PD-1/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-21

AUTHORS

Ling Li, Ruifang Sun, Yi Miao, Thai Tran, Lisa Adams, Nathan Roscoe, Bing Xu, Ganiraju C. Manyam, Xiaohong Tan, Hongwei Zhang, Min Xiao, Alexandar Tzankov, Carlo Visco, Karen Dybkaer, Govind Bhagat, Wayne Tam, Eric D. Hsi, J. Han van Krieken, Hua You, Jooryung Huh, Maurilio Ponzoni, Andrés J. M. Ferreri, Michael B. Møller, Miguel A. Piris, Mingzhi Zhang, Jane N. Winter, L. Jeffrey Medeiros, George Z. Rassidakis, Christine A. Vaupel, Yong Li, Naveen Dakappagari, Zijun Y. Xu-Monette, Ken H. Young

ABSTRACT

Programmed cell death protein 1/programmed cell death protein ligand1 (PD-1/PD-L1) interaction is an important immune checkpoint targeted by anti-PD-1/PD-L1 immunotherapies. However, the observed prognostic significance of PD-1/PD-L1 expression in diffuse large B-cell lymphoma treated with the standard of care has been inconsistent and even contradictory. To clarify the prognostic role of PD-1/PD-L1 expression and interaction in diffuse large B-cell lymphoma, in this study we used 3-marker fluorescent multiplex immunohistochemistry and Automated Quantitative Analysis Technology to assess the CD3+, PD-L1+, and PD-1+CD3+ expression in diagnostic samples and PD-1/PD-L1 interaction as indicated by presence of PD-1+CD3+ cells in the vicinity of PD-L1+ cells, analyzed their prognostic effects in 414 patients with de novo diffuse large B-cell lymphoma, and examined whether PD-1/PD-L1 interaction is required for the prognostic role of PD-1+/PD-L1+ expression. We found that low T-cell tissue cellularity, tissue PD-L1+ expression (irrespective of cell types), PD-1+CD3+ expression, and PD-1/PD-L1 interaction showed hierarchical adverse prognostic effects in the study cohort. PD-1/PD-L1 interaction showed higher sensitivity and specificity than PD-1+ and PD-L1+ expression in predicting inferior prognosis in patients with high CD3+ tissue cellularity ("hot"/inflammatory tumors). However, both PD-1+ and PD-L1+ expression showed adverse prognostic effects independent of PD-1/PD-L1 interaction, and PD-1/PD-L1 interaction showed favorable prognostic effect in PD-L1+ patients without high CD3+ tissue cellularity. Macrophage function and tumor-cell MYC expression may contribute to the PD-1-independent adverse prognostic effect of PD-L1+ expression. In summary, low T-cell tissue cellularity has unfavorable prognostic impact in diffuse large B-cell lymphoma, and tissue PD-L1+ expression and T-cell-derived PD-1+ expression have significant adverse impact only in patients with high T-cell infiltration. PD-1/PD-L1 interaction in tissue is essential but not always responsible for the inhibitory effect of PD-L1+/PD-1+ expression. These results suggest the benefit of PD-1/PD-L1 blockade therapies only in patients with sufficient T-cell infiltration, and the potential of immunofluorescent assays and Automated Quantitative Analysis in the clinical assessment of PD-1/PD-L1 expression and interaction. More... »

PAGES

1-14

References to SciGraph publications

  • 2017-12. Cytotoxic response against Epstein Barr virus coexists with diffuse large B-cell lymphoma tolerogenic microenvironment: clinical features and survival impact in SCIENTIFIC REPORTS
  • 2001-03. PD-L2 is a second ligand for PD-1 and inhibits T cell activation in NATURE IMMUNOLOGY
  • 2018-01. Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy in NATURE IMMUNOLOGY
  • 2014-11. PD-1 blockade induces responses by inhibiting adaptive immune resistance in NATURE
  • 2010-07-21. Automated Analysis of Tissue Microarrays in TISSUE MICROARRAYS
  • 2014-09. Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma in VIRCHOWS ARCHIV
  • 1999-12. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion in NATURE MEDICINE
  • 2012-09. Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study in LEUKEMIA
  • 2017-04. Soluble programmed death-ligand 1 as a prognostic biomarker for overall survival in patients with diffuse large B-cell lymphoma: a replication study and combined analysis of 508 patients in LEUKEMIA
  • 2017-04-27. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer in NATURE COMMUNICATIONS
  • 2015-12. Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP in MODERN PATHOLOGY
  • 2017-05. Chromatin states define tumour-specific T cell dysfunction and reprogramming in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41379-018-0193-5

    DOI

    http://dx.doi.org/10.1038/s41379-018-0193-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111569928

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30666052


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Ling", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pathology, Shanxi Cancer Hospital, Taiyuan, Shanxi, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sun", 
            "givenName": "Ruifang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miao", 
            "givenName": "Yi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tran", 
            "givenName": "Thai", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adams", 
            "givenName": "Lisa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roscoe", 
            "givenName": "Nathan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Affiliated Hospital of Xiamen University", 
              "id": "https://www.grid.ac/institutes/grid.412625.6", 
              "name": [
                "Department of Hematology, The First Affiliated Hospital of Xiamen University, Fujian, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Bing", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manyam", 
            "givenName": "Ganiraju C.", 
            "id": "sg:person.01171002273.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171002273.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tan", 
            "givenName": "Xiaohong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Hongwei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xiao", 
            "givenName": "Min", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Department of Histopathology, University Hospital of Basel, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tzankov", 
            "givenName": "Alexandar", 
            "id": "sg:person.014451205157.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014451205157.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Bortolo", 
              "id": "https://www.grid.ac/institutes/grid.416303.3", 
              "name": [
                "San Bortolo Hospital, Vicenza, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Visco", 
            "givenName": "Carlo", 
            "id": "sg:person.01151262701.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151262701.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aalborg Hospital", 
              "id": "https://www.grid.ac/institutes/grid.27530.33", 
              "name": [
                "Aalborg University Hospital, Aalborg, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dybkaer", 
            "givenName": "Karen", 
            "id": "sg:person.0643357345.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643357345.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "New York-Presbyterian/Columbia University Medical Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhagat", 
            "givenName": "Govind", 
            "id": "sg:person.01342263612.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342263612.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cornell University", 
              "id": "https://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Weill Cornell Medicine, Cornell University, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tam", 
            "givenName": "Wayne", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Pathology, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hsi", 
            "givenName": "Eric D.", 
            "id": "sg:person.01164244211.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164244211.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radboud University Nijmegen Medical Centre", 
              "id": "https://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Radboud University Medical Centre, Nijmegen, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Krieken", 
            "givenName": "J. Han", 
            "id": "sg:person.013245604437.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245604437.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guangzhou Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410737.6", 
              "name": [
                "Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "You", 
            "givenName": "Hua", 
            "id": "sg:person.0676075730.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676075730.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Asan Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.413967.e", 
              "name": [
                "Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huh", 
            "givenName": "Jooryung", 
            "id": "sg:person.01316416372.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316416372.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "San Raffaele Hospital", 
              "id": "https://www.grid.ac/institutes/grid.18887.3e", 
              "name": [
                "San Raffaele H. Scientific Institute, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ponzoni", 
            "givenName": "Maurilio", 
            "id": "sg:person.01141551130.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141551130.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "San Raffaele Hospital", 
              "id": "https://www.grid.ac/institutes/grid.18887.3e", 
              "name": [
                "San Raffaele H. Scientific Institute, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreri", 
            "givenName": "Andr\u00e9s J. M.", 
            "id": "sg:person.01043423326.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043423326.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Odense University Hospital, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00f8ller", 
            "givenName": "Michael B.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Marqu\u00e9s de Valdecilla University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411325.0", 
              "name": [
                "Marqu\u00e9s de Valdecilla University Hospital, Santander, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piris", 
            "givenName": "Miguel A.", 
            "id": "sg:person.0665360572.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665360572.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Affiliated Hospital of Zhengzhou University", 
              "id": "https://www.grid.ac/institutes/grid.412633.1", 
              "name": [
                "Department of Oncology, The First Affiliated Hospital Zhengzhou University, Zhengzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Mingzhi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winter", 
            "givenName": "Jane N.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Medeiros", 
            "givenName": "L. Jeffrey", 
            "id": "sg:person.01146036343.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146036343.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Karolinska Institutet, Karolinska University Hospital, Solna, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rassidakis", 
            "givenName": "George Z.", 
            "id": "sg:person.01360735515.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360735515.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vaupel", 
            "givenName": "Christine A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Yong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dakappagari", 
            "givenName": "Naveen", 
            "id": "sg:person.01100635635.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100635635.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu-Monette", 
            "givenName": "Zijun Y.", 
            "id": "sg:person.01173704251.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173704251.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at Houston", 
              "id": "https://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
                "Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Young", 
            "givenName": "Ken H.", 
            "id": "sg:person.0643760517.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643760517.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/978-1-60761-806-5_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003156792", 
              "https://doi.org/10.1007/978-1-60761-806-5_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60761-806-5_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003156792", 
              "https://doi.org/10.1007/978-1-60761-806-5_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/70932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005008226", 
              "https://doi.org/10.1038/70932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.07.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006096408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-014-1615-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006234647", 
              "https://doi.org/10.1007/s00428-014-1615-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.11045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008499980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0403342101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011209907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-01-265975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014009443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2016.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018478194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020455470", 
              "https://doi.org/10.1038/nature13954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-10-460063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022690452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaf2807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022846243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2012.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024719201", 
              "https://doi.org/10.1038/leu.2012.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2015-02-629600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026624796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028604363", 
              "https://doi.org/10.1038/85330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028604363", 
              "https://doi.org/10.1038/85330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-10-461848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030681561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032811074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.05.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034397938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2015.65.9789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034760721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1305569110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044541921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac9935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045067225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2007.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048033224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2016.385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048576610", 
              "https://doi.org/10.1038/leu.2016.385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2015.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050601443", 
              "https://doi.org/10.1038/modpathol.2015.118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/2162402x.2015.1026530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058420485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2010/404069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063203312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2016-05-715094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05481.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076153991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.171.8.4156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076576951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2017.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084064539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1620498114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084152922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000006398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084786495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000006398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084786495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085073388", 
              "https://doi.org/10.1038/ncomms15095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085428066", 
              "https://doi.org/10.1038/nature22367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085428066", 
              "https://doi.org/10.1038/nature22367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-11052-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091465507", 
              "https://doi.org/10.1038/s41598-017-11052-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-11052-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091465507", 
              "https://doi.org/10.1038/s41598-017-11052-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2017-03-770719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091618172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2017-07-740993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092595687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41590-017-0004-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093026473", 
              "https://doi.org/10.1038/s41590-017-0004-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2017.01597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093167507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-18-0309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105679519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-18-0309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105679519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1807315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107948495"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-01-21", 
        "datePublishedReg": "2019-01-21", 
        "description": "Programmed cell death protein 1/programmed cell death protein ligand1 (PD-1/PD-L1) interaction is an important immune checkpoint targeted by anti-PD-1/PD-L1 immunotherapies. However, the observed prognostic significance of PD-1/PD-L1 expression in diffuse large B-cell lymphoma treated with the standard of care has been inconsistent and even contradictory. To clarify the prognostic role of PD-1/PD-L1 expression and interaction in diffuse large B-cell lymphoma, in this study we used 3-marker fluorescent multiplex immunohistochemistry and Automated Quantitative Analysis Technology to assess the CD3+, PD-L1+, and PD-1+CD3+ expression in diagnostic samples and PD-1/PD-L1 interaction as indicated by presence of PD-1+CD3+ cells in the vicinity of PD-L1+ cells, analyzed their prognostic effects in 414 patients with de novo diffuse large B-cell lymphoma, and examined whether PD-1/PD-L1 interaction is required for the prognostic role of PD-1+/PD-L1+ expression. We found that low T-cell tissue cellularity, tissue PD-L1+ expression (irrespective of cell types), PD-1+CD3+ expression, and PD-1/PD-L1 interaction showed hierarchical adverse prognostic effects in the study cohort. PD-1/PD-L1 interaction showed higher sensitivity and specificity than PD-1+ and PD-L1+ expression in predicting inferior prognosis in patients with high CD3+ tissue cellularity (\"hot\"/inflammatory tumors). However, both PD-1+ and PD-L1+ expression showed adverse prognostic effects independent of PD-1/PD-L1 interaction, and PD-1/PD-L1 interaction showed favorable prognostic effect in PD-L1+ patients without high CD3+ tissue cellularity. Macrophage function and tumor-cell MYC expression may contribute to the PD-1-independent adverse prognostic effect of PD-L1+ expression. In summary, low T-cell tissue cellularity has unfavorable prognostic impact in diffuse large B-cell lymphoma, and tissue PD-L1+ expression and T-cell-derived PD-1+ expression have significant adverse impact only in patients with high T-cell infiltration. PD-1/PD-L1 interaction in tissue is essential but not always responsible for the inhibitory effect of PD-L1+/PD-1+ expression. These results suggest the benefit of PD-1/PD-L1 blockade therapies only in patients with sufficient T-cell infiltration, and the potential of immunofluorescent assays and Automated Quantitative Analysis in the clinical assessment of PD-1/PD-L1 expression and interaction.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41379-018-0193-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1098208", 
            "issn": [
              "0893-3952", 
              "1530-0285"
            ], 
            "name": "Modern Pathology", 
            "type": "Periodical"
          }
        ], 
        "name": "PD-1/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma having T-cell infiltration: a study from the International DLBCL Consortium Program", 
        "pagination": "1-14", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8da0fc61da67ccca3bde660748677000525938817ad302db1c925dfad53ac5ef"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30666052"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8806605"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41379-018-0193-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111569928"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41379-018-0193-5", 
          "https://app.dimensions.ai/details/publication/pub.1111569928"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:43", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000322_0000000322/records_65005_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41379-018-0193-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0193-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0193-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0193-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0193-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    467 TRIPLES      21 PREDICATES      66 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41379-018-0193-5 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author Nc8b793bda19d41c89774680ea151f2d2
    4 schema:citation sg:pub.10.1007/978-1-60761-806-5_15
    5 sg:pub.10.1007/s00428-014-1615-5
    6 sg:pub.10.1038/70932
    7 sg:pub.10.1038/85330
    8 sg:pub.10.1038/leu.2012.83
    9 sg:pub.10.1038/leu.2016.385
    10 sg:pub.10.1038/modpathol.2015.118
    11 sg:pub.10.1038/nature13954
    12 sg:pub.10.1038/nature22367
    13 sg:pub.10.1038/ncomms15095
    14 sg:pub.10.1038/s41590-017-0004-z
    15 sg:pub.10.1038/s41598-017-11052-z
    16 https://doi.org/10.1002/j.1460-2075.1992.tb05481.x
    17 https://doi.org/10.1016/j.cell.2010.07.044
    18 https://doi.org/10.1016/j.celrep.2017.02.011
    19 https://doi.org/10.1016/j.humpath.2007.11.012
    20 https://doi.org/10.1016/j.humpath.2016.03.005
    21 https://doi.org/10.1016/j.immuni.2007.05.016
    22 https://doi.org/10.1056/nejmoa1807315
    23 https://doi.org/10.1073/pnas.0403342101
    24 https://doi.org/10.1073/pnas.1305569110
    25 https://doi.org/10.1073/pnas.1620498114
    26 https://doi.org/10.1080/2162402x.2015.1026530
    27 https://doi.org/10.1097/md.0000000000006398
    28 https://doi.org/10.1111/his.12882
    29 https://doi.org/10.1126/science.aac9935
    30 https://doi.org/10.1126/science.aaf2807
    31 https://doi.org/10.1155/2010/404069
    32 https://doi.org/10.1158/1078-0432.ccr-18-0309
    33 https://doi.org/10.1182/blood-2010-01-265975
    34 https://doi.org/10.1182/blood-2012-10-460063
    35 https://doi.org/10.1182/blood-2012-10-461848
    36 https://doi.org/10.1182/blood-2015-02-629600
    37 https://doi.org/10.1182/blood-2016-05-715094
    38 https://doi.org/10.1182/blood-2017-03-770719
    39 https://doi.org/10.1182/blood-2017-07-740993
    40 https://doi.org/10.1200/jco.2015.65.9789
    41 https://doi.org/10.18632/oncotarget.11045
    42 https://doi.org/10.3389/fimmu.2017.01597
    43 https://doi.org/10.4049/jimmunol.171.8.4156
    44 schema:datePublished 2019-01-21
    45 schema:datePublishedReg 2019-01-21
    46 schema:description Programmed cell death protein 1/programmed cell death protein ligand1 (PD-1/PD-L1) interaction is an important immune checkpoint targeted by anti-PD-1/PD-L1 immunotherapies. However, the observed prognostic significance of PD-1/PD-L1 expression in diffuse large B-cell lymphoma treated with the standard of care has been inconsistent and even contradictory. To clarify the prognostic role of PD-1/PD-L1 expression and interaction in diffuse large B-cell lymphoma, in this study we used 3-marker fluorescent multiplex immunohistochemistry and Automated Quantitative Analysis Technology to assess the CD3<sup>+</sup>, PD-L1<sup>+</sup>, and PD-1<sup>+</sup>CD3<sup>+</sup> expression in diagnostic samples and PD-1/PD-L1 interaction as indicated by presence of PD-1<sup>+</sup>CD3<sup>+</sup> cells in the vicinity of PD-L1<sup>+</sup> cells, analyzed their prognostic effects in 414 patients with de novo diffuse large B-cell lymphoma, and examined whether PD-1/PD-L1 interaction is required for the prognostic role of PD-1<sup>+</sup>/PD-L1<sup>+</sup> expression. We found that low T-cell tissue cellularity, tissue PD-L1<sup>+</sup> expression (irrespective of cell types), PD-1<sup>+</sup>CD3<sup>+</sup> expression, and PD-1/PD-L1 interaction showed hierarchical adverse prognostic effects in the study cohort. PD-1/PD-L1 interaction showed higher sensitivity and specificity than PD-1<sup>+</sup> and PD-L1<sup>+</sup> expression in predicting inferior prognosis in patients with high CD3<sup>+</sup> tissue cellularity ("hot"/inflammatory tumors). However, both PD-1<sup>+</sup> and PD-L1<sup>+</sup> expression showed adverse prognostic effects independent of PD-1/PD-L1 interaction, and PD-1/PD-L1 interaction showed favorable prognostic effect in PD-L1<sup>+</sup> patients without high CD3<sup>+</sup> tissue cellularity. Macrophage function and tumor-cell MYC expression may contribute to the PD-1-independent adverse prognostic effect of PD-L1<sup>+</sup> expression. In summary, low T-cell tissue cellularity has unfavorable prognostic impact in diffuse large B-cell lymphoma, and tissue PD-L1<sup>+</sup> expression and T-cell-derived PD-1<sup>+</sup> expression have significant adverse impact only in patients with high T-cell infiltration. PD-1/PD-L1 interaction in tissue is essential but not always responsible for the inhibitory effect of PD-L1<sup>+</sup>/PD-1<sup>+</sup> expression. These results suggest the benefit of PD-1/PD-L1 blockade therapies only in patients with sufficient T-cell infiltration, and the potential of immunofluorescent assays and Automated Quantitative Analysis in the clinical assessment of PD-1/PD-L1 expression and interaction.
    47 schema:genre research_article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree false
    50 schema:isPartOf sg:journal.1098208
    51 schema:name PD-1/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma having T-cell infiltration: a study from the International DLBCL Consortium Program
    52 schema:pagination 1-14
    53 schema:productId N02ba2af018ac47fba697d2ffd254c0ed
    54 N304bf23282824322a8c4e13b9c28c8ed
    55 N599d80ca9d27454ab0cb804c606f0468
    56 Naf9a4d627c954ccd910a8bbf1e96893d
    57 Necd874bddda441f6824a60786c00ffa8
    58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111569928
    59 https://doi.org/10.1038/s41379-018-0193-5
    60 schema:sdDatePublished 2019-04-11T08:43
    61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    62 schema:sdPublisher N0d6c74482473484694106d21753a1919
    63 schema:url https://www.nature.com/articles/s41379-018-0193-5
    64 sgo:license sg:explorer/license/
    65 sgo:sdDataset articles
    66 rdf:type schema:ScholarlyArticle
    67 N01e5863b9cd94b68810071c4096daf78 rdf:first sg:person.0676075730.23
    68 rdf:rest N8fca070632d44b7997f39f78347f0d58
    69 N0286f1c6c8d64c95b0b689f6a63eadfd rdf:first sg:person.013245604437.70
    70 rdf:rest N01e5863b9cd94b68810071c4096daf78
    71 N02ba2af018ac47fba697d2ffd254c0ed schema:name dimensions_id
    72 schema:value pub.1111569928
    73 rdf:type schema:PropertyValue
    74 N03f967f989c8428d86248f0aadf4426f schema:affiliation Nb67eddfa3a284632a7563b363707da01
    75 schema:familyName Vaupel
    76 schema:givenName Christine A.
    77 rdf:type schema:Person
    78 N0443ffa58d2a4ca095dd3904c9067399 schema:name Department of Pathology, Shanxi Cancer Hospital, Taiyuan, Shanxi, China
    79 rdf:type schema:Organization
    80 N04ff25c37044468fb643afca256fd352 schema:affiliation Nc52d9326dc0c4dbb86d7f876b4365810
    81 schema:familyName Roscoe
    82 schema:givenName Nathan
    83 rdf:type schema:Person
    84 N09b56c828d25468b86373c4f4a7ea002 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    85 schema:familyName Zhang
    86 schema:givenName Hongwei
    87 rdf:type schema:Person
    88 N0b07fa01834942308078430fa6532b87 rdf:first sg:person.01171002273.18
    89 rdf:rest N724d70576ba24c2098e3edd60337515e
    90 N0d6c74482473484694106d21753a1919 schema:name Springer Nature - SN SciGraph project
    91 rdf:type schema:Organization
    92 N108a064bddc3425ba894ae3734e10a3e rdf:first Ne3d9bcaafba0447c8189f2ef1e67fd7a
    93 rdf:rest N546bc5ddac574a989dbe243b4648503e
    94 N1336ac7c667c4d2881eadd2f924f6bf9 rdf:first N35dea6fa3d7f47549f33e9f69bdc08d1
    95 rdf:rest N7626cd6b3cf84f3c9dfc7e7d9cc229d7
    96 N13fc2d90d7b34c6a960a97ee3ce305f1 rdf:first N6ef7f786716c4c50a67a3bc4062f2de5
    97 rdf:rest N5b7e90bac41c4782b479e84cba90d7d6
    98 N1b031aa60baf47d69309c63e77222dc5 schema:name New York-Presbyterian/Columbia University Medical Center, New York, NY, USA
    99 rdf:type schema:Organization
    100 N1ed03b6c6d624e238fdb49c675dd4b0c schema:affiliation N0443ffa58d2a4ca095dd3904c9067399
    101 schema:familyName Sun
    102 schema:givenName Ruifang
    103 rdf:type schema:Person
    104 N2a5916d0408d489ea3687a7a56b9340d rdf:first N03f967f989c8428d86248f0aadf4426f
    105 rdf:rest N698d1eeb064041d5ba461535a220e904
    106 N304bf23282824322a8c4e13b9c28c8ed schema:name nlm_unique_id
    107 schema:value 8806605
    108 rdf:type schema:PropertyValue
    109 N35dea6fa3d7f47549f33e9f69bdc08d1 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    110 schema:familyName Miao
    111 schema:givenName Yi
    112 rdf:type schema:Person
    113 N3c2ccc71eb5e48f9ae592dbd6649d0fa rdf:first sg:person.01100635635.82
    114 rdf:rest N6677bb05b06c4b90bd4d6e5b97a7894a
    115 N3d4e2e9d27044462ba3664c68a5fdd20 rdf:first sg:person.014451205157.18
    116 rdf:rest Nc3f74193ceb24d28b97805dca04bbaff
    117 N420f20f2dd264541bc80202c1c4a259b rdf:first N1ed03b6c6d624e238fdb49c675dd4b0c
    118 rdf:rest N1336ac7c667c4d2881eadd2f924f6bf9
    119 N468a2d5448d34b928abfc05dd44c887b schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    120 schema:familyName Winter
    121 schema:givenName Jane N.
    122 rdf:type schema:Person
    123 N498d9c0694a949e89b32dece17d0544b schema:affiliation https://www.grid.ac/institutes/grid.412625.6
    124 schema:familyName Xu
    125 schema:givenName Bing
    126 rdf:type schema:Person
    127 N546bc5ddac574a989dbe243b4648503e rdf:first sg:person.0665360572.29
    128 rdf:rest N13fc2d90d7b34c6a960a97ee3ce305f1
    129 N589aa82507d443e6a02052e27fabce31 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    130 schema:familyName Tan
    131 schema:givenName Xiaohong
    132 rdf:type schema:Person
    133 N599d80ca9d27454ab0cb804c606f0468 schema:name doi
    134 schema:value 10.1038/s41379-018-0193-5
    135 rdf:type schema:PropertyValue
    136 N5b7e90bac41c4782b479e84cba90d7d6 rdf:first N468a2d5448d34b928abfc05dd44c887b
    137 rdf:rest N7db5212298b545ea8135dffd43d16a34
    138 N60dd7b90a4ac444e84c0bc26b99d080e rdf:first N8b62832401564ce184e1748f4a9486d8
    139 rdf:rest Nb7f0ab9f60e9426ea5bec9acaf1868af
    140 N661d6cbc43934b6abb1eefc3372d62c7 schema:name Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    141 rdf:type schema:Organization
    142 N6677bb05b06c4b90bd4d6e5b97a7894a rdf:first sg:person.01173704251.04
    143 rdf:rest Naa441da009954828b54e3dcd43d527d4
    144 N698d1eeb064041d5ba461535a220e904 rdf:first Nb42b8b1eff984852864e5859b4a2f167
    145 rdf:rest N3c2ccc71eb5e48f9ae592dbd6649d0fa
    146 N6b317937c6d041b29f7e971871b567a0 rdf:first N04ff25c37044468fb643afca256fd352
    147 rdf:rest N8980f0f95e494555862b56aa4f10e253
    148 N6ef7f786716c4c50a67a3bc4062f2de5 schema:affiliation https://www.grid.ac/institutes/grid.412633.1
    149 schema:familyName Zhang
    150 schema:givenName Mingzhi
    151 rdf:type schema:Person
    152 N724d70576ba24c2098e3edd60337515e rdf:first N589aa82507d443e6a02052e27fabce31
    153 rdf:rest Nedfc574e602f46b6a0c462d1b076b0bb
    154 N7626cd6b3cf84f3c9dfc7e7d9cc229d7 rdf:first Nd5e22213b7c141eb89d404d3392a945a
    155 rdf:rest N80eb4c274d7e48fab65a5dbdb6b5a43a
    156 N7cee8c1070b841268c60695a56a1b51b rdf:first sg:person.01360735515.54
    157 rdf:rest N2a5916d0408d489ea3687a7a56b9340d
    158 N7db5212298b545ea8135dffd43d16a34 rdf:first sg:person.01146036343.46
    159 rdf:rest N7cee8c1070b841268c60695a56a1b51b
    160 N80eb4c274d7e48fab65a5dbdb6b5a43a rdf:first N9838f06fab1f4fb7b43b9f6a6da6ff18
    161 rdf:rest N6b317937c6d041b29f7e971871b567a0
    162 N83e2df5376fc422987e23e88ebfacf4a rdf:first sg:person.0643357345.43
    163 rdf:rest Nbfafc4040206456caae31c7b6450e92e
    164 N842807f298cd42a482d5aadc74f9883d schema:name Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA
    165 rdf:type schema:Organization
    166 N857c8df3279d4aa9a7ab450b30851b7b schema:name Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA
    167 rdf:type schema:Organization
    168 N8980f0f95e494555862b56aa4f10e253 rdf:first N498d9c0694a949e89b32dece17d0544b
    169 rdf:rest N0b07fa01834942308078430fa6532b87
    170 N8b62832401564ce184e1748f4a9486d8 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
    171 schema:familyName Tam
    172 schema:givenName Wayne
    173 rdf:type schema:Person
    174 N8fca070632d44b7997f39f78347f0d58 rdf:first sg:person.01316416372.52
    175 rdf:rest Nb519127629f9440bb57432ae1fd6bec2
    176 N9838f06fab1f4fb7b43b9f6a6da6ff18 schema:affiliation Nfe172853263e4a56a29faa28b07548a6
    177 schema:familyName Adams
    178 schema:givenName Lisa
    179 rdf:type schema:Person
    180 Na83f61f1d6564651b2ecd7905c5135ff schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    181 schema:familyName Xiao
    182 schema:givenName Min
    183 rdf:type schema:Person
    184 Naa441da009954828b54e3dcd43d527d4 rdf:first sg:person.0643760517.35
    185 rdf:rest rdf:nil
    186 Naf9a4d627c954ccd910a8bbf1e96893d schema:name readcube_id
    187 schema:value 8da0fc61da67ccca3bde660748677000525938817ad302db1c925dfad53ac5ef
    188 rdf:type schema:PropertyValue
    189 Nb42b8b1eff984852864e5859b4a2f167 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    190 schema:familyName Li
    191 schema:givenName Yong
    192 rdf:type schema:Person
    193 Nb519127629f9440bb57432ae1fd6bec2 rdf:first sg:person.01141551130.83
    194 rdf:rest Nf0bee29dab774f7e9d5e3ae75b3fb655
    195 Nb67eddfa3a284632a7563b363707da01 schema:name Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA
    196 rdf:type schema:Organization
    197 Nb7f0ab9f60e9426ea5bec9acaf1868af rdf:first sg:person.01164244211.23
    198 rdf:rest N0286f1c6c8d64c95b0b689f6a63eadfd
    199 Nb8cedcde3ee94dcc94d05fb9227345ec schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    200 schema:familyName Li
    201 schema:givenName Ling
    202 rdf:type schema:Person
    203 Nbfafc4040206456caae31c7b6450e92e rdf:first sg:person.01342263612.33
    204 rdf:rest N60dd7b90a4ac444e84c0bc26b99d080e
    205 Nc1a5f8c551a249beaf8b53e06910634c rdf:first Na83f61f1d6564651b2ecd7905c5135ff
    206 rdf:rest N3d4e2e9d27044462ba3664c68a5fdd20
    207 Nc3f74193ceb24d28b97805dca04bbaff rdf:first sg:person.01151262701.09
    208 rdf:rest N83e2df5376fc422987e23e88ebfacf4a
    209 Nc52d9326dc0c4dbb86d7f876b4365810 schema:name Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA
    210 rdf:type schema:Organization
    211 Nc8b793bda19d41c89774680ea151f2d2 rdf:first Nb8cedcde3ee94dcc94d05fb9227345ec
    212 rdf:rest N420f20f2dd264541bc80202c1c4a259b
    213 Nd5e22213b7c141eb89d404d3392a945a schema:affiliation N842807f298cd42a482d5aadc74f9883d
    214 schema:familyName Tran
    215 schema:givenName Thai
    216 rdf:type schema:Person
    217 Ne3d9bcaafba0447c8189f2ef1e67fd7a schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    218 schema:familyName Møller
    219 schema:givenName Michael B.
    220 rdf:type schema:Person
    221 Necd874bddda441f6824a60786c00ffa8 schema:name pubmed_id
    222 schema:value 30666052
    223 rdf:type schema:PropertyValue
    224 Nedfc574e602f46b6a0c462d1b076b0bb rdf:first N09b56c828d25468b86373c4f4a7ea002
    225 rdf:rest Nc1a5f8c551a249beaf8b53e06910634c
    226 Nf0bee29dab774f7e9d5e3ae75b3fb655 rdf:first sg:person.01043423326.91
    227 rdf:rest N108a064bddc3425ba894ae3734e10a3e
    228 Nfe172853263e4a56a29faa28b07548a6 schema:name Navigate BioPharma Services, Inc., a Novartis subsidiary, Carlsbad, CA, USA
    229 rdf:type schema:Organization
    230 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Medical and Health Sciences
    232 rdf:type schema:DefinedTerm
    233 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    234 schema:name Oncology and Carcinogenesis
    235 rdf:type schema:DefinedTerm
    236 sg:journal.1098208 schema:issn 0893-3952
    237 1530-0285
    238 schema:name Modern Pathology
    239 rdf:type schema:Periodical
    240 sg:person.01043423326.91 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
    241 schema:familyName Ferreri
    242 schema:givenName Andrés J. M.
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043423326.91
    244 rdf:type schema:Person
    245 sg:person.01100635635.82 schema:affiliation N857c8df3279d4aa9a7ab450b30851b7b
    246 schema:familyName Dakappagari
    247 schema:givenName Naveen
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100635635.82
    249 rdf:type schema:Person
    250 sg:person.01141551130.83 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
    251 schema:familyName Ponzoni
    252 schema:givenName Maurilio
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141551130.83
    254 rdf:type schema:Person
    255 sg:person.01146036343.46 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    256 schema:familyName Medeiros
    257 schema:givenName L. Jeffrey
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146036343.46
    259 rdf:type schema:Person
    260 sg:person.01151262701.09 schema:affiliation https://www.grid.ac/institutes/grid.416303.3
    261 schema:familyName Visco
    262 schema:givenName Carlo
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151262701.09
    264 rdf:type schema:Person
    265 sg:person.01164244211.23 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    266 schema:familyName Hsi
    267 schema:givenName Eric D.
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164244211.23
    269 rdf:type schema:Person
    270 sg:person.01171002273.18 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    271 schema:familyName Manyam
    272 schema:givenName Ganiraju C.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171002273.18
    274 rdf:type schema:Person
    275 sg:person.01173704251.04 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    276 schema:familyName Xu-Monette
    277 schema:givenName Zijun Y.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173704251.04
    279 rdf:type schema:Person
    280 sg:person.01316416372.52 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
    281 schema:familyName Huh
    282 schema:givenName Jooryung
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316416372.52
    284 rdf:type schema:Person
    285 sg:person.013245604437.70 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
    286 schema:familyName van Krieken
    287 schema:givenName J. Han
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245604437.70
    289 rdf:type schema:Person
    290 sg:person.01342263612.33 schema:affiliation N1b031aa60baf47d69309c63e77222dc5
    291 schema:familyName Bhagat
    292 schema:givenName Govind
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342263612.33
    294 rdf:type schema:Person
    295 sg:person.01360735515.54 schema:affiliation N661d6cbc43934b6abb1eefc3372d62c7
    296 schema:familyName Rassidakis
    297 schema:givenName George Z.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360735515.54
    299 rdf:type schema:Person
    300 sg:person.014451205157.18 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    301 schema:familyName Tzankov
    302 schema:givenName Alexandar
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014451205157.18
    304 rdf:type schema:Person
    305 sg:person.0643357345.43 schema:affiliation https://www.grid.ac/institutes/grid.27530.33
    306 schema:familyName Dybkaer
    307 schema:givenName Karen
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643357345.43
    309 rdf:type schema:Person
    310 sg:person.0643760517.35 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
    311 schema:familyName Young
    312 schema:givenName Ken H.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643760517.35
    314 rdf:type schema:Person
    315 sg:person.0665360572.29 schema:affiliation https://www.grid.ac/institutes/grid.411325.0
    316 schema:familyName Piris
    317 schema:givenName Miguel A.
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665360572.29
    319 rdf:type schema:Person
    320 sg:person.0676075730.23 schema:affiliation https://www.grid.ac/institutes/grid.410737.6
    321 schema:familyName You
    322 schema:givenName Hua
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676075730.23
    324 rdf:type schema:Person
    325 sg:pub.10.1007/978-1-60761-806-5_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003156792
    326 https://doi.org/10.1007/978-1-60761-806-5_15
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1007/s00428-014-1615-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006234647
    329 https://doi.org/10.1007/s00428-014-1615-5
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/70932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005008226
    332 https://doi.org/10.1038/70932
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/85330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028604363
    335 https://doi.org/10.1038/85330
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/leu.2012.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024719201
    338 https://doi.org/10.1038/leu.2012.83
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/leu.2016.385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048576610
    341 https://doi.org/10.1038/leu.2016.385
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/modpathol.2015.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050601443
    344 https://doi.org/10.1038/modpathol.2015.118
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nature13954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020455470
    347 https://doi.org/10.1038/nature13954
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/nature22367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085428066
    350 https://doi.org/10.1038/nature22367
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/ncomms15095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085073388
    353 https://doi.org/10.1038/ncomms15095
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/s41590-017-0004-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1093026473
    356 https://doi.org/10.1038/s41590-017-0004-z
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/s41598-017-11052-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1091465507
    359 https://doi.org/10.1038/s41598-017-11052-z
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1002/j.1460-2075.1992.tb05481.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076153991
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/j.cell.2010.07.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006096408
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/j.celrep.2017.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084064539
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/j.humpath.2007.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048033224
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/j.humpath.2016.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018478194
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/j.immuni.2007.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034397938
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1056/nejmoa1807315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107948495
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1073/pnas.0403342101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011209907
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1073/pnas.1305569110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044541921
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1073/pnas.1620498114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084152922
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1080/2162402x.2015.1026530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058420485
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1097/md.0000000000006398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084786495
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1111/his.12882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032811074
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1126/science.aac9935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045067225
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1126/science.aaf2807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022846243
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1155/2010/404069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063203312
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1158/1078-0432.ccr-18-0309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105679519
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1182/blood-2010-01-265975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014009443
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1182/blood-2012-10-460063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022690452
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1182/blood-2012-10-461848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030681561
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1182/blood-2015-02-629600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026624796
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1182/blood-2016-05-715094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123107
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1182/blood-2017-03-770719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091618172
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1182/blood-2017-07-740993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092595687
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1200/jco.2015.65.9789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034760721
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.18632/oncotarget.11045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008499980
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.3389/fimmu.2017.01597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093167507
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.4049/jimmunol.171.8.4156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076576951
    416 rdf:type schema:CreativeWork
    417 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
    418 schema:name Radboud University Medical Centre, Nijmegen, Netherlands
    419 rdf:type schema:Organization
    420 https://www.grid.ac/institutes/grid.16753.36 schema:alternateName Northwestern University
    421 schema:name Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    422 rdf:type schema:Organization
    423 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
    424 schema:name San Raffaele H. Scientific Institute, Milan, Italy
    425 rdf:type schema:Organization
    426 https://www.grid.ac/institutes/grid.239578.2 schema:alternateName Cleveland Clinic
    427 schema:name Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    428 Department of Pathology, Cleveland Clinic, Cleveland, OH, USA
    429 rdf:type schema:Organization
    430 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    431 schema:name Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    432 Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    433 rdf:type schema:Organization
    434 https://www.grid.ac/institutes/grid.267308.8 schema:alternateName The University of Texas Health Science Center at Houston
    435 schema:name Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    436 Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA
    437 rdf:type schema:Organization
    438 https://www.grid.ac/institutes/grid.27530.33 schema:alternateName Aalborg Hospital
    439 schema:name Aalborg University Hospital, Aalborg, Denmark
    440 rdf:type schema:Organization
    441 https://www.grid.ac/institutes/grid.410567.1 schema:alternateName University Hospital of Basel
    442 schema:name Department of Histopathology, University Hospital of Basel, Basel, Switzerland
    443 rdf:type schema:Organization
    444 https://www.grid.ac/institutes/grid.410737.6 schema:alternateName Guangzhou Medical University
    445 schema:name Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China
    446 rdf:type schema:Organization
    447 https://www.grid.ac/institutes/grid.411325.0 schema:alternateName Marqués de Valdecilla University Hospital
    448 schema:name Marqués de Valdecilla University Hospital, Santander, Spain
    449 rdf:type schema:Organization
    450 https://www.grid.ac/institutes/grid.412625.6 schema:alternateName First Affiliated Hospital of Xiamen University
    451 schema:name Department of Hematology, The First Affiliated Hospital of Xiamen University, Fujian, China
    452 rdf:type schema:Organization
    453 https://www.grid.ac/institutes/grid.412633.1 schema:alternateName First Affiliated Hospital of Zhengzhou University
    454 schema:name Department of Oncology, The First Affiliated Hospital Zhengzhou University, Zhengzhou, China
    455 rdf:type schema:Organization
    456 https://www.grid.ac/institutes/grid.413967.e schema:alternateName Asan Medical Center
    457 schema:name Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    458 rdf:type schema:Organization
    459 https://www.grid.ac/institutes/grid.416303.3 schema:alternateName Ospedale San Bortolo
    460 schema:name San Bortolo Hospital, Vicenza, Italy
    461 rdf:type schema:Organization
    462 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
    463 schema:name Weill Cornell Medicine, Cornell University, New York, NY, USA
    464 rdf:type schema:Organization
    465 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
    466 schema:name Odense University Hospital, Odense, Denmark
    467 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...