Neurobiology of maternal regulation of infant fear: the role of mesolimbic dopamine and its disruption by maltreatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-13

AUTHORS

Maya Opendak, Patrese Robinson-Drummer, Anna Blomkvist, Roseanna M. Zanca, Kira Wood, Lily Jacobs, Stephanie Chan, Stephen Tan, Joyce Woo, Gayatri Venkataraman, Emma Kirschner, Johan N. Lundström, Donald A. Wilson, Peter A. Serrano, Regina M. Sullivan

ABSTRACT

Child development research highlights caregiver regulation of infant physiology and behavior as a key feature of early life attachment, although mechanisms for maternal control of infant neural circuits remain elusive. Here we explored the neurobiology of maternal regulation of infant fear using neural network and molecular levels of analysis in a rodent model. Previous research has shown maternal suppression of amygdala-dependent fear learning during a sensitive period. Here we characterize changes in neural networks engaged during maternal regulation and the transition to infant self-regulation. Metabolic mapping of 2-deoxyglucose uptake during odor-shock conditioning in postnatal day (PN)14 rat pups showed that maternal presence blocked fear learning, disengaged mesolimbic circuitry, basolateral amygdala (BLA), and plasticity-related AMPA receptor subunit trafficking. At PN18, when maternal presence only socially buffers threat learning (similar to social modulation in adults), maternal presence failed to disengage the mesolimbic dopaminergic system, and failed to disengage both the BLA and plasticity-related AMPA receptor subunit trafficking. Further, maternal presence failed to block threat learning at PN14 pups following abuse, and mesolimbic dopamine engagement and AMPA were not significantly altered by maternal presence-analogous to compromised maternal regulation of children in abusive relationships. Our results highlight three key features of maternal regulation: (1) maternal presence blocks fear learning and amygdala plasticity through age-dependent suppression of amygdala AMPA receptor subunit trafficking, (2) maternal presence suppresses engagement of brain regions within the mesolimbic dopamine circuit, and (3) early-life abuse compromises network and molecular biomarkers of maternal regulation, suggesting reduced social scaffolding of the brain. More... »

PAGES

1-11

References to SciGraph publications

  • 2003-04. Biologic findings of post-traumatic stress disorder and child maltreatment in CURRENT PSYCHIATRY REPORTS
  • 2017-02. Ventral tegmental area: cellular heterogeneity, connectivity and behaviour in NATURE REVIEWS NEUROSCIENCE
  • 2000-09. Neurophysiology: Good memories of bad events in infancy in NATURE
  • 2006-08. Maternal presence serves as a switch between learning fear and attraction in infancy in NATURE NEUROSCIENCE
  • 2015-03. Paradoxical Neurobehavioral Rescue by Memories of Early-Life Abuse: The Safety Signal Value of Odors Learned during Abusive Attachment in NEUROPSYCHOPHARMACOLOGY
  • 2015-03. Excitatory Synaptic Function and Plasticity is Persistently Altered in Ventral Tegmental Area Dopamine Neurons after Prenatal Ethanol Exposure in NEUROPSYCHOPHARMACOLOGY
  • 2012-06. What and when to “want”? Amygdala-based focusing of incentive salience upon sugar and sex in PSYCHOPHARMACOLOGY
  • 2011-05. Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety in NATURE NEUROSCIENCE
  • 2014-07. Engineering a memory with LTD and LTP in NATURE
  • 2018-12. Social support rescues acute stress-induced cognitive impairments by modulating ERK1/2 phosphorylation in adolescent mice in SCIENTIFIC REPORTS
  • 2010-04. Methylphenidate facilitates learning-induced amygdala plasticity in NATURE NEUROSCIENCE
  • 2009-11. Transitions in infant learning are modulated by dopamine in the amygdala in NATURE NEUROSCIENCE
  • 2018-12. Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats in SCIENTIFIC REPORTS
  • 2017-07. Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate in NEUROPSYCHOPHARMACOLOGY
  • 2018-02-16. Imaging structural and functional brain development in early childhood in NATURE REVIEWS NEUROSCIENCE
  • 2002-05. Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41386-019-0340-9

    DOI

    http://dx.doi.org/10.1038/s41386-019-0340-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112094987

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30758321


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Opendak", 
            "givenName": "Maya", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Robinson-Drummer", 
            "givenName": "Patrese", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stockholm University", 
              "id": "https://www.grid.ac/institutes/grid.10548.38", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA", 
                "Department of Psychology, Stockholm University, 10691, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blomkvist", 
            "givenName": "Anna", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Graduate Center, CUNY", 
              "id": "https://www.grid.ac/institutes/grid.253482.a", 
              "name": [
                "Department of Psychology, CUNY Hunter College, 10065, New York, NY, USA", 
                "The Graduate Center of CUNY, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zanca", 
            "givenName": "Roseanna M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nathan Kline Institute for Psychiatric Research", 
              "id": "https://www.grid.ac/institutes/grid.250263.0", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wood", 
            "givenName": "Kira", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jacobs", 
            "givenName": "Lily", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chan", 
            "givenName": "Stephanie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tan", 
            "givenName": "Stephen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Woo", 
            "givenName": "Joyce", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Venkataraman", 
            "givenName": "Gayatri", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kirschner", 
            "givenName": "Emma", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stockholm University", 
              "id": "https://www.grid.ac/institutes/grid.10548.38", 
              "name": [
                "Clinical Neuroscience Department, Karolinska Institute, 17177, Stockholm, Sweden", 
                "Stockholm University Brain Imaging Centre, Stockholm University, 10691, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lundstr\u00f6m", 
            "givenName": "Johan N.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "Donald A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Graduate Center, CUNY", 
              "id": "https://www.grid.ac/institutes/grid.253482.a", 
              "name": [
                "Department of Psychology, CUNY Hunter College, 10065, New York, NY, USA", 
                "The Graduate Center of CUNY, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serrano", 
            "givenName": "Peter A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA", 
                "Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sullivan", 
            "givenName": "Regina M.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.neuron.2008.01.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000189735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/14616734.2015.1042487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000939477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dev.20448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001375835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dev.20448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001375835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2008.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001376450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35024156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002163621", 
              "https://doi.org/10.1038/35024156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35024156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002163621", 
              "https://doi.org/10.1038/35024156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dev.20531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003093193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dev.21260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004737435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jcpp.12622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004960467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-0173(98)00019-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005443582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2013.10.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005563816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80775-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005658667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5843-11.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006300740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2014.266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006470565", 
              "https://doi.org/10.1038/npp.2014.266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0022-3514.95.1.197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006974462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dev.21230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007513242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2013.03.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007711544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.17328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007715585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3333-15.2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007768569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2007.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007921568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.neuro.24.1.897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010137826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2006.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010291460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dev.420280403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011340013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2009.12.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011410709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2014.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012648776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2005.01.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012956018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tics.2005.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013323184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1524838015627147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013395681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1524838015627147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013395681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014721634", 
              "https://doi.org/10.1038/nn.2808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pneurobio.2008.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015287063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015299269", 
              "https://doi.org/10.1038/nn.2403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015299269", 
              "https://doi.org/10.1038/nn.2403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2603-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015612780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nlm.2016.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016091328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nlm.2016.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016091328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nlm.2016.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016091328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nlm.2016.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016091328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yfrne.2009.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016963502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.6588-10.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017423358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017907167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17470919.2015.1087424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020639529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jcpp.12642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021014513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021102928", 
              "https://doi.org/10.1038/nn.2506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021102928", 
              "https://doi.org/10.1038/nn.2506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000095581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021746368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1616-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022714816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1467-8624.1996.tb01748.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022782836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1307893110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023388125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026200705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2302(199604)29:3<191::aid-dev1>3.0.co;2-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026375940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3446-12.2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031050375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/nmd.0000000000000049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032536220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/nmd.0000000000000049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032536220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/acer.12024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032713925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1196/annals.1301.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033013813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/417282a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033520598", 
              "https://doi.org/10.1038/417282a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/417282a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033520598", 
              "https://doi.org/10.1038/417282a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2010.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034335561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.05.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036061512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1310163110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036361923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036871078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0149-7634(03)00007-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037943243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0149-7634(03)00007-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037943243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2008.04.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038079295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11920-003-0027-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038880549", 
              "https://doi.org/10.1007/s11920-003-0027-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neubiorev.2011.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038891607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17470919.2015.1070198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039079289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fphys.2013.00088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039708497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-011-2588-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039836636", 
              "https://doi.org/10.1007/s00213-011-2588-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17470919.2016.1149095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039961273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropsychologia.2010.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040440690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17470919.2016.1159605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040626542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13294", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040773333", 
              "https://doi.org/10.1038/nature13294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0954579401003029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041244907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0954579401003029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041244907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2085-11.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041325790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5944-10.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042590393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1999.0721088.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042856394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3557-12.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042894744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2014.265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043575776", 
              "https://doi.org/10.1038/npp.2014.265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0079077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045144936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0079077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045144936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0079077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045144936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnsys.2016.00092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045282895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6123(07)67010-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046244754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/psy.0b013e3182359335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046623322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/psy.0b013e3182359335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046623322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047962276", 
              "https://doi.org/10.1038/nn1733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047962276", 
              "https://doi.org/10.1038/nn1733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn.2016.165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048765373", 
              "https://doi.org/10.1038/nrn.2016.165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnana.2015.00059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050193531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/neuro.08.022.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051210701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dcn.2016.04.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051685898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17470919.2015.1087426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052642898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4324/9781315808888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052853132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2011.07221.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053154694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1423363112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053336950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnbeh.2015.00303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053372462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0632-16.2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067642752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.22-24-10819.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075204817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076626185", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2017.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083852494", 
              "https://doi.org/10.1038/npp.2017.38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dcn.2017.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083870095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.copsyc.2017.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085057759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1745691616680612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085618755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1745691616680612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085618755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10253890.2017.1343296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086038639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dev.21547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090951120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn.2018.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101076195", 
              "https://doi.org/10.1038/nrn.2018.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-30524-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106062657", 
              "https://doi.org/10.1038/s41598-018-30524-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-32762-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107263183", 
              "https://doi.org/10.1038/s41598-018-32762-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-32762-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107263183", 
              "https://doi.org/10.1038/s41598-018-32762-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-32762-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107263183", 
              "https://doi.org/10.1038/s41598-018-32762-y"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-02-13", 
        "datePublishedReg": "2019-02-13", 
        "description": "Child development research highlights caregiver regulation of infant physiology and behavior as a key feature of early life attachment, although mechanisms for maternal control of infant neural circuits remain elusive. Here we explored the neurobiology of maternal regulation of infant fear using neural network and molecular levels of analysis in a rodent model. Previous research has shown maternal suppression of amygdala-dependent fear learning during a sensitive period. Here we characterize changes in neural networks engaged during maternal regulation and the transition to infant self-regulation. Metabolic mapping of 2-deoxyglucose uptake during odor-shock conditioning in postnatal day (PN)14 rat pups showed that maternal presence blocked fear learning, disengaged mesolimbic circuitry, basolateral amygdala (BLA), and plasticity-related AMPA receptor subunit trafficking. At PN18, when maternal presence only socially buffers threat learning (similar to social modulation in adults), maternal presence failed to disengage the mesolimbic dopaminergic system, and failed to disengage both the BLA and plasticity-related AMPA receptor subunit trafficking. Further, maternal presence failed to block threat learning at PN14 pups following abuse, and mesolimbic dopamine engagement and AMPA were not significantly altered by maternal presence-analogous to compromised maternal regulation of children in abusive relationships. Our results highlight three key features of maternal regulation: (1) maternal presence blocks fear learning and amygdala plasticity through age-dependent suppression of amygdala AMPA receptor subunit trafficking, (2) maternal presence suppresses engagement of brain regions within the mesolimbic dopamine circuit, and (3) early-life abuse compromises network and molecular biomarkers of maternal regulation, suggesting reduced social scaffolding of the brain.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41386-019-0340-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6500974", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2685308", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4730009", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5124235", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1099176", 
            "issn": [
              "0893-133X", 
              "1740-634X"
            ], 
            "name": "Neuropsychopharmacology", 
            "type": "Periodical"
          }
        ], 
        "name": "Neurobiology of maternal regulation of infant fear: the role of mesolimbic dopamine and its disruption by maltreatment", 
        "pagination": "1-11", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f24b2e59f0ec24e7fa67f9d8562bed759aa9c162a5dada3c0db5212427008dfb"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30758321"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8904907"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41386-019-0340-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112094987"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41386-019-0340-9", 
          "https://app.dimensions.ai/details/publication/pub.1112094987"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99833_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41386-019-0340-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41386-019-0340-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41386-019-0340-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41386-019-0340-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41386-019-0340-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    472 TRIPLES      21 PREDICATES      122 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41386-019-0340-9 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N0889e4524a864c2d92178f3d7adc964b
    4 schema:citation sg:pub.10.1007/s00213-011-2588-6
    5 sg:pub.10.1007/s11920-003-0027-z
    6 sg:pub.10.1038/35024156
    7 sg:pub.10.1038/417282a
    8 sg:pub.10.1038/nature13294
    9 sg:pub.10.1038/nn.2403
    10 sg:pub.10.1038/nn.2506
    11 sg:pub.10.1038/nn.2808
    12 sg:pub.10.1038/nn1733
    13 sg:pub.10.1038/npp.2014.265
    14 sg:pub.10.1038/npp.2014.266
    15 sg:pub.10.1038/npp.2017.38
    16 sg:pub.10.1038/nrn.2016.165
    17 sg:pub.10.1038/nrn.2018.1
    18 sg:pub.10.1038/s41598-018-30524-4
    19 sg:pub.10.1038/s41598-018-32762-y
    20 https://app.dimensions.ai/details/publication/pub.1076626185
    21 https://doi.org/10.1002/(sici)1098-2302(199604)29:3<191::aid-dev1>3.0.co;2-m
    22 https://doi.org/10.1002/dev.20448
    23 https://doi.org/10.1002/dev.20531
    24 https://doi.org/10.1002/dev.21230
    25 https://doi.org/10.1002/dev.21260
    26 https://doi.org/10.1002/dev.21547
    27 https://doi.org/10.1002/dev.420280403
    28 https://doi.org/10.1016/j.biopsych.2005.01.032
    29 https://doi.org/10.1016/j.biopsych.2009.12.019
    30 https://doi.org/10.1016/j.cell.2011.10.009
    31 https://doi.org/10.1016/j.cell.2014.05.017
    32 https://doi.org/10.1016/j.copsyc.2017.04.022
    33 https://doi.org/10.1016/j.dcn.2016.04.005
    34 https://doi.org/10.1016/j.dcn.2017.02.002
    35 https://doi.org/10.1016/j.neubiorev.2011.12.014
    36 https://doi.org/10.1016/j.neuron.2008.01.022
    37 https://doi.org/10.1016/j.neuron.2008.07.004
    38 https://doi.org/10.1016/j.neuron.2010.11.022
    39 https://doi.org/10.1016/j.neuron.2012.02.004
    40 https://doi.org/10.1016/j.neuron.2012.03.017
    41 https://doi.org/10.1016/j.neuron.2013.10.025
    42 https://doi.org/10.1016/j.neuropharm.2013.03.019
    43 https://doi.org/10.1016/j.neuropsychologia.2010.03.002
    44 https://doi.org/10.1016/j.neuroscience.2008.04.019
    45 https://doi.org/10.1016/j.neuroscience.2014.09.008
    46 https://doi.org/10.1016/j.nlm.2016.07.008
    47 https://doi.org/10.1016/j.pneurobio.2008.09.010
    48 https://doi.org/10.1016/j.tics.2005.01.011
    49 https://doi.org/10.1016/j.tins.2006.01.005
    50 https://doi.org/10.1016/j.yfrne.2009.06.001
    51 https://doi.org/10.1016/j.yhbeh.2007.06.004
    52 https://doi.org/10.1016/s0079-6123(07)67010-1
    53 https://doi.org/10.1016/s0149-7634(03)00007-1
    54 https://doi.org/10.1016/s0165-0173(98)00019-8
    55 https://doi.org/10.1016/s0896-6273(00)80775-8
    56 https://doi.org/10.1017/s0954579401003029
    57 https://doi.org/10.1037/0022-3514.95.1.197
    58 https://doi.org/10.1046/j.1471-4159.1999.0721088.x
    59 https://doi.org/10.1073/pnas.1307893110
    60 https://doi.org/10.1073/pnas.1310163110
    61 https://doi.org/10.1073/pnas.1423363112
    62 https://doi.org/10.1080/10253890.2017.1343296
    63 https://doi.org/10.1080/14616734.2015.1042487
    64 https://doi.org/10.1080/17470919.2015.1070198
    65 https://doi.org/10.1080/17470919.2015.1087424
    66 https://doi.org/10.1080/17470919.2015.1087426
    67 https://doi.org/10.1080/17470919.2016.1149095
    68 https://doi.org/10.1080/17470919.2016.1159605
    69 https://doi.org/10.1097/nmd.0000000000000049
    70 https://doi.org/10.1097/psy.0b013e3182359335
    71 https://doi.org/10.1111/acer.12024
    72 https://doi.org/10.1111/j.1467-8624.1996.tb01748.x
    73 https://doi.org/10.1111/j.1471-4159.2011.07221.x
    74 https://doi.org/10.1111/jcpp.12622
    75 https://doi.org/10.1111/jcpp.12642
    76 https://doi.org/10.1146/annurev.neuro.24.1.897
    77 https://doi.org/10.1159/000095581
    78 https://doi.org/10.1177/1524838015627147
    79 https://doi.org/10.1177/1745691616680612
    80 https://doi.org/10.1196/annals.1301.014
    81 https://doi.org/10.1371/journal.pone.0079077
    82 https://doi.org/10.1523/jneurosci.0632-16.2016
    83 https://doi.org/10.1523/jneurosci.1616-09.2009
    84 https://doi.org/10.1523/jneurosci.2085-11.2011
    85 https://doi.org/10.1523/jneurosci.22-24-10819.2002
    86 https://doi.org/10.1523/jneurosci.2603-07.2007
    87 https://doi.org/10.1523/jneurosci.3333-15.2016
    88 https://doi.org/10.1523/jneurosci.3446-12.2013
    89 https://doi.org/10.1523/jneurosci.3557-12.2012
    90 https://doi.org/10.1523/jneurosci.5843-11.2012
    91 https://doi.org/10.1523/jneurosci.5944-10.2011
    92 https://doi.org/10.1523/jneurosci.6588-10.2011
    93 https://doi.org/10.3389/fnana.2015.00059
    94 https://doi.org/10.3389/fnbeh.2015.00303
    95 https://doi.org/10.3389/fnsys.2016.00092
    96 https://doi.org/10.3389/fphys.2013.00088
    97 https://doi.org/10.3389/neuro.08.022.2009
    98 https://doi.org/10.4324/9781315808888
    99 https://doi.org/10.7554/elife.17328
    100 schema:datePublished 2019-02-13
    101 schema:datePublishedReg 2019-02-13
    102 schema:description Child development research highlights caregiver regulation of infant physiology and behavior as a key feature of early life attachment, although mechanisms for maternal control of infant neural circuits remain elusive. Here we explored the neurobiology of maternal regulation of infant fear using neural network and molecular levels of analysis in a rodent model. Previous research has shown maternal suppression of amygdala-dependent fear learning during a sensitive period. Here we characterize changes in neural networks engaged during maternal regulation and the transition to infant self-regulation. Metabolic mapping of 2-deoxyglucose uptake during odor-shock conditioning in postnatal day (PN)14 rat pups showed that maternal presence blocked fear learning, disengaged mesolimbic circuitry, basolateral amygdala (BLA), and plasticity-related AMPA receptor subunit trafficking. At PN18, when maternal presence only socially buffers threat learning (similar to social modulation in adults), maternal presence failed to disengage the mesolimbic dopaminergic system, and failed to disengage both the BLA and plasticity-related AMPA receptor subunit trafficking. Further, maternal presence failed to block threat learning at PN14 pups following abuse, and mesolimbic dopamine engagement and AMPA were not significantly altered by maternal presence-analogous to compromised maternal regulation of children in abusive relationships. Our results highlight three key features of maternal regulation: (1) maternal presence blocks fear learning and amygdala plasticity through age-dependent suppression of amygdala AMPA receptor subunit trafficking, (2) maternal presence suppresses engagement of brain regions within the mesolimbic dopamine circuit, and (3) early-life abuse compromises network and molecular biomarkers of maternal regulation, suggesting reduced social scaffolding of the brain.
    103 schema:genre research_article
    104 schema:inLanguage en
    105 schema:isAccessibleForFree false
    106 schema:isPartOf sg:journal.1099176
    107 schema:name Neurobiology of maternal regulation of infant fear: the role of mesolimbic dopamine and its disruption by maltreatment
    108 schema:pagination 1-11
    109 schema:productId N082ad88548ca4934bd6c0be716f09a15
    110 N1e6b6214d81f4e66bca9b08680f08d48
    111 N5522a719af7340d3bd170c488e1d7b41
    112 Nbaf98cf443f14ee68797bff8aa4e525c
    113 Nd8b7e496fda9411991f2b4a50f448c6b
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112094987
    115 https://doi.org/10.1038/s41386-019-0340-9
    116 schema:sdDatePublished 2019-04-11T09:39
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher N2608000583644fafae635ebbcacdc26a
    119 schema:url https://www.nature.com/articles/s41386-019-0340-9
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N082ad88548ca4934bd6c0be716f09a15 schema:name pubmed_id
    124 schema:value 30758321
    125 rdf:type schema:PropertyValue
    126 N0889e4524a864c2d92178f3d7adc964b rdf:first Naadb1ca19b664426ac2512e9e41c7b38
    127 rdf:rest N49a2242e5a784b9cac53cdeabf9b0fb3
    128 N0e119fcc58254a3cb102c5e99a6c5e15 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    129 schema:familyName Robinson-Drummer
    130 schema:givenName Patrese
    131 rdf:type schema:Person
    132 N0ef7bf7ff61f4d0a973864a1827ba358 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    133 schema:familyName Sullivan
    134 schema:givenName Regina M.
    135 rdf:type schema:Person
    136 N137da8e56c4b45b98237390e731bde3b schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    137 schema:familyName Chan
    138 schema:givenName Stephanie
    139 rdf:type schema:Person
    140 N140bd56bc8f24562ae8a9e044c03d030 rdf:first N137da8e56c4b45b98237390e731bde3b
    141 rdf:rest N634a63e44f514361874993116bc8a178
    142 N1e6b6214d81f4e66bca9b08680f08d48 schema:name doi
    143 schema:value 10.1038/s41386-019-0340-9
    144 rdf:type schema:PropertyValue
    145 N21823d655d534ec89f8b44b32f33d86e schema:affiliation https://www.grid.ac/institutes/grid.253482.a
    146 schema:familyName Serrano
    147 schema:givenName Peter A.
    148 rdf:type schema:Person
    149 N25061124513549e486c5524848b3121d schema:affiliation https://www.grid.ac/institutes/grid.250263.0
    150 schema:familyName Wood
    151 schema:givenName Kira
    152 rdf:type schema:Person
    153 N2608000583644fafae635ebbcacdc26a schema:name Springer Nature - SN SciGraph project
    154 rdf:type schema:Organization
    155 N272455d0aeb84d2f88d14458c1324cfd rdf:first N41f109073aea4935953421da49a21105
    156 rdf:rest Nfb5c442985004a7bbd9646359a7bdc86
    157 N3ae26bbd6740481cb0979c97d7f1046c rdf:first Nd835510763d2486786a712c729cfdeac
    158 rdf:rest N6ecde6a8ad5e41c7a350f124b47afece
    159 N3bda6fff3fb14129bdad406bbcf0d8b8 schema:affiliation https://www.grid.ac/institutes/grid.10548.38
    160 schema:familyName Lundström
    161 schema:givenName Johan N.
    162 rdf:type schema:Person
    163 N41f109073aea4935953421da49a21105 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    164 schema:familyName Kirschner
    165 schema:givenName Emma
    166 rdf:type schema:Person
    167 N43cccf23636a4678bff94f5fb1b6a958 rdf:first Nc08db1b3b09a4ecc9ce9f8dcaeae9083
    168 rdf:rest N140bd56bc8f24562ae8a9e044c03d030
    169 N4470c7169276447ab04383f3f34b8b7a rdf:first N0ef7bf7ff61f4d0a973864a1827ba358
    170 rdf:rest rdf:nil
    171 N49a2242e5a784b9cac53cdeabf9b0fb3 rdf:first N0e119fcc58254a3cb102c5e99a6c5e15
    172 rdf:rest N8df581bc53504ac9b87ef40c35b658a9
    173 N5522a719af7340d3bd170c488e1d7b41 schema:name readcube_id
    174 schema:value f24b2e59f0ec24e7fa67f9d8562bed759aa9c162a5dada3c0db5212427008dfb
    175 rdf:type schema:PropertyValue
    176 N634a63e44f514361874993116bc8a178 rdf:first Ne3772ed1f99e4c8597c5fd2351125a99
    177 rdf:rest N3ae26bbd6740481cb0979c97d7f1046c
    178 N685082ef096f4e2986f4c4f4b5853146 rdf:first Nf3c8f35fb72246c8b0c7c771c0be0c44
    179 rdf:rest Nafa6b18305df40d8b81d2188024f1503
    180 N68d238fcda0f46418731335f95f271ee rdf:first N25061124513549e486c5524848b3121d
    181 rdf:rest N43cccf23636a4678bff94f5fb1b6a958
    182 N6ecde6a8ad5e41c7a350f124b47afece rdf:first N898fcc072fda41d8be392bb7209d794b
    183 rdf:rest N272455d0aeb84d2f88d14458c1324cfd
    184 N898fcc072fda41d8be392bb7209d794b schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    185 schema:familyName Venkataraman
    186 schema:givenName Gayatri
    187 rdf:type schema:Person
    188 N8df581bc53504ac9b87ef40c35b658a9 rdf:first Ndb4396feff36456b887525f5aefd0781
    189 rdf:rest Ne6d889b8b3c14afe82906b80bb36f47e
    190 N9e1ccbac9ea04da69f5c1bdb37fe061b schema:affiliation https://www.grid.ac/institutes/grid.253482.a
    191 schema:familyName Zanca
    192 schema:givenName Roseanna M.
    193 rdf:type schema:Person
    194 Naadb1ca19b664426ac2512e9e41c7b38 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    195 schema:familyName Opendak
    196 schema:givenName Maya
    197 rdf:type schema:Person
    198 Nafa6b18305df40d8b81d2188024f1503 rdf:first N21823d655d534ec89f8b44b32f33d86e
    199 rdf:rest N4470c7169276447ab04383f3f34b8b7a
    200 Nbaf98cf443f14ee68797bff8aa4e525c schema:name nlm_unique_id
    201 schema:value 8904907
    202 rdf:type schema:PropertyValue
    203 Nc08db1b3b09a4ecc9ce9f8dcaeae9083 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    204 schema:familyName Jacobs
    205 schema:givenName Lily
    206 rdf:type schema:Person
    207 Nd835510763d2486786a712c729cfdeac schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    208 schema:familyName Woo
    209 schema:givenName Joyce
    210 rdf:type schema:Person
    211 Nd8b7e496fda9411991f2b4a50f448c6b schema:name dimensions_id
    212 schema:value pub.1112094987
    213 rdf:type schema:PropertyValue
    214 Ndb4396feff36456b887525f5aefd0781 schema:affiliation https://www.grid.ac/institutes/grid.10548.38
    215 schema:familyName Blomkvist
    216 schema:givenName Anna
    217 rdf:type schema:Person
    218 Ne3772ed1f99e4c8597c5fd2351125a99 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    219 schema:familyName Tan
    220 schema:givenName Stephen
    221 rdf:type schema:Person
    222 Ne6d889b8b3c14afe82906b80bb36f47e rdf:first N9e1ccbac9ea04da69f5c1bdb37fe061b
    223 rdf:rest N68d238fcda0f46418731335f95f271ee
    224 Nf3c8f35fb72246c8b0c7c771c0be0c44 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    225 schema:familyName Wilson
    226 schema:givenName Donald A.
    227 rdf:type schema:Person
    228 Nfb5c442985004a7bbd9646359a7bdc86 rdf:first N3bda6fff3fb14129bdad406bbcf0d8b8
    229 rdf:rest N685082ef096f4e2986f4c4f4b5853146
    230 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Medical and Health Sciences
    232 rdf:type schema:DefinedTerm
    233 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    234 schema:name Neurosciences
    235 rdf:type schema:DefinedTerm
    236 sg:grant.2685308 http://pending.schema.org/fundedItem sg:pub.10.1038/s41386-019-0340-9
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.4730009 http://pending.schema.org/fundedItem sg:pub.10.1038/s41386-019-0340-9
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.5124235 http://pending.schema.org/fundedItem sg:pub.10.1038/s41386-019-0340-9
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.6500974 http://pending.schema.org/fundedItem sg:pub.10.1038/s41386-019-0340-9
    243 rdf:type schema:MonetaryGrant
    244 sg:journal.1099176 schema:issn 0893-133X
    245 1740-634X
    246 schema:name Neuropsychopharmacology
    247 rdf:type schema:Periodical
    248 sg:pub.10.1007/s00213-011-2588-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039836636
    249 https://doi.org/10.1007/s00213-011-2588-6
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s11920-003-0027-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1038880549
    252 https://doi.org/10.1007/s11920-003-0027-z
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/35024156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002163621
    255 https://doi.org/10.1038/35024156
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/417282a schema:sameAs https://app.dimensions.ai/details/publication/pub.1033520598
    258 https://doi.org/10.1038/417282a
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nature13294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040773333
    261 https://doi.org/10.1038/nature13294
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nn.2403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015299269
    264 https://doi.org/10.1038/nn.2403
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nn.2506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021102928
    267 https://doi.org/10.1038/nn.2506
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nn.2808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014721634
    270 https://doi.org/10.1038/nn.2808
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nn1733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047962276
    273 https://doi.org/10.1038/nn1733
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/npp.2014.265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043575776
    276 https://doi.org/10.1038/npp.2014.265
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/npp.2014.266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006470565
    279 https://doi.org/10.1038/npp.2014.266
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/npp.2017.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083852494
    282 https://doi.org/10.1038/npp.2017.38
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nrn.2016.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048765373
    285 https://doi.org/10.1038/nrn.2016.165
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nrn.2018.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101076195
    288 https://doi.org/10.1038/nrn.2018.1
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/s41598-018-30524-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106062657
    291 https://doi.org/10.1038/s41598-018-30524-4
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/s41598-018-32762-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1107263183
    294 https://doi.org/10.1038/s41598-018-32762-y
    295 rdf:type schema:CreativeWork
    296 https://app.dimensions.ai/details/publication/pub.1076626185 schema:CreativeWork
    297 https://doi.org/10.1002/(sici)1098-2302(199604)29:3<191::aid-dev1>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1026375940
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1002/dev.20448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001375835
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1002/dev.20531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003093193
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1002/dev.21230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007513242
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1002/dev.21260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004737435
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1002/dev.21547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090951120
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1002/dev.420280403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011340013
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.biopsych.2005.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012956018
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.biopsych.2009.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011410709
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.cell.2011.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026200705
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.cell.2014.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036061512
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.copsyc.2017.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085057759
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.dcn.2016.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051685898
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.dcn.2017.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083870095
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.neubiorev.2011.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038891607
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.neuron.2008.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000189735
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.neuron.2008.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001376450
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.neuron.2010.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034335561
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.neuron.2012.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017907167
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.neuron.2012.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036871078
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/j.neuron.2013.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005563816
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/j.neuropharm.2013.03.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007711544
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/j.neuropsychologia.2010.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040440690
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/j.neuroscience.2008.04.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038079295
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.neuroscience.2014.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012648776
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/j.nlm.2016.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016091328
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/j.pneurobio.2008.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015287063
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/j.tics.2005.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013323184
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/j.tins.2006.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010291460
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.yfrne.2009.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016963502
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/j.yhbeh.2007.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007921568
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/s0079-6123(07)67010-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046244754
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s0149-7634(03)00007-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037943243
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/s0165-0173(98)00019-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005443582
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/s0896-6273(00)80775-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005658667
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1017/s0954579401003029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041244907
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1037/0022-3514.95.1.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006974462
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1046/j.1471-4159.1999.0721088.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042856394
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1073/pnas.1307893110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023388125
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1073/pnas.1310163110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036361923
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1073/pnas.1423363112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053336950
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1080/10253890.2017.1343296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086038639
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1080/14616734.2015.1042487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000939477
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1080/17470919.2015.1070198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039079289
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1080/17470919.2015.1087424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020639529
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1080/17470919.2015.1087426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052642898
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1080/17470919.2016.1149095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039961273
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1080/17470919.2016.1159605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040626542
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1097/nmd.0000000000000049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032536220
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1097/psy.0b013e3182359335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046623322
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1111/acer.12024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032713925
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1111/j.1467-8624.1996.tb01748.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022782836
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1111/j.1471-4159.2011.07221.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053154694
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1111/jcpp.12622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004960467
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1111/jcpp.12642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021014513
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1146/annurev.neuro.24.1.897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010137826
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1159/000095581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021746368
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1177/1524838015627147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013395681
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1177/1745691616680612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085618755
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1196/annals.1301.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033013813
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1371/journal.pone.0079077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045144936
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1523/jneurosci.0632-16.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067642752
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1523/jneurosci.1616-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022714816
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1523/jneurosci.2085-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041325790
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1523/jneurosci.22-24-10819.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075204817
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1523/jneurosci.2603-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015612780
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1523/jneurosci.3333-15.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007768569
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1523/jneurosci.3446-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031050375
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1523/jneurosci.3557-12.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042894744
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1523/jneurosci.5843-11.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006300740
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1523/jneurosci.5944-10.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042590393
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1523/jneurosci.6588-10.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017423358
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.3389/fnana.2015.00059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050193531
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.3389/fnbeh.2015.00303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053372462
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.3389/fnsys.2016.00092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045282895
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.3389/fphys.2013.00088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039708497
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.3389/neuro.08.022.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051210701
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.4324/9781315808888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052853132
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.7554/elife.17328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007715585
    454 rdf:type schema:CreativeWork
    455 https://www.grid.ac/institutes/grid.10548.38 schema:alternateName Stockholm University
    456 schema:name Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA
    457 Clinical Neuroscience Department, Karolinska Institute, 17177, Stockholm, Sweden
    458 Department of Psychology, Stockholm University, 10691, Stockholm, Sweden
    459 Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA
    460 Stockholm University Brain Imaging Centre, Stockholm University, 10691, Stockholm, Sweden
    461 rdf:type schema:Organization
    462 https://www.grid.ac/institutes/grid.137628.9 schema:alternateName New York University
    463 schema:name Child Study Center, Child & Adolescent Psychiatry, New York University School of Medicine, 10016, New York, NY, USA
    464 Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA
    465 rdf:type schema:Organization
    466 https://www.grid.ac/institutes/grid.250263.0 schema:alternateName Nathan Kline Institute for Psychiatric Research
    467 schema:name Emotional Brain Institute, Nathan Kline Institute, 10962, Orangeburg, NY, USA
    468 rdf:type schema:Organization
    469 https://www.grid.ac/institutes/grid.253482.a schema:alternateName The Graduate Center, CUNY
    470 schema:name Department of Psychology, CUNY Hunter College, 10065, New York, NY, USA
    471 The Graduate Center of CUNY, 10016, New York, NY, USA
    472 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...