Genomic analysis of family data reveals additional genetic effects on intelligence and personality View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

W. David Hill, Ruben C. Arslan, Charley Xia, Michelle Luciano, Carmen Amador, Pau Navarro, Caroline Hayward, Reka Nagy, David J. Porteous, Andrew M. McIntosh, Ian J. Deary, Chris S. Haley, Lars Penke

ABSTRACT

Pedigree-based analyses of intelligence have reported that genetic differences account for 50-80% of the phenotypic variation. For personality traits these effects are smaller, with 34-48% of the variance being explained by genetic differences. However, molecular genetic studies using unrelated individuals typically report a heritability estimate of around 30% for intelligence and between 0 and 15% for personality variables. Pedigree-based estimates and molecular genetic estimates may differ because current genotyping platforms are poor at tagging causal variants, variants with low minor allele frequency, copy number variants, and structural variants. Using ~20,000 individuals in the Generation Scotland family cohort genotyped for ~700,000 single-nucleotide polymorphisms (SNPs), we exploit the high levels of linkage disequilibrium (LD) found in members of the same family to quantify the total effect of genetic variants that are not tagged in GWAS of unrelated individuals. In our models, genetic variants in low LD with genotyped SNPs explain over half of the genetic variance in intelligence, education, and neuroticism. By capturing these additional genetic effects our models closely approximate the heritability estimates from twin studies for intelligence and education, but not for neuroticism and extraversion. We then replicated our finding using imputed molecular genetic data from unrelated individuals to show that ~50% of differences in intelligence, and ~40% of the differences in education, can be explained by genetic effects when a larger number of rare SNPs are included. From an evolutionary genetic perspective, a substantial contribution of rare genetic variants to individual differences in intelligence, and education is consistent with mutation-selection balance. More... »

PAGES

2347-2362

References to SciGraph publications

  • 2016-01. The contribution of rare variation to prostate cancer heritability in NATURE GENETICS
  • 2016-10. A reference panel of 64,976 haplotypes for genotype imputation in NATURE GENETICS
  • 2017-12. Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants in GENOME MEDICINE
  • 2012-04. Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion in TRANSLATIONAL PSYCHIATRY
  • 2015-02. Genetics and intelligence differences: five special findings in MOLECULAR PSYCHIATRY
  • 2012-02. A linear complexity phasing method for thousands of genomes in NATURE METHODS
  • 2015-10. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index in NATURE GENETICS
  • 2017-01. The Role of Genes and Environment in Degree of Partner Self-Similarity in BEHAVIOR GENETICS
  • 2015-02. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) in MOLECULAR PSYCHIATRY
  • 2013-05. No Association Between General Cognitive Ability and Rare Copy Number Variation in BEHAVIOR GENETICS
  • 1977-03. Effects of inbreeding on cognitive performance in NATURE
  • 2016-03. Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium in BEHAVIOR GENETICS
  • 2016-06. Physical and neurobehavioral determinants of reproductive onset and success in NATURE GENETICS
  • 2016-09. Phenome-wide analysis of genome-wide polygenic scores in MOLECULAR PSYCHIATRY
  • 2015-07-01. Directional dominance on stature and cognition in diverse human populations in NATURE
  • 2016-12. Genome-wide analysis identifies 12 loci influencing human reproductive behavior in NATURE GENETICS
  • 2017-01. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders in NATURE GENETICS
  • 2016-06. Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci in MOLECULAR PSYCHIATRY
  • 2016-06. Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151) in MOLECULAR PSYCHIATRY
  • 2016-05. Genome-wide association study identifies 74 loci associated with educational attainment in NATURE
  • 2011-10. Genome-wide association studies establish that human intelligence is highly heritable and polygenic in MOLECULAR PSYCHIATRY
  • 2009-01-16. Whole-Genome Genotyping on Bead Arrays in DNA MICROARRAYS FOR BIOMEDICAL RESEARCH
  • 2014-06. Testing the key assumption of heritability estimates based on genome-wide genetic relatedness in JOURNAL OF HUMAN GENETICS
  • 2014-03. The deleterious mutation load is insensitive to recent population history in NATURE GENETICS
  • 2006-12. Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability in BMC MEDICAL GENETICS
  • 2014-03. Genome-wide estimates of inbreeding in unrelated individuals and their association with cognitive ability in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2015-12. Recent genomic heritage in Scotland in BMC GENOMICS
  • 2014-01. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins in TRANSLATIONAL PSYCHIATRY
  • 2001-11. Perceptual Speed and IQ Are Associated Through Common Genetic Factors in BEHAVIOR GENETICS
  • 2015-07. Meta-analysis of the heritability of human traits based on fifty years of twin studies in NATURE GENETICS
  • 2013-12. Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study in BMC MEDICAL GENETICS
  • 2012-05. Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses in MOLECULAR PSYCHIATRY
  • 2010-07. Common SNPs explain a large proportion of the heritability for human height in NATURE GENETICS
  • 2016-02. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease in NATURE NEUROSCIENCE
  • 2013-01. Improved whole-chromosome phasing for disease and population genetic studies in NATURE METHODS
  • 2016-12. Ultra-rare disruptive and damaging mutations influence educational attainment in the general population in NATURE NEUROSCIENCE
  • 2015-11. An atlas of genetic correlations across human diseases and traits in NATURE GENETICS
  • 2016-12. Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions in TRANSLATIONAL PSYCHIATRY
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    http://scigraph.springernature.com/pub.10.1038/s41380-017-0005-1

    DOI

    http://dx.doi.org/10.1038/s41380-017-0005-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100275534

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29321673


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