Transcriptional analysis distinguishes breast implant-associated anaplastic large cell lymphoma from other peripheral T-cell lymphomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-11

AUTHORS

Arianna Di Napoli, Loris De Cecco, Pier Paolo Piccaluga, Mohsen Navari, Valeria Cancila, Claudia Cippitelli, Giuseppina Pepe, Gianluca Lopez, Francesca Monardo, Antonella Bianchi, Emanuele Stefano Giovanni D’Amore, Umberto Gianelli, Fabio Facchetti, Emilio Berti, Govind Bhagat

ABSTRACT

Breast implant-associated anaplastic large cell lymphoma is a new provisional entity in the revised World Health Organization classification of lymphoid malignancies, the pathogenesis and cell of origin of which are still unknown. We performed gene expression profiling of microdissected breast implant-associated anaplastic large cell lymphoma samples and compared their transcriptional profiles with those previously obtained from normal T-cells and other peripheral T-cell lymphomas and validated expression of selected markers by immunohistochemistry. Our results indicate that most breast implant-associated anaplastic large cell lymphomas exhibit an activated CD4+ memory T-cell phenotype, which is associated with CD25 and FoxP3 expression. Gene ontology analyses revealed upregulation of genes involved in cell motility programs (e.g., CCR6, MET, HGF, CXCL14) in breast implant-associated anaplastic large cell lymphomas compared to normal CD4+ T-cells and upregulation of genes involved in myeloid cell differentiation (e.g., PPARg, JAK2, SPI-1, GAB2) and viral gene transcription (e.g., RPS10, RPL17, RPS29, RPL18A) compared to other types of peripheral T-cell lymphomas. Gene set enrichment analyses also revealed shared features between the molecular profiles of breast implant-associated anaplastic large cell lymphomas and other types of anaplastic large cell lymphomas, including downregulation of T-cell receptor signaling and STAT3 activation. Our findings provide novel insights into the biology of this rare disease and further evidence that breast implant-associated anaplastic large cell lymphoma represents a distinct peripheral T-cell lymphoma entity. More... »

PAGES

1-15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41379-018-0130-7

DOI

http://dx.doi.org/10.1038/s41379-018-0130-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106906184

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30206415


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