Autologous or allogeneic hematopoietic cell transplantation for relapsed or refractory PTCL-NOS or AITL View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-03-28

AUTHORS

Kazuaki Kameda, Shinichi Kako, Sung-Won Kim, Yoshiaki Usui, Koji Kato, Takahiro Fukuda, Naoyuki Uchida, Hikaru Kobayashi, Toshio Wakayama, Emiko Sakaida, Shingo Yano, Kazunori Imada, Miho Nara, Takashi Ikeda, Shin-ichi Fuchida, Jun Ishikawa, Hiroyuki Sugahara, Junya Kanda, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Eisei Kondo

ABSTRACT

Fit patients with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL) in relapsed or refractory (R/R) disease status often receive salvage chemotherapy followed by autologous hematopoietic stem cell transplantation (autoHCT) or allogeneic HCT (alloHCT). However, there is no consensus on the type of HCT that should be applied for such patients. Herein, we retrospectively evaluated the survival outcome of 760 adult R/R PTCL-NOS or AITL patients who underwent the first HCT. Among them, 318 relapsed after first remission (REL) and 442 were refractory to the primary therapy (PIF). The 4-year overall survival (OS) of autoHCT and alloHCT was 50 and 50% for REL patients, and 52 and 49% for PIF patients, respectively. In the multivariable analysis, alloHCT tended to be associated with better progression-free survival (PFS) in REL (hazard ratio [HR] 0.74; 95% confidence interval [CI]: 0.53–1.03), and significantly better PFS in PIF (HR 0.64; 95% CI: 0.46–0.88) compared with autoHCT. The subgroup analysis with propensity-score matching showed that alloHCT was associated with better OS for REL-sensitive and PIF-nonremission disease. This study suggested that the advantage of alloHCT for R/R PTCL-NOS or AITL is different, depending on the disease status at HCT. More... »

PAGES

1361-1370

References to SciGraph publications

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  • Journal

    TITLE

    Leukemia

    ISSUE

    5

    VOLUME

    36

    Author Affiliations

  • Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
  • Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital, Fukuoka, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan
  • Department of Hematology and Oncology, Shimane Prefectural Central Hospital, Izumo, Japan
  • Department of Hematology, Chiba University Hospital, Chiba, Japan
  • Division of Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Osaka Hospital, Osaka, Japan
  • Division of Hematology, Nephrology and Rheumatology, Akita University Hospital, Akita, Japan
  • Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, Shizuoka, Japan
  • Department of Hematology, Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center, Kyoto, Japan
  • Department of Hematology, Osaka International Cancer Institute, Osaka, Japan
  • Department of Hematology, Sumitomo Hospital, Osaka, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Preparation Department, Japanese Red Cross Kinki Block Blood Center, Osaka, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
  • Department of Hematology, Kawasaki Medical School, Kurashiki, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-022-01545-w

    DOI

    http://dx.doi.org/10.1038/s41375-022-01545-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1146617648

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35347237


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