Comparing cord blood transplantation and matched related donor transplantation in non-remission acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-24

AUTHORS

Yoshimitsu Shimomura, Tomotaka Sobue, Shigeki Hirabayashi, Tadakazu Kondo, Shohei Mizuno, Junya Kanda, Takahiro Fujino, Keisuke Kataoka, Naoyuki Uchida, Tetsuya Eto, Shigesaburo Miyakoshi, Masatsugu Tanaka, Toshiro Kawakita, Hisayuki Yokoyama, Noriko Doki, Kaito Harada, Atsushi Wake, Shuichi Ota, Satoru Takada, Satoshi Takahashi, Takafumi Kimura, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Masamitsu Yanada

ABSTRACT

Cord blood transplantation (CBT) is an alternative donor transplantation method and has the advantages of rapid availability and the possibility of inducing a more potent graft-versus-leukemia effect, leading to a lower relapse rate for patients with non-remission relapse and refractory acute myeloid leukemia (R/R AML). This study aimed to investigate the impact of CBT, compared to human leukocyte antigen-matched related donor transplantation (MRDT). This study included 2451 adult patients with non-remission R/R AML who received CBT (1738 patients) or MRDT (713 patients) between January 2009 and December 2018. Five-year progression-free survival (PFS) and the prognostic impact of CBT were evaluated using a propensity score (PS) matching analysis. After PS matching, the patient characteristics were well balanced between the groups. The five-year PFS was 25.2% (95% confidence interval [CI]: 21.2–29.5%) in the CBT group and 18.1% (95% CI: 14.5–22.0%) in the MRDT group (P = 0.009). The adjusted hazard ratio (HR) was 0.83 (95% CI: 0.69–1.00, P = 0.045); this was due to a more pronounced decrease in the relapse rate (HR: 0.78, 95% CI: 0.69–0.89, P < 0.001) than an increase in the NRM (1.42, 1.15–1.76, P = 0.001). In this population, CBT was associated with a better 5-year PFS than MRDT after allogeneic HSCT. More... »

PAGES

1132-1138

References to SciGraph publications

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  • Journal

    TITLE

    Leukemia

    ISSUE

    4

    VOLUME

    36

    Author Affiliations

  • Department of Environmental Medicine and Population Science, Graduate School of Medicine, Osaka University, Suita, Japan
  • Division of Precision Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
  • Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Division of Hematology and Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
  • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
  • Department of Hematology, National Hospital Organization Sendai Medical Center, Sendai, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology/Oncology, Tokai University School of Medicine, Kanagawa, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Kajigaya, Kawasaki, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
  • Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Preparation Department, Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
  • Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-021-01474-0

    DOI

    http://dx.doi.org/10.1038/s41375-021-01474-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142904915

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34815516


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