Rediscovering the value of families for psychiatric genetics research View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

David C. Glahn, Vishwajit L. Nimgaonkar, Henriette Raventós, Javier Contreras, Andrew M. McIntosh, Pippa A. Thomson, Assen Jablensky, Nina S. McCarthy, Jac C. Charlesworth, Nicholas B. Blackburn, Juan Manuel Peralta, Emma E. M. Knowles, Samuel R. Mathias, Seth A. Ament, Francis J. McMahon, Ruben C. Gur, Maja Bucan, Joanne E. Curran, Laura Almasy, Raquel E. Gur, John Blangero

ABSTRACT

As it is likely that both common and rare genetic variation are important for complex disease risk, studies that examine the full range of the allelic frequency distribution should be utilized to dissect the genetic influences on mental illness. The rate limiting factor for inferring an association between a variant and a phenotype is inevitably the total number of copies of the minor allele captured in the studied sample. For rare variation, with minor allele frequencies of 0.5% or less, very large samples of unrelated individuals are necessary to unambiguously associate a locus with an illness. Unfortunately, such large samples are often cost prohibitive. However, by using alternative analytic strategies and studying related individuals, particularly those from large multiplex families, it is possible to reduce the required sample size while maintaining statistical power. We contend that using whole genome sequence (WGS) in extended pedigrees provides a cost-effective strategy for psychiatric gene mapping that complements common variant approaches and WGS in unrelated individuals. This was our impetus for forming the "Pedigree-Based Whole Genome Sequencing of Affective and Psychotic Disorders" consortium. In this review, we provide a rationale for the use of WGS with pedigrees in modern psychiatric genetics research. We begin with a focused review of the current literature, followed by a short history of family-based research in psychiatry. Next, we describe several advantages of pedigrees for WGS research, including power estimates, methods for studying the environment, and endophenotypes. We conclude with a brief description of our consortium and its goals. More... »

PAGES

523-535

References to SciGraph publications

  • 2011-12. Old lessons learned anew: family-based methods for detecting genes responsible for quantitative and qualitative traits in the Genetic Analysis Workshop 17 mini-exome sequence data in BMC PROCEEDINGS
  • 2016-12. Family-based approaches: design, imputation, analysis, and beyond in BMC GENETICS
  • 2017-11. Genome-wide compound heterozygote analysis highlights alleles associated with adult height in Europeans in HUMAN GENETICS
  • 2012-08. De novo mutations in human genetic disease in NATURE REVIEWS GENETICS
  • 2015-08. The support of human genetic evidence for approved drug indications in NATURE GENETICS
  • 2008-07. Psychiatric genetics: progress amid controversy in NATURE REVIEWS GENETICS
  • 2009-10-08. Finding the missing heritability of complex diseases in NATURE
  • 2016-07. Identification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia in SCIENTIFIC REPORTS
  • 2014-06. Influence of age, sex and genetic factors on the human brain in BRAIN IMAGING AND BEHAVIOR
  • 2017-03. Increased Sensory Processing Atypicalities in Parents of Multiplex ASD Families Versus Typically Developing and Simplex ASD Families in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 2014-11. The contribution of de novo coding mutations to autism spectrum disorder in NATURE
  • 2017-07. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders in NATURE GENETICS
  • 2011-03. Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p in MOLECULAR PSYCHIATRY
  • 2018-05. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression in NATURE GENETICS
  • 2012-10. The role of large pedigrees in an era of high-throughput sequencing in HUMAN GENETICS
  • 2012-10. Sampling strategies for rare variant tests in case–control studies in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2011-09. The functional spectrum of low-frequency coding variation in GENOME BIOLOGY
  • 1989-11. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish in NATURE
  • 2010-06. Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes in MOLECULAR PSYCHIATRY
  • 2017-12. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia in MOLECULAR AUTISM
  • 2012-04-04. De novo mutations revealed by whole-exome sequencing are strongly associated with autism in NATURE
  • 2013-07. Pitfalls of predicting complex traits from SNPs in NATURE REVIEWS GENETICS
  • 2012-03. Differential confounding of rare and common variants in spatially structured populations in NATURE GENETICS
  • 2004-10. The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology in NATURE GENETICS
  • 2010-11-11. The environment and schizophrenia in NATURE
  • 2016-11. Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia in NATURE NEUROSCIENCE
  • 2016-09. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent in NATURE GENETICS
  • 1987-03. Genetic linkage between X-chromosome markers and bipolar affective illness in NATURE
  • 2016-04. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders in NATURE NEUROSCIENCE
  • 2006-09. In silico method for inferring genotypes in pedigrees in NATURE GENETICS
  • 2016-08. Common alleles contribute to schizophrenia in CNV carriers in MOLECULAR PSYCHIATRY
  • 2014-07. Biological insights from 108 schizophrenia-associated genetic loci in NATURE
  • 2017-04-25. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability in MOLECULAR PSYCHIATRY
  • 2016-12. Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness in MOLECULAR PSYCHIATRY
  • 2017-02-01. Rare and low-frequency coding variants alter human adult height in NATURE
  • 2010-06. Uncovering the roles of rare variants in common disease through whole-genome sequencing in NATURE REVIEWS GENETICS
  • 2002-12. Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error? in HUMAN GENETICS
  • 2000-12. Use of population isolates for mapping complex traits in NATURE REVIEWS GENETICS
  • 2006-05. Family-based designs in the age of large-scale gene-association studies in NATURE REVIEWS GENETICS
  • 2008-06. Common and rare variants in multifactorial susceptibility to common diseases in NATURE GENETICS
  • 2001-06. Finding the molecular basis of quatitative traits: successes and pitfalls in NATURE REVIEWS GENETICS
  • 2005-02. Genome-wide association studies for common diseases and complex traits in NATURE REVIEWS GENETICS
  • 2017-01. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder in TRANSLATIONAL PSYCHIATRY
  • 2012-02. Rare and common variants: twenty arguments in NATURE REVIEWS GENETICS
  • 2016-10-12. Genomics is failing on diversity in NATURE
  • 2017-12. Whole genome sequencing in psychiatric disorders: the WGSPD consortium in NATURE NEUROSCIENCE
  • 2009-07-01. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder in NATURE
  • 2011-12. Successful identification of rare variants using oligogenic segregation analysis as a prioritizing tool for whole-exome sequencing studies in BMC PROCEEDINGS
  • 1987-02. Bipolar affective disorders linked to DNA markers on chromosome 11 in NATURE
  • 2017-07. Rare deleterious mutations are associated with disease in bipolar disorder families in MOLECULAR PSYCHIATRY
  • 2010-11. Statistical analysis strategies for association studies involving rare variants in NATURE REVIEWS GENETICS
  • 2005-08. High-throughput pedigree drawing in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2017-12. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses in MOLECULAR AUTISM
  • 2015-12. Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder in BMC GENETICS
  • 2014-11. Synaptic, transcriptional and chromatin genes disrupted in autism in NATURE
  • 2016-11. Translating genome-wide association findings into new therapeutics for psychiatry in NATURE NEUROSCIENCE
  • 2016-03. Weighting sequence variants based on their annotation increases power of whole-genome association studies in NATURE GENETICS
  • 2016-01. Genetic studies in intellectual disability and related disorders in NATURE REVIEWS GENETICS
  • 2014-06. Evaluation of estimated genetic values and their application to genome-wide investigation of systolic blood pressure in BMC PROCEEDINGS
  • 2016-11. Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function in NPJ SCHIZOPHRENIA
  • 2004-12. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology in BMC MEDICINE
  • 2014-02. De novo mutations in schizophrenia implicate synaptic networks in NATURE
  • 2017-08. Truncating mutations in RBM12 are associated with psychosis in NATURE GENETICS
  • 2015-11. An atlas of genetic correlations across human diseases and traits in NATURE GENETICS
  • 2013-10. Family-based association tests for sequence data, and comparisons with population-based association tests in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2014-02. A polygenic burden of rare disruptive mutations in schizophrenia in NATURE
  • 2017-01. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects in NATURE GENETICS
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    http://scigraph.springernature.com/pub.10.1038/s41380-018-0073-x

    DOI

    http://dx.doi.org/10.1038/s41380-018-0073-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105172435

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29955165


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