“Interchangeability” of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-08-05

AUTHORS

Emina Torlakovic, Hyun J. Lim, Julien Adam, Penny Barnes, Gilbert Bigras, Anthony W. H. Chan, Carol C. Cheung, Jin-Haeng Chung, Christian Couture, Pierre O. Fiset, Daichi Fujimoto, Gang Han, Fred R. Hirsch, Marius Ilie, Diana Ionescu, Chao Li, Enrico Munari, Katsuhiro Okuda, Marianne J. Ratcliffe, David L. Rimm, Catherine Ross, Rasmus Røge, Andreas H. Scheel, Ross A. Soo, Paul E. Swanson, Maria Tretiakova, Ka F. To, Gilad W. Vainer, Hangjun Wang, Zhaolin Xu, Dirk Zielinski, Ming-Sound Tsao

ABSTRACT

Different clones, protocol conditions, instruments, and scoring/readout methods may pose challenges in introducing different PD-L1 assays for immunotherapy. The diagnostic accuracy of using different PD-L1 assays interchangeably for various purposes is unknown. The primary objective of this meta-analysis was to address PD-L1 assay interchangeability based on assay diagnostic accuracy for established clinical uses/purposes. A systematic search of the MEDLINE database using PubMed platform was conducted using "PD-L1" as a search term for 01/01/2015 to 31/08/2018, with limitations "English" and "human". 2,515 abstracts were reviewed to select for original contributions only. 57 studies on comparison of two or more PD-L1 assays were fully reviewed. 22 publications were selected for meta-analysis. Additional data were requested from authors of 20/22 studies in order to enable the meta-analysis. Modified GRADE and QUADAS-2 criteria were used for grading published evidence and designing data abstraction templates for extraction by reviewers. PRISMA was used to guide reporting of systematic review and meta-analysis and STARD 2015 for reporting diagnostic accuracy study. CLSI EP12-A2 was used to guide test comparisons. Data were pooled using random-effects model. The main outcome measure was diagnostic accuracy of various PD-L1 assays. The 22 included studies provided 376 2×2 contingency tables for analyses. Results of our study suggest that, when the testing laboratory is not able to use an Food and Drug Administration-approved companion diagnostic(s) for PD-L1 assessment for its specific clinical purpose(s), it is better to develop a properly validated laboratory developed test for the same purpose(s) as the original PD-L1 Food and Drug Administration-approved immunohistochemistry companion diagnostic, than to replace the original PD-L1 Food and Drug Administration-approved immunohistochemistry companion diagnostic with a another PD-L1 Food and Drug Administration-approved companion diagnostic that was developed for a different purpose. More... »

PAGES

4-17

References to SciGraph publications

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  • Journal

    TITLE

    Modern Pathology

    ISSUE

    1

    VOLUME

    33

    Author Affiliations

  • College of Medicine, University of Saskatchewan, Saskatoon, SK Canada
  • Gustave-Roussy Cancer Campus, Villejuif, France
  • Dalhousie University, Halifax, NS Canada
  • Cross Cancer Institute, Edmonton, AB Canada
  • The Chinese University of Hong Kong, New Territories, Hong Kong
  • University of Toronto, Toronto, ON Canada
  • Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do Republic of Korea
  • Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (IUCPQ-UL), Quebec City, QC Canada
  • McGill University Health Science Centre, Montreal, QC Canada
  • Kobe City Medical Center General Hospital, Kobe, Japan
  • School of Public Health, Texas A&M University, College Station, TX USA
  • Center for Thoracic Oncology, Mount Sinai Cancer, Mount Sinai Health System, New York, NY USA
  • Hôpital Pasteur, FHU OncoAge, Biobanque BB-0033-00025, Université Côte d’Azur, CHU de Nice, Nice, France
  • British Columbia Cancer Agency, Vancouver, BC Canada
  • Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian China
  • IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona Italy
  • Nagoya City University Graduate School of Medical Science, Nagoya, Japan
  • Precision Medicine and Genomics, AstraZeneca, Cambridge, UK
  • Yale University School of Medicine, New Haven, CT USA
  • Hamilton Health Sciences, McMaster University, Hamilton, ON Canada
  • Aalborg University Hospital, Aalborg, Denmark
  • University Hospital Cologne, Institute of Pathology, Cologne, Germany
  • National University Hospital, Singapore, Singapore
  • Cumming School of Medicine, University of Calgary, Calgary, AB Canada
  • University of Washington, Seattle, WA USA
  • University Health Network, Toronto, ON Canada
  • Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  • McGill University Health Center and McGill University, Montreal, QC Canada
  • TARGOS Molecular Pathology GmbH, Kassel, Germany
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41379-019-0327-4

    DOI

    http://dx.doi.org/10.1038/s41379-019-0327-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1120128240

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31383961


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