A screen of Crohn’s disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-25

AUTHORS

Yu-Ling Chang, Maura Rossetti, Hera Vlamakis, David Casero, Gemalene Sunga, Nicholas Harre, Shelley Miller, Romney Humphries, Thaddeus Stappenbeck, Kenneth W. Simpson, R. Balfour Sartor, Gary Wu, James Lewis, Frederic Bushman, Dermot P. B. McGovern, Nita Salzman, James Borneman, Ramnik Xavier, Curtis Huttenhower, Jonathan Braun

ABSTRACT

Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn’s disease, we screened 139 predicted Crohn’s disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions induced by disease-associated T helper 17 (Th17) polarizing conditions. We observed 15 metabolites with CD4+ T-cell bioactivity, 3 previously reported, and 12 unprecedented. A deeper investigation of the microbe-derived metabolite, ascorbate, revealed its selective inhibition on activated human CD4+ effector T cells, including IL-17A-, IL-4-, and IFNγ-producing cells. Mechanistic assessment suggested the apoptosis of activated human CD4+ T cells associated with selective inhibition of energy metabolism. These findings suggest a substantial rate of relevant T-cell bioactivity among Crohn’s disease-associated microbial metabolites, and evidence for novel modes of bioactivity, including targeting of T-cell energy metabolism. More... »

PAGES

457-467

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  • Journal

    TITLE

    Mucosal Immunology

    ISSUE

    2

    VOLUME

    12

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41385-018-0022-7

    DOI

    http://dx.doi.org/10.1038/s41385-018-0022-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103624759

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29695840


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