The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Chadi G. Abdallah, Henk M. De Feyter, Lynnette A. Averill, Lihong Jiang, Christopher L. Averill, Golam M. I. Chowdhury, Prerana Purohit, Robin A. de Graaf, Irina Esterlis, Christoph Juchem, Brian P. Pittman, John H. Krystal, Douglas L. Rothman, Gerard Sanacora, Graeme F. Mason

ABSTRACT

The ability of ketamine administration to activate prefrontal glutamate neurotransmission is thought to be a key mechanism contributing to its transient psychotomimetic effects and its delayed and sustained antidepressant effects. Rodent studies employing carbon-13 magnetic resonance spectroscopy (13C MRS) methods have shown ketamine and other N-methyl-D-aspartate (NMDA) receptor antagonists to transiently increase measures reflecting glutamate-glutamine cycling and glutamate neurotransmission in the frontal cortex. However, there are not yet direct measures of glutamate neurotransmission in vivo in humans to support these hypotheses. The current first-level pilot study employed a novel prefrontal 13C MRS approach similar to that used in the rodent studies for direct measurement of ketamine effects on glutamate-glutamine cycling. Twenty-one participants (14 healthy and 7 depressed) completed two 13C MRS scans during infusion of normal saline or subanesthetic doses of ketamine. Compared to placebo, ketamine increased prefrontal glutamate-glutamine cycling, as indicated by a 13% increase in 13C glutamine enrichment (t = 2.4, p = 0.02). We found no evidence of ketamine effects on oxidative energy production, as reflected by 13C glutamate enrichment. During ketamine infusion, the ratio of 13C glutamate/glutamine enrichments, a putative measure of neurotransmission strength, was correlated with the Clinician-Administered Dissociative States Scale (r = -0.54, p = 0.048). These findings provide the most direct evidence in humans to date that ketamine increases glutamate release in the prefrontal cortex, a mechanism previously linked to schizophrenia pathophysiology and implicated in the induction of rapid antidepressant effects. More... »

PAGES

2154-2160

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41386-018-0136-3

    DOI

    http://dx.doi.org/10.1038/s41386-018-0136-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105228661

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29977074


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