Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11-06

AUTHORS

Cécile Picard, Daniel Orbach, Matthieu Carton, Laurence Brugieres, Karine Renaudin, Sébastien Aubert, Dominique Berrebi, Louise Galmiche, Fanny Dujardin, Pierre Leblond, Cécile Thomas-Teinturier, Frédérique Dijoud

ABSTRACT

The prognosis of malignant pediatric adrenocortical tumors is closely related to disease stage, which is used to guide perioperative treatment recommendations. However, current scoring systems are inadequate to distinguish between benign and malignant adrenocortical tumors. Robust microscopic prognostic features that could help determine perioperative therapy are also lacking. The aim of this national study was to review the prognostic value of the Wieneke scoring criteria and Ki67 labeling index in unselected pediatric adrenocortical tumors. Using strict definitions previously defined by expert pathologists, a Wieneke score was re-attributed to each tumor after an independent and centralized review. In addition, Ki67 proliferation index was performed and reviewed for each case. A total of 95 cases were selected; all were treated between 2000 and 2018 and had histopathologic material and sufficient outcome-related information available. Localized disease was found in 88% of patients. Among those with advanced disease, 6% had tumor extension into adjacent organs and 5% had metastases at diagnosis. Median follow-up was 5 years and 3 months. The 5-year PFS was 82%, 95% CI [73%-91%]. Tumor stage significantly correlated with PFS (p < 0.0001). Tumor weight up to 200 g, extra-adrenal extension and initial non-complete surgical resection were statistically associated with worse outcomes. No recurrences nor metastases occurred when the Ki67 index was < 15%. Up to two of the following five factors including tumor necrosis, adrenal capsular invasion, venous invasion, mitotic count > 15/20 high-power fields, and Ki67 index > 15%, significantly correlated with worse outcomes. We propose a pathological scoring system incorporating the Ki67 index as part of a two-step approach after disease staging to guide adjuvant treatment in pediatric adrenocortical tumors, especially after incomplete resection. These results should be validated in an independent cohort. More... »

PAGES

546-559

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41379-018-0174-8

DOI

http://dx.doi.org/10.1038/s41379-018-0174-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1108037649

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30401946


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospices Civils de Lyon", 
          "id": "https://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Department of Pathology, Groupement Hospitalier Est, Hospices Civils de Lyon, UCBL Lyon 1 University, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Picard", 
        "givenName": "C\u00e9cile", 
        "id": "sg:person.01370263727.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370263727.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "SIREDO Oncology Center, Institut Curie, PSL University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orbach", 
        "givenName": "Daniel", 
        "id": "sg:person.01354414571.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354414571.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Unit\u00e9 de Biom\u00e9trie, DRCI-Ensemble hospitalier, Institut Curie, 92210, Saint-Cloud, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carton", 
        "givenName": "Matthieu", 
        "id": "sg:person.01346404152.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346404152.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "D\u00e9partement de Canc\u00e9rologie de l\u2019Enfant et l\u2019Adolescent, Gustave Roussy Cancer Campus, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brugieres", 
        "givenName": "Laurence", 
        "id": "sg:person.01025544401.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025544401.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Nantes", 
          "id": "https://www.grid.ac/institutes/grid.277151.7", 
          "name": [
            "Department of Pathology, Centre Hospitalier Universitaire de Nantes, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renaudin", 
        "givenName": "Karine", 
        "id": "sg:person.01145014347.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145014347.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Centre de Biologie Pathologie, 59037, Lille Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aubert", 
        "givenName": "S\u00e9bastien", 
        "id": "sg:person.01034504316.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034504316.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Robert Debr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.413235.2", 
          "name": [
            "Department of Pathology, H\u00f4pital Robert Debr\u00e9, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berrebi", 
        "givenName": "Dominique", 
        "id": "sg:person.01056501523.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056501523.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Necker-Enfants Malades Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Department of Pathology, H\u00f4pital Necker, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galmiche", 
        "givenName": "Louise", 
        "id": "sg:person.01077655257.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077655257.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Centre Hospitalier de Tours, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dujardin", 
        "givenName": "Fanny", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Oscar Lambret", 
          "id": "https://www.grid.ac/institutes/grid.452351.4", 
          "name": [
            "Department of Pediatric Oncology, Centre Oscar Lambret, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leblond", 
        "givenName": "Pierre", 
        "id": "sg:person.01304561424.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304561424.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "AP-HP, H\u00f4pitaux Universitaires Paris-Sud, Site Bic\u00eatre, Department of Pediatric Endocrinology, 94270, Le Kremlin-Bic\u00eatre, France", 
            "INSERM UMR 1018, Cancer and Radiation Team, Institut Gustave Roussy, F-94805, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas-Teinturier", 
        "givenName": "C\u00e9cile", 
        "id": "sg:person.0602774003.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602774003.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospices Civils de Lyon", 
          "id": "https://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Department of Pathology, Groupement Hospitalier Est, Hospices Civils de Lyon, UCBL Lyon 1 University, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dijoud", 
        "givenName": "Fr\u00e9d\u00e9rique", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1037/h0026256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001724590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200307000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004109461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200307000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004109461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200307000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004109461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2013.230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005541174", 
          "https://doi.org/10.1038/modpathol.2013.230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010349104", 
          "https://doi.org/10.1038/modpathol.3800160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010349104", 
          "https://doi.org/10.1038/modpathol.3800160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.08.085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011001954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198403000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013121578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198403000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013121578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpedsurg.2016.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017912030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198903000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019442101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198903000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019442101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00383-015-3708-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020490450", 
          "https://doi.org/10.1007/s00383-015-3708-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.26368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021846910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19991015)86:8<1583::aid-cncr28>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021850442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2011.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022690047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2013-3020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026764102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.161479898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030767494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000180645.89054.fd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031104515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fendo.2015.00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031149696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2011.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032202841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0004-27302004000500009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035320845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19860601)57:11<2235::aid-cncr2820571127>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038078701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041176543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1450335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041595071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1450335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041595071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1450335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041595071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2350/08-06-0489.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047013260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2350/08-06-0489.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047013260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpedsurg.2014.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047180069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2004.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050672079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biomet/80.1.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059420374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2014-3182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064295455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.82.7.2027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064299675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074741682", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077103133", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1684/bdc.2011.1357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078399376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00383-017-4073-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084021309", 
          "https://doi.org/10.1007/s00383-017-4073-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00383-017-4073-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084021309", 
          "https://doi.org/10.1007/s00383-017-4073-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.74.2460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092329966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.13255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099665329"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-11-06", 
    "datePublishedReg": "2018-11-06", 
    "description": "The prognosis of malignant pediatric adrenocortical tumors is closely related to disease stage, which is used to guide perioperative treatment recommendations. However, current scoring systems are inadequate to distinguish between benign and malignant adrenocortical tumors. Robust microscopic prognostic features that could help determine perioperative therapy are also lacking. The aim of this national study was to review the prognostic value of the Wieneke scoring criteria and Ki67 labeling index in unselected pediatric adrenocortical tumors. Using strict definitions previously defined by expert pathologists, a Wieneke score was re-attributed to each tumor after an independent and centralized review. In addition, Ki67 proliferation index was performed and reviewed for each case. A total of 95 cases were selected; all were treated between 2000 and 2018 and had histopathologic material and sufficient outcome-related information available. Localized disease was found in 88% of patients. Among those with advanced disease, 6% had tumor extension into adjacent organs and 5% had metastases at diagnosis. Median follow-up was 5 years and 3 months. The 5-year PFS was 82%, 95% CI [73%-91%]. Tumor stage significantly correlated with PFS (p\u2009<\u20090.0001). Tumor weight up to 200\u2009g, extra-adrenal extension and initial non-complete surgical resection were statistically associated with worse outcomes. No recurrences nor metastases occurred when the Ki67 index was <\u200915%. Up to two of the following five factors including tumor necrosis, adrenal capsular invasion, venous invasion, mitotic count >\u200915/20 high-power fields, and Ki67 index >\u200915%, significantly correlated with worse outcomes. We propose a pathological scoring system incorporating the Ki67 index as part of a two-step approach after disease staging to guide adjuvant treatment in pediatric adrenocortical tumors, especially after incomplete resection. These results should be validated in an independent cohort.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41379-018-0174-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological review", 
    "pagination": "546-559", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "706911200e651bab52a529d79051aabdb3e89bfd57e2497f7216be3863accea9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30401946"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41379-018-0174-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1108037649"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41379-018-0174-8", 
      "https://app.dimensions.ai/details/publication/pub.1108037649"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78938_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41379-018-0174-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0174-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0174-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0174-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0174-8'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      61 URIs      20 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41379-018-0174-8 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N671d984d873c4e10955d02b442cc53a0
4 schema:citation sg:pub.10.1007/s00383-015-3708-x
5 sg:pub.10.1007/s00383-017-4073-8
6 sg:pub.10.1038/modpathol.2013.230
7 sg:pub.10.1038/modpathol.3800160
8 https://app.dimensions.ai/details/publication/pub.1074741682
9 https://app.dimensions.ai/details/publication/pub.1077103133
10 https://doi.org/10.1002/(sici)1097-0142(19991015)86:8<1583::aid-cncr28>3.0.co;2-#
11 https://doi.org/10.1002/1097-0142(19860601)57:11<2235::aid-cncr2820571127>3.0.co;2-o
12 https://doi.org/10.1002/cncr.23886
13 https://doi.org/10.1002/pbc.26368
14 https://doi.org/10.1016/j.ejca.2004.01.031
15 https://doi.org/10.1016/j.humpath.2011.04.016
16 https://doi.org/10.1016/j.jpedsurg.2014.03.006
17 https://doi.org/10.1016/j.jpedsurg.2016.07.014
18 https://doi.org/10.1016/j.mce.2011.10.015
19 https://doi.org/10.1037/h0026256
20 https://doi.org/10.1073/pnas.161479898
21 https://doi.org/10.1093/biomet/80.1.27
22 https://doi.org/10.1097/00000478-198403000-00001
23 https://doi.org/10.1097/00000478-198903000-00004
24 https://doi.org/10.1097/00000478-200307000-00001
25 https://doi.org/10.1097/01.ju.0000180645.89054.fd
26 https://doi.org/10.1111/his.13255
27 https://doi.org/10.1200/jco.2004.08.085
28 https://doi.org/10.1200/jco.2017.74.2460
29 https://doi.org/10.1210/jc.2013-3020
30 https://doi.org/10.1210/jc.2014-3182
31 https://doi.org/10.1210/jc.82.7.2027
32 https://doi.org/10.1530/eje.0.1450335
33 https://doi.org/10.1590/s0004-27302004000500009
34 https://doi.org/10.1684/bdc.2011.1357
35 https://doi.org/10.2350/08-06-0489.1
36 https://doi.org/10.3389/fendo.2015.00023
37 schema:datePublished 2018-11-06
38 schema:datePublishedReg 2018-11-06
39 schema:description The prognosis of malignant pediatric adrenocortical tumors is closely related to disease stage, which is used to guide perioperative treatment recommendations. However, current scoring systems are inadequate to distinguish between benign and malignant adrenocortical tumors. Robust microscopic prognostic features that could help determine perioperative therapy are also lacking. The aim of this national study was to review the prognostic value of the Wieneke scoring criteria and Ki67 labeling index in unselected pediatric adrenocortical tumors. Using strict definitions previously defined by expert pathologists, a Wieneke score was re-attributed to each tumor after an independent and centralized review. In addition, Ki67 proliferation index was performed and reviewed for each case. A total of 95 cases were selected; all were treated between 2000 and 2018 and had histopathologic material and sufficient outcome-related information available. Localized disease was found in 88% of patients. Among those with advanced disease, 6% had tumor extension into adjacent organs and 5% had metastases at diagnosis. Median follow-up was 5 years and 3 months. The 5-year PFS was 82%, 95% CI [73%-91%]. Tumor stage significantly correlated with PFS (p < 0.0001). Tumor weight up to 200 g, extra-adrenal extension and initial non-complete surgical resection were statistically associated with worse outcomes. No recurrences nor metastases occurred when the Ki67 index was < 15%. Up to two of the following five factors including tumor necrosis, adrenal capsular invasion, venous invasion, mitotic count > 15/20 high-power fields, and Ki67 index > 15%, significantly correlated with worse outcomes. We propose a pathological scoring system incorporating the Ki67 index as part of a two-step approach after disease staging to guide adjuvant treatment in pediatric adrenocortical tumors, especially after incomplete resection. These results should be validated in an independent cohort.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree false
43 schema:isPartOf N48d777c18005419fb9023381a6efad90
44 Nc1ac53b39e9646d48fa6a53d3a664221
45 sg:journal.1098208
46 schema:name Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological review
47 schema:pagination 546-559
48 schema:productId N2db70e32aa2c49c583dbca5e58535052
49 N485380dd172f4c84b43763a6d60b0ab8
50 N661b40a7b75846ed962345027fa5c904
51 N6c3dfb314ecd495b92ad919e8780912a
52 N9e5ef96829884f4bb4520b83816e0fe6
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1108037649
54 https://doi.org/10.1038/s41379-018-0174-8
55 schema:sdDatePublished 2019-04-11T13:18
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N1e51ff472efd4397b4690aac78c7b69f
58 schema:url https://www.nature.com/articles/s41379-018-0174-8
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N1e51ff472efd4397b4690aac78c7b69f schema:name Springer Nature - SN SciGraph project
63 rdf:type schema:Organization
64 N275f9308350a4bf0aff27e83b978f620 rdf:first Nfe7a00da803a4af383abddcd02a2d78c
65 rdf:rest rdf:nil
66 N2db70e32aa2c49c583dbca5e58535052 schema:name doi
67 schema:value 10.1038/s41379-018-0174-8
68 rdf:type schema:PropertyValue
69 N2ed93e926ce24f23b96ab7fe252d4d5d schema:name Department of Pathology, Centre Hospitalier de Tours, Tours, France
70 rdf:type schema:Organization
71 N393d1e5a7bbb46398fdc9c7a57980123 rdf:first sg:person.01145014347.22
72 rdf:rest Nbee52bdb1bc549fea7d59b75c8c1f638
73 N46cc93766c6841b5b5785b7c8822e13a rdf:first sg:person.01025544401.42
74 rdf:rest N393d1e5a7bbb46398fdc9c7a57980123
75 N485380dd172f4c84b43763a6d60b0ab8 schema:name pubmed_id
76 schema:value 30401946
77 rdf:type schema:PropertyValue
78 N48d777c18005419fb9023381a6efad90 schema:issueNumber 4
79 rdf:type schema:PublicationIssue
80 N4abe2480f4b648429dffa5dc68969d48 rdf:first sg:person.01304561424.72
81 rdf:rest N93998dea3def48c9ab893b6e125b3a30
82 N4b14c7903b7a442fbdafa35d91549c42 schema:affiliation N2ed93e926ce24f23b96ab7fe252d4d5d
83 schema:familyName Dujardin
84 schema:givenName Fanny
85 rdf:type schema:Person
86 N661b40a7b75846ed962345027fa5c904 schema:name dimensions_id
87 schema:value pub.1108037649
88 rdf:type schema:PropertyValue
89 N671d984d873c4e10955d02b442cc53a0 rdf:first sg:person.01370263727.24
90 rdf:rest Ncaec5e08b27f4972be15f3c71f1c837a
91 N6c3dfb314ecd495b92ad919e8780912a schema:name nlm_unique_id
92 schema:value 8806605
93 rdf:type schema:PropertyValue
94 N93998dea3def48c9ab893b6e125b3a30 rdf:first sg:person.0602774003.14
95 rdf:rest N275f9308350a4bf0aff27e83b978f620
96 N9e5ef96829884f4bb4520b83816e0fe6 schema:name readcube_id
97 schema:value 706911200e651bab52a529d79051aabdb3e89bfd57e2497f7216be3863accea9
98 rdf:type schema:PropertyValue
99 Na14d0588993248779cf37c79766b0dcd schema:name Department of Pathology, Centre de Biologie Pathologie, 59037, Lille Cedex, France
100 rdf:type schema:Organization
101 Naafbe35c763948d6849122ffd51950f6 rdf:first sg:person.01346404152.58
102 rdf:rest N46cc93766c6841b5b5785b7c8822e13a
103 Nab0047e6d544486a9df1d3d886434229 rdf:first sg:person.01077655257.05
104 rdf:rest Nb10d9b26f6fc4690b780b90059c02111
105 Nb10d9b26f6fc4690b780b90059c02111 rdf:first N4b14c7903b7a442fbdafa35d91549c42
106 rdf:rest N4abe2480f4b648429dffa5dc68969d48
107 Nb3e2706f1a124ca9bf3f8c2b529a918f rdf:first sg:person.01056501523.20
108 rdf:rest Nab0047e6d544486a9df1d3d886434229
109 Nbee52bdb1bc549fea7d59b75c8c1f638 rdf:first sg:person.01034504316.92
110 rdf:rest Nb3e2706f1a124ca9bf3f8c2b529a918f
111 Nc1ac53b39e9646d48fa6a53d3a664221 schema:volumeNumber 32
112 rdf:type schema:PublicationVolume
113 Ncaec5e08b27f4972be15f3c71f1c837a rdf:first sg:person.01354414571.52
114 rdf:rest Naafbe35c763948d6849122ffd51950f6
115 Nfe7a00da803a4af383abddcd02a2d78c schema:affiliation https://www.grid.ac/institutes/grid.413852.9
116 schema:familyName Dijoud
117 schema:givenName Frédérique
118 rdf:type schema:Person
119 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
120 schema:name Medical and Health Sciences
121 rdf:type schema:DefinedTerm
122 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
123 schema:name Clinical Sciences
124 rdf:type schema:DefinedTerm
125 sg:journal.1098208 schema:issn 0893-3952
126 1530-0285
127 schema:name Modern Pathology
128 rdf:type schema:Periodical
129 sg:person.01025544401.42 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
130 schema:familyName Brugieres
131 schema:givenName Laurence
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025544401.42
133 rdf:type schema:Person
134 sg:person.01034504316.92 schema:affiliation Na14d0588993248779cf37c79766b0dcd
135 schema:familyName Aubert
136 schema:givenName Sébastien
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034504316.92
138 rdf:type schema:Person
139 sg:person.01056501523.20 schema:affiliation https://www.grid.ac/institutes/grid.413235.2
140 schema:familyName Berrebi
141 schema:givenName Dominique
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056501523.20
143 rdf:type schema:Person
144 sg:person.01077655257.05 schema:affiliation https://www.grid.ac/institutes/grid.412134.1
145 schema:familyName Galmiche
146 schema:givenName Louise
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077655257.05
148 rdf:type schema:Person
149 sg:person.01145014347.22 schema:affiliation https://www.grid.ac/institutes/grid.277151.7
150 schema:familyName Renaudin
151 schema:givenName Karine
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145014347.22
153 rdf:type schema:Person
154 sg:person.01304561424.72 schema:affiliation https://www.grid.ac/institutes/grid.452351.4
155 schema:familyName Leblond
156 schema:givenName Pierre
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304561424.72
158 rdf:type schema:Person
159 sg:person.01346404152.58 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
160 schema:familyName Carton
161 schema:givenName Matthieu
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346404152.58
163 rdf:type schema:Person
164 sg:person.01354414571.52 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
165 schema:familyName Orbach
166 schema:givenName Daniel
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354414571.52
168 rdf:type schema:Person
169 sg:person.01370263727.24 schema:affiliation https://www.grid.ac/institutes/grid.413852.9
170 schema:familyName Picard
171 schema:givenName Cécile
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370263727.24
173 rdf:type schema:Person
174 sg:person.0602774003.14 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
175 schema:familyName Thomas-Teinturier
176 schema:givenName Cécile
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602774003.14
178 rdf:type schema:Person
179 sg:pub.10.1007/s00383-015-3708-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020490450
180 https://doi.org/10.1007/s00383-015-3708-x
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/s00383-017-4073-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084021309
183 https://doi.org/10.1007/s00383-017-4073-8
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/modpathol.2013.230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005541174
186 https://doi.org/10.1038/modpathol.2013.230
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/modpathol.3800160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010349104
189 https://doi.org/10.1038/modpathol.3800160
190 rdf:type schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1074741682 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1077103133 schema:CreativeWork
193 https://doi.org/10.1002/(sici)1097-0142(19991015)86:8<1583::aid-cncr28>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1021850442
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1002/1097-0142(19860601)57:11<2235::aid-cncr2820571127>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1038078701
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1002/cncr.23886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041176543
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/pbc.26368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021846910
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.ejca.2004.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050672079
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.humpath.2011.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032202841
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.jpedsurg.2014.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047180069
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.jpedsurg.2016.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017912030
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.mce.2011.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022690047
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1037/h0026256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001724590
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1073/pnas.161479898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030767494
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/biomet/80.1.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059420374
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1097/00000478-198403000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013121578
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1097/00000478-198903000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019442101
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1097/00000478-200307000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004109461
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1097/01.ju.0000180645.89054.fd schema:sameAs https://app.dimensions.ai/details/publication/pub.1031104515
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1111/his.13255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099665329
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1200/jco.2004.08.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011001954
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1200/jco.2017.74.2460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092329966
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1210/jc.2013-3020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026764102
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1210/jc.2014-3182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064295455
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1210/jc.82.7.2027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064299675
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1530/eje.0.1450335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041595071
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1590/s0004-27302004000500009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035320845
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1684/bdc.2011.1357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078399376
242 rdf:type schema:CreativeWork
243 https://doi.org/10.2350/08-06-0489.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047013260
244 rdf:type schema:CreativeWork
245 https://doi.org/10.3389/fendo.2015.00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031149696
246 rdf:type schema:CreativeWork
247 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
248 schema:name AP-HP, Hôpitaux Universitaires Paris-Sud, Site Bicêtre, Department of Pediatric Endocrinology, 94270, Le Kremlin-Bicêtre, France
249 Département de Cancérologie de l’Enfant et l’Adolescent, Gustave Roussy Cancer Campus, Villejuif, France
250 INSERM UMR 1018, Cancer and Radiation Team, Institut Gustave Roussy, F-94805, Villejuif, France
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.277151.7 schema:alternateName Centre Hospitalier Universitaire de Nantes
253 schema:name Department of Pathology, Centre Hospitalier Universitaire de Nantes, Nantes, France
254 rdf:type schema:Organization
255 https://www.grid.ac/institutes/grid.412134.1 schema:alternateName Necker-Enfants Malades Hospital
256 schema:name Department of Pathology, Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Paris, France
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.413235.2 schema:alternateName Hôpital Robert Debré
259 schema:name Department of Pathology, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Paris, France
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.413852.9 schema:alternateName Hospices Civils de Lyon
262 schema:name Department of Pathology, Groupement Hospitalier Est, Hospices Civils de Lyon, UCBL Lyon 1 University, Lyon, France
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
265 schema:name SIREDO Oncology Center, Institut Curie, PSL University, Paris, France
266 Unité de Biométrie, DRCI-Ensemble hospitalier, Institut Curie, 92210, Saint-Cloud, France
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.452351.4 schema:alternateName Centre Oscar Lambret
269 schema:name Department of Pediatric Oncology, Centre Oscar Lambret, Lille, France
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...