Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-28

AUTHORS

Islam M. Miligy, Kylie L. Gorringe, Michael S. Toss, Abdulbaqi A. Al-Kawaz, Peter Simpson, Maria Diez-Rodriguez, Christopher C. Nolan, Ian O. Ellis, Andrew R. Green, Emad A. Rakha

ABSTRACT

Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behavior, but they are insufficient to define high-risk patients for disease progression precisely. Thioredoxin-interacting protein (TXNIP) is a key player of oxidative stress. This study aims to evaluate the role of TXNIP as a predictor of ductal carcinoma in situ progression. Tissue microarrays from 776 pure ductal carcinoma in situ and 239 mixed ductal carcinoma in situ and invasive tumors were constructed. All patients were treated at a single institution with a long-term follow-up and TXNIP expression was assessed using immunohistochemistry. TXNIP expression was investigated in terms of associations with clinicopathological and molecular features and patient outcome. Loss/reduced cytoplasmic expression of TXNIP was associated with features of aggressiveness including high nuclear grade (p = 1.6 × 10-5), presence of comedo necrosis (p = 0.001), and estrogen receptor negative (ER-)/HER2- ductal carcinoma in situ (p = 4.6 × 10-5). Univariate analysis showed an inverse association between TXNIP expression and outcome in terms of shorter local recurrence-free survival (p = 0.009). Multivariable analyses showed that independent predictors of ductal carcinoma in situ recurrence were low TXNIP expression (p = 0.005, HR = 0.51, and 95% CI: 0.32-0.81), larger ductal carcinoma in situ size, and high nuclear grade. TXNIP functions as a tumor suppressor gene with loss of its expression associated with ductal carcinoma in situ recurrence. TXNIP can be used as a potentially useful marker in prognostic stratification of ductal carcinoma in situ for management decisions. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7

DOI

http://dx.doi.org/10.1038/s41379-018-0086-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105172581

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29955142


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Menoufia University", 
          "id": "https://www.grid.ac/institutes/grid.411775.1", 
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK", 
            "Histopathology Department, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miligy", 
        "givenName": "Islam M.", 
        "id": "sg:person.01144652371.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144652371.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Cancer Genomics Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia", 
            "The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gorringe", 
        "givenName": "Kylie L.", 
        "id": "sg:person.01005547451.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005547451.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assiut University", 
          "id": "https://www.grid.ac/institutes/grid.252487.e", 
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK", 
            "Histopathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toss", 
        "givenName": "Michael S.", 
        "id": "sg:person.012771505765.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771505765.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Al-Kawaz", 
        "givenName": "Abdulbaqi A.", 
        "id": "sg:person.012150651354.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012150651354.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simpson", 
        "givenName": "Peter", 
        "id": "sg:person.01355116121.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355116121.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diez-Rodriguez", 
        "givenName": "Maria", 
        "id": "sg:person.01040530365.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040530365.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nolan", 
        "givenName": "Christopher C.", 
        "id": "sg:person.01217144077.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217144077.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellis", 
        "givenName": "Ian O.", 
        "id": "sg:person.01054612302.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Green", 
        "givenName": "Andrew R.", 
        "id": "sg:person.016416665412.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416665412.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Menoufia University", 
          "id": "https://www.grid.ac/institutes/grid.411775.1", 
          "name": [
            "Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK", 
            "Histopathology Department, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rakha", 
        "givenName": "Emad A.", 
        "id": "sg:person.0743637501.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743637501.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2016.67.8532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001246088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601910389604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002428283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601910389604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002428283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2011.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003235897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2014.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003760394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-016-3862-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005699008", 
          "https://doi.org/10.1007/s10549-016-3862-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-016-3862-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005699008", 
          "https://doi.org/10.1007/s10549-016-3862-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2007.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010981335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2014-202571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012178962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014607335", 
          "https://doi.org/10.1038/nature10983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4048/jbc.2016.19.2.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018698869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2012.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023910261", 
          "https://doi.org/10.1038/modpathol.2012.60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/ajcp4m2vuzcldaln", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024749332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.182372299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025936051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bsr20130077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026047312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djp485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027158115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-13-62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027351284", 
          "https://doi.org/10.1186/1476-4598-13-62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030125540", 
          "https://doi.org/10.1038/onc.2011.102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030683885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mito.2012.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030860654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031102903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-02-0487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032924511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgr137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032945745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2013.00514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033458549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2015.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034531596", 
          "https://doi.org/10.1038/modpathol.2015.75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jop.777003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038031406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djt067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038235824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.3096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043013837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044575386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/0022155415576540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045174769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/0022155415576540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045174769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047674609", 
          "https://doi.org/10.1038/sj.onc.1209394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047674609", 
          "https://doi.org/10.1038/sj.onc.1209394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.110.209643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048294649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.110.209643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048294649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048973885", 
          "https://doi.org/10.1186/bcr2228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052881095", 
          "https://doi.org/10.1186/1471-2407-10-653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2012.4650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059231889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1184003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062461378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1184003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062461378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4149/bll_2014_088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072260469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075116301", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075223352", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077510707", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081725012", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2017.5577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084953152"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-06-28", 
    "datePublishedReg": "2018-06-28", 
    "description": "Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behavior, but they are insufficient to define high-risk patients for disease progression precisely. Thioredoxin-interacting protein (TXNIP) is a key player of oxidative stress. This study aims to evaluate the role of TXNIP as a predictor of ductal carcinoma in situ progression. Tissue microarrays from 776 pure ductal carcinoma in situ and 239 mixed ductal carcinoma in situ and invasive tumors were constructed. All patients were treated at a single institution with a long-term follow-up and TXNIP expression was assessed using immunohistochemistry. TXNIP expression was investigated in terms of associations with clinicopathological and molecular features and patient outcome. Loss/reduced cytoplasmic expression of TXNIP was associated with features of aggressiveness including high nuclear grade (p\u2009=\u20091.6\u2009\u00d7\u200910-5), presence of comedo necrosis (p\u2009=\u20090.001), and estrogen receptor negative (ER-)/HER2- ductal carcinoma in situ (p\u2009=\u20094.6\u2009\u00d7\u200910-5). Univariate analysis showed an inverse association between TXNIP expression and outcome in terms of shorter local recurrence-free survival (p\u2009=\u20090.009). Multivariable analyses showed that independent predictors of ductal carcinoma in situ recurrence were low TXNIP expression (p\u2009=\u20090.005, HR\u2009=\u20090.51, and 95% CI: 0.32-0.81), larger ductal carcinoma in situ size, and high nuclear grade. TXNIP functions as a tumor suppressor gene with loss of its expression associated with ductal carcinoma in situ recurrence. TXNIP can be used as a potentially useful marker in prognostic stratification of ductal carcinoma in situ for management decisions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41379-018-0086-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }
    ], 
    "name": "Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "86112f10744454cd90dc6860afb28d76f09969aec8f824b34b55853916d7020f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29955142"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41379-018-0086-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105172581"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41379-018-0086-7", 
      "https://app.dimensions.ai/details/publication/pub.1105172581"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000566.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41379-018-0086-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      66 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41379-018-0086-7 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nbd3e5e49e5e04aa688317089685d89f7
4 schema:citation sg:pub.10.1007/s10549-016-3862-4
5 sg:pub.10.1038/modpathol.2012.60
6 sg:pub.10.1038/modpathol.2015.75
7 sg:pub.10.1038/nature10983
8 sg:pub.10.1038/onc.2011.102
9 sg:pub.10.1038/sj.onc.1209394
10 sg:pub.10.1186/1471-2407-10-653
11 sg:pub.10.1186/1476-4598-13-62
12 sg:pub.10.1186/bcr2228
13 https://app.dimensions.ai/details/publication/pub.1075116301
14 https://app.dimensions.ai/details/publication/pub.1075223352
15 https://app.dimensions.ai/details/publication/pub.1077510707
16 https://app.dimensions.ai/details/publication/pub.1081725012
17 https://doi.org/10.1016/j.biocel.2011.09.005
18 https://doi.org/10.1016/j.ccr.2007.10.017
19 https://doi.org/10.1016/j.mito.2012.06.004
20 https://doi.org/10.1016/j.radonc.2014.06.011
21 https://doi.org/10.1042/bsr20130077
22 https://doi.org/10.1073/pnas.182372299
23 https://doi.org/10.1089/ars.2012.4650
24 https://doi.org/10.1093/carcin/bgr137
25 https://doi.org/10.1093/jnci/djp485
26 https://doi.org/10.1093/jnci/djt067
27 https://doi.org/10.1126/science.1184003
28 https://doi.org/10.1136/jclinpath-2014-202571
29 https://doi.org/10.1158/0008-5472.can-06-0100
30 https://doi.org/10.1158/1078-0432.ccr-04-0713
31 https://doi.org/10.1158/1078-0432.ccr-07-1465
32 https://doi.org/10.1161/atvbaha.110.209643
33 https://doi.org/10.1177/1947601910389604
34 https://doi.org/10.1182/blood-2005-02-0487
35 https://doi.org/10.1200/jco.2016.67.8532
36 https://doi.org/10.1200/jop.777003
37 https://doi.org/10.1309/ajcp4m2vuzcldaln
38 https://doi.org/10.1369/0022155415576540
39 https://doi.org/10.18632/oncotarget.3096
40 https://doi.org/10.3389/fimmu.2013.00514
41 https://doi.org/10.3892/or.2017.5577
42 https://doi.org/10.4048/jbc.2016.19.2.185
43 https://doi.org/10.4149/bll_2014_088
44 schema:datePublished 2018-06-28
45 schema:datePublishedReg 2018-06-28
46 schema:description Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behavior, but they are insufficient to define high-risk patients for disease progression precisely. Thioredoxin-interacting protein (TXNIP) is a key player of oxidative stress. This study aims to evaluate the role of TXNIP as a predictor of ductal carcinoma in situ progression. Tissue microarrays from 776 pure ductal carcinoma in situ and 239 mixed ductal carcinoma in situ and invasive tumors were constructed. All patients were treated at a single institution with a long-term follow-up and TXNIP expression was assessed using immunohistochemistry. TXNIP expression was investigated in terms of associations with clinicopathological and molecular features and patient outcome. Loss/reduced cytoplasmic expression of TXNIP was associated with features of aggressiveness including high nuclear grade (p = 1.6 × 10<sup>-5</sup>), presence of comedo necrosis (p = 0.001), and estrogen receptor negative (ER-)/HER2- ductal carcinoma in situ (p = 4.6 × 10<sup>-5</sup>). Univariate analysis showed an inverse association between TXNIP expression and outcome in terms of shorter local recurrence-free survival (p = 0.009). Multivariable analyses showed that independent predictors of ductal carcinoma in situ recurrence were low TXNIP expression (p = 0.005, HR = 0.51, and 95% CI: 0.32-0.81), larger ductal carcinoma in situ size, and high nuclear grade. TXNIP functions as a tumor suppressor gene with loss of its expression associated with ductal carcinoma in situ recurrence. TXNIP can be used as a potentially useful marker in prognostic stratification of ductal carcinoma in situ for management decisions.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf sg:journal.1098208
51 schema:name Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ
52 schema:pagination 1-9
53 schema:productId N3e318c42df1f4ad3bf7be81f10d39bf9
54 N4633dede7f8547c48e33d755e06a864e
55 N958d43f0e2fc4259ba6d0b8fbf3bae8d
56 Nae42e63f1817495bb469ea673ddaa8a0
57 Ndb401b2b7e964e4ca7afe99b52dc3073
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105172581
59 https://doi.org/10.1038/s41379-018-0086-7
60 schema:sdDatePublished 2019-04-11T02:23
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N15bc1c6106234c1dbba8b967e24c33e3
63 schema:url https://www.nature.com/articles/s41379-018-0086-7
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N15bc1c6106234c1dbba8b967e24c33e3 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N18eac7f49820490abb7ed9f606e7cbc6 schema:name Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK
70 rdf:type schema:Organization
71 N1ce90eb93a5b4e41a6b07e478bdb9185 schema:name Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK
72 rdf:type schema:Organization
73 N3e318c42df1f4ad3bf7be81f10d39bf9 schema:name nlm_unique_id
74 schema:value 8806605
75 rdf:type schema:PropertyValue
76 N409b5d5ecf0a4735a606c1939c0ec6bf rdf:first sg:person.01005547451.81
77 rdf:rest N5d3d67f78cc24717a199c6aa386ff2e1
78 N4633dede7f8547c48e33d755e06a864e schema:name readcube_id
79 schema:value 86112f10744454cd90dc6860afb28d76f09969aec8f824b34b55853916d7020f
80 rdf:type schema:PropertyValue
81 N478c0a3058894e4bac221fb6cd18fd37 rdf:first sg:person.012150651354.52
82 rdf:rest Ne9cb6845e3d34693a3e93ec890841d8c
83 N5b29e31a378c4c8c90d31c9f4cdd7cc3 rdf:first sg:person.01040530365.43
84 rdf:rest N7ea6623143d043f2a65e7659d44d7acd
85 N5d3d67f78cc24717a199c6aa386ff2e1 rdf:first sg:person.012771505765.00
86 rdf:rest N478c0a3058894e4bac221fb6cd18fd37
87 N5fdfbf3bf0734d7fac596b8270ab14bb rdf:first sg:person.01054612302.65
88 rdf:rest N62086be34def451d90c45d15d4071e37
89 N62086be34def451d90c45d15d4071e37 rdf:first sg:person.016416665412.02
90 rdf:rest N8c7f22a1cec247d6972058477fbd8362
91 N7ea6623143d043f2a65e7659d44d7acd rdf:first sg:person.01217144077.65
92 rdf:rest N5fdfbf3bf0734d7fac596b8270ab14bb
93 N8c7f22a1cec247d6972058477fbd8362 rdf:first sg:person.0743637501.84
94 rdf:rest rdf:nil
95 N958d43f0e2fc4259ba6d0b8fbf3bae8d schema:name pubmed_id
96 schema:value 29955142
97 rdf:type schema:PropertyValue
98 N9de0cffea2ff4074ad201edd25c56458 schema:name Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK
99 rdf:type schema:Organization
100 N9ef81f8d9bc14db9b30a0f1030438762 schema:name Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK
101 rdf:type schema:Organization
102 Nae42e63f1817495bb469ea673ddaa8a0 schema:name dimensions_id
103 schema:value pub.1105172581
104 rdf:type schema:PropertyValue
105 Nbd3e5e49e5e04aa688317089685d89f7 rdf:first sg:person.01144652371.40
106 rdf:rest N409b5d5ecf0a4735a606c1939c0ec6bf
107 Ndb401b2b7e964e4ca7afe99b52dc3073 schema:name doi
108 schema:value 10.1038/s41379-018-0086-7
109 rdf:type schema:PropertyValue
110 Ne9cb6845e3d34693a3e93ec890841d8c rdf:first sg:person.01355116121.91
111 rdf:rest N5b29e31a378c4c8c90d31c9f4cdd7cc3
112 Nfaf6e347ac57476389eac92e18526792 schema:name Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK
113 rdf:type schema:Organization
114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical and Health Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
118 schema:name Oncology and Carcinogenesis
119 rdf:type schema:DefinedTerm
120 sg:journal.1098208 schema:issn 0893-3952
121 1530-0285
122 schema:name Modern Pathology
123 rdf:type schema:Periodical
124 sg:person.01005547451.81 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
125 schema:familyName Gorringe
126 schema:givenName Kylie L.
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005547451.81
128 rdf:type schema:Person
129 sg:person.01040530365.43 schema:affiliation N18eac7f49820490abb7ed9f606e7cbc6
130 schema:familyName Diez-Rodriguez
131 schema:givenName Maria
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040530365.43
133 rdf:type schema:Person
134 sg:person.01054612302.65 schema:affiliation Nfaf6e347ac57476389eac92e18526792
135 schema:familyName Ellis
136 schema:givenName Ian O.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65
138 rdf:type schema:Person
139 sg:person.01144652371.40 schema:affiliation https://www.grid.ac/institutes/grid.411775.1
140 schema:familyName Miligy
141 schema:givenName Islam M.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144652371.40
143 rdf:type schema:Person
144 sg:person.012150651354.52 schema:affiliation N1ce90eb93a5b4e41a6b07e478bdb9185
145 schema:familyName Al-Kawaz
146 schema:givenName Abdulbaqi A.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012150651354.52
148 rdf:type schema:Person
149 sg:person.01217144077.65 schema:affiliation N9de0cffea2ff4074ad201edd25c56458
150 schema:familyName Nolan
151 schema:givenName Christopher C.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217144077.65
153 rdf:type schema:Person
154 sg:person.012771505765.00 schema:affiliation https://www.grid.ac/institutes/grid.252487.e
155 schema:familyName Toss
156 schema:givenName Michael S.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771505765.00
158 rdf:type schema:Person
159 sg:person.01355116121.91 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
160 schema:familyName Simpson
161 schema:givenName Peter
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355116121.91
163 rdf:type schema:Person
164 sg:person.016416665412.02 schema:affiliation N9ef81f8d9bc14db9b30a0f1030438762
165 schema:familyName Green
166 schema:givenName Andrew R.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416665412.02
168 rdf:type schema:Person
169 sg:person.0743637501.84 schema:affiliation https://www.grid.ac/institutes/grid.411775.1
170 schema:familyName Rakha
171 schema:givenName Emad A.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743637501.84
173 rdf:type schema:Person
174 sg:pub.10.1007/s10549-016-3862-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005699008
175 https://doi.org/10.1007/s10549-016-3862-4
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/modpathol.2012.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023910261
178 https://doi.org/10.1038/modpathol.2012.60
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/modpathol.2015.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034531596
181 https://doi.org/10.1038/modpathol.2015.75
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
184 https://doi.org/10.1038/nature10983
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/onc.2011.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030125540
187 https://doi.org/10.1038/onc.2011.102
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/sj.onc.1209394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047674609
190 https://doi.org/10.1038/sj.onc.1209394
191 rdf:type schema:CreativeWork
192 sg:pub.10.1186/1471-2407-10-653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052881095
193 https://doi.org/10.1186/1471-2407-10-653
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/1476-4598-13-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027351284
196 https://doi.org/10.1186/1476-4598-13-62
197 rdf:type schema:CreativeWork
198 sg:pub.10.1186/bcr2228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048973885
199 https://doi.org/10.1186/bcr2228
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1075116301 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1075223352 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1077510707 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1081725012 schema:CreativeWork
205 https://doi.org/10.1016/j.biocel.2011.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003235897
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.ccr.2007.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010981335
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.mito.2012.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030860654
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.radonc.2014.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003760394
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1042/bsr20130077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026047312
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1073/pnas.182372299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025936051
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1089/ars.2012.4650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231889
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/carcin/bgr137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032945745
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1093/jnci/djp485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027158115
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1093/jnci/djt067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038235824
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1126/science.1184003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062461378
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1136/jclinpath-2014-202571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012178962
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1158/0008-5472.can-06-0100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044575386
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1158/1078-0432.ccr-04-0713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031102903
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1158/1078-0432.ccr-07-1465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030683885
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1161/atvbaha.110.209643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048294649
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1177/1947601910389604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002428283
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1182/blood-2005-02-0487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032924511
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1200/jco.2016.67.8532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001246088
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1200/jop.777003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038031406
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1309/ajcp4m2vuzcldaln schema:sameAs https://app.dimensions.ai/details/publication/pub.1024749332
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1369/0022155415576540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045174769
248 rdf:type schema:CreativeWork
249 https://doi.org/10.18632/oncotarget.3096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043013837
250 rdf:type schema:CreativeWork
251 https://doi.org/10.3389/fimmu.2013.00514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033458549
252 rdf:type schema:CreativeWork
253 https://doi.org/10.3892/or.2017.5577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084953152
254 rdf:type schema:CreativeWork
255 https://doi.org/10.4048/jbc.2016.19.2.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018698869
256 rdf:type schema:CreativeWork
257 https://doi.org/10.4149/bll_2014_088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072260469
258 rdf:type schema:CreativeWork
259 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
260 schema:name Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
261 rdf:type schema:Organization
262 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
263 schema:name Cancer Genomics Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
264 The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.252487.e schema:alternateName Assiut University
267 schema:name Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK
268 Histopathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
269 rdf:type schema:Organization
270 https://www.grid.ac/institutes/grid.411775.1 schema:alternateName Menoufia University
271 schema:name Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK
272 Histopathology Department, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...