Impact of prior JAK-inhibitor therapy with ruxolitinib on outcome after allogeneic hematopoietic stem cell transplantation for myelofibrosis: a study of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-22

AUTHORS

Nicolaus Kröger, Giulia Sbianchi, Tiarlan Sirait, Christine Wolschke, Dietrich Beelen, Jakob Passweg, Marie Robin, Radovan Vrhovac, Grzegorz Helbig, Katja Sockel, Eibhlin Conneally, Marie Thérèse Rubio, Yves Beguin, Jürgen Finke, Paolo Bernasconi, Elena Morozova, Johannes Clausen, Peter von dem Borne, Nicolaas Schaap, Wilfried Schroyens, Francesca Patriarca, Nicola Di Renzo, Zeynep Arzu Yeğin, Patrick Hayden, Donal McLornan, Ibrahim Yakoub-Agha

ABSTRACT

JAK1/2 inhibitor ruxolitinib (RUX) is approved in patients with myelofibrosis but the impact of pretreatment with RUX on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) remains to be determined. We evaluated the impact of RUX on outcome in 551 myelofibrosis patients who received HSCT without (n = 274) or with (n = 277) RUX pretreatment. The overall leukocyte engraftment on day 45 was 92% and significantly higher in RUX responsive patients than those who had no or lost response to RUX (94% vs. 85%, p = 0.05). The 1-year non-relapse mortality was 22% without significant difference between the arms. In a multivariate analysis (MVA) RUX pretreated patients with ongoing spleen response at transplant had a significantly lower risk of relapse (8.1% vs. 19.1%; p = 0.04)] and better 2-year event-free survival (68.9% vs. 53.7%; p = 0.02) in comparison to patients without RUX pretreatment. For overall survival the only significant factors were age > 58 years (p = 0.03) and HLA mismatch donor (p = 0.001). RUX prior to HSCT did not negatively impact outcome after transplantation and patients with ongoing spleen response at time of transplantation had best outcome. More... »

PAGES

3551-3560

Journal

TITLE

Leukemia

ISSUE

12

VOLUME

35

Author Affiliations

  • Department of Stem Cell Transplantation University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
  • EBMT Data Office, Leiden, Netherlands
  • Essen University Hospital, Essen, Germany
  • University Hospital of Basel, Basel, Switzerland
  • Hopital St. Louis, Paris, France
  • University Hospital Center Rebro, Zagreb, Croatia
  • Silesian Medica Academy, Katowice, Poland
  • University Hospital Dresden, Dresden, Germany
  • Hope Directorate St. James’s Hospital, Dublin, Ireland
  • Hopital d’Enfants, Vandoeuvre Nancy, France
  • University of Liege and CHU of Liege, Liege, Belgium
  • University of Freiburg, Freiburg, Germany
  • IRCCS Policlinico San Matteo, Pavia, Italy
  • First State Pavlov Medical University of St. Petersburg, St. Petersburg, Russia
  • Ordensklinikum Linz - Elisabethinen, Linz, Austria
  • Leiden University Hospital, Leiden, Netherlands
  • Radboud University Medical Centre, Nijmegen, Netherlands
  • Antwerp University Hospital (UZA), Antwerp Edegem, Belgium
  • Division of Hematology and Stem Cell Transplantation Center, University Hospital and DAME, Udine, Italy
  • Unita Operativa di Ematologia e Trapianto di Cellule Staminali, Lecce, Italy
  • Gazi University Faculty of Medicine, Ankara, Turkey
  • Department of Haematology, Trinity College Dublin, St. James’s Hospital, Dublin 8, Ireland
  • Department of Haematology, Guy’s Hospital and Department of Stem Cell Transplantation, University College London Hospital, London, England
  • CHU de Lille, Univ Lille, INSERM U1286, Infinite, Lille, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-021-01276-4

    DOI

    http://dx.doi.org/10.1038/s41375-021-01276-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1138267202

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34023851


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