ERK5 is activated by oncogenic BRAF and promotes melanoma growth View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05

AUTHORS

Ignazia Tusa, Sinforosa Gagliardi, Alessandro Tubita, Silvia Pandolfi, Carmelo Urso, Lorenzo Borgognoni, Jinhua Wang, Xianming Deng, Nathanael S Gray, Barbara Stecca, Elisabetta Rovida

ABSTRACT

Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments are still unsatisfactory. While the role of the BRAF-MEK1/2-ERK1/2 pathway in melanoma is well established, the involvement of mitogen-activated protein kinases MEK5-ERK5 remains poorly explored. Here we investigated the function of ERK5 signaling in melanoma. We show that ERK5 is consistently expressed in human melanoma tissues and is active in melanoma cells. Genetic silencing and pharmacological inhibition of ERK5 pathway drastically reduce the growth of melanoma cells and xenografts harboring wild-type (wt) or mutated BRAF (V600E). We also found that oncogenic BRAF positively regulates expression, phosphorylation, and nuclear localization of ERK5. Importantly, ERK5 kinase and transcriptional transactivator activities are enhanced by BRAF. Nevertheless, combined pharmacological inhibition of BRAFV600E and MEK5 is required to decrease nuclear ERK5, that is critical for the regulation of cell proliferation. Accordingly, combination of MEK5 or ERK5 inhibitors with BRAFV600E inhibitor vemurafenib is more effective than single treatments in reducing colony formation and growth of BRAFV600E melanoma cells and xenografts. Overall, these data support a key role of the ERK5 pathway for melanoma growth in vitro and in vivo and suggest that targeting ERK5, alone or in combination with BRAF-MEK1/2 inhibitors, might represent a novel approach for melanoma treatment. More... »

PAGES

2601-2614

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41388-018-0164-9

DOI

http://dx.doi.org/10.1038/s41388-018-0164-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101201627

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29483645


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vemurafenib", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tusa", 
        "givenName": "Ignazia", 
        "id": "sg:person.01306066760.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306066760.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
          "id": "https://www.grid.ac/institutes/grid.24704.35", 
          "name": [
            "Core Research Laboratory - Istituto Toscano Tumori, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gagliardi", 
        "givenName": "Sinforosa", 
        "id": "sg:person.012576313115.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012576313115.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tubita", 
        "givenName": "Alessandro", 
        "id": "sg:person.012705425520.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705425520.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
          "id": "https://www.grid.ac/institutes/grid.24704.35", 
          "name": [
            "Core Research Laboratory - Istituto Toscano Tumori, Florence, Italy", 
            "VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pandolfi", 
        "givenName": "Silvia", 
        "id": "sg:person.01107242747.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107242747.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria Annunziata", 
          "id": "https://www.grid.ac/institutes/grid.415194.c", 
          "name": [
            "Anatomic Pathology Unit, Dermatopathology Section, S.M. Annunziata Hospital, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Urso", 
        "givenName": "Carmelo", 
        "id": "sg:person.01010451263.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010451263.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria Annunziata", 
          "id": "https://www.grid.ac/institutes/grid.415194.c", 
          "name": [
            "Plastic Surgery Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borgognoni", 
        "givenName": "Lorenzo", 
        "id": "sg:person.0653251344.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653251344.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA", 
            "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jinhua", 
        "id": "sg:person.014621721634.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014621721634.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xiamen University", 
          "id": "https://www.grid.ac/institutes/grid.12955.3a", 
          "name": [
            "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA", 
            "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA", 
            "State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, Fujian, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "Xianming", 
        "id": "sg:person.01363402343.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363402343.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA", 
            "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gray", 
        "givenName": "Nathanael S", 
        "id": "sg:person.01100730461.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100730461.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
          "id": "https://www.grid.ac/institutes/grid.24704.35", 
          "name": [
            "Core Research Laboratory - Istituto Toscano Tumori, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stecca", 
        "givenName": "Barbara", 
        "id": "sg:person.01220200153.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220200153.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rovida", 
        "givenName": "Elisabetta", 
        "id": "sg:person.0621314445.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621314445.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ccr.2010.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001630944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.070516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004083905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.1.270-285.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006395649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009497250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m704079200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010529249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011831914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012432963", 
          "https://doi.org/10.1038/nrd4281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.4799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013277178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2012.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015705492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms11551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015819509", 
          "https://doi.org/10.1038/ncomms11551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1609019113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016062429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.2a0115-034r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018221901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2014-306761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019711659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m412599200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020873622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.07.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021918737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.1865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022229872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0600447103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022558372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022611192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-07-2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023191843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1504030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024843336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2011.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025903738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.6.4166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028147428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cam4.667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029312069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.09.087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031172488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2004088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033807182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01246-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034372440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2010.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034579689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1210093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036427533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.05.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037671653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2014.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038272915", 
          "https://doi.org/10.1038/onc.2014.71"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038965314", 
          "https://doi.org/10.1038/nprot.2006.339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038965314", 
          "https://doi.org/10.1038/nprot.2006.339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2016.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039585310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1253735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039813424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drudis.2016.06.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039818373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040467727", 
          "https://doi.org/10.1038/ng.3361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040736334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041864150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0117914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041894756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fcell.2016.00105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042924614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m001573200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043470487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2012.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043526843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-13-0070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043550331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046340258", 
          "https://doi.org/10.1038/sj.onc.1210963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-08-2985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050465029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15384101.2015.1120915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058402132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075201525", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3978/j.issn.2305-5839.2015.05.07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079167517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep46244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084538237", 
          "https://doi.org/10.1038/srep46244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-16-2565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085470484"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05", 
    "datePublishedReg": "2018-05-01", 
    "description": "Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments are still unsatisfactory. While the role of the BRAF-MEK1/2-ERK1/2 pathway in melanoma is well established, the involvement of mitogen-activated protein kinases MEK5-ERK5 remains poorly explored. Here we investigated the function of ERK5 signaling in melanoma. We show that ERK5 is consistently expressed in human melanoma tissues and is active in melanoma cells. Genetic silencing and pharmacological inhibition of ERK5 pathway drastically reduce the growth of melanoma cells and xenografts harboring wild-type (wt) or mutated BRAF (V600E). We also found that oncogenic BRAF positively regulates expression, phosphorylation, and nuclear localization of ERK5. Importantly, ERK5 kinase and transcriptional transactivator activities are enhanced by BRAF. Nevertheless, combined pharmacological inhibition of BRAFV600E and MEK5 is required to decrease nuclear ERK5, that is critical for the regulation of cell proliferation. Accordingly, combination of MEK5 or ERK5 inhibitors with BRAFV600E inhibitor vemurafenib is more effective than single treatments in reducing colony formation and growth of BRAFV600E melanoma cells and xenografts. Overall, these data support a key role of the ERK5 pathway for melanoma growth in vitro and in vivo and suggest that targeting ERK5, alone or in combination with BRAF-MEK1/2 inhibitors, might represent a novel approach for melanoma treatment.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41388-018-0164-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "19", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "ERK5 is activated by oncogenic BRAF and promotes melanoma growth", 
    "pagination": "2601-2614", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9ab7cbf80202abf5c41da817e0dc93cd8ff0f722bf4d295936e69b75270eacd3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29483645"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41388-018-0164-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101201627"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41388-018-0164-9", 
      "https://app.dimensions.ai/details/publication/pub.1101201627"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54322_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41388-018-0164-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0164-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0164-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0164-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41388-018-0164-9'


 

This table displays all metadata directly associated to this object as RDF triples.

369 TRIPLES      21 PREDICATES      93 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41388-018-0164-9 schema:about N02cfb5088fab49509fa2325ad75d6ea4
2 N2d109a9c66ea4bb58fe2e5669b53ca4a
3 N562060eabcdb430abb8875ea66bd94c0
4 N59665966ed984456b66db2e8daa1a729
5 N5f69dbae07d240ff8cfc925f38af4879
6 N7704f7e3652843fcbf2d37b9caa66b10
7 N82ce0858a4654db5bdc51e2e11468fb6
8 N9cbf643584b5474f84002c3bb14a8913
9 Nafa4fcc5cc854273921a22732a734009
10 Nb2ac8387df154e6f8325ab54e65e0a27
11 Nb5957d2a12e54e75a60c54da891bbc27
12 Ndc90b8c4315241508e1d95ef7a7d0e9b
13 Ne31afe3086414807b01468a0ff11cfd1
14 Nf9519fa19f404d5fb7e0fd1dca77f8cb
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N75f9aa4ed8e0489d8eae7b0bb5b3ebbf
18 schema:citation sg:pub.10.1038/nature00766
19 sg:pub.10.1038/ncomms11551
20 sg:pub.10.1038/ng.3361
21 sg:pub.10.1038/nprot.2006.339
22 sg:pub.10.1038/nrd4281
23 sg:pub.10.1038/onc.2014.71
24 sg:pub.10.1038/sj.onc.1210963
25 sg:pub.10.1038/srep46244
26 https://app.dimensions.ai/details/publication/pub.1075201525
27 https://doi.org/10.1002/cam4.667
28 https://doi.org/10.1016/j.bbcan.2011.10.002
29 https://doi.org/10.1016/j.bbrc.2008.09.087
30 https://doi.org/10.1016/j.ccr.2010.08.008
31 https://doi.org/10.1016/j.cell.2015.05.044
32 https://doi.org/10.1016/j.cellsig.2010.07.010
33 https://doi.org/10.1016/j.cellsig.2012.07.007
34 https://doi.org/10.1016/j.cellsig.2012.08.001
35 https://doi.org/10.1016/j.celrep.2016.07.033
36 https://doi.org/10.1016/j.cmet.2016.12.010
37 https://doi.org/10.1016/j.drudis.2016.06.010
38 https://doi.org/10.1056/nejmoa1103782
39 https://doi.org/10.1056/nejmoa1210093
40 https://doi.org/10.1056/nejmoa1504030
41 https://doi.org/10.1073/pnas.0600447103
42 https://doi.org/10.1073/pnas.1609019113
43 https://doi.org/10.1074/jbc.m001573200
44 https://doi.org/10.1074/jbc.m412599200
45 https://doi.org/10.1074/jbc.m704079200
46 https://doi.org/10.1080/15384101.2015.1120915
47 https://doi.org/10.1126/science.1253735
48 https://doi.org/10.1126/scisignal.2004088
49 https://doi.org/10.1128/mcb.01246-12
50 https://doi.org/10.1128/mcb.22.1.270-285.2002
51 https://doi.org/10.1136/gutjnl-2014-306761
52 https://doi.org/10.1158/0008-5472.can-10-0646
53 https://doi.org/10.1158/0008-5472.can-16-2565
54 https://doi.org/10.1158/1078-0432.ccr-10-2504
55 https://doi.org/10.1158/1541-7786.mcr-07-2001
56 https://doi.org/10.1158/2159-8290.cd-12-0095
57 https://doi.org/10.1158/2159-8290.cd-13-0070
58 https://doi.org/10.1182/blood-2004-08-2985
59 https://doi.org/10.1189/jlb.2a0115-034r
60 https://doi.org/10.1200/jco.2009.23.4799
61 https://doi.org/10.1242/jcs.01040
62 https://doi.org/10.1242/jcs.070516
63 https://doi.org/10.1371/journal.pone.0117914
64 https://doi.org/10.18632/oncotarget.1865
65 https://doi.org/10.3389/fcell.2016.00105
66 https://doi.org/10.3978/j.issn.2305-5839.2015.05.07
67 https://doi.org/10.4049/jimmunol.180.6.4166
68 schema:datePublished 2018-05
69 schema:datePublishedReg 2018-05-01
70 schema:description Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments are still unsatisfactory. While the role of the BRAF-MEK1/2-ERK1/2 pathway in melanoma is well established, the involvement of mitogen-activated protein kinases MEK5-ERK5 remains poorly explored. Here we investigated the function of ERK5 signaling in melanoma. We show that ERK5 is consistently expressed in human melanoma tissues and is active in melanoma cells. Genetic silencing and pharmacological inhibition of ERK5 pathway drastically reduce the growth of melanoma cells and xenografts harboring wild-type (wt) or mutated BRAF (V600E). We also found that oncogenic BRAF positively regulates expression, phosphorylation, and nuclear localization of ERK5. Importantly, ERK5 kinase and transcriptional transactivator activities are enhanced by BRAF. Nevertheless, combined pharmacological inhibition of BRAFV600E and MEK5 is required to decrease nuclear ERK5, that is critical for the regulation of cell proliferation. Accordingly, combination of MEK5 or ERK5 inhibitors with BRAFV600E inhibitor vemurafenib is more effective than single treatments in reducing colony formation and growth of BRAFV600E melanoma cells and xenografts. Overall, these data support a key role of the ERK5 pathway for melanoma growth in vitro and in vivo and suggest that targeting ERK5, alone or in combination with BRAF-MEK1/2 inhibitors, might represent a novel approach for melanoma treatment.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N90a6a37ca42147928b706853f65f7d75
75 Ned4c59ab8ba34b30bfd52295385be36c
76 sg:journal.1097543
77 schema:name ERK5 is activated by oncogenic BRAF and promotes melanoma growth
78 schema:pagination 2601-2614
79 schema:productId N1eac229e89bf4018b961f2c0457a17ed
80 N4d581c23644a4055abfbbdcef7f2bd69
81 N760ee73abd47471ba3e529f9f3e46198
82 N79e6b6b5fc0f4fdc8bbca633029c5745
83 N7a7833bd018144f7b6bcaf5542651921
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101201627
85 https://doi.org/10.1038/s41388-018-0164-9
86 schema:sdDatePublished 2019-04-11T10:19
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher Nba8e9000baea40d28c5a3b049dbea139
89 schema:url https://www.nature.com/articles/s41388-018-0164-9
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N02cfb5088fab49509fa2325ad75d6ea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Signal Transduction
95 rdf:type schema:DefinedTerm
96 N1eac229e89bf4018b961f2c0457a17ed schema:name readcube_id
97 schema:value 9ab7cbf80202abf5c41da817e0dc93cd8ff0f722bf4d295936e69b75270eacd3
98 rdf:type schema:PropertyValue
99 N2d109a9c66ea4bb58fe2e5669b53ca4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Protein Kinase Inhibitors
101 rdf:type schema:DefinedTerm
102 N3080efc09df04e10923876c9d88ca79b rdf:first sg:person.01010451263.92
103 rdf:rest N7bc3f7d4054448a69710d05866909b60
104 N4d581c23644a4055abfbbdcef7f2bd69 schema:name nlm_unique_id
105 schema:value 8711562
106 rdf:type schema:PropertyValue
107 N562060eabcdb430abb8875ea66bd94c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Proto-Oncogene Proteins B-raf
109 rdf:type schema:DefinedTerm
110 N59665966ed984456b66db2e8daa1a729 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mice
112 rdf:type schema:DefinedTerm
113 N5f69dbae07d240ff8cfc925f38af4879 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Melanoma
115 rdf:type schema:DefinedTerm
116 N61e2c62574f04dcb8040afbd482ada19 rdf:first sg:person.014621721634.64
117 rdf:rest Na114a85fff274403a9af746a8922856e
118 N622f32eb946d45c2b8eb0c4a4feafcb9 rdf:first sg:person.012576313115.82
119 rdf:rest N9be4f26d1fb840e8b853081df99c8b17
120 N75f9aa4ed8e0489d8eae7b0bb5b3ebbf rdf:first sg:person.01306066760.30
121 rdf:rest N622f32eb946d45c2b8eb0c4a4feafcb9
122 N760ee73abd47471ba3e529f9f3e46198 schema:name dimensions_id
123 schema:value pub.1101201627
124 rdf:type schema:PropertyValue
125 N7704f7e3652843fcbf2d37b9caa66b10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N79e6b6b5fc0f4fdc8bbca633029c5745 schema:name pubmed_id
129 schema:value 29483645
130 rdf:type schema:PropertyValue
131 N7a7833bd018144f7b6bcaf5542651921 schema:name doi
132 schema:value 10.1038/s41388-018-0164-9
133 rdf:type schema:PropertyValue
134 N7bc3f7d4054448a69710d05866909b60 rdf:first sg:person.0653251344.12
135 rdf:rest N61e2c62574f04dcb8040afbd482ada19
136 N7d5a1620780b49d8ab2231eeaf0bd4f9 rdf:first sg:person.0621314445.55
137 rdf:rest rdf:nil
138 N7f87a36f8ca846feb2237e1f20ebe340 rdf:first sg:person.01220200153.86
139 rdf:rest N7d5a1620780b49d8ab2231eeaf0bd4f9
140 N82ce0858a4654db5bdc51e2e11468fb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Mitogen-Activated Protein Kinase 7
142 rdf:type schema:DefinedTerm
143 N90a6a37ca42147928b706853f65f7d75 schema:volumeNumber 37
144 rdf:type schema:PublicationVolume
145 N98305871e00841908f8a4b473153080f rdf:first sg:person.01107242747.39
146 rdf:rest N3080efc09df04e10923876c9d88ca79b
147 N9be4f26d1fb840e8b853081df99c8b17 rdf:first sg:person.012705425520.96
148 rdf:rest N98305871e00841908f8a4b473153080f
149 N9cbf643584b5474f84002c3bb14a8913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Gene Expression Regulation, Neoplastic
151 rdf:type schema:DefinedTerm
152 Na114a85fff274403a9af746a8922856e rdf:first sg:person.01363402343.40
153 rdf:rest Nbbc7c80d782a4e978e65665928b83a84
154 Nafa4fcc5cc854273921a22732a734009 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Animals
156 rdf:type schema:DefinedTerm
157 Nb2ac8387df154e6f8325ab54e65e0a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cell Line, Tumor
159 rdf:type schema:DefinedTerm
160 Nb5957d2a12e54e75a60c54da891bbc27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Vemurafenib
162 rdf:type schema:DefinedTerm
163 Nba8e9000baea40d28c5a3b049dbea139 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nbbc7c80d782a4e978e65665928b83a84 rdf:first sg:person.01100730461.01
166 rdf:rest N7f87a36f8ca846feb2237e1f20ebe340
167 Ndc90b8c4315241508e1d95ef7a7d0e9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Neoplasm Transplantation
169 rdf:type schema:DefinedTerm
170 Ne31afe3086414807b01468a0ff11cfd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cell Proliferation
172 rdf:type schema:DefinedTerm
173 Ned4c59ab8ba34b30bfd52295385be36c schema:issueNumber 19
174 rdf:type schema:PublicationIssue
175 Nf9519fa19f404d5fb7e0fd1dca77f8cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Cell Nucleus
177 rdf:type schema:DefinedTerm
178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biological Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biochemistry and Cell Biology
183 rdf:type schema:DefinedTerm
184 sg:journal.1097543 schema:issn 0950-9232
185 1476-5594
186 schema:name Oncogene
187 rdf:type schema:Periodical
188 sg:person.01010451263.92 schema:affiliation https://www.grid.ac/institutes/grid.415194.c
189 schema:familyName Urso
190 schema:givenName Carmelo
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010451263.92
192 rdf:type schema:Person
193 sg:person.01100730461.01 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
194 schema:familyName Gray
195 schema:givenName Nathanael S
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100730461.01
197 rdf:type schema:Person
198 sg:person.01107242747.39 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
199 schema:familyName Pandolfi
200 schema:givenName Silvia
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107242747.39
202 rdf:type schema:Person
203 sg:person.01220200153.86 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
204 schema:familyName Stecca
205 schema:givenName Barbara
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220200153.86
207 rdf:type schema:Person
208 sg:person.012576313115.82 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
209 schema:familyName Gagliardi
210 schema:givenName Sinforosa
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012576313115.82
212 rdf:type schema:Person
213 sg:person.012705425520.96 schema:affiliation https://www.grid.ac/institutes/grid.8404.8
214 schema:familyName Tubita
215 schema:givenName Alessandro
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705425520.96
217 rdf:type schema:Person
218 sg:person.01306066760.30 schema:affiliation https://www.grid.ac/institutes/grid.8404.8
219 schema:familyName Tusa
220 schema:givenName Ignazia
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306066760.30
222 rdf:type schema:Person
223 sg:person.01363402343.40 schema:affiliation https://www.grid.ac/institutes/grid.12955.3a
224 schema:familyName Deng
225 schema:givenName Xianming
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363402343.40
227 rdf:type schema:Person
228 sg:person.014621721634.64 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
229 schema:familyName Wang
230 schema:givenName Jinhua
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014621721634.64
232 rdf:type schema:Person
233 sg:person.0621314445.55 schema:affiliation https://www.grid.ac/institutes/grid.8404.8
234 schema:familyName Rovida
235 schema:givenName Elisabetta
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621314445.55
237 rdf:type schema:Person
238 sg:person.0653251344.12 schema:affiliation https://www.grid.ac/institutes/grid.415194.c
239 schema:familyName Borgognoni
240 schema:givenName Lorenzo
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653251344.12
242 rdf:type schema:Person
243 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
244 https://doi.org/10.1038/nature00766
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/ncomms11551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015819509
247 https://doi.org/10.1038/ncomms11551
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/ng.3361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040467727
250 https://doi.org/10.1038/ng.3361
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nprot.2006.339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038965314
253 https://doi.org/10.1038/nprot.2006.339
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nrd4281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012432963
256 https://doi.org/10.1038/nrd4281
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/onc.2014.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038272915
259 https://doi.org/10.1038/onc.2014.71
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/sj.onc.1210963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046340258
262 https://doi.org/10.1038/sj.onc.1210963
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/srep46244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084538237
265 https://doi.org/10.1038/srep46244
266 rdf:type schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1075201525 schema:CreativeWork
268 https://doi.org/10.1002/cam4.667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029312069
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.bbcan.2011.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025903738
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.bbrc.2008.09.087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031172488
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.ccr.2010.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001630944
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.cell.2015.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037671653
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.cellsig.2010.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034579689
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.cellsig.2012.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015705492
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.cellsig.2012.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043526843
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.celrep.2016.07.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021918737
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.cmet.2016.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039585310
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.drudis.2016.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039818373
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1056/nejmoa1210093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036427533
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1056/nejmoa1504030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024843336
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1073/pnas.0600447103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022558372
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.1609019113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016062429
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.m001573200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043470487
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m412599200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020873622
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1074/jbc.m704079200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010529249
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1080/15384101.2015.1120915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058402132
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1126/science.1253735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039813424
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1128/mcb.01246-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034372440
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1128/mcb.22.1.270-285.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006395649
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1136/gutjnl-2014-306761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019711659
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1158/0008-5472.can-10-0646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022611192
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1158/0008-5472.can-16-2565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085470484
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1158/1078-0432.ccr-10-2504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009497250
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1158/1541-7786.mcr-07-2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023191843
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1158/2159-8290.cd-13-0070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043550331
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1182/blood-2004-08-2985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050465029
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1189/jlb.2a0115-034r schema:sameAs https://app.dimensions.ai/details/publication/pub.1018221901
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1200/jco.2009.23.4799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013277178
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1242/jcs.01040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040736334
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1242/jcs.070516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004083905
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1371/journal.pone.0117914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041894756
341 rdf:type schema:CreativeWork
342 https://doi.org/10.18632/oncotarget.1865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022229872
343 rdf:type schema:CreativeWork
344 https://doi.org/10.3389/fcell.2016.00105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042924614
345 rdf:type schema:CreativeWork
346 https://doi.org/10.3978/j.issn.2305-5839.2015.05.07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079167517
347 rdf:type schema:CreativeWork
348 https://doi.org/10.4049/jimmunol.180.6.4166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028147428
349 rdf:type schema:CreativeWork
350 https://www.grid.ac/institutes/grid.12955.3a schema:alternateName Xiamen University
351 schema:name Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
352 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
353 State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, Fujian, China
354 rdf:type schema:Organization
355 https://www.grid.ac/institutes/grid.24704.35 schema:alternateName Azienda Ospedaliero-Universitaria Careggi
356 schema:name Core Research Laboratory - Istituto Toscano Tumori, Florence, Italy
357 VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium
358 rdf:type schema:Organization
359 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
360 schema:name Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
361 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.415194.c schema:alternateName Ospedale Santa Maria Annunziata
364 schema:name Anatomic Pathology Unit, Dermatopathology Section, S.M. Annunziata Hospital, Florence, Italy
365 Plastic Surgery Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.8404.8 schema:alternateName University of Florence
368 schema:name Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy
369 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...