Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-30

AUTHORS

K. Gapp, G. van Steenwyk, P. L. Germain, W. Matsushima, K. L. M. Rudolph, F. Manuella, M. Roszkowski, G. Vernaz, T. Ghosh, P. Pelczar, I. M. Mansuy, E. A. Miska

ABSTRACT

Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we show that alterations in long RNA in sperm contribute to the inheritance of specific trauma symptoms. Injection of long RNA fraction from sperm of males exposed to postnatal trauma recapitulates the effects on food intake, glucose response to insulin and risk-taking in adulthood whereas the small RNA fraction alters body weight and behavioural despair. Alterations in long RNA are maintained after fertilization, suggesting a direct link between sperm and embryo RNA. More... »

PAGES

2162-2174

References to SciGraph publications

  • 2006-05. RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse in NATURE
  • 2017-03-06. Salmon provides fast and bias-aware quantification of transcript expression in NATURE METHODS
  • 2010-05-16. Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2014-11-18. Early life stress in fathers improves behavioural flexibility in their offspring in NATURE COMMUNICATIONS
  • 2014-08-05. Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress in MOLECULAR PSYCHIATRY
  • 2015-08-17. Intergenerational Transmission of Stress in Humans in NEUROPSYCHOPHARMACOLOGY
  • 2016-06-14. Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring in TRANSLATIONAL PSYCHIATRY
  • 2018-02-05. CRISPR interference-based specific and efficient gene inactivation in the brain in NATURE NEUROSCIENCE
  • 2018-03-08. Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders in MOLECULAR PSYCHIATRY
  • 2004-02-13. Long terminal repeat retrotransposons of Mus musculus in GENOME BIOLOGY
  • 2015-12-14. RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders in SCIENTIFIC REPORTS
  • 2010-02-04. Gene ontology analysis for RNA-seq: accounting for selection bias in GENOME BIOLOGY
  • 2013-02-14. Genome differentiation in a species pair of coregonine fishes: an extremely rapid speciation driven by stress-activated retrotransposons mediating extensive ribosomal DNA multiplications in BMC ECOLOGY AND EVOLUTION
  • 2016-06-09. Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal Trauma in NEUROPSYCHOPHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41380-018-0271-6

    DOI

    http://dx.doi.org/10.1038/s41380-018-0271-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107871591

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30374190


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