Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-06-08

AUTHORS

Matthew Salmon, Helen E. White, Hana Zizkova, Andrea Gottschalk, Eliska Motlova, Nuno Cerveira, Dolors Colomer, Daniel Coriu, Georg N. Franke, Enrico Gottardi, Barbara Izzo, Tomas Jurcek, Thomas Lion, Vivien Schäfer, Claudia Venturi, Paolo Vigneri, Magdalena Zawada, Jan Zuna, Lenka Hovorkova, Jitka Koblihova, Hana Klamova, Marketa Stastna Markova, Dana Srbova, Adela Benesova, Vaclava Polivkova, Daniela Zackova, Jiri Mayer, Ingo Roeder, Ingmar Glauche, Thomas Ernst, Andreas Hochhaus, Katerina Machova Polakova, Nicholas C. P. Cross

ABSTRACT

Several studies have reported that chronic myeloid leukaemia (CML) patients expressing e14a2 BCR::ABL1 have a faster molecular response to therapy compared to patients expressing e13a2. To explore the reason for this difference we undertook a detailed technical comparison of the commonly used Europe Against Cancer (EAC) BCR::ABL1 reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) assay in European Treatment and Outcome Study (EUTOS) reference laboratories (n = 10). We found the amplification ratio of the e13a2 amplicon was 38% greater than e14a2 (p = 0.015), and the amplification efficiency was 2% greater (P = 0.17). This subtle difference led to measurable transcript-type dependent variation in estimates of residual disease which could be corrected by (i) taking the qPCR amplification efficiency into account, (ii) using alternative RT-qPCR approaches or (iii) droplet digital PCR (ddPCR), a technique which is relatively insensitive to differences in amplification kinetics. In CML patients, higher levels of BCR::ABL1/GUSB were identified at diagnosis for patients expressing e13a2 (n = 67) compared to e14a2 (n = 78) when analysed by RT-qPCR (P = 0.0005) but not ddPCR (P = 0.5). These data indicate that widely used RT-qPCR assays result in subtly different estimates of disease depending on BCR::ABL1 transcript type; these differences are small but may need to be considered for optimal patient management. More... »

PAGES

1879-1886

References to SciGraph publications

  • 2014-07-18. A certified plasmid reference material for the standardisation of BCR–ABL1 mRNA quantification by real-time quantitative PCR in LEUKEMIA
  • 2014-05-06. Velocity of early BCR-ABL transcript elimination as an optimized predictor of outcome in chronic myeloid leukemia (CML) patients in chronic phase on treatment with imatinib in LEUKEMIA
  • 2003-10-09. Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – A Europe Against Cancer Program in LEUKEMIA
  • 2015-03-27. Natural course and biology of CML in ANNALS OF HEMATOLOGY
  • 2020-05-29. Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission in LEUKEMIA
  • 2019-01-23. The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview in LEUKEMIA
  • 2017-01-12. No influence of BCR-ABL1 transcript types e13a2 and e14a2 on long-term survival: results in 1494 patients with chronic myeloid leukemia treated with imatinib in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2019-08-27. Chronic myeloid leukemia: the concepts of resistance and persistence and the relationship with the BCR-ABL1 transcript type in LEUKEMIA
  • 2020-03-03. European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia in LEUKEMIA
  • 2019-11-25. Lineage of measurable residual disease in patients with chronic myeloid leukemia in treatment-free remission in LEUKEMIA
  • 2015-02-05. Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia in LEUKEMIA
  • 2013-04-16. Distribution of genomic breakpoints in chronic myeloid leukemia: analysis of 308 patients in LEUKEMIA
  • 2018-08-17. Quantitative prediction of long-term molecular response in TKI-treated CML – Lessons from an imatinib versus dasatinib comparison in SCIENTIFIC REPORTS
  • 2021-03-07. Assessment of individual molecular response in chronic myeloid leukemia patients with atypical BCR-ABL1 fusion transcripts: recommendations by the EUTOS cooperative network in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal

    TITLE

    Leukemia

    ISSUE

    7

    VOLUME

    36

    Author Affiliations

  • Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK
  • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany
  • Portuguese Oncology Institute of Porto, Porto, Portugal
  • Pathology Department, Hospital Clinic, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona, Spain
  • Hematology Department, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
  • University of Leipzig Medical Center, Department for Hematology, Cellular Therapies and Hemostaseology, Leipzig, Germany
  • Laboratory of Chemical and Clinical Analysis “Area 3” A.O.U San Luigi Gonzaga-Orbassano, Turin, Italy
  • Department of Molecular Medicine and Medical Biotechnology University ‘Federico II’ and CEINGE - Advanced Biotechnologies, Naples, Italy
  • Center of Molecular Biology and Gene Therapy, Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
  • Labdia Labordiagnostik / St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria
  • Abteilung Hämatologie/Onkologie, Klinik für Innere Medizin II, University of Jena, Jena, Germany
  • IRCSS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
  • University of Catania, Department of Clinical and Experimental Medicine, Center of Experimental Oncology and Hematology, Catania, Italy
  • The University Hospital in Krakow, Krakow, Poland
  • CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
  • Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
  • National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany. Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Dresden, Germany
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-022-01612-2

    DOI

    http://dx.doi.org/10.1038/s41375-022-01612-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1148515396

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35676453


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fusion Proteins, bcr-abl", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Imatinib Mesylate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myelogenous, Chronic, BCR-ABL Positive", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm, Residual", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Real-Time Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK", 
              "id": "http://www.grid.ac/institutes/grid.433814.9", 
              "name": [
                "Faculty of Medicine, University of Southampton, Southampton, UK", 
                "Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salmon", 
            "givenName": "Matthew", 
            "id": "sg:person.013111676417.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013111676417.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK", 
              "id": "http://www.grid.ac/institutes/grid.433814.9", 
              "name": [
                "Faculty of Medicine, University of Southampton, Southampton, UK", 
                "Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "White", 
            "givenName": "Helen E.", 
            "id": "sg:person.015277754322.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015277754322.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zizkova", 
            "givenName": "Hana", 
            "id": "sg:person.01114710777.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114710777.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4488.0", 
              "name": [
                "Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gottschalk", 
            "givenName": "Andrea", 
            "id": "sg:person.0631727227.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631727227.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Motlova", 
            "givenName": "Eliska", 
            "id": "sg:person.010131572043.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010131572043.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Portuguese Oncology Institute of Porto, Porto, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.435544.7", 
              "name": [
                "Portuguese Oncology Institute of Porto, Porto, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cerveira", 
            "givenName": "Nuno", 
            "id": "sg:person.01012771330.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012771330.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pathology Department, Hospital Clinic, Institut d\u2019 Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10403.36", 
              "name": [
                "Pathology Department, Hospital Clinic, Institut d\u2019 Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Colomer", 
            "givenName": "Dolors", 
            "id": "sg:person.01242360741.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242360741.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Department, Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, Bucharest, Romania", 
              "id": "http://www.grid.ac/institutes/grid.8194.4", 
              "name": [
                "Fundeni Clinical Institute, Hematology Department, Bucharest, Romania", 
                "Hematology Department, Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, Bucharest, Romania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coriu", 
            "givenName": "Daniel", 
            "id": "sg:person.01326567212.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326567212.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Leipzig Medical Center, Department for Hematology, Cellular Therapies and Hemostaseology, Leipzig, Germany", 
              "id": "http://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "University of Leipzig Medical Center, Department for Hematology, Cellular Therapies and Hemostaseology, Leipzig, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franke", 
            "givenName": "Georg N.", 
            "id": "sg:person.01177311532.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177311532.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Chemical and Clinical Analysis \u201cArea 3\u201d A.O.U San Luigi Gonzaga-Orbassano, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Laboratory of Chemical and Clinical Analysis \u201cArea 3\u201d A.O.U San Luigi Gonzaga-Orbassano, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gottardi", 
            "givenName": "Enrico", 
            "id": "sg:person.011404033154.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011404033154.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Medicine and Medical Biotechnology University \u2018Federico II\u2019 and CEINGE - Advanced Biotechnologies, Naples, Italy", 
              "id": "http://www.grid.ac/institutes/grid.4691.a", 
              "name": [
                "Department of Molecular Medicine and Medical Biotechnology University \u2018Federico II\u2019 and CEINGE - Advanced Biotechnologies, Naples, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Izzo", 
            "givenName": "Barbara", 
            "id": "sg:person.0661410706.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661410706.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center of Molecular Biology and Gene Therapy, Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.10267.32", 
              "name": [
                "Center of Molecular Biology and Gene Therapy, Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jurcek", 
            "givenName": "Tomas", 
            "id": "sg:person.01301247371.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301247371.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Labdia Labordiagnostik / St. Anna Children\u00b4s Cancer Research Institute (CCRI), Vienna, Austria", 
              "id": "http://www.grid.ac/institutes/grid.416346.2", 
              "name": [
                "Labdia Labordiagnostik / St. Anna Children\u00b4s Cancer Research Institute (CCRI), Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lion", 
            "givenName": "Thomas", 
            "id": "sg:person.01170113522.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170113522.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Abteilung H\u00e4matologie/Onkologie, Klinik f\u00fcr Innere Medizin II, University of Jena, Jena, Germany", 
              "id": "http://www.grid.ac/institutes/grid.9613.d", 
              "name": [
                "Abteilung H\u00e4matologie/Onkologie, Klinik f\u00fcr Innere Medizin II, University of Jena, Jena, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sch\u00e4fer", 
            "givenName": "Vivien", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IRCSS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.6292.f", 
              "name": [
                "IRCSS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Venturi", 
            "givenName": "Claudia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Catania, Department of Clinical and Experimental Medicine, Center of Experimental Oncology and Hematology, Catania, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8158.4", 
              "name": [
                "University of Catania, Department of Clinical and Experimental Medicine, Center of Experimental Oncology and Hematology, Catania, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vigneri", 
            "givenName": "Paolo", 
            "id": "sg:person.01061656433.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061656433.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University Hospital in Krakow, Krakow, Poland", 
              "id": "http://www.grid.ac/institutes/grid.412700.0", 
              "name": [
                "The University Hospital in Krakow, Krakow, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zawada", 
            "givenName": "Magdalena", 
            "id": "sg:person.01254702737.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254702737.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.412826.b", 
              "name": [
                "CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zuna", 
            "givenName": "Jan", 
            "id": "sg:person.0724710167.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724710167.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.412826.b", 
              "name": [
                "CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hovorkova", 
            "givenName": "Lenka", 
            "id": "sg:person.0602011272.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602011272.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koblihova", 
            "givenName": "Jitka", 
            "id": "sg:person.01150574132.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150574132.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klamova", 
            "givenName": "Hana", 
            "id": "sg:person.0630121343.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630121343.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Markova", 
            "givenName": "Marketa Stastna", 
            "id": "sg:person.01053107420.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053107420.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Srbova", 
            "givenName": "Dana", 
            "id": "sg:person.016337203057.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016337203057.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benesova", 
            "givenName": "Adela", 
            "id": "sg:person.01107047131.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107047131.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Polivkova", 
            "givenName": "Vaclava", 
            "id": "sg:person.0622733615.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622733615.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.10267.32", 
              "name": [
                "Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zackova", 
            "givenName": "Daniela", 
            "id": "sg:person.01030415745.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030415745.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.10267.32", 
              "name": [
                "Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mayer", 
            "givenName": "Jiri", 
            "id": "sg:person.01045667334.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045667334.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany. Helmholtz-Zentrum Dresden\u2013Rossendorf (HZDR), Dresden, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4488.0", 
              "name": [
                "Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany", 
                "National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany. Helmholtz-Zentrum Dresden\u2013Rossendorf (HZDR), Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roeder", 
            "givenName": "Ingo", 
            "id": "sg:person.01352775766.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352775766.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4488.0", 
              "name": [
                "Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Glauche", 
            "givenName": "Ingmar", 
            "id": "sg:person.01006072366.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006072366.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Abteilung H\u00e4matologie/Onkologie, Klinik f\u00fcr Innere Medizin II, University of Jena, Jena, Germany", 
              "id": "http://www.grid.ac/institutes/grid.9613.d", 
              "name": [
                "Abteilung H\u00e4matologie/Onkologie, Klinik f\u00fcr Innere Medizin II, University of Jena, Jena, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ernst", 
            "givenName": "Thomas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Abteilung H\u00e4matologie/Onkologie, Klinik f\u00fcr Innere Medizin II, University of Jena, Jena, Germany", 
              "id": "http://www.grid.ac/institutes/grid.9613.d", 
              "name": [
                "Abteilung H\u00e4matologie/Onkologie, Klinik f\u00fcr Innere Medizin II, University of Jena, Jena, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hochhaus", 
            "givenName": "Andreas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Hematology and Blood Transfusion, Prague, Czech Republic", 
              "id": "http://www.grid.ac/institutes/grid.419035.a", 
              "name": [
                "Institute of Hematology and Blood Transfusion, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Polakova", 
            "givenName": "Katerina Machova", 
            "id": "sg:person.01054615031.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054615031.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK", 
              "id": "http://www.grid.ac/institutes/grid.433814.9", 
              "name": [
                "Faculty of Medicine, University of Southampton, Southampton, UK", 
                "Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cross", 
            "givenName": "Nicholas C. P.", 
            "id": "sg:person.014247202557.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014247202557.54"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41375-019-0647-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1122865185", 
              "https://doi.org/10.1038/s41375-019-0647-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-015-2325-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039807375", 
              "https://doi.org/10.1007/s00277-015-2325-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-29923-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106133501", 
              "https://doi.org/10.1038/s41598-018-29923-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042288603", 
              "https://doi.org/10.1038/sj.leu.2403135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-016-2321-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003815725", 
              "https://doi.org/10.1007/s00432-016-2321-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-021-03569-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1136212777", 
              "https://doi.org/10.1007/s00432-021-03569-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2015.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023059213", 
              "https://doi.org/10.1038/leu.2015.29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41375-020-0882-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1127979850", 
              "https://doi.org/10.1038/s41375-020-0882-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41375-020-0776-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1125320161", 
              "https://doi.org/10.1038/s41375-020-0776-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032603709", 
              "https://doi.org/10.1038/leu.2014.153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026781931", 
              "https://doi.org/10.1038/leu.2014.217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41375-019-0562-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120606070", 
              "https://doi.org/10.1038/s41375-019-0562-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41375-018-0341-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111614747", 
              "https://doi.org/10.1038/s41375-018-0341-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040222073", 
              "https://doi.org/10.1038/leu.2013.116"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-06-08", 
        "datePublishedReg": "2022-06-08", 
        "description": "Several studies have reported that chronic myeloid leukaemia (CML) patients expressing e14a2 BCR::ABL1 have a faster molecular response to therapy compared to patients expressing e13a2. To explore the reason for this difference we undertook a detailed technical comparison of the commonly used Europe Against Cancer (EAC) BCR::ABL1 reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) assay in European Treatment and Outcome Study (EUTOS) reference laboratories (n\u2009=\u200910). We found the amplification ratio of the e13a2 amplicon was 38% greater than e14a2 (p\u2009=\u20090.015), and the amplification efficiency was 2% greater (P\u2009=\u20090.17). This subtle difference led to measurable transcript-type dependent variation in estimates of residual disease which could be corrected by (i) taking the qPCR amplification efficiency into account, (ii) using alternative RT-qPCR approaches or (iii) droplet digital PCR (ddPCR), a technique which is relatively insensitive to differences in amplification kinetics. In CML patients, higher levels of BCR::ABL1/GUSB were identified at diagnosis for patients expressing e13a2 (n\u2009=\u200967) compared to e14a2 (n\u2009=\u200978) when analysed by RT-qPCR (P\u2009=\u20090.0005) but not ddPCR (P\u2009=\u20090.5). These data indicate that widely used RT-qPCR assays result in subtly different estimates of disease depending on BCR::ABL1 transcript type; these differences are small but may need to be considered for optimal patient management.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41375-022-01612-2", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097065", 
            "issn": [
              "0887-6924", 
              "1476-5551"
            ], 
            "name": "Leukemia", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "keywords": [
          "droplet digital PCR", 
          "chronic myeloid leukemia patients", 
          "myeloid leukemia patients", 
          "RT-qPCR", 
          "optimal patient management", 
          "quantitative polymerase chain reaction", 
          "transcript type", 
          "residual disease", 
          "CML patients", 
          "polymerase chain reaction", 
          "leukemia patients", 
          "patient management", 
          "molecular response", 
          "patients", 
          "RT-qPCR assays", 
          "European Treatment", 
          "reference laboratory", 
          "chain reaction", 
          "therapy", 
          "disease", 
          "digital PCR", 
          "high levels", 
          "differences", 
          "cancer", 
          "e14a2", 
          "diagnosis", 
          "response", 
          "treatment", 
          "PCR", 
          "assays", 
          "GUSB", 
          "management", 
          "levels", 
          "amplification efficiency", 
          "study", 
          "subtle differences", 
          "types", 
          "amplicons", 
          "different estimates", 
          "laboratory", 
          "dependent variation", 
          "data", 
          "reasons", 
          "ratio", 
          "impact", 
          "comparison", 
          "estimates", 
          "reaction", 
          "technique", 
          "Europe", 
          "variation", 
          "kinetics", 
          "technical comparison", 
          "amplification kinetics", 
          "account", 
          "performance", 
          "efficiency", 
          "amplification ratio", 
          "amplification performance", 
          "qPCR amplification efficiency"
        ], 
        "name": "Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy", 
        "pagination": "1879-1886", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1148515396"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41375-022-01612-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35676453"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41375-022-01612-2", 
          "https://app.dimensions.ai/details/publication/pub.1148515396"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_948.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41375-022-01612-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01612-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01612-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01612-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01612-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    472 TRIPLES      21 PREDICATES      105 URIs      83 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41375-022-01612-2 schema:about N4e7a73b5531044299196024427aee427
    2 N59c57bb537a24e0f8976e24b8751f62c
    3 N7175052c33e84933bea6401ea5cba9ef
    4 N851402a76e7d46c7be43b3db3c940fba
    5 Na36a12dac36c4b0f949a15e2ee5f4f49
    6 Nd73d44752cfa424d942ced1cf4a4c8f9
    7 anzsrc-for:11
    8 anzsrc-for:1112
    9 schema:author Nba7a42e12d9742b9b9717d4b7c5199df
    10 schema:citation sg:pub.10.1007/s00277-015-2325-z
    11 sg:pub.10.1007/s00432-016-2321-2
    12 sg:pub.10.1007/s00432-021-03569-8
    13 sg:pub.10.1038/leu.2013.116
    14 sg:pub.10.1038/leu.2014.153
    15 sg:pub.10.1038/leu.2014.217
    16 sg:pub.10.1038/leu.2015.29
    17 sg:pub.10.1038/s41375-018-0341-4
    18 sg:pub.10.1038/s41375-019-0562-1
    19 sg:pub.10.1038/s41375-019-0647-x
    20 sg:pub.10.1038/s41375-020-0776-2
    21 sg:pub.10.1038/s41375-020-0882-1
    22 sg:pub.10.1038/s41598-018-29923-4
    23 sg:pub.10.1038/sj.leu.2403135
    24 schema:datePublished 2022-06-08
    25 schema:datePublishedReg 2022-06-08
    26 schema:description Several studies have reported that chronic myeloid leukaemia (CML) patients expressing e14a2 BCR::ABL1 have a faster molecular response to therapy compared to patients expressing e13a2. To explore the reason for this difference we undertook a detailed technical comparison of the commonly used Europe Against Cancer (EAC) BCR::ABL1 reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) assay in European Treatment and Outcome Study (EUTOS) reference laboratories (n = 10). We found the amplification ratio of the e13a2 amplicon was 38% greater than e14a2 (p = 0.015), and the amplification efficiency was 2% greater (P = 0.17). This subtle difference led to measurable transcript-type dependent variation in estimates of residual disease which could be corrected by (i) taking the qPCR amplification efficiency into account, (ii) using alternative RT-qPCR approaches or (iii) droplet digital PCR (ddPCR), a technique which is relatively insensitive to differences in amplification kinetics. In CML patients, higher levels of BCR::ABL1/GUSB were identified at diagnosis for patients expressing e13a2 (n = 67) compared to e14a2 (n = 78) when analysed by RT-qPCR (P = 0.0005) but not ddPCR (P = 0.5). These data indicate that widely used RT-qPCR assays result in subtly different estimates of disease depending on BCR::ABL1 transcript type; these differences are small but may need to be considered for optimal patient management.
    27 schema:genre article
    28 schema:isAccessibleForFree false
    29 schema:isPartOf Nd01c10dd2a364e53a784516a02313d81
    30 Ndbee480e1468484396d6c76e29745d5b
    31 sg:journal.1097065
    32 schema:keywords CML patients
    33 Europe
    34 European Treatment
    35 GUSB
    36 PCR
    37 RT-qPCR
    38 RT-qPCR assays
    39 account
    40 amplicons
    41 amplification efficiency
    42 amplification kinetics
    43 amplification performance
    44 amplification ratio
    45 assays
    46 cancer
    47 chain reaction
    48 chronic myeloid leukemia patients
    49 comparison
    50 data
    51 dependent variation
    52 diagnosis
    53 differences
    54 different estimates
    55 digital PCR
    56 disease
    57 droplet digital PCR
    58 e14a2
    59 efficiency
    60 estimates
    61 high levels
    62 impact
    63 kinetics
    64 laboratory
    65 leukemia patients
    66 levels
    67 management
    68 molecular response
    69 myeloid leukemia patients
    70 optimal patient management
    71 patient management
    72 patients
    73 performance
    74 polymerase chain reaction
    75 qPCR amplification efficiency
    76 quantitative polymerase chain reaction
    77 ratio
    78 reaction
    79 reasons
    80 reference laboratory
    81 residual disease
    82 response
    83 study
    84 subtle differences
    85 technical comparison
    86 technique
    87 therapy
    88 transcript type
    89 treatment
    90 types
    91 variation
    92 schema:name Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy
    93 schema:pagination 1879-1886
    94 schema:productId N49ed36611edf49758d985589798cf317
    95 N774f8d361be74f138a232d7ce60e5c99
    96 Nc8dcb08b2c16450a932ee808b3901e57
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1148515396
    98 https://doi.org/10.1038/s41375-022-01612-2
    99 schema:sdDatePublished 2022-09-02T16:08
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher Nb3965d3967f84bb692b632921d5a16a9
    102 schema:url https://doi.org/10.1038/s41375-022-01612-2
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N0522612ff9c94c7d81f260d2391cddbb rdf:first sg:person.01254702737.20
    107 rdf:rest N4f07cc40ff5346518e6a1c625f9c2d4f
    108 N09e3984ae5544f5aba27ddabd1e48be9 rdf:first sg:person.01242360741.31
    109 rdf:rest N36e0afe0e78a4db5af5d91e7b216b1df
    110 N0a35d845fd304db0b2aa40a3e23e0e29 rdf:first sg:person.0631727227.13
    111 rdf:rest N66a7b71d4bc44a839afeeff9db394f17
    112 N0af7ee76f9f24679a5b1e1b28d9e5269 rdf:first sg:person.01301247371.07
    113 rdf:rest N2ba64359b5b04b048a48d6a83b2e37b8
    114 N10f5341ea35c49b8a84386edc178a782 rdf:first N299c98d32d85400185c52f9c9fc8c5d7
    115 rdf:rest N83430f13059446e2b11b4ad9eaa3ef70
    116 N13758c2061104743a95e4fcf07a8459c rdf:first sg:person.01012771330.04
    117 rdf:rest N09e3984ae5544f5aba27ddabd1e48be9
    118 N1455c69b38194e1ea1acaa55827cf564 schema:affiliation grid-institutes:grid.9613.d
    119 schema:familyName Schäfer
    120 schema:givenName Vivien
    121 rdf:type schema:Person
    122 N1553259c063e451b81458e110b06250f rdf:first sg:person.01061656433.18
    123 rdf:rest N0522612ff9c94c7d81f260d2391cddbb
    124 N19f72a29376445618f36c14dd363b6a7 rdf:first sg:person.01053107420.89
    125 rdf:rest N1a2149421af34580908ae6095b64a4d1
    126 N1a2149421af34580908ae6095b64a4d1 rdf:first sg:person.016337203057.31
    127 rdf:rest N94de78c32932468fb5d51bb25cc0cbdd
    128 N1e29a46866654fdba75ce8799f73a4eb rdf:first sg:person.0661410706.40
    129 rdf:rest N0af7ee76f9f24679a5b1e1b28d9e5269
    130 N23a3bc46d6164f918df9ef8d2b58c9ff schema:affiliation grid-institutes:grid.6292.f
    131 schema:familyName Venturi
    132 schema:givenName Claudia
    133 rdf:type schema:Person
    134 N299c98d32d85400185c52f9c9fc8c5d7 schema:affiliation grid-institutes:grid.9613.d
    135 schema:familyName Ernst
    136 schema:givenName Thomas
    137 rdf:type schema:Person
    138 N2ba64359b5b04b048a48d6a83b2e37b8 rdf:first sg:person.01170113522.42
    139 rdf:rest N853370bcd62a47b0a816893420a11328
    140 N2d96af3a766d4363a5fadd48ef4b967d rdf:first sg:person.0630121343.27
    141 rdf:rest N19f72a29376445618f36c14dd363b6a7
    142 N36e0afe0e78a4db5af5d91e7b216b1df rdf:first sg:person.01326567212.22
    143 rdf:rest N4381c52516764e58af0c8c39fda2cbc8
    144 N4381c52516764e58af0c8c39fda2cbc8 rdf:first sg:person.01177311532.54
    145 rdf:rest N559c77ee69b24bd3beaaa638f9b8e66f
    146 N49ed36611edf49758d985589798cf317 schema:name doi
    147 schema:value 10.1038/s41375-022-01612-2
    148 rdf:type schema:PropertyValue
    149 N4e7a73b5531044299196024427aee427 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    151 rdf:type schema:DefinedTerm
    152 N4f07cc40ff5346518e6a1c625f9c2d4f rdf:first sg:person.0724710167.08
    153 rdf:rest Nf3943e239dbb428281f8c48f0acecece
    154 N559c77ee69b24bd3beaaa638f9b8e66f rdf:first sg:person.011404033154.24
    155 rdf:rest N1e29a46866654fdba75ce8799f73a4eb
    156 N59c57bb537a24e0f8976e24b8751f62c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Real-Time Polymerase Chain Reaction
    158 rdf:type schema:DefinedTerm
    159 N5bbe9774ae6847a9a93bfb5f84c32263 rdf:first sg:person.01045667334.08
    160 rdf:rest Naa90ffeca896451a827307059d25d55d
    161 N5d9512c4805344a4b3d190e48ca04a5f rdf:first sg:person.01030415745.29
    162 rdf:rest N5bbe9774ae6847a9a93bfb5f84c32263
    163 N63a42b4c2ed640cc816b8cc2741900ec rdf:first sg:person.01114710777.47
    164 rdf:rest N0a35d845fd304db0b2aa40a3e23e0e29
    165 N66a7b71d4bc44a839afeeff9db394f17 rdf:first sg:person.010131572043.47
    166 rdf:rest N13758c2061104743a95e4fcf07a8459c
    167 N7175052c33e84933bea6401ea5cba9ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Humans
    169 rdf:type schema:DefinedTerm
    170 N7230c4afc9c54ac89693b585b6d66d1e rdf:first N23a3bc46d6164f918df9ef8d2b58c9ff
    171 rdf:rest N1553259c063e451b81458e110b06250f
    172 N774f8d361be74f138a232d7ce60e5c99 schema:name dimensions_id
    173 schema:value pub.1148515396
    174 rdf:type schema:PropertyValue
    175 N83430f13059446e2b11b4ad9eaa3ef70 rdf:first N896f6d8ee239492a9cf7e58545d8491b
    176 rdf:rest N9bed51db9b94412f9bb36d4155098da6
    177 N851402a76e7d46c7be43b3db3c940fba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Imatinib Mesylate
    179 rdf:type schema:DefinedTerm
    180 N853370bcd62a47b0a816893420a11328 rdf:first N1455c69b38194e1ea1acaa55827cf564
    181 rdf:rest N7230c4afc9c54ac89693b585b6d66d1e
    182 N896f6d8ee239492a9cf7e58545d8491b schema:affiliation grid-institutes:grid.9613.d
    183 schema:familyName Hochhaus
    184 schema:givenName Andreas
    185 rdf:type schema:Person
    186 N8e77a2b96b1e4cdaa9247e9cc9b071c5 rdf:first sg:person.0622733615.39
    187 rdf:rest N5d9512c4805344a4b3d190e48ca04a5f
    188 N94de78c32932468fb5d51bb25cc0cbdd rdf:first sg:person.01107047131.47
    189 rdf:rest N8e77a2b96b1e4cdaa9247e9cc9b071c5
    190 N9bed51db9b94412f9bb36d4155098da6 rdf:first sg:person.01054615031.54
    191 rdf:rest Nd563139d34a84004857628c7fcd2ae32
    192 N9e7d7937e02d476c922b58f9cb9c84ea rdf:first sg:person.01006072366.21
    193 rdf:rest N10f5341ea35c49b8a84386edc178a782
    194 Na36a12dac36c4b0f949a15e2ee5f4f49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Neoplasm, Residual
    196 rdf:type schema:DefinedTerm
    197 Naa90ffeca896451a827307059d25d55d rdf:first sg:person.01352775766.10
    198 rdf:rest N9e7d7937e02d476c922b58f9cb9c84ea
    199 Nb3965d3967f84bb692b632921d5a16a9 schema:name Springer Nature - SN SciGraph project
    200 rdf:type schema:Organization
    201 Nba7a42e12d9742b9b9717d4b7c5199df rdf:first sg:person.013111676417.34
    202 rdf:rest Nbc02cdd13bbd4a5d8e9d64a44efc8c92
    203 Nbc02cdd13bbd4a5d8e9d64a44efc8c92 rdf:first sg:person.015277754322.00
    204 rdf:rest N63a42b4c2ed640cc816b8cc2741900ec
    205 Nc8dcb08b2c16450a932ee808b3901e57 schema:name pubmed_id
    206 schema:value 35676453
    207 rdf:type schema:PropertyValue
    208 Nd01c10dd2a364e53a784516a02313d81 schema:issueNumber 7
    209 rdf:type schema:PublicationIssue
    210 Nd563139d34a84004857628c7fcd2ae32 rdf:first sg:person.014247202557.54
    211 rdf:rest rdf:nil
    212 Nd73d44752cfa424d942ced1cf4a4c8f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Fusion Proteins, bcr-abl
    214 rdf:type schema:DefinedTerm
    215 Ndbee480e1468484396d6c76e29745d5b schema:volumeNumber 36
    216 rdf:type schema:PublicationVolume
    217 Nf3943e239dbb428281f8c48f0acecece rdf:first sg:person.0602011272.14
    218 rdf:rest Nf7fef407a70341bea68f63467db36bc6
    219 Nf7fef407a70341bea68f63467db36bc6 rdf:first sg:person.01150574132.19
    220 rdf:rest N2d96af3a766d4363a5fadd48ef4b967d
    221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Medical and Health Sciences
    223 rdf:type schema:DefinedTerm
    224 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Oncology and Carcinogenesis
    226 rdf:type schema:DefinedTerm
    227 sg:journal.1097065 schema:issn 0887-6924
    228 1476-5551
    229 schema:name Leukemia
    230 schema:publisher Springer Nature
    231 rdf:type schema:Periodical
    232 sg:person.01006072366.21 schema:affiliation grid-institutes:grid.4488.0
    233 schema:familyName Glauche
    234 schema:givenName Ingmar
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006072366.21
    236 rdf:type schema:Person
    237 sg:person.01012771330.04 schema:affiliation grid-institutes:grid.435544.7
    238 schema:familyName Cerveira
    239 schema:givenName Nuno
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012771330.04
    241 rdf:type schema:Person
    242 sg:person.010131572043.47 schema:affiliation grid-institutes:grid.419035.a
    243 schema:familyName Motlova
    244 schema:givenName Eliska
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010131572043.47
    246 rdf:type schema:Person
    247 sg:person.01030415745.29 schema:affiliation grid-institutes:grid.10267.32
    248 schema:familyName Zackova
    249 schema:givenName Daniela
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030415745.29
    251 rdf:type schema:Person
    252 sg:person.01045667334.08 schema:affiliation grid-institutes:grid.10267.32
    253 schema:familyName Mayer
    254 schema:givenName Jiri
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045667334.08
    256 rdf:type schema:Person
    257 sg:person.01053107420.89 schema:affiliation grid-institutes:grid.419035.a
    258 schema:familyName Markova
    259 schema:givenName Marketa Stastna
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053107420.89
    261 rdf:type schema:Person
    262 sg:person.01054615031.54 schema:affiliation grid-institutes:grid.419035.a
    263 schema:familyName Polakova
    264 schema:givenName Katerina Machova
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054615031.54
    266 rdf:type schema:Person
    267 sg:person.01061656433.18 schema:affiliation grid-institutes:grid.8158.4
    268 schema:familyName Vigneri
    269 schema:givenName Paolo
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061656433.18
    271 rdf:type schema:Person
    272 sg:person.01107047131.47 schema:affiliation grid-institutes:grid.419035.a
    273 schema:familyName Benesova
    274 schema:givenName Adela
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107047131.47
    276 rdf:type schema:Person
    277 sg:person.01114710777.47 schema:affiliation grid-institutes:grid.419035.a
    278 schema:familyName Zizkova
    279 schema:givenName Hana
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114710777.47
    281 rdf:type schema:Person
    282 sg:person.011404033154.24 schema:affiliation grid-institutes:None
    283 schema:familyName Gottardi
    284 schema:givenName Enrico
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011404033154.24
    286 rdf:type schema:Person
    287 sg:person.01150574132.19 schema:affiliation grid-institutes:grid.419035.a
    288 schema:familyName Koblihova
    289 schema:givenName Jitka
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150574132.19
    291 rdf:type schema:Person
    292 sg:person.01170113522.42 schema:affiliation grid-institutes:grid.416346.2
    293 schema:familyName Lion
    294 schema:givenName Thomas
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170113522.42
    296 rdf:type schema:Person
    297 sg:person.01177311532.54 schema:affiliation grid-institutes:grid.9647.c
    298 schema:familyName Franke
    299 schema:givenName Georg N.
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177311532.54
    301 rdf:type schema:Person
    302 sg:person.01242360741.31 schema:affiliation grid-institutes:grid.10403.36
    303 schema:familyName Colomer
    304 schema:givenName Dolors
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242360741.31
    306 rdf:type schema:Person
    307 sg:person.01254702737.20 schema:affiliation grid-institutes:grid.412700.0
    308 schema:familyName Zawada
    309 schema:givenName Magdalena
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254702737.20
    311 rdf:type schema:Person
    312 sg:person.01301247371.07 schema:affiliation grid-institutes:grid.10267.32
    313 schema:familyName Jurcek
    314 schema:givenName Tomas
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301247371.07
    316 rdf:type schema:Person
    317 sg:person.013111676417.34 schema:affiliation grid-institutes:grid.433814.9
    318 schema:familyName Salmon
    319 schema:givenName Matthew
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013111676417.34
    321 rdf:type schema:Person
    322 sg:person.01326567212.22 schema:affiliation grid-institutes:grid.8194.4
    323 schema:familyName Coriu
    324 schema:givenName Daniel
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326567212.22
    326 rdf:type schema:Person
    327 sg:person.01352775766.10 schema:affiliation grid-institutes:grid.4488.0
    328 schema:familyName Roeder
    329 schema:givenName Ingo
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352775766.10
    331 rdf:type schema:Person
    332 sg:person.014247202557.54 schema:affiliation grid-institutes:grid.433814.9
    333 schema:familyName Cross
    334 schema:givenName Nicholas C. P.
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014247202557.54
    336 rdf:type schema:Person
    337 sg:person.015277754322.00 schema:affiliation grid-institutes:grid.433814.9
    338 schema:familyName White
    339 schema:givenName Helen E.
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015277754322.00
    341 rdf:type schema:Person
    342 sg:person.016337203057.31 schema:affiliation grid-institutes:grid.419035.a
    343 schema:familyName Srbova
    344 schema:givenName Dana
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016337203057.31
    346 rdf:type schema:Person
    347 sg:person.0602011272.14 schema:affiliation grid-institutes:grid.412826.b
    348 schema:familyName Hovorkova
    349 schema:givenName Lenka
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602011272.14
    351 rdf:type schema:Person
    352 sg:person.0622733615.39 schema:affiliation grid-institutes:grid.419035.a
    353 schema:familyName Polivkova
    354 schema:givenName Vaclava
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622733615.39
    356 rdf:type schema:Person
    357 sg:person.0630121343.27 schema:affiliation grid-institutes:grid.419035.a
    358 schema:familyName Klamova
    359 schema:givenName Hana
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630121343.27
    361 rdf:type schema:Person
    362 sg:person.0631727227.13 schema:affiliation grid-institutes:grid.4488.0
    363 schema:familyName Gottschalk
    364 schema:givenName Andrea
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631727227.13
    366 rdf:type schema:Person
    367 sg:person.0661410706.40 schema:affiliation grid-institutes:grid.4691.a
    368 schema:familyName Izzo
    369 schema:givenName Barbara
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661410706.40
    371 rdf:type schema:Person
    372 sg:person.0724710167.08 schema:affiliation grid-institutes:grid.412826.b
    373 schema:familyName Zuna
    374 schema:givenName Jan
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724710167.08
    376 rdf:type schema:Person
    377 sg:pub.10.1007/s00277-015-2325-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039807375
    378 https://doi.org/10.1007/s00277-015-2325-z
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1007/s00432-016-2321-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003815725
    381 https://doi.org/10.1007/s00432-016-2321-2
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1007/s00432-021-03569-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1136212777
    384 https://doi.org/10.1007/s00432-021-03569-8
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/leu.2013.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040222073
    387 https://doi.org/10.1038/leu.2013.116
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/leu.2014.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032603709
    390 https://doi.org/10.1038/leu.2014.153
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/leu.2014.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026781931
    393 https://doi.org/10.1038/leu.2014.217
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/leu.2015.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023059213
    396 https://doi.org/10.1038/leu.2015.29
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/s41375-018-0341-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111614747
    399 https://doi.org/10.1038/s41375-018-0341-4
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/s41375-019-0562-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120606070
    402 https://doi.org/10.1038/s41375-019-0562-1
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/s41375-019-0647-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1122865185
    405 https://doi.org/10.1038/s41375-019-0647-x
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/s41375-020-0776-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125320161
    408 https://doi.org/10.1038/s41375-020-0776-2
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/s41375-020-0882-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127979850
    411 https://doi.org/10.1038/s41375-020-0882-1
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/s41598-018-29923-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106133501
    414 https://doi.org/10.1038/s41598-018-29923-4
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/sj.leu.2403135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042288603
    417 https://doi.org/10.1038/sj.leu.2403135
    418 rdf:type schema:CreativeWork
    419 grid-institutes:None schema:alternateName Laboratory of Chemical and Clinical Analysis “Area 3” A.O.U San Luigi Gonzaga-Orbassano, Turin, Italy
    420 schema:name Laboratory of Chemical and Clinical Analysis “Area 3” A.O.U San Luigi Gonzaga-Orbassano, Turin, Italy
    421 rdf:type schema:Organization
    422 grid-institutes:grid.10267.32 schema:alternateName Center of Molecular Biology and Gene Therapy, Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    423 Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    424 schema:name Center of Molecular Biology and Gene Therapy, Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    425 Internal Hematology and Oncology Clinic, Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
    426 rdf:type schema:Organization
    427 grid-institutes:grid.10403.36 schema:alternateName Pathology Department, Hospital Clinic, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona, Spain
    428 schema:name Pathology Department, Hospital Clinic, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona, Spain
    429 rdf:type schema:Organization
    430 grid-institutes:grid.412700.0 schema:alternateName The University Hospital in Krakow, Krakow, Poland
    431 schema:name The University Hospital in Krakow, Krakow, Poland
    432 rdf:type schema:Organization
    433 grid-institutes:grid.412826.b schema:alternateName CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
    434 schema:name CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
    435 rdf:type schema:Organization
    436 grid-institutes:grid.416346.2 schema:alternateName Labdia Labordiagnostik / St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria
    437 schema:name Labdia Labordiagnostik / St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria
    438 rdf:type schema:Organization
    439 grid-institutes:grid.419035.a schema:alternateName Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    440 schema:name Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    441 rdf:type schema:Organization
    442 grid-institutes:grid.433814.9 schema:alternateName Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK
    443 schema:name Faculty of Medicine, University of Southampton, Southampton, UK
    444 Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, UK
    445 rdf:type schema:Organization
    446 grid-institutes:grid.435544.7 schema:alternateName Portuguese Oncology Institute of Porto, Porto, Portugal
    447 schema:name Portuguese Oncology Institute of Porto, Porto, Portugal
    448 rdf:type schema:Organization
    449 grid-institutes:grid.4488.0 schema:alternateName Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany
    450 National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany. Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Dresden, Germany
    451 schema:name Institute for Medical Informatics and Biometry (IMB), Carl Gustav Carus Faculty of Medicine, TU Dresden, Dresden, Germany
    452 National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany. Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Dresden, Germany
    453 rdf:type schema:Organization
    454 grid-institutes:grid.4691.a schema:alternateName Department of Molecular Medicine and Medical Biotechnology University ‘Federico II’ and CEINGE - Advanced Biotechnologies, Naples, Italy
    455 schema:name Department of Molecular Medicine and Medical Biotechnology University ‘Federico II’ and CEINGE - Advanced Biotechnologies, Naples, Italy
    456 rdf:type schema:Organization
    457 grid-institutes:grid.6292.f schema:alternateName IRCSS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
    458 schema:name IRCSS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
    459 rdf:type schema:Organization
    460 grid-institutes:grid.8158.4 schema:alternateName University of Catania, Department of Clinical and Experimental Medicine, Center of Experimental Oncology and Hematology, Catania, Italy
    461 schema:name University of Catania, Department of Clinical and Experimental Medicine, Center of Experimental Oncology and Hematology, Catania, Italy
    462 rdf:type schema:Organization
    463 grid-institutes:grid.8194.4 schema:alternateName Hematology Department, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
    464 schema:name Fundeni Clinical Institute, Hematology Department, Bucharest, Romania
    465 Hematology Department, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
    466 rdf:type schema:Organization
    467 grid-institutes:grid.9613.d schema:alternateName Abteilung Hämatologie/Onkologie, Klinik für Innere Medizin II, University of Jena, Jena, Germany
    468 schema:name Abteilung Hämatologie/Onkologie, Klinik für Innere Medizin II, University of Jena, Jena, Germany
    469 rdf:type schema:Organization
    470 grid-institutes:grid.9647.c schema:alternateName University of Leipzig Medical Center, Department for Hematology, Cellular Therapies and Hemostaseology, Leipzig, Germany
    471 schema:name University of Leipzig Medical Center, Department for Hematology, Cellular Therapies and Hemostaseology, Leipzig, Germany
    472 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...