Ontology type: schema:ScholarlyArticle
2019-01
AUTHORSAyline Maier, Dirk Scheele, Franny B. Spengler, Tugba Menba, Franziska Mohr, Onur Güntürkün, Birgit Stoffel-Wagner, Thomas M. Kinfe, Wolfgang Maier, Sahib S. Khalsa, René Hurlemann
ABSTRACTSocial transmission of fear is not restricted to visual or auditory cues, but extends to the phylogenetically more ancient olfactory domain. Anxious individuals exhibit heightened sensitivity towards chemosensory stress signals in sweat; however, it is still unknown whether endogenous neuromodulators such as the peptide hormone oxytocin (OXT) influence the chemosensory communication of stress. Here, we investigated whether OXT selectively diminishes behavioral and neural responses to social chemosensory stress cues utilizing a randomized, double-blind, placebo (PLC)-controlled, within-subject functional MRI study design. Axillary sweat was obtained from 30 healthy male donors undergoing the Trier Social Stress Test (stress) and bicycle ergometer training (sport). Subsequently, 58 healthy participants (30 females) completed a forced-choice emotional face recognition task with stimuli of varying intensities (neutral to fearful) while they were exposed to both sweat stimuli and a non-social control odor following intranasal OXT or PLC administration, respectively. OXT diminished stress-induced recognition accuracy and response time biases towards fear. On the neural level, OXT reduced stress-evoked responses in the amygdala in both sexes, the anterior cingulate cortex (ACC) in females, and the hippocampus in males. Furthermore, OXT reinstated the functional connectivity between the ACC and the fusiform face area that was disrupted by stress odors under PLC. Our findings reveal a new role for OXT signaling in the modulation of chemosensory communication of stress in humans. Mechanistically, this effect appears to be rooted in a downregulation of stress-induced limbic activations and concomitant strengthening of top-down control descending from the ACC to the fusiform face area. More... »
PAGES281-288
http://scigraph.springernature.com/pub.10.1038/s41386-018-0063-3
DOIhttp://dx.doi.org/10.1038/s41386-018-0063-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1103221280
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29703998
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Psychology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Psychology and Cognitive Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amygdala",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Mapping",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Choice Behavior",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Double-Blind Method",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Emotions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Facial Recognition",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fear",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hippocampus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Magnetic Resonance Imaging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxytocin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reaction Time",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Social Perception",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stress, Psychological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Maier",
"givenName": "Ayline",
"id": "sg:person.014271315222.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014271315222.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Scheele",
"givenName": "Dirk",
"id": "sg:person.01133020472.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133020472.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Spengler",
"givenName": "Franny B.",
"id": "sg:person.011735771467.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011735771467.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Menba",
"givenName": "Tugba",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Mohr",
"givenName": "Franziska",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ruhr University Bochum",
"id": "https://www.grid.ac/institutes/grid.5570.7",
"name": [
"Institute for Cognitive Neuroscience, Biopsychology, Ruhr-University of Bochum, 44780, Bochum, Germany"
],
"type": "Organization"
},
"familyName": "G\u00fcnt\u00fcrk\u00fcn",
"givenName": "Onur",
"id": "sg:person.01243204271.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243204271.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Institute for Clinical Chemistry and Pharmacology, University of Bonn, 53105, Bonn, Germany",
"Department of Psychiatry, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Stoffel-Wagner",
"givenName": "Birgit",
"id": "sg:person.01343266122.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343266122.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Kinfe",
"givenName": "Thomas M.",
"id": "sg:person.0756773307.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756773307.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Center for Neurodegenerative Diseases",
"id": "https://www.grid.ac/institutes/grid.424247.3",
"name": [
"Department of Psychiatry, University of Bonn, 53105, Bonn, Germany",
"German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Maier",
"givenName": "Wolfgang",
"id": "sg:person.01277630113.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277630113.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tulsa",
"id": "https://www.grid.ac/institutes/grid.267360.6",
"name": [
"Laureate Institute for Brain Research, 74136, Tulsa, OK, USA",
"Oxley College of Health Sciences, University of Tulsa, 74104, Tulsa, OK, USA"
],
"type": "Organization"
},
"familyName": "Khalsa",
"givenName": "Sahib S.",
"id": "sg:person.01206323735.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206323735.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bonn",
"id": "https://www.grid.ac/institutes/grid.10388.32",
"name": [
"Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany",
"Department of Psychiatry, University of Bonn, 53105, Bonn, Germany"
],
"type": "Organization"
},
"familyName": "Hurlemann",
"givenName": "Ren\u00e9",
"id": "sg:person.01300152067.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300152067.10"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1098/rsif.2006.0182",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001059509"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cne.20749",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002233986"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cne.20749",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002233986"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.conb.2008.06.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004787385"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn2647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006137598",
"https://doi.org/10.1038/nrn2647"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn2647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006137598",
"https://doi.org/10.1038/nrn2647"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neubiorev.2008.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007585160"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0031-9384(00)00370-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010760275"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000119004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011484143"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hipo.22073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013906413"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0010342",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015347310"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0896-6273(03)00392-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016513115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.psyneuen.2014.04.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017148854"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.4086",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017526538",
"https://doi.org/10.1038/nn.4086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biopsycho.2012.02.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018550274"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0074655",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019186714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuroimage.2016.09.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021179273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuroimage.2016.09.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021179273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neubiorev.2015.04.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022969176"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tics.2010.11.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024611368"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/chemse/bjh245",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026258872"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1749-6632.2009.05331.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027838770"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1749-6632.2009.05331.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027838770"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.psyneuen.2014.12.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028062316"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.psyneuen.2014.12.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028062316"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/77040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029694213",
"https://doi.org/10.1038/77040"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/77040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029694213",
"https://doi.org/10.1038/77040"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neulet.2008.12.039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029835796"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1467-9280.2009.02263.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030985183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1467-9280.2009.02263.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030985183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3984-05.2005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034238694"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0083-6729(10)83001-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034690146"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuropsychologia.2012.03.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035910898"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biopsych.2012.04.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035914640"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuropsychologia.2011.12.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036785845"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0006415",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037536565"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neulet.2005.10.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040926321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2006.12.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041444532"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2006.12.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041444532"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.schres.2014.12.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041791735"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0005987",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042272522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuroimage.2012.03.068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042944212"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuroimage.2012.03.068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042944212"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biopsych.2014.10.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045199994"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1037/0033-2909.133.1.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045425245"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/lm.70504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045671697"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbr.2011.12.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047919826"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-3223(03)00465-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048582769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-3223(03)00465-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048582769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/scan/nsu147",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049107617"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/scan/nsu147",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049107617"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn3044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049254175",
"https://doi.org/10.1038/nrn3044"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpsycho.2009.07.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051143648"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0068485",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052238096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/scan/nsm018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053132841"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/s0033291707001456",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053857352"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.21-20-08278.2001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074890225"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuropsychologia.2017.02.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084098944"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/tp.2017.72",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084903042",
"https://doi.org/10.1038/tp.2017.72"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hbm.23679",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085861994"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-017-05811-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090852129",
"https://doi.org/10.1038/s41598-017-05811-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-017-05811-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090852129",
"https://doi.org/10.1038/s41598-017-05811-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1705853114",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091223378"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-01",
"datePublishedReg": "2019-01-01",
"description": "Social transmission of fear is not restricted to visual or auditory cues, but extends to the phylogenetically more ancient olfactory domain. Anxious individuals exhibit heightened sensitivity towards chemosensory stress signals in sweat; however,\u00a0it is still unknown whether endogenous neuromodulators such as the peptide hormone oxytocin (OXT) influence the chemosensory communication of stress. Here, we investigated whether OXT selectively diminishes behavioral and neural responses to social chemosensory stress cues utilizing a randomized, double-blind, placebo (PLC)-controlled, within-subject functional MRI study design. Axillary sweat was obtained from 30 healthy male donors undergoing the Trier Social Stress Test (stress) and bicycle ergometer training (sport). Subsequently, 58 healthy participants (30 females) completed a forced-choice emotional face recognition task with stimuli of varying intensities (neutral to fearful) while they were exposed to both sweat stimuli and a non-social control odor following intranasal OXT or PLC administration, respectively. OXT diminished stress-induced recognition accuracy and response time biases towards fear. On the neural level, OXT reduced stress-evoked responses in the amygdala in both sexes, the anterior cingulate cortex (ACC) in females, and the hippocampus in males. Furthermore, OXT reinstated the functional connectivity between the ACC and the fusiform face area that was disrupted by stress odors under PLC. Our findings reveal a new role for OXT signaling in the modulation of chemosensory communication of stress in humans. Mechanistically, this effect appears to be rooted in a downregulation of stress-induced limbic activations and concomitant strengthening of top-down control descending from the ACC to the fusiform face area.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41386-018-0063-3",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1099176",
"issn": [
"0893-133X",
"1740-634X"
],
"name": "Neuropsychopharmacology",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "44"
}
],
"name": "Oxytocin reduces a chemosensory-induced stress bias in social perception",
"pagination": "281-288",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41386-018-0063-3"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1103221280"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"97cdf47ad15d03277f30a40e0c42f7030f6cb520aef3bec341c948f8dd97e184"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8904907"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29703998"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41386-018-0063-3",
"https://app.dimensions.ai/details/publication/pub.1103221280"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-16T06:23",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106819_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41386-018-0063-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41386-018-0063-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41386-018-0063-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41386-018-0063-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41386-018-0063-3'
This table displays all metadata directly associated to this object as RDF triples.
385 TRIPLES
21 PREDICATES
99 URIs
40 LITERALS
28 BLANK NODES