc739faf2c45f4444aea52ed03a47d57f schema:name Biomedical Sciences Graduate Program, University of California, La Jolla, San Diego, CA, USA
    213 Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    214 rdf:type schema:Organization
    215 Ncbb9dbcb52884b838e279a857852dd17 schema:name Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    216 rdf:type schema:Organization
    217 Ne39f66788de042cd9f8080109fe0f08a rdf:first sg:person.0776315206.46
    218 rdf:rest N67dee2940d93415faff38ef66e24b409
    219 Nee1fad902e1045dc964fbe8a9ffbc32b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Animals
    221 rdf:type schema:DefinedTerm
    222 Nf2733d70a2804744bf3a265b723db702 rdf:first sg:person.013044464647.55
    223 rdf:rest N9693ab28f0094498a2a4b22694218d5b
    224 Nf3787ce90a50407ab5e43fbe18631d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Heterografts
    226 rdf:type schema:DefinedTerm
    227 Nfa4bd336517f4a0fb96a8da7445098b0 schema:name pubmed_id
    228 schema:value 29887596
    229 rdf:type schema:PropertyValue
    230 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Biological Sciences
    232 rdf:type schema:DefinedTerm
    233 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    234 schema:name Biochemistry and Cell Biology
    235 rdf:type schema:DefinedTerm
    236 sg:grant.2437043 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.2453543 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.2511743 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.2530405 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.2542628 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.2563454 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    247 rdf:type schema:MonetaryGrant
    248 sg:grant.2635652 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    249 rdf:type schema:MonetaryGrant
    250 sg:grant.2683814 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    251 rdf:type schema:MonetaryGrant
    252 sg:grant.3805543 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    253 rdf:type schema:MonetaryGrant
    254 sg:grant.7439852 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0301-5
    255 rdf:type schema:MonetaryGrant
    256 sg:journal.1097543 schema:issn 0950-9232
    257 1476-5594
    258 schema:name Oncogene
    259 rdf:type schema:Periodical
    260 sg:person.01066170100.97 schema:affiliation Nc739faf2c45f4444aea52ed03a47d57f
    261 schema:familyName Plouffe
    262 schema:givenName Steven W.
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066170100.97
    264 rdf:type schema:Person
    265 sg:person.01147567650.98 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
    266 schema:familyName Greenbaum
    267 schema:givenName Jason
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147567650.98
    269 rdf:type schema:Person
    270 sg:person.01220650203.57 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    271 schema:familyName Furnari
    272 schema:givenName Frank B.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220650203.57
    274 rdf:type schema:Person
    275 sg:person.013044464647.55 schema:affiliation https://www.grid.ac/institutes/grid.1052.6
    276 schema:familyName Benitez
    277 schema:givenName Jorge A.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013044464647.55
    279 rdf:type schema:Person
    280 sg:person.013251403237.77 schema:affiliation https://www.grid.ac/institutes/grid.185006.a
    281 schema:familyName Delatte
    282 schema:givenName Benjamin
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013251403237.77
    284 rdf:type schema:Person
    285 sg:person.01337330044.67 schema:affiliation N863a6df4d2f14ce18c27978afa78906e
    286 schema:familyName Yu
    287 schema:givenName Olivia M.
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337330044.67
    289 rdf:type schema:Person
    290 sg:person.01371336651.62 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    291 schema:familyName Brown
    292 schema:givenName Joan Heller
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371336651.62
    294 rdf:type schema:Person
    295 sg:person.014367272257.59 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    296 schema:familyName Guan
    297 schema:givenName Kun-Liang
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014367272257.59
    299 rdf:type schema:Person
    300 sg:person.0607343473.23 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    301 schema:familyName Rao
    302 schema:givenName Anjana
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607343473.23
    304 rdf:type schema:Person
    305 sg:person.0672775210.67 schema:affiliation https://www.grid.ac/institutes/grid.20736.30
    306 schema:familyName Chaim
    307 schema:givenName Olga Meiri
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672775210.67
    309 rdf:type schema:Person
    310 sg:person.0776315206.46 schema:affiliation Nae9548a0518c4ca39dd99c604bb99cfe
    311 schema:familyName Miyamoto
    312 schema:givenName Shigeki
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776315206.46
    314 rdf:type schema:Person
    315 sg:pub.10.1007/s004010050901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001327978
    316 https://doi.org/10.1007/s004010050901
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1007/s10555-011-9319-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022594213
    319 https://doi.org/10.1007/s10555-011-9319-7
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1007/s12035-016-0053-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028635046
    322 https://doi.org/10.1007/s12035-016-0053-6
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1007/s13277-014-2915-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047448838
    325 https://doi.org/10.1007/s13277-014-2915-8
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
    328 https://doi.org/10.1038/nature07385
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nature10137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028063527
    331 https://doi.org/10.1038/nature10137
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nature12912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043554069
    334 https://doi.org/10.1038/nature12912
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/ncb3216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022417218
    337 https://doi.org/10.1038/ncb3216
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/ncomms5632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010337312
    340 https://doi.org/10.1038/ncomms5632
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/ncomms7333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038003798
    343 https://doi.org/10.1038/ncomms7333
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nprot.2008.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005355981
    346 https://doi.org/10.1038/nprot.2008.73
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nprot.2013.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534425
    349 https://doi.org/10.1038/nprot.2013.143
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nrc725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022902509
    352 https://doi.org/10.1038/nrc725
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/onc.2013.400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035590916
    355 https://doi.org/10.1038/onc.2013.400
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/sj.onc.1204281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016979695
    358 https://doi.org/10.1038/sj.onc.1204281
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/sj.onc.1208238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019728507
    361 https://doi.org/10.1038/sj.onc.1208238
    362 rdf:type schema:CreativeWork
    363 https://app.dimensions.ai/details/publication/pub.1082741020 schema:CreativeWork
    364 https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1877::aid-cncr18>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029725307
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1002/jcb.20199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027329243
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/0014-5793(93)80896-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035747393
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/j.ajpath.2013.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036281093
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/j.bbrc.2007.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045412505
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/j.bbrc.2014.10.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046068240
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/j.beha.2008.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046845961
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/j.ccell.2016.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043928907
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/j.ccr.2006.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015784412
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/j.ccr.2014.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036809098
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/j.ccr.2014.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053117511
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/j.cell.2012.06.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039287087
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/j.cell.2013.07.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013737934
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/j.cell.2013.09.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044472205
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/j.cell.2015.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001535285
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/j.cellsig.2009.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024208329
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/j.celrep.2017.04.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085567554
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/j.molmed.2015.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007105952
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1016/s0014-5793(00)02224-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053452305
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1016/s0049-3848(16)30369-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050303968
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/s0092-8674(03)00278-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812734
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/s0092-8674(05)80020-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012846308
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1073/pnas.1314118111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022165361
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1073/pnas.90.14.6741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049326973
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1073/pnas.92.17.7819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039577962
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1073/pnas.92.25.11781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052510457
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1074/jbc.m103565200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033321426
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1074/jbc.m116.739722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058215248
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1074/jbc.m601803200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016974828
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1074/jbc.m708241200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031049089
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1091/mbc.7.11.1679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046546727
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1093/emboj/17.5.1350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017546180
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1096/fj.08-113266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002480097
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1096/fj.201600828r schema:sameAs https://app.dimensions.ai/details/publication/pub.1083717325
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1101/gad.1664408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045064078
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1101/gad.197582.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051369887
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1101/gad.239327.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022810043
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1101/gad.261982.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043286434
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1111/j.1476-5381.2009.00180.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033005708
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1111/j.1538-7836.2005.01446.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050451599
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1111/j.1538-7836.2011.04318.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051676577
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1111/j.1699-0463.1968.tb03502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027093163
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1124/mol.115.097857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025286886
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1126/science.1230184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042755313
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1126/science.7652575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648307
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1128/mcb.00772-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008294123
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1128/mcb.01623-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050905482
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1128/mcb.15.11.6443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019440731
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1128/mcb.23.18.6597-6608.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044479776
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1158/0008-5472.can-08-2997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024678882
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1158/0008-5472.can-09-0664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048615053
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1158/0008-5472.can-11-2526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009990102
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1158/1078-0432.ccr-05-2510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033628784
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1158/1078-0432.ccr-0659-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046898806
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1158/1535-7163.mct-06-0691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024529659
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1215/s1152851704000821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000798317
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1227/01.neu.0000489786.22041.2d schema:sameAs https://app.dimensions.ai/details/publication/pub.1036722646
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1371/journal.pone.0003769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050732391
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.18632/oncotarget.5219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036913944
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.18632/oncotarget.7366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001603536
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.3389/fonc.2013.00241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012713911
    485 rdf:type schema:CreativeWork
    486 https://www.grid.ac/institutes/grid.1052.6 schema:alternateName Ludwig Cancer Research
    487 schema:name Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, San Diego, CA, USA
    488 rdf:type schema:Organization
    489 https://www.grid.ac/institutes/grid.185006.a schema:alternateName La Jolla Institute For Allergy & Immunology
    490 schema:name Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    491 rdf:type schema:Organization
    492 https://www.grid.ac/institutes/grid.20736.30 schema:alternateName Federal University of Paraná
    493 schema:name Department of Cell Biology, Federal University of Paraná, Curitiba, Brazil
    494 Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    495 rdf:type schema:Organization
    496 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
    497 schema:name Department of Pathology, School of Medicine, University of California, La Jolla, San Diego, CA, USA
    498 Department of Pharmacology, University of California, La Jolla, San Diego, CA, USA
    499 Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    500 Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, San Diego, CA, USA
    501 Moores Cancer Center, University of California at San Diego, La Jolla, San Diego, CA, USA
    502 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...