The kynurenine pathway: a finger in every pie. View Full Text


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Article Info

DATE

2019-04-12

AUTHORS

Jonathan Savitz

ABSTRACT

The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the immune system. Perhaps more importantly in the context of psychiatry, many kynurenines are neuroactive, modulating neuroplasticity and/or exerting neurotoxic effects in part through their effects on NMDA receptor signaling and glutamatergic neurotransmission. As such, it is not surprising that the kynurenines have been implicated in psychiatric illness in the context of inflammation. However, because of their neuromodulatory properties, the kynurenines are not just additional members of a list of inflammatory mediators linked with psychiatric illness, but in preclinical studies have been shown to be necessary components of the behavioral analogs of depression and schizophrenia-like cognitive deficits. Further, as the title suggests, the KP is regulated by, and in turn regulates multiple other physiological systems that are commonly disrupted in psychiatric disorders, including endocrine, metabolic, and hormonal systems. This review provides a broad overview of the mechanistic pathways through which the kynurenines interact with these systems, thus impacting emotion, cognition, pain, metabolic function, and aging, and in so doing potentially increasing the risk of developing psychiatric disorders. Novel therapeutic approaches targeting the KP are discussed. Moreover, electroconvulsive therapy, ketamine, physical exercise, and certain non-steroidal anti-inflammatories have been shown to alter kynurenine metabolism, raising the possibility that kynurenine metabolites may have utility as treatment response or therapeutic monitoring biomarkers. More... »

References to SciGraph publications

  • 2006-05. Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons in JOURNAL OF NEURAL TRANSMISSION
  • 2017-05-02. Serum kynurenic acid is reduced in affective psychosis in TRANSLATIONAL PSYCHIATRY
  • 2010-07. Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior in NEUROPSYCHOPHARMACOLOGY
  • 2009-07. Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis in GENES & IMMUNITY
  • 2018-03. Kynurenine pathway and white matter microstructure in bipolar disorder in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • 2012-07. Kynurenines in the mammalian brain: when physiology meets pathology in NATURE REVIEWS NEUROSCIENCE
  • 2013-08. Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression in NEUROPSYCHOPHARMACOLOGY
  • 2017-01. Role of Adiposity-Driven Inflammation in Depressive Morbidity in NEUROPSYCHOPHARMACOLOGY
  • 2013-10. Insulin Resistance and Dysregulation of Tryptophan–Kynurenine and Kynurenine–Nicotinamide Adenine Dinucleotide Metabolic Pathways in MOLECULAR NEUROBIOLOGY
  • 2011-12. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission? in JOURNAL OF NEUROINFLAMMATION
  • 2011-10. Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory in NEUROPSYCHOPHARMACOLOGY
  • 2017-01. Role of Inflammation in Suicide: From Mechanisms to Treatment in NEUROPSYCHOPHARMACOLOGY
  • 2005-06. IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity in MOLECULAR PSYCHIATRY
  • 2018-10. Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects in PSYCHOPHARMACOLOGY
  • 2002-06. Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy in MOLECULAR PSYCHIATRY
  • 2015-12. Targeting the indoleamine 2,3-dioxygenase pathway in cancer in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2016-10. Sex differences in immune responses in NATURE REVIEWS IMMUNOLOGY
  • 2018-12. Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial in TRANSLATIONAL PSYCHIATRY
  • 2003-08. Tryptophan and the immune response in IMMUNOLOGY AND CELL BIOLOGY
  • 2016-11. Neuropathology of mood disorders: do we see the stigmata of inflammation? in TRANSLATIONAL PSYCHIATRY
  • 2018-07-09. Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice in MOLECULAR PSYCHIATRY
  • 2009-12. Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice in MOLECULAR BRAIN
  • 2010-04. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression in MOLECULAR PSYCHIATRY
  • 2016-01. The role of inflammation in depression: from evolutionary imperative to modern treatment target in NATURE REVIEWS IMMUNOLOGY
  • 2015-01. Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder in NEUROPSYCHOPHARMACOLOGY
  • 2016-12. Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients in JOURNAL OF NEUROINFLAMMATION
  • 2019-04. Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms in NEUROTOXICITY RESEARCH
  • 2005-06. Preliminary array analysis reveals novel genes regulated by ovarian steroids in the monkey raphe region in PSYCHOPHARMACOLOGY
  • 2012-03. Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis in NEUROPSYCHOPHARMACOLOGY
  • 2016-08. An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation in TRANSLATIONAL PSYCHIATRY
  • 2014-03. The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression in MOLECULAR PSYCHIATRY
  • 2016-12. Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity in SCIENTIFIC REPORTS
  • 2011-10. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor in NATURE
  • 2005-06. Prostaglandin-mediated control of rat brain kynurenic acid synthesis – opposite actions by COX-1 and COX-2 isoforms in JOURNAL OF NEURAL TRANSMISSION
  • 2018-07. Salivary kynurenic acid response to psychological stress: inverse relationship to cortical glutamate in schizophrenia in NEUROPSYCHOPHARMACOLOGY
  • 2017-12. Hopes for the Future of Pain Control in PAIN AND THERAPY
  • 2013-04. Connecting inflammation with glutamate agonism in suicidality in NEUROPSYCHOPHARMACOLOGY
  • 2018-08. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health in NATURE MEDICINE
  • 2013-08. NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice in NEUROPSYCHOPHARMACOLOGY
  • 2016-10. Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation in TRANSLATIONAL PSYCHIATRY
  • 2017-12. Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives in SCIENTIFIC REPORTS
  • 2018-02-16. Depression and obesity: evidence of shared biological mechanisms in MOLECULAR PSYCHIATRY
  • 2012-04. Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine in PSYCHOPHARMACOLOGY
  • 2013-01. Kynurenines in the CNS: recent advances and new questions in NATURE REVIEWS DRUG DISCOVERY
  • 2016-12. Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge in JOURNAL OF NEUROINFLAMMATION
  • Journal

    TITLE

    Molecular Psychiatry

    ISSUE

    N/A

    VOLUME

    N/A

    Author Affiliations

    From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41380-019-0414-4

    DOI

    http://dx.doi.org/10.1038/s41380-019-0414-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113380389

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30980044


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