Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-05-28

AUTHORS

Vishal Sinha, Liisa Ukkola-Vuoti, Alfredo Ortega-Alonso, Minna Torniainen-Holm, Sebastian Therman, Annamari Tuulio-Henriksson, Pekka Jylhä, Jaakko Kaprio, Iiris Hovatta, Erkki Isometsä, Tyrone D. Cannon, Jouko Lönnqvist, Tiina Paunio, Jaana Suvisaari, William Hennah

ABSTRACT

We have previously reported a replicable association between variants at the PDE4D gene and familial schizophrenia in a Finnish cohort. In order to identify the potential functional mutations underlying these previous findings, we sequenced 1.5 Mb of the PDE4D genomic locus in 20 families (consisting of 96 individuals and 79 independent chromosomes), followed by two stages of genotyping across 6668 individuals from multiple Finnish cohorts for major mental illnesses. We identified 4570 SNPs across the PDE4D gene, with 380 associated to schizophrenia (p ≤ 0.05). Importantly, two of these variants, rs35278 and rs165940, are located at transcription factor-binding sites, and displayed replicable association in the two-stage enlargement of the familial schizophrenia cohort (combined statistics for rs35278 p = 0.0012; OR = 1.18, 95% CI: 1.06–1.32; and rs165940 p = 0.0016; OR = 1.27, 95% CI: 1.13–1.41). Further analysis using additional cohorts and endophenotypes revealed that rs165940 principally associates within the psychosis (p = 0.025, OR = 1.18, 95% CI: 1.07–1.30) and cognitive domains of major mental illnesses (g-score p = 0.044, β = –0.033). Specifically, the cognitive domains represented verbal learning and memory (p = 0.0091, β = –0.044) and verbal working memory (p = 0.0062, β = −0.036). Moreover, expression data from the GTEx database demonstrated that rs165940 significantly correlates with the mRNA expression levels of PDE4D in the cerebellum (p-value = 0.04; m-value = 0.9), demonstrating a potential functional consequence for this variant. Thus, rs165940 represents the most likely functional variant for major mental illness at the PDE4D locus in the Finnish population, increasing risk broadly to psychotic disorders. More... »

PAGES

816-824

References to SciGraph publications

  • 2018-02-26. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection in NATURE GENETICS
  • 2014-02-17. PSEUDOMARKER 2.0: efficient computation of likelihoods using NOMAD in BMC BIOINFORMATICS
  • 2007-07-31. A whole genome association study of neuroticism using DNA pooling in MOLECULAR PSYCHIATRY
  • 2011-09-28. Comparison of solution-based exome capture methods for next generation sequencing in GENOME BIOLOGY
  • 2007-08-07. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families in MOLECULAR PSYCHIATRY
  • 2018-06-07. DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders in MOLECULAR PSYCHIATRY
  • 2018-09-21. Cerebello-thalamo-cortical hyperconnectivity as a state-independent functional neural signature for psychosis prediction and characterization in NATURE COMMUNICATIONS
  • 2002-06-18. Bipolar disorder susceptibility region on Xq24–q27.1 in Finnish families in MOLECULAR PSYCHIATRY
  • 2013-05-29. The Genotype-Tissue Expression (GTEx) project in NATURE GENETICS
  • 1995-08. The cyclic AMP system andDrosophila learning in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2005-08-16. A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia in MOLECULAR PSYCHIATRY
  • 2011-08-11. Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex in PSYCHOPHARMACOLOGY
  • 2007-12-01. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme in PSYCHOPHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41380-019-0429-x

    DOI

    http://dx.doi.org/10.1038/s41380-019-0429-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1115931972

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31138891


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclic Nucleotide Phosphodiesterases, Type 4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endophenotypes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Finland", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Psychotic Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Schizophrenia", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Medicum, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
                "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland", 
                "Medicum, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sinha", 
            "givenName": "Vishal", 
            "id": "sg:person.07724717247.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07724717247.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medicum, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
                "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland", 
                "Medicum, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ukkola-Vuoti", 
            "givenName": "Liisa", 
            "id": "sg:person.01157141572.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157141572.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
                "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ortega-Alonso", 
            "givenName": "Alfredo", 
            "id": "sg:person.0776772133.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776772133.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
                "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Torniainen-Holm", 
            "givenName": "Minna", 
            "id": "sg:person.01173172613.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173172613.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.14758.3f", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Therman", 
            "givenName": "Sebastian", 
            "id": "sg:person.01306021013.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306021013.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychology and Logopedics, Medicum, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Psychology and Logopedics, Medicum, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tuulio-Henriksson", 
            "givenName": "Annamari", 
            "id": "sg:person.01321141612.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321141612.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
                "Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jylh\u00e4", 
            "givenName": "Pekka", 
            "id": "sg:person.0611311454.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611311454.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland", 
                "Department of Public Health, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaprio", 
            "givenName": "Jaakko", 
            "id": "sg:person.015767231737.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015767231737.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Medicum, University of Helsinki, Helsinki, Finland", 
                "Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hovatta", 
            "givenName": "Iiris", 
            "id": "sg:person.01340127760.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340127760.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Isomets\u00e4", 
            "givenName": "Erkki", 
            "id": "sg:person.0731101000.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731101000.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychology, Yale University, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Psychology, Yale University, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cannon", 
            "givenName": "Tyrone D.", 
            "id": "sg:person.013674166537.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013674166537.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.15485.3d", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
                "Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f6nnqvist", 
            "givenName": "Jouko", 
            "id": "sg:person.01130515604.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130515604.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health Solutions, Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.14758.3f", 
              "name": [
                "Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland", 
                "Department of Public Health Solutions, Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paunio", 
            "givenName": "Tiina", 
            "id": "sg:person.01017202010.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017202010.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.14758.3f", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suvisaari", 
            "givenName": "Jaana", 
            "id": "sg:person.01222345271.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222345271.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medicum, University of Helsinki, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland", 
                "Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland", 
                "Medicum, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hennah", 
            "givenName": "William", 
            "id": "sg:person.01350645663.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350645663.24"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41467-018-06350-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107062174", 
              "https://doi.org/10.1038/s41467-018-06350-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028150397", 
              "https://doi.org/10.1038/sj.mp.4002048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-9-r94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028092143", 
              "https://doi.org/10.1186/gb-2011-12-9-r94"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0059-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101216525", 
              "https://doi.org/10.1038/s41588-018-0059-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014392987", 
              "https://doi.org/10.1038/sj.mp.4001104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01076588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027727530", 
              "https://doi.org/10.1007/bf01076588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032523118", 
              "https://doi.org/10.1038/sj.mp.4002047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032444369", 
              "https://doi.org/10.1038/ng.2653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-15-47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001557935", 
              "https://doi.org/10.1186/1471-2105-15-47"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010115007", 
              "https://doi.org/10.1038/sj.mp.4001731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41380-018-0087-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104428043", 
              "https://doi.org/10.1038/s41380-018-0087-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-007-1014-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052894377", 
              "https://doi.org/10.1007/s00213-007-1014-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-011-2436-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001646575", 
              "https://doi.org/10.1007/s00213-011-2436-8"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-05-28", 
        "datePublishedReg": "2019-05-28", 
        "description": "We have previously reported a replicable association between variants at the PDE4D gene and familial schizophrenia in a Finnish cohort. In order to identify the potential functional mutations underlying these previous findings, we sequenced 1.5\u2009Mb of the PDE4D genomic locus in 20 families (consisting of 96 individuals and 79 independent chromosomes), followed by two stages of genotyping across 6668 individuals from multiple Finnish cohorts for major mental illnesses. We identified 4570 SNPs across the PDE4D gene, with 380 associated to schizophrenia (p\u2009\u2264\u20090.05). Importantly, two of these variants, rs35278 and rs165940, are located at transcription factor-binding sites, and displayed replicable association in the two-stage enlargement of the familial schizophrenia cohort (combined statistics for rs35278 p\u2009=\u20090.0012; OR\u2009=\u20091.18, 95% CI: 1.06\u20131.32; and rs165940 p\u2009=\u20090.0016; OR\u2009=\u20091.27, 95% CI: 1.13\u20131.41). Further analysis using additional cohorts and endophenotypes revealed that rs165940 principally associates within the psychosis (p\u2009=\u20090.025, OR\u2009=\u20091.18, 95% CI: 1.07\u20131.30) and cognitive domains of major mental illnesses (g-score p\u2009=\u20090.044, \u03b2\u2009=\u2009\u20130.033). Specifically, the cognitive domains represented verbal learning and memory (p\u2009=\u20090.0091, \u03b2\u2009=\u2009\u20130.044) and verbal working memory (p\u2009=\u20090.0062, \u03b2\u2009=\u2009\u22120.036). Moreover, expression data from the GTEx database demonstrated that rs165940 significantly correlates with the mRNA expression levels of PDE4D in the cerebellum (p-value\u2009=\u20090.04; m-value\u2009=\u20090.9), demonstrating a potential functional consequence for this variant. Thus, rs165940 represents the most likely functional variant for major mental illness at the PDE4D locus in the Finnish population, increasing risk broadly to psychotic disorders.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41380-019-0429-x", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4251168", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3797735", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4250872", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1115540", 
            "issn": [
              "1359-4184", 
              "1476-5578"
            ], 
            "name": "Molecular Psychiatry", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "26"
          }
        ], 
        "keywords": [
          "major mental illness", 
          "mental illness", 
          "Finnish cohort", 
          "Finnish population", 
          "mRNA expression levels", 
          "replicable associations", 
          "cognitive domains", 
          "additional cohort", 
          "psychotic disorders", 
          "cohort", 
          "illness", 
          "GTEx database", 
          "schizophrenia cohort", 
          "potential functional consequences", 
          "expression levels", 
          "familial schizophrenia", 
          "verbal learning", 
          "schizophrenia", 
          "functional consequences", 
          "functional variants", 
          "association", 
          "functional mutations", 
          "previous findings", 
          "population", 
          "variants", 
          "psychosis", 
          "cerebellum", 
          "factor-binding sites", 
          "likely functional variants", 
          "disorders", 
          "transcription factor-binding sites", 
          "Further analysis", 
          "risk", 
          "enlargement", 
          "genes", 
          "endophenotypes", 
          "findings", 
          "mutations", 
          "individuals", 
          "levels", 
          "database", 
          "expression data", 
          "SNPs", 
          "regulatory elements", 
          "memory", 
          "loci", 
          "family", 
          "stage", 
          "data", 
          "associates", 
          "sites", 
          "consequences", 
          "analysis", 
          "genomic loci", 
          "domain", 
          "MB", 
          "order", 
          "learning", 
          "elements", 
          "potential functional mutations", 
          "multiple Finnish cohorts", 
          "rs35278", 
          "rs165940", 
          "two-stage enlargement", 
          "familial schizophrenia cohort", 
          "PDE4D locus"
        ], 
        "name": "Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population", 
        "pagination": "816-824", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1115931972"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41380-019-0429-x"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31138891"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41380-019-0429-x", 
          "https://app.dimensions.ai/details/publication/pub.1115931972"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:51", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_795.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41380-019-0429-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41380-019-0429-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41380-019-0429-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41380-019-0429-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41380-019-0429-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    334 TRIPLES      22 PREDICATES      112 URIs      91 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41380-019-0429-x schema:about N190328c58afc4d76aaae495d9a2b7296
    2 N546119dbc55b414daca32fb6a244df23
    3 N78f5cca7fe3e423faf50e6adec78249d
    4 N9d5ca99fb3814ff1a026e8c0051c4573
    5 Na1b4bcae583c42e998659a428c348794
    6 Nd023756e3eeb4568b346215a670a9960
    7 Nfde5092389ea448494e41194dd41119b
    8 anzsrc-for:06
    9 anzsrc-for:0604
    10 schema:author N8458a5c5fcd04ed8bfc3927c2bc71e5d
    11 schema:citation sg:pub.10.1007/bf01076588
    12 sg:pub.10.1007/s00213-007-1014-6
    13 sg:pub.10.1007/s00213-011-2436-8
    14 sg:pub.10.1038/ng.2653
    15 sg:pub.10.1038/s41380-018-0087-4
    16 sg:pub.10.1038/s41467-018-06350-7
    17 sg:pub.10.1038/s41588-018-0059-2
    18 sg:pub.10.1038/sj.mp.4001104
    19 sg:pub.10.1038/sj.mp.4001731
    20 sg:pub.10.1038/sj.mp.4002047
    21 sg:pub.10.1038/sj.mp.4002048
    22 sg:pub.10.1186/1471-2105-15-47
    23 sg:pub.10.1186/gb-2011-12-9-r94
    24 schema:datePublished 2019-05-28
    25 schema:datePublishedReg 2019-05-28
    26 schema:description We have previously reported a replicable association between variants at the PDE4D gene and familial schizophrenia in a Finnish cohort. In order to identify the potential functional mutations underlying these previous findings, we sequenced 1.5 Mb of the PDE4D genomic locus in 20 families (consisting of 96 individuals and 79 independent chromosomes), followed by two stages of genotyping across 6668 individuals from multiple Finnish cohorts for major mental illnesses. We identified 4570 SNPs across the PDE4D gene, with 380 associated to schizophrenia (p ≤ 0.05). Importantly, two of these variants, rs35278 and rs165940, are located at transcription factor-binding sites, and displayed replicable association in the two-stage enlargement of the familial schizophrenia cohort (combined statistics for rs35278 p = 0.0012; OR = 1.18, 95% CI: 1.06–1.32; and rs165940 p = 0.0016; OR = 1.27, 95% CI: 1.13–1.41). Further analysis using additional cohorts and endophenotypes revealed that rs165940 principally associates within the psychosis (p = 0.025, OR = 1.18, 95% CI: 1.07–1.30) and cognitive domains of major mental illnesses (g-score p = 0.044, β = –0.033). Specifically, the cognitive domains represented verbal learning and memory (p = 0.0091, β = –0.044) and verbal working memory (p = 0.0062, β = −0.036). Moreover, expression data from the GTEx database demonstrated that rs165940 significantly correlates with the mRNA expression levels of PDE4D in the cerebellum (p-value = 0.04; m-value = 0.9), demonstrating a potential functional consequence for this variant. Thus, rs165940 represents the most likely functional variant for major mental illness at the PDE4D locus in the Finnish population, increasing risk broadly to psychotic disorders.
    27 schema:genre article
    28 schema:inLanguage en
    29 schema:isAccessibleForFree true
    30 schema:isPartOf N8e277fa147d74ce687f3a06f398bbd81
    31 Nb123fad2654f4f288fe293d2da6ccd48
    32 sg:journal.1115540
    33 schema:keywords Finnish cohort
    34 Finnish population
    35 Further analysis
    36 GTEx database
    37 MB
    38 PDE4D locus
    39 SNPs
    40 additional cohort
    41 analysis
    42 associates
    43 association
    44 cerebellum
    45 cognitive domains
    46 cohort
    47 consequences
    48 data
    49 database
    50 disorders
    51 domain
    52 elements
    53 endophenotypes
    54 enlargement
    55 expression data
    56 expression levels
    57 factor-binding sites
    58 familial schizophrenia
    59 familial schizophrenia cohort
    60 family
    61 findings
    62 functional consequences
    63 functional mutations
    64 functional variants
    65 genes
    66 genomic loci
    67 illness
    68 individuals
    69 learning
    70 levels
    71 likely functional variants
    72 loci
    73 mRNA expression levels
    74 major mental illness
    75 memory
    76 mental illness
    77 multiple Finnish cohorts
    78 mutations
    79 order
    80 population
    81 potential functional consequences
    82 potential functional mutations
    83 previous findings
    84 psychosis
    85 psychotic disorders
    86 regulatory elements
    87 replicable associations
    88 risk
    89 rs165940
    90 rs35278
    91 schizophrenia
    92 schizophrenia cohort
    93 sites
    94 stage
    95 transcription factor-binding sites
    96 two-stage enlargement
    97 variants
    98 verbal learning
    99 schema:name Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population
    100 schema:pagination 816-824
    101 schema:productId N7d079818ba924f0abb74e8a806c9514c
    102 N9e372edf1d344679b52c8e68eb4959a5
    103 Nba6dfb71be1f418eb47e74af1b698dde
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1115931972
    105 https://doi.org/10.1038/s41380-019-0429-x
    106 schema:sdDatePublished 2022-01-01T18:51
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher N8b7c87fb4dd54cae96717b15fa802c51
    109 schema:url https://doi.org/10.1038/s41380-019-0429-x
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N190328c58afc4d76aaae495d9a2b7296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Psychotic Disorders
    115 rdf:type schema:DefinedTerm
    116 N2813797033ce4df099751ae175cac620 rdf:first sg:person.01157141572.46
    117 rdf:rest Nbf6b91128a3249f2a706cd35c7599fac
    118 N399dcd2ac1e8401cba3b9951ca35bf18 rdf:first sg:person.01350645663.24
    119 rdf:rest rdf:nil
    120 N3a17748662cc493cb56005e8aa3ea7c6 rdf:first sg:person.01173172613.46
    121 rdf:rest Nb2ed590ecdaf4268a7ac694e89d06a9f
    122 N4c3ddfe45293467e9d0683e4b98e7b76 rdf:first sg:person.0611311454.58
    123 rdf:rest N6c60caad98374a8da8ca209ceb0217e0
    124 N546119dbc55b414daca32fb6a244df23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Humans
    126 rdf:type schema:DefinedTerm
    127 N68e49331b49a4289bc81e3a01217f29d rdf:first sg:person.01340127760.25
    128 rdf:rest Ne87134b45d7b4a4db7b3ba0d0cd440f3
    129 N69883b156d524c1b89a822c600098eca rdf:first sg:person.01130515604.30
    130 rdf:rest N9a1790c7f2f345219a25bdb456162eb2
    131 N6c60caad98374a8da8ca209ceb0217e0 rdf:first sg:person.015767231737.16
    132 rdf:rest N68e49331b49a4289bc81e3a01217f29d
    133 N78f5cca7fe3e423faf50e6adec78249d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Polymorphism, Single Nucleotide
    135 rdf:type schema:DefinedTerm
    136 N7d079818ba924f0abb74e8a806c9514c schema:name pubmed_id
    137 schema:value 31138891
    138 rdf:type schema:PropertyValue
    139 N7e1bc9cfefa34b628f5f90149ff913dc rdf:first sg:person.01321141612.58
    140 rdf:rest N4c3ddfe45293467e9d0683e4b98e7b76
    141 N8458a5c5fcd04ed8bfc3927c2bc71e5d rdf:first sg:person.07724717247.37
    142 rdf:rest N2813797033ce4df099751ae175cac620
    143 N8b7c87fb4dd54cae96717b15fa802c51 schema:name Springer Nature - SN SciGraph project
    144 rdf:type schema:Organization
    145 N8e277fa147d74ce687f3a06f398bbd81 schema:volumeNumber 26
    146 rdf:type schema:PublicationVolume
    147 N95dc13e3cb6949a5b37b432fb86c7a69 rdf:first sg:person.01222345271.18
    148 rdf:rest N399dcd2ac1e8401cba3b9951ca35bf18
    149 N9a1790c7f2f345219a25bdb456162eb2 rdf:first sg:person.01017202010.21
    150 rdf:rest N95dc13e3cb6949a5b37b432fb86c7a69
    151 N9d5ca99fb3814ff1a026e8c0051c4573 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Endophenotypes
    153 rdf:type schema:DefinedTerm
    154 N9e372edf1d344679b52c8e68eb4959a5 schema:name doi
    155 schema:value 10.1038/s41380-019-0429-x
    156 rdf:type schema:PropertyValue
    157 Na1b4bcae583c42e998659a428c348794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Schizophrenia
    159 rdf:type schema:DefinedTerm
    160 Nb123fad2654f4f288fe293d2da6ccd48 schema:issueNumber 3
    161 rdf:type schema:PublicationIssue
    162 Nb2ed590ecdaf4268a7ac694e89d06a9f rdf:first sg:person.01306021013.01
    163 rdf:rest N7e1bc9cfefa34b628f5f90149ff913dc
    164 Nba6dfb71be1f418eb47e74af1b698dde schema:name dimensions_id
    165 schema:value pub.1115931972
    166 rdf:type schema:PropertyValue
    167 Nbf6b91128a3249f2a706cd35c7599fac rdf:first sg:person.0776772133.91
    168 rdf:rest N3a17748662cc493cb56005e8aa3ea7c6
    169 Nd023756e3eeb4568b346215a670a9960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Cyclic Nucleotide Phosphodiesterases, Type 4
    171 rdf:type schema:DefinedTerm
    172 Ne34899165ec2458991135804136e9ee7 rdf:first sg:person.013674166537.11
    173 rdf:rest N69883b156d524c1b89a822c600098eca
    174 Ne87134b45d7b4a4db7b3ba0d0cd440f3 rdf:first sg:person.0731101000.51
    175 rdf:rest Ne34899165ec2458991135804136e9ee7
    176 Nfde5092389ea448494e41194dd41119b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Finland
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Biological Sciences
    181 rdf:type schema:DefinedTerm
    182 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    183 schema:name Genetics
    184 rdf:type schema:DefinedTerm
    185 sg:grant.3797735 http://pending.schema.org/fundedItem sg:pub.10.1038/s41380-019-0429-x
    186 rdf:type schema:MonetaryGrant
    187 sg:grant.4250872 http://pending.schema.org/fundedItem sg:pub.10.1038/s41380-019-0429-x
    188 rdf:type schema:MonetaryGrant
    189 sg:grant.4251168 http://pending.schema.org/fundedItem sg:pub.10.1038/s41380-019-0429-x
    190 rdf:type schema:MonetaryGrant
    191 sg:journal.1115540 schema:issn 1359-4184
    192 1476-5578
    193 schema:name Molecular Psychiatry
    194 schema:publisher Springer Nature
    195 rdf:type schema:Periodical
    196 sg:person.01017202010.21 schema:affiliation grid-institutes:grid.14758.3f
    197 schema:familyName Paunio
    198 schema:givenName Tiina
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017202010.21
    200 rdf:type schema:Person
    201 sg:person.01130515604.30 schema:affiliation grid-institutes:grid.15485.3d
    202 schema:familyName Lönnqvist
    203 schema:givenName Jouko
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130515604.30
    205 rdf:type schema:Person
    206 sg:person.01157141572.46 schema:affiliation grid-institutes:grid.7737.4
    207 schema:familyName Ukkola-Vuoti
    208 schema:givenName Liisa
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157141572.46
    210 rdf:type schema:Person
    211 sg:person.01173172613.46 schema:affiliation grid-institutes:grid.7737.4
    212 schema:familyName Torniainen-Holm
    213 schema:givenName Minna
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173172613.46
    215 rdf:type schema:Person
    216 sg:person.01222345271.18 schema:affiliation grid-institutes:grid.14758.3f
    217 schema:familyName Suvisaari
    218 schema:givenName Jaana
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222345271.18
    220 rdf:type schema:Person
    221 sg:person.01306021013.01 schema:affiliation grid-institutes:grid.14758.3f
    222 schema:familyName Therman
    223 schema:givenName Sebastian
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306021013.01
    225 rdf:type schema:Person
    226 sg:person.01321141612.58 schema:affiliation grid-institutes:grid.7737.4
    227 schema:familyName Tuulio-Henriksson
    228 schema:givenName Annamari
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321141612.58
    230 rdf:type schema:Person
    231 sg:person.01340127760.25 schema:affiliation grid-institutes:grid.7737.4
    232 schema:familyName Hovatta
    233 schema:givenName Iiris
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340127760.25
    235 rdf:type schema:Person
    236 sg:person.01350645663.24 schema:affiliation grid-institutes:grid.7737.4
    237 schema:familyName Hennah
    238 schema:givenName William
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350645663.24
    240 rdf:type schema:Person
    241 sg:person.013674166537.11 schema:affiliation grid-institutes:grid.47100.32
    242 schema:familyName Cannon
    243 schema:givenName Tyrone D.
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013674166537.11
    245 rdf:type schema:Person
    246 sg:person.015767231737.16 schema:affiliation grid-institutes:grid.7737.4
    247 schema:familyName Kaprio
    248 schema:givenName Jaakko
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015767231737.16
    250 rdf:type schema:Person
    251 sg:person.0611311454.58 schema:affiliation grid-institutes:grid.15485.3d
    252 schema:familyName Jylhä
    253 schema:givenName Pekka
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611311454.58
    255 rdf:type schema:Person
    256 sg:person.0731101000.51 schema:affiliation grid-institutes:grid.15485.3d
    257 schema:familyName Isometsä
    258 schema:givenName Erkki
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731101000.51
    260 rdf:type schema:Person
    261 sg:person.07724717247.37 schema:affiliation grid-institutes:grid.7737.4
    262 schema:familyName Sinha
    263 schema:givenName Vishal
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07724717247.37
    265 rdf:type schema:Person
    266 sg:person.0776772133.91 schema:affiliation grid-institutes:grid.7737.4
    267 schema:familyName Ortega-Alonso
    268 schema:givenName Alfredo
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776772133.91
    270 rdf:type schema:Person
    271 sg:pub.10.1007/bf01076588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027727530
    272 https://doi.org/10.1007/bf01076588
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/s00213-007-1014-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052894377
    275 https://doi.org/10.1007/s00213-007-1014-6
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/s00213-011-2436-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001646575
    278 https://doi.org/10.1007/s00213-011-2436-8
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/ng.2653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032444369
    281 https://doi.org/10.1038/ng.2653
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/s41380-018-0087-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104428043
    284 https://doi.org/10.1038/s41380-018-0087-4
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/s41467-018-06350-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107062174
    287 https://doi.org/10.1038/s41467-018-06350-7
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/s41588-018-0059-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101216525
    290 https://doi.org/10.1038/s41588-018-0059-2
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/sj.mp.4001104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014392987
    293 https://doi.org/10.1038/sj.mp.4001104
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/sj.mp.4001731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010115007
    296 https://doi.org/10.1038/sj.mp.4001731
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/sj.mp.4002047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032523118
    299 https://doi.org/10.1038/sj.mp.4002047
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/sj.mp.4002048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028150397
    302 https://doi.org/10.1038/sj.mp.4002048
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1186/1471-2105-15-47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001557935
    305 https://doi.org/10.1186/1471-2105-15-47
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1186/gb-2011-12-9-r94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028092143
    308 https://doi.org/10.1186/gb-2011-12-9-r94
    309 rdf:type schema:CreativeWork
    310 grid-institutes:grid.14758.3f schema:alternateName Department of Public Health Solutions, Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland
    311 Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland
    312 schema:name Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    313 Department of Public Health Solutions, Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland
    314 Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland
    315 rdf:type schema:Organization
    316 grid-institutes:grid.15485.3d schema:alternateName Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    317 schema:name Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    318 Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland
    319 rdf:type schema:Organization
    320 grid-institutes:grid.47100.32 schema:alternateName Department of Psychology, Yale University, New Haven, Connecticut, USA
    321 schema:name Department of Psychology, Yale University, New Haven, Connecticut, USA
    322 rdf:type schema:Organization
    323 grid-institutes:grid.7737.4 schema:alternateName Department of Psychology and Logopedics, Medicum, University of Helsinki, Helsinki, Finland
    324 Department of Public Health, University of Helsinki, Helsinki, Finland
    325 Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland
    326 Medicum, University of Helsinki, Helsinki, Finland
    327 Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland
    328 schema:name Department of Psychology and Logopedics, Medicum, University of Helsinki, Helsinki, Finland
    329 Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland
    330 Department of Public Health, University of Helsinki, Helsinki, Finland
    331 Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland
    332 Medicum, University of Helsinki, Helsinki, Finland
    333 Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland
    334 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...