BRD4 facilitates replication stress-induced DNA damage response View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Jingwen Zhang, Austin M. Dulak, Maureen M. Hattersley, Brandon S. Willis, Jenni Nikkilä, Anderson Wang, Alan Lau, Corinne Reimer, Michael Zinda, Stephen E. Fawell, Gordon B. Mills, Huawei Chen

ABSTRACT

Previous reports have demonstrated that select cancers depend on BRD4 to regulate oncogenic gene transcriptional programs. Here we describe a novel role for BRD4 in DNA damage response (DDR). BRD4 associates with and regulates the function of pre-replication factor CDC6 and plays an indispensable part in DNA replication checkpoint signaling. Inhibition of BRD4 by JQ1 or AZD5153 resulted in a rapid, time-dependent reduction in CHK1 phosphorylation and aberrant DNA replication re-initiation. Furthermore, BRD4 inhibition sensitized cancer cells to various replication stress-inducing agents, and synergized with ATR inhibitor AZD6738 to induce cell killing across a number of cancer cell lines. The synergistic interaction between AZD5153 and AZD6738 is translatable to in vivo ovarian cell-line and patient-derived xenograft models. Taken together, our study uncovers a new biological function of BRD4 and provides mechanistic rationale for combining BET inhibitors with DDR-targeted agents for cancer therapy. More... »

PAGES

3763-3777

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-018-0194-3

DOI

http://dx.doi.org/10.1038/s41388-018-0194-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103202611

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29636547


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterocyclic Compounds, 2-Ring", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrimidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfoxides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jingwen", 
        "id": "sg:person.014732301554.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014732301554.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dulak", 
        "givenName": "Austin M.", 
        "id": "sg:person.01311401332.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311401332.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hattersley", 
        "givenName": "Maureen M.", 
        "id": "sg:person.013306675215.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013306675215.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willis", 
        "givenName": "Brandon S.", 
        "id": "sg:person.013727472172.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013727472172.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.417815.e", 
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nikkil\u00e4", 
        "givenName": "Jenni", 
        "id": "sg:person.01363376377.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363376377.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.417815.e", 
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Anderson", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.417815.e", 
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lau", 
        "givenName": "Alan", 
        "id": "sg:person.01242754161.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242754161.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reimer", 
        "givenName": "Corinne", 
        "id": "sg:person.01220721265.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220721265.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zinda", 
        "givenName": "Michael", 
        "id": "sg:person.0745153714.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745153714.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fawell", 
        "givenName": "Stephen E.", 
        "id": "sg:person.01316160552.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316160552.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mills", 
        "givenName": "Gordon B.", 
        "id": "sg:person.012742742357.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Huawei", 
        "id": "sg:person.01165014530.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165014530.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2013.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000925772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.13.4129-4139.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001510102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.10.10.3263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002396759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002438933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200311044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003492421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.248914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005241630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1108297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005911474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2014.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009145097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2014.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009145097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-1337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010132301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01020-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011117404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.29568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012128004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.29568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012128004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.13574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012892735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/genes6020267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016073813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016822016", 
          "https://doi.org/10.1038/nature12147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-3026(16)00021-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018308218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021276429", 
          "https://doi.org/10.1038/nsmb.2076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021494737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2012.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023539296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024174782", 
          "https://doi.org/10.1038/nchembio.90"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025340748", 
          "https://doi.org/10.1038/nrd4553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-16-0141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025423446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2006.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027099080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms10530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029377119", 
          "https://doi.org/10.1038/ncomms10530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.18.6509-6520.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029650655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030076294", 
          "https://doi.org/10.1038/nature10334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.11.6193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030982179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2015.10.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031572579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032847790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2015.3062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032889475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2015.3062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032889475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1006272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033726490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2352-3026(15)00247-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034741344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3410/b1-98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036088640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036187922", 
          "https://doi.org/10.1038/nrc1296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036187922", 
          "https://doi.org/10.1038/nrc1296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0900212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036199013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1422165112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038050169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1422165112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038050169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-04-1678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039586723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649759", 
          "https://doi.org/10.1038/nature03445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649759", 
          "https://doi.org/10.1038/nature03445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4155/fmc.15.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041655830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0976-500x.72351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042746170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047783808", 
          "https://doi.org/10.1038/nbt.1549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.2210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048520040", 
          "https://doi.org/10.1038/nchembio.2210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049104507", 
          "https://doi.org/10.1038/ncb2897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1433065100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049950314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050082312", 
          "https://doi.org/10.1038/nrc2342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r700001200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050432137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgm268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050907984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2014.05.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050985392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.06.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052115863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.06.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052115863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m806530200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053389210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.6b00070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055100016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.6b00519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055100155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-15-1070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063215831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-15-1335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063281031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.4.12.2193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298167"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-07", 
    "datePublishedReg": "2018-07-01", 
    "description": "Previous reports have demonstrated that select cancers depend on BRD4 to regulate oncogenic gene transcriptional programs. Here we describe a novel role for BRD4 in DNA damage response (DDR). BRD4 associates with and regulates the function of pre-replication factor CDC6 and plays an indispensable part in DNA replication checkpoint signaling. Inhibition of BRD4 by JQ1 or AZD5153 resulted in a rapid, time-dependent reduction in CHK1 phosphorylation and aberrant DNA replication re-initiation. Furthermore, BRD4 inhibition sensitized cancer cells to various replication stress-inducing agents, and synergized with ATR inhibitor AZD6738 to induce cell killing across a number of cancer cell lines. The synergistic interaction between AZD5153 and AZD6738 is translatable to in vivo ovarian cell-line and patient-derived xenograft models. Taken together, our study uncovers a new biological function of BRD4 and provides mechanistic rationale for combining BET inhibitors with DDR-targeted agents for cancer therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41388-018-0194-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7028997", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "28", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "BRD4 facilitates replication stress-induced DNA damage response", 
    "pagination": "3763-3777", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41388-018-0194-3"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4d7ff9e24049a6faa32a474a33645d11dc2f150ff6191709887aa8b0681d64aa"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103202611"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29636547"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41388-018-0194-3", 
      "https://app.dimensions.ai/details/publication/pub.1103202611"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56182_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41388-018-0194-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0194-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0194-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0194-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0194-3'


 

This table displays all metadata directly associated to this object as RDF triples.

412 TRIPLES      21 PREDICATES      101 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41388-018-0194-3 schema:about N032d209fa1494586b7aa21e801678501
2 N06c29d1811b049729a1ede4fb3822cc1
3 N152d28f233b84527b45c184cfaa47d78
4 N1cf15fbd0a844e36a08e96ff75bddb58
5 N2d965320ce8846768daa6eab73226dd2
6 N4dd5bb671c6c48d28609942d8ccab39f
7 N5138f6d3e491430cbdd08abb755c2a96
8 N542db6dbdf7a4b7aadbdbe90e29ece55
9 N7e6780e539294829b17ed77fc2a7f7e4
10 N95027cd835b941a28482e79368ec55cb
11 Nab9e50c2403c4e999c85489182331661
12 Nc0b89316278c4297ba52507c2a022c65
13 Nc79fb6f9a2de4a109cb91f4bea74a946
14 Ne30bf73f097f4c4ea2a97faa33240917
15 Nede7aa522d5c41238dcac7f843fc3c3a
16 Nf45e7d57df1c4a708cde77c37939e89a
17 Nf5197d821b3f44019b1866c750854afb
18 Nf6758b93611045a6be6dddec2f9bbf4d
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author Nb3094d3b08014ff3837b39c66089fcaf
22 schema:citation sg:pub.10.1038/nature03445
23 sg:pub.10.1038/nature10334
24 sg:pub.10.1038/nature12147
25 sg:pub.10.1038/nbt.1549
26 sg:pub.10.1038/ncb2897
27 sg:pub.10.1038/nchembio.2210
28 sg:pub.10.1038/nchembio.90
29 sg:pub.10.1038/ncomms10530
30 sg:pub.10.1038/nrc1296
31 sg:pub.10.1038/nrc2342
32 sg:pub.10.1038/nrd4553
33 sg:pub.10.1038/nsmb.2076
34 https://doi.org/10.1002/ijc.29568
35 https://doi.org/10.1016/j.bmcl.2012.04.024
36 https://doi.org/10.1016/j.canlet.2006.11.005
37 https://doi.org/10.1016/j.cell.2005.08.013
38 https://doi.org/10.1016/j.cell.2013.02.011
39 https://doi.org/10.1016/j.molcel.2005.06.027
40 https://doi.org/10.1016/j.molcel.2014.05.016
41 https://doi.org/10.1016/j.molcel.2014.05.018
42 https://doi.org/10.1016/j.molcel.2015.10.040
43 https://doi.org/10.1016/s2352-3026(15)00247-1
44 https://doi.org/10.1016/s2352-3026(16)00021-1
45 https://doi.org/10.1021/acs.jmedchem.6b00070
46 https://doi.org/10.1021/acs.jmedchem.6b00519
47 https://doi.org/10.1056/nejmoa0900212
48 https://doi.org/10.1073/pnas.1422165112
49 https://doi.org/10.1073/pnas.1433065100
50 https://doi.org/10.1073/pnas.96.11.6193
51 https://doi.org/10.1074/jbc.m111.248914
52 https://doi.org/10.1074/jbc.m806530200
53 https://doi.org/10.1074/jbc.r700001200
54 https://doi.org/10.1083/jcb.200311044
55 https://doi.org/10.1091/mbc.10.10.3263
56 https://doi.org/10.1093/carcin/bgm268
57 https://doi.org/10.1111/febs.13574
58 https://doi.org/10.1126/science.1108297
59 https://doi.org/10.1128/mcb.01020-07
60 https://doi.org/10.1128/mcb.21.13.4129-4139.2001
61 https://doi.org/10.1128/mcb.22.18.6509-6520.2002
62 https://doi.org/10.1158/0008-5472.can-05-4443
63 https://doi.org/10.1158/0008-5472.can-15-1070
64 https://doi.org/10.1158/1078-0432.ccr-13-1337
65 https://doi.org/10.1158/1535-7163.mct-16-0141
66 https://doi.org/10.1158/2159-8290.cd-15-1335
67 https://doi.org/10.1182/blood-2005-04-1678
68 https://doi.org/10.1371/journal.pgen.1006272
69 https://doi.org/10.18632/oncotarget.6247
70 https://doi.org/10.3390/genes6020267
71 https://doi.org/10.3410/b1-98
72 https://doi.org/10.3892/ijo.2015.3062
73 https://doi.org/10.4103/0976-500x.72351
74 https://doi.org/10.4155/fmc.15.33
75 https://doi.org/10.4161/cc.4.12.2193
76 schema:datePublished 2018-07
77 schema:datePublishedReg 2018-07-01
78 schema:description Previous reports have demonstrated that select cancers depend on BRD4 to regulate oncogenic gene transcriptional programs. Here we describe a novel role for BRD4 in DNA damage response (DDR). BRD4 associates with and regulates the function of pre-replication factor CDC6 and plays an indispensable part in DNA replication checkpoint signaling. Inhibition of BRD4 by JQ1 or AZD5153 resulted in a rapid, time-dependent reduction in CHK1 phosphorylation and aberrant DNA replication re-initiation. Furthermore, BRD4 inhibition sensitized cancer cells to various replication stress-inducing agents, and synergized with ATR inhibitor AZD6738 to induce cell killing across a number of cancer cell lines. The synergistic interaction between AZD5153 and AZD6738 is translatable to in vivo ovarian cell-line and patient-derived xenograft models. Taken together, our study uncovers a new biological function of BRD4 and provides mechanistic rationale for combining BET inhibitors with DDR-targeted agents for cancer therapy.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree false
82 schema:isPartOf N234e1b17a3a1416c90f3c31715933247
83 Ne00b199280c2496e9293fade6ed57a76
84 sg:journal.1097543
85 schema:name BRD4 facilitates replication stress-induced DNA damage response
86 schema:pagination 3763-3777
87 schema:productId N141cdef9f47b478f9ed04f0cef03b9eb
88 N227dd28ff4b84e05a1283c5b5c21eb44
89 N6f879c1b3e354cacbc6d7390dcbc3382
90 N8919d7677fa345268e85bfed777d1226
91 N8a1c8fa7bc034004ba36bf0c870320d9
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103202611
93 https://doi.org/10.1038/s41388-018-0194-3
94 schema:sdDatePublished 2019-04-15T09:21
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher Ncc7fbb78b15c4dbaaa826ed01e36f55b
97 schema:url https://www.nature.com/articles/s41388-018-0194-3
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N008e7857e9da495697d94a27192d1160 rdf:first sg:person.01316160552.36
102 rdf:rest N0ea64f5163394c5b95d4e6ed6d5d0c7d
103 N032d209fa1494586b7aa21e801678501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Phosphorylation
105 rdf:type schema:DefinedTerm
106 N03bd7a55d62f47acb17a644064b961f1 schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
107 rdf:type schema:Organization
108 N04353107e65b40009aaab723e9e32f23 rdf:first N94d4dcbf62a6414aa58c5df2c4d2639a
109 rdf:rest N96eff83ef8d2485980c3b6de001cfde3
110 N05159de1011044c5a7e0d60d5d26c1dd rdf:first sg:person.013727472172.89
111 rdf:rest Nfb8ba6e58f4f45528276f08e9c99d45e
112 N06c29d1811b049729a1ede4fb3822cc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Heterocyclic Compounds, 2-Ring
114 rdf:type schema:DefinedTerm
115 N0ea64f5163394c5b95d4e6ed6d5d0c7d rdf:first sg:person.012742742357.13
116 rdf:rest Ned826c23160d44e58dc2836f7a38a751
117 N141cdef9f47b478f9ed04f0cef03b9eb schema:name readcube_id
118 schema:value 4d7ff9e24049a6faa32a474a33645d11dc2f150ff6191709887aa8b0681d64aa
119 rdf:type schema:PropertyValue
120 N152d28f233b84527b45c184cfaa47d78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Transcription Factors
122 rdf:type schema:DefinedTerm
123 N1cf15fbd0a844e36a08e96ff75bddb58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cell Line, Tumor
125 rdf:type schema:DefinedTerm
126 N227dd28ff4b84e05a1283c5b5c21eb44 schema:name nlm_unique_id
127 schema:value 8711562
128 rdf:type schema:PropertyValue
129 N234e1b17a3a1416c90f3c31715933247 schema:volumeNumber 37
130 rdf:type schema:PublicationVolume
131 N2b2deb3aa2b9477dbd7910418e3c7f2b schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
132 rdf:type schema:Organization
133 N2d965320ce8846768daa6eab73226dd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name DNA Damage
135 rdf:type schema:DefinedTerm
136 N409d31b455374288ba73f59d56ea71dc schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
137 rdf:type schema:Organization
138 N41b3b1fe031a45578e2192ffb4cc9a06 rdf:first sg:person.013306675215.92
139 rdf:rest N05159de1011044c5a7e0d60d5d26c1dd
140 N4dd5bb671c6c48d28609942d8ccab39f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Signal Transduction
142 rdf:type schema:DefinedTerm
143 N5138f6d3e491430cbdd08abb755c2a96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name DNA Replication
145 rdf:type schema:DefinedTerm
146 N542db6dbdf7a4b7aadbdbe90e29ece55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Humans
148 rdf:type schema:DefinedTerm
149 N5e868c832f2a4dfabc4fca88ee49475e schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
150 rdf:type schema:Organization
151 N6f879c1b3e354cacbc6d7390dcbc3382 schema:name dimensions_id
152 schema:value pub.1103202611
153 rdf:type schema:PropertyValue
154 N77281ecf157e4cd0bf508242856228cc rdf:first sg:person.01311401332.13
155 rdf:rest N41b3b1fe031a45578e2192ffb4cc9a06
156 N7e6780e539294829b17ed77fc2a7f7e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Nuclear Proteins
158 rdf:type schema:DefinedTerm
159 N8919d7677fa345268e85bfed777d1226 schema:name pubmed_id
160 schema:value 29636547
161 rdf:type schema:PropertyValue
162 N8a1c8fa7bc034004ba36bf0c870320d9 schema:name doi
163 schema:value 10.1038/s41388-018-0194-3
164 rdf:type schema:PropertyValue
165 N8c918179b0f24565a6d140e90bff889d rdf:first sg:person.0745153714.84
166 rdf:rest N008e7857e9da495697d94a27192d1160
167 N94d4dcbf62a6414aa58c5df2c4d2639a schema:affiliation https://www.grid.ac/institutes/grid.417815.e
168 schema:familyName Wang
169 schema:givenName Anderson
170 rdf:type schema:Person
171 N95027cd835b941a28482e79368ec55cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Xenograft Model Antitumor Assays
173 rdf:type schema:DefinedTerm
174 N96eff83ef8d2485980c3b6de001cfde3 rdf:first sg:person.01242754161.79
175 rdf:rest Ndee65bd5f5ca460aa6cc199dc3e89f0b
176 Nab9e50c2403c4e999c85489182331661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Pyrimidines
178 rdf:type schema:DefinedTerm
179 Nb3094d3b08014ff3837b39c66089fcaf rdf:first sg:person.014732301554.39
180 rdf:rest N77281ecf157e4cd0bf508242856228cc
181 Nba0a735befa84c708c478e617e0f2b0e schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
182 rdf:type schema:Organization
183 Nc0b89316278c4297ba52507c2a022c65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Female
185 rdf:type schema:DefinedTerm
186 Nc79fb6f9a2de4a109cb91f4bea74a946 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Piperazines
188 rdf:type schema:DefinedTerm
189 Ncc7fbb78b15c4dbaaa826ed01e36f55b schema:name Springer Nature - SN SciGraph project
190 rdf:type schema:Organization
191 Nd6d32bf523314023bd41e7ad17795c2e schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
192 rdf:type schema:Organization
193 Ndee65bd5f5ca460aa6cc199dc3e89f0b rdf:first sg:person.01220721265.87
194 rdf:rest N8c918179b0f24565a6d140e90bff889d
195 Ne00b199280c2496e9293fade6ed57a76 schema:issueNumber 28
196 rdf:type schema:PublicationIssue
197 Ne30bf73f097f4c4ea2a97faa33240917 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Animals
199 rdf:type schema:DefinedTerm
200 Ne6a8e1a0d9154ad7a8ac02a912eae1c4 schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
201 rdf:type schema:Organization
202 Ned826c23160d44e58dc2836f7a38a751 rdf:first sg:person.01165014530.90
203 rdf:rest rdf:nil
204 Nede7aa522d5c41238dcac7f843fc3c3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mice
206 rdf:type schema:DefinedTerm
207 Nf3eb286416324aa99276a778f4042ffb schema:name Oncology, IMED Biotech Unit, AstraZeneca R&D, Boston, USA
208 rdf:type schema:Organization
209 Nf45e7d57df1c4a708cde77c37939e89a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Sulfoxides
211 rdf:type schema:DefinedTerm
212 Nf5197d821b3f44019b1866c750854afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Gene Expression Regulation, Neoplastic
214 rdf:type schema:DefinedTerm
215 Nf6758b93611045a6be6dddec2f9bbf4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Mice, SCID
217 rdf:type schema:DefinedTerm
218 Nfb8ba6e58f4f45528276f08e9c99d45e rdf:first sg:person.01363376377.85
219 rdf:rest N04353107e65b40009aaab723e9e32f23
220 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
221 schema:name Biological Sciences
222 rdf:type schema:DefinedTerm
223 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
224 schema:name Biochemistry and Cell Biology
225 rdf:type schema:DefinedTerm
226 sg:grant.7028997 http://pending.schema.org/fundedItem sg:pub.10.1038/s41388-018-0194-3
227 rdf:type schema:MonetaryGrant
228 sg:journal.1097543 schema:issn 0950-9232
229 1476-5594
230 schema:name Oncogene
231 rdf:type schema:Periodical
232 sg:person.01165014530.90 schema:affiliation N409d31b455374288ba73f59d56ea71dc
233 schema:familyName Chen
234 schema:givenName Huawei
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165014530.90
236 rdf:type schema:Person
237 sg:person.01220721265.87 schema:affiliation Nba0a735befa84c708c478e617e0f2b0e
238 schema:familyName Reimer
239 schema:givenName Corinne
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220721265.87
241 rdf:type schema:Person
242 sg:person.01242754161.79 schema:affiliation https://www.grid.ac/institutes/grid.417815.e
243 schema:familyName Lau
244 schema:givenName Alan
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242754161.79
246 rdf:type schema:Person
247 sg:person.012742742357.13 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
248 schema:familyName Mills
249 schema:givenName Gordon B.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13
251 rdf:type schema:Person
252 sg:person.01311401332.13 schema:affiliation N5e868c832f2a4dfabc4fca88ee49475e
253 schema:familyName Dulak
254 schema:givenName Austin M.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311401332.13
256 rdf:type schema:Person
257 sg:person.01316160552.36 schema:affiliation Ne6a8e1a0d9154ad7a8ac02a912eae1c4
258 schema:familyName Fawell
259 schema:givenName Stephen E.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316160552.36
261 rdf:type schema:Person
262 sg:person.013306675215.92 schema:affiliation N03bd7a55d62f47acb17a644064b961f1
263 schema:familyName Hattersley
264 schema:givenName Maureen M.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013306675215.92
266 rdf:type schema:Person
267 sg:person.01363376377.85 schema:affiliation https://www.grid.ac/institutes/grid.417815.e
268 schema:familyName Nikkilä
269 schema:givenName Jenni
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363376377.85
271 rdf:type schema:Person
272 sg:person.013727472172.89 schema:affiliation Nf3eb286416324aa99276a778f4042ffb
273 schema:familyName Willis
274 schema:givenName Brandon S.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013727472172.89
276 rdf:type schema:Person
277 sg:person.014732301554.39 schema:affiliation Nd6d32bf523314023bd41e7ad17795c2e
278 schema:familyName Zhang
279 schema:givenName Jingwen
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014732301554.39
281 rdf:type schema:Person
282 sg:person.0745153714.84 schema:affiliation N2b2deb3aa2b9477dbd7910418e3c7f2b
283 schema:familyName Zinda
284 schema:givenName Michael
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745153714.84
286 rdf:type schema:Person
287 sg:pub.10.1038/nature03445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649759
288 https://doi.org/10.1038/nature03445
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nature10334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030076294
291 https://doi.org/10.1038/nature10334
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nature12147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016822016
294 https://doi.org/10.1038/nature12147
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nbt.1549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047783808
297 https://doi.org/10.1038/nbt.1549
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/ncb2897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049104507
300 https://doi.org/10.1038/ncb2897
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/nchembio.2210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048520040
303 https://doi.org/10.1038/nchembio.2210
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/nchembio.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024174782
306 https://doi.org/10.1038/nchembio.90
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/ncomms10530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029377119
309 https://doi.org/10.1038/ncomms10530
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/nrc1296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036187922
312 https://doi.org/10.1038/nrc1296
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/nrc2342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050082312
315 https://doi.org/10.1038/nrc2342
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/nrd4553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025340748
318 https://doi.org/10.1038/nrd4553
319 rdf:type schema:CreativeWork
320 sg:pub.10.1038/nsmb.2076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021276429
321 https://doi.org/10.1038/nsmb.2076
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1002/ijc.29568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012128004
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.bmcl.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023539296
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.canlet.2006.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027099080
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.cell.2005.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002438933
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.cell.2013.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000925772
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.molcel.2005.06.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052115863
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.molcel.2014.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009145097
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.molcel.2014.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050985392
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.molcel.2015.10.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031572579
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s2352-3026(15)00247-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034741344
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s2352-3026(16)00021-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018308218
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1021/acs.jmedchem.6b00070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055100016
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1021/acs.jmedchem.6b00519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055100155
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1056/nejmoa0900212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199013
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1073/pnas.1422165112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038050169
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1073/pnas.1433065100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049950314
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1073/pnas.96.11.6193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030982179
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1074/jbc.m111.248914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005241630
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1074/jbc.m806530200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053389210
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1074/jbc.r700001200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050432137
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1083/jcb.200311044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003492421
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1091/mbc.10.10.3263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002396759
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1093/carcin/bgm268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050907984
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1111/febs.13574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012892735
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1126/science.1108297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005911474
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1128/mcb.01020-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011117404
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1128/mcb.21.13.4129-4139.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001510102
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1128/mcb.22.18.6509-6520.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029650655
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/0008-5472.can-05-4443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021494737
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1158/0008-5472.can-15-1070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215831
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1158/1078-0432.ccr-13-1337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010132301
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1158/1535-7163.mct-16-0141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025423446
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1158/2159-8290.cd-15-1335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063281031
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1182/blood-2005-04-1678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039586723
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1371/journal.pgen.1006272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033726490
392 rdf:type schema:CreativeWork
393 https://doi.org/10.18632/oncotarget.6247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032847790
394 rdf:type schema:CreativeWork
395 https://doi.org/10.3390/genes6020267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016073813
396 rdf:type schema:CreativeWork
397 https://doi.org/10.3410/b1-98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036088640
398 rdf:type schema:CreativeWork
399 https://doi.org/10.3892/ijo.2015.3062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032889475
400 rdf:type schema:CreativeWork
401 https://doi.org/10.4103/0976-500x.72351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042746170
402 rdf:type schema:CreativeWork
403 https://doi.org/10.4155/fmc.15.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041655830
404 rdf:type schema:CreativeWork
405 https://doi.org/10.4161/cc.4.12.2193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298167
406 rdf:type schema:CreativeWork
407 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
408 schema:name Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.417815.e schema:alternateName AstraZeneca (United Kingdom)
411 schema:name Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK
412 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...