Ontology type: schema:ScholarlyArticle
2022-03-28
AUTHORSKazuaki Kameda, Shinichi Kako, Sung-Won Kim, Yoshiaki Usui, Koji Kato, Takahiro Fukuda, Naoyuki Uchida, Hikaru Kobayashi, Toshio Wakayama, Emiko Sakaida, Shingo Yano, Kazunori Imada, Miho Nara, Takashi Ikeda, Shin-ichi Fuchida, Jun Ishikawa, Hiroyuki Sugahara, Junya Kanda, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Eisei Kondo
ABSTRACTFit patients with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL) in relapsed or refractory (R/R) disease status often receive salvage chemotherapy followed by autologous hematopoietic stem cell transplantation (autoHCT) or allogeneic HCT (alloHCT). However, there is no consensus on the type of HCT that should be applied for such patients. Herein, we retrospectively evaluated the survival outcome of 760 adult R/R PTCL-NOS or AITL patients who underwent the first HCT. Among them, 318 relapsed after first remission (REL) and 442 were refractory to the primary therapy (PIF). The 4-year overall survival (OS) of autoHCT and alloHCT was 50 and 50% for REL patients, and 52 and 49% for PIF patients, respectively. In the multivariable analysis, alloHCT tended to be associated with better progression-free survival (PFS) in REL (hazard ratio [HR] 0.74; 95% confidence interval [CI]: 0.53–1.03), and significantly better PFS in PIF (HR 0.64; 95% CI: 0.46–0.88) compared with autoHCT. The subgroup analysis with propensity-score matching showed that alloHCT was associated with better OS for REL-sensitive and PIF-nonremission disease. This study suggested that the advantage of alloHCT for R/R PTCL-NOS or AITL is different, depending on the disease status at HCT. More... »
PAGES1361-1370
http://scigraph.springernature.com/pub.10.1038/s41375-022-01545-w
DOIhttp://dx.doi.org/10.1038/s41375-022-01545-w
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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01545-w'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01545-w'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01545-w'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-022-01545-w'
This table displays all metadata directly associated to this object as RDF triples.
383 TRIPLES
21 PREDICATES
92 URIs
75 LITERALS
14 BLANK NODES