Pancreatic cancer arising in the remnant pancreas is not always a relapse of the preceding primary View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11-22

AUTHORS

Claudio Luchini, Antonio Pea, Jun Yu, Jin He, Roberto Salvia, Giulio Riva, Matthew J. Weiss, Claudio Bassi, John L. Cameron, Ralph H. Hruban, Michael Goggins, Christopher L. Wolfgang, Aldo Scarpa, Laura D. Wood, Rita T. Lawlor

ABSTRACT

This study aimed to understand the biology of pancreatic ductal adenocarcinoma that arises in the remnant pancreas after surgical resection of a primary pancreatic ductal adenocarcinoma, using integrated histological and molecular analysis. Patients who underwent a completion pancreatectomy for local recurrence following resection of a primary pancreatic ductal adenocarcinoma were studied with histological analysis and next-generation sequencing of the primary and the recurrent cancer. Of six patients that met the inclusion criteria, three cases were classified as "true" recurrences, i.e., the primary and the cancer in the remnant pancreas shared both morphological features and molecular alterations. Two cases were identified as having independent cancers that exhibited different histological and molecular profiles. In the remaining case, the relationship could not be determined. Pancreatic ductal adenocarcinoma that arises in the remnant pancreas can be either a second primary or a "true" relapse of the preceding primary. The differentiation of second primaries from local recurrences may have important implications for patient management. More... »

PAGES

1-7

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41379-018-0183-7

DOI

http://dx.doi.org/10.1038/s41379-018-0183-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110097244

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30467323


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0183-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0183-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0183-7'


 

This table displays all metadata directly associated to this object as RDF triples.

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