Ontology type: schema:ScholarlyArticle Open Access: True
2018-06-28
AUTHORSIslam M. Miligy, Kylie L. Gorringe, Michael S. Toss, Abdulbaqi A. Al-Kawaz, Peter Simpson, Maria Diez-Rodriguez, Christopher C. Nolan, Ian O. Ellis, Andrew R. Green, Emad A. Rakha
ABSTRACTCurrent clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behavior, but they are insufficient to define high-risk patients for disease progression precisely. Thioredoxin-interacting protein (TXNIP) is a key player of oxidative stress. This study aims to evaluate the role of TXNIP as a predictor of ductal carcinoma in situ progression. Tissue microarrays from 776 pure ductal carcinoma in situ and 239 mixed ductal carcinoma in situ and invasive tumors were constructed. All patients were treated at a single institution with a long-term follow-up and TXNIP expression was assessed using immunohistochemistry. TXNIP expression was investigated in terms of associations with clinicopathological and molecular features and patient outcome. Loss/reduced cytoplasmic expression of TXNIP was associated with features of aggressiveness including high nuclear grade (p = 1.6 × 10-5), presence of comedo necrosis (p = 0.001), and estrogen receptor negative (ER-)/HER2- ductal carcinoma in situ (p = 4.6 × 10-5). Univariate analysis showed an inverse association between TXNIP expression and outcome in terms of shorter local recurrence-free survival (p = 0.009). Multivariable analyses showed that independent predictors of ductal carcinoma in situ recurrence were low TXNIP expression (p = 0.005, HR = 0.51, and 95% CI: 0.32-0.81), larger ductal carcinoma in situ size, and high nuclear grade. TXNIP functions as a tumor suppressor gene with loss of its expression associated with ductal carcinoma in situ recurrence. TXNIP can be used as a potentially useful marker in prognostic stratification of ductal carcinoma in situ for management decisions. More... »
PAGES1-9
http://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7
DOIhttp://dx.doi.org/10.1038/s41379-018-0086-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105172581
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29955142
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Menoufia University",
"id": "https://www.grid.ac/institutes/grid.411775.1",
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK",
"Histopathology Department, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt"
],
"type": "Organization"
},
"familyName": "Miligy",
"givenName": "Islam M.",
"id": "sg:person.01144652371.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144652371.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Cancer Genomics Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia",
"The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"
],
"type": "Organization"
},
"familyName": "Gorringe",
"givenName": "Kylie L.",
"id": "sg:person.01005547451.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005547451.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Assiut University",
"id": "https://www.grid.ac/institutes/grid.252487.e",
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK",
"Histopathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt"
],
"type": "Organization"
},
"familyName": "Toss",
"givenName": "Michael S.",
"id": "sg:person.012771505765.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771505765.00"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Al-Kawaz",
"givenName": "Abdulbaqi A.",
"id": "sg:person.012150651354.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012150651354.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Queensland",
"id": "https://www.grid.ac/institutes/grid.1003.2",
"name": [
"Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"
],
"type": "Organization"
},
"familyName": "Simpson",
"givenName": "Peter",
"id": "sg:person.01355116121.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355116121.91"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Diez-Rodriguez",
"givenName": "Maria",
"id": "sg:person.01040530365.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040530365.43"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Nolan",
"givenName": "Christopher C.",
"id": "sg:person.01217144077.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217144077.65"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Ellis",
"givenName": "Ian O.",
"id": "sg:person.01054612302.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK"
],
"type": "Organization"
},
"familyName": "Green",
"givenName": "Andrew R.",
"id": "sg:person.016416665412.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416665412.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Menoufia University",
"id": "https://www.grid.ac/institutes/grid.411775.1",
"name": [
"Academic Pathology, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK",
"Histopathology Department, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt"
],
"type": "Organization"
},
"familyName": "Rakha",
"givenName": "Emad A.",
"id": "sg:person.0743637501.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743637501.84"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1200/jco.2016.67.8532",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001246088"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1947601910389604",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002428283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1947601910389604",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002428283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.biocel.2011.09.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003235897"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.radonc.2014.06.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003760394"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-016-3862-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005699008",
"https://doi.org/10.1007/s10549-016-3862-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-016-3862-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005699008",
"https://doi.org/10.1007/s10549-016-3862-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2007.10.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010981335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jclinpath-2014-202571",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012178962"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10983",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014607335",
"https://doi.org/10.1038/nature10983"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4048/jbc.2016.19.2.185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018698869"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2012.60",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023910261",
"https://doi.org/10.1038/modpathol.2012.60"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1309/ajcp4m2vuzcldaln",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024749332"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.182372299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025936051"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bsr20130077",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026047312"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djp485",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027158115"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-4598-13-62",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027351284",
"https://doi.org/10.1186/1476-4598-13-62"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2011.102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030125540",
"https://doi.org/10.1038/onc.2011.102"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-07-1465",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030683885"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mito.2012.06.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030860654"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-04-0713",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031102903"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2005-02-0487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032924511"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/carcin/bgr137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032945745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fimmu.2013.00514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033458549"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2015.75",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034531596",
"https://doi.org/10.1038/modpathol.2015.75"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jop.777003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038031406"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djt067",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038235824"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.3096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043013837"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-06-0100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044575386"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1369/0022155415576540",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045174769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1369/0022155415576540",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045174769"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209394",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047674609",
"https://doi.org/10.1038/sj.onc.1209394"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1209394",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047674609",
"https://doi.org/10.1038/sj.onc.1209394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/atvbaha.110.209643",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048294649"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/atvbaha.110.209643",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048294649"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr2228",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048973885",
"https://doi.org/10.1186/bcr2228"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2407-10-653",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052881095",
"https://doi.org/10.1186/1471-2407-10-653"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/ars.2012.4650",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059231889"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1184003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062461378"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1184003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062461378"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4149/bll_2014_088",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072260469"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075116301",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075223352",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077510707",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081725012",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/or.2017.5577",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084953152"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-06-28",
"datePublishedReg": "2018-06-28",
"description": "Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behavior, but they are insufficient to define high-risk patients for disease progression precisely. Thioredoxin-interacting protein (TXNIP) is a key player of oxidative stress. This study aims to evaluate the role of TXNIP as a predictor of ductal carcinoma in situ progression. Tissue microarrays from 776 pure ductal carcinoma in situ and 239 mixed ductal carcinoma in situ and invasive tumors were constructed. All patients were treated at a single institution with a long-term follow-up and TXNIP expression was assessed using immunohistochemistry. TXNIP expression was investigated in terms of associations with clinicopathological and molecular features and patient outcome. Loss/reduced cytoplasmic expression of TXNIP was associated with features of aggressiveness including high nuclear grade (p\u2009=\u20091.6\u2009\u00d7\u200910-5), presence of comedo necrosis (p\u2009=\u20090.001), and estrogen receptor negative (ER-)/HER2- ductal carcinoma in situ (p\u2009=\u20094.6\u2009\u00d7\u200910-5). Univariate analysis showed an inverse association between TXNIP expression and outcome in terms of shorter local recurrence-free survival (p\u2009=\u20090.009). Multivariable analyses showed that independent predictors of ductal carcinoma in situ recurrence were low TXNIP expression (p\u2009=\u20090.005, HR\u2009=\u20090.51, and 95% CI: 0.32-0.81), larger ductal carcinoma in situ size, and high nuclear grade. TXNIP functions as a tumor suppressor gene with loss of its expression associated with ductal carcinoma in situ recurrence. TXNIP can be used as a potentially useful marker in prognostic stratification of ductal carcinoma in situ for management decisions.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41379-018-0086-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1098208",
"issn": [
"0893-3952",
"1530-0285"
],
"name": "Modern Pathology",
"type": "Periodical"
}
],
"name": "Thioredoxin-interacting protein is an independent risk stratifier for breast ductal carcinoma in situ",
"pagination": "1-9",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"86112f10744454cd90dc6860afb28d76f09969aec8f824b34b55853916d7020f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29955142"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8806605"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41379-018-0086-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1105172581"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41379-018-0086-7",
"https://app.dimensions.ai/details/publication/pub.1105172581"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T02:23",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000566.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41379-018-0086-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41379-018-0086-7'
This table displays all metadata directly associated to this object as RDF triples.
273 TRIPLES
21 PREDICATES
66 URIs
18 LITERALS
7 BLANK NODES