Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-30

AUTHORS

K. Gapp, G. van Steenwyk, P. L. Germain, W. Matsushima, K. L. M. Rudolph, F. Manuella, M. Roszkowski, G. Vernaz, T. Ghosh, P. Pelczar, I. M. Mansuy, E. A. Miska

ABSTRACT

Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we show that alterations in long RNA in sperm contribute to the inheritance of specific trauma symptoms. Injection of long RNA fraction from sperm of males exposed to postnatal trauma recapitulates the effects on food intake, glucose response to insulin and risk-taking in adulthood whereas the small RNA fraction alters body weight and behavioural despair. Alterations in long RNA are maintained after fertilization, suggesting a direct link between sperm and embryo RNA. More... »

PAGES

2162-2174

References to SciGraph publications

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  • 2018-03-08. Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders in MOLECULAR PSYCHIATRY
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  • 2015-12-14. RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders in SCIENTIFIC REPORTS
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41380-018-0271-6

    DOI

    http://dx.doi.org/10.1038/s41380-018-0271-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107871591

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30374190


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