Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06-29

AUTHORS

Hidenori Yamasue, Takashi Okada, Toshio Munesue, Miho Kuroda, Toru Fujioka, Yota Uno, Kaori Matsumoto, Hitoshi Kuwabara, Daisuke Mori, Yuko Okamoto, Yuko Yoshimura, Yuki Kawakubo, Yuko Arioka, Masaki Kojima, Teruko Yuhi, Keiho Owada, Walid Yassin, Itaru Kushima, Seico Benner, Nanayo Ogawa, Yosuke Eriguchi, Naoko Kawano, Yukari Uemura, Maeri Yamamoto, Yukiko Kano, Kiyoto Kasai, Haruhiro Higashida, Norio Ozaki, Hirotaka Kosaka

ABSTRACT

Although small-scale studies have described the effects of oxytocin on social deficits in autism spectrum disorder (ASD), no large-scale study has been conducted. In this randomized, parallel-group, multicenter, placebo-controlled, double-blind trial in Japan, 106 ASD individuals (18-48 y.o.) were enrolled between Jan 2015 and March 2016. Participants were randomly assigned to a 6-week intranasal oxytocin (48IU/day, n = 53) or placebo (n = 53) group. One-hundred-three participants were analyzed. Since oxytocin reduced the primary endpoint, Autism Diagnostic Observation Schedule (ADOS) reciprocity, (from 8.5 to 7.7; P < .001) but placebo also reduced the score (8.3 to 7.2; P < .001), no between-group difference was found (effect size -0.08; 95% CI, -0.46 to 0.31; P = .69); however, plasma oxytocin was only elevated from baseline to endpoint in the oxytocin-group compared with the placebo-group (effect size -1.12; -1.53 to -0.70; P < .0001). Among the secondary endpoints, oxytocin reduced ADOS repetitive behavior (2.0 to 1.5; P < .0001) compared with placebo (2.0 to 1.8; P = .43) (effect size 0.44; 0.05 to 0.83; P = .026). In addition, the duration of gaze fixation on socially relevant regions, another secondary endpoint, was increased by oxytocin (41.2 to 52.3; P = .03) compared with placebo (45.7 to 40.4; P = .25) (effect size 0.55; 0.10 to 1.0; P = .018). No significant effects were observed for the other secondary endpoints. No significant difference in the prevalence of adverse events was observed between groups, although one participant experienced temporary gynecomastia during oxytocin administration. Based on the present findings, we cannot recommend continuous intranasal oxytocin treatment alone at the current dose and duration for treatment of the core social symptoms of high-functioning ASD in adult men, although this large-scale trial suggests oxytocin's possibility to treat ASD repetitive behavior. More... »

PAGES

1-10

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41380-018-0097-2

    DOI

    http://dx.doi.org/10.1038/s41380-018-0097-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105107272

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29955161


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    408 schema:name Graduate School of Psychology, Kanazawa Institute of Technology, 7-1 Ohgigaoka, 921-8054, Nonoichi, Japan
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    411 schema:name Research Center for Child Mental Development, Kanazawa University, 13-1 Takara-machi, 920-8640, Kanazawa, Japan
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