Treatment-free remission following frontline nilotinib in patients with chronic phase chronic myeloid leukemia: 5-year update of the ENESTfreedom trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-03-11

AUTHORS

Jerald P. Radich, Andreas Hochhaus, Tamás Masszi, Andrzej Hellmann, Jesper Stentoft, María Teresa Gómez Casares, J. Valentín García-Gutiérrez, Eibhlin Conneally, Philipp D. le Coutre, Norbert Gattermann, Bruno Martino, Susanne Saussele, Francis J. Giles, David M. Ross, Paola Aimone, Sai Li, Ksenia Titorenko, Giuseppe Saglio

ABSTRACT

The ENESTfreedom trial assessed the feasibility of treatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase (CML-CP) following frontline nilotinib treatment. Results for long-term outcomes after a 5-year follow-up are presented herein. Patients who had received ≥2 years of frontline nilotinib therapy and achieved MR4.5 underwent a 1-year nilotinib treatment consolidation phase before attempting TFR. At the 5-year data cut-off, 81/190 patients entering the TFR phase (42.6%) were still in TFR, with 76 (40.0%) in MR4.5. Patients who lost major molecular response (MMR) entered a treatment re-initiation phase; 90/91 patients entering this phase (98.9%) regained MMR and 84/91 patients (92.3%) regained MR4.5. The Kaplan–Meier estimated treatment-free survival rate at 5 years was 48.2%. No disease progression or CML-related deaths were reported. Whereas the incidence of adverse events (AEs) declined from 96 weeks following the start of TFR, an increase in AE frequency was observed for patients in the treatment re-initiation phase. Low Sokal risk score, BCR-ABL1IS levels at 48 weeks of TFR and stable MR4.5 response for the first year of TFR were associated with higher TFR rates. Overall, these results support the efficacy and safety of attempting TFR following upfront nilotinib therapy of >3 years in patients with CML-CP. More... »

PAGES

1344-1355

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41375-021-01205-5

DOI

http://dx.doi.org/10.1038/s41375-021-01205-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1136297746

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33707652


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myelogenous, Chronic, BCR-ABL Positive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Chronic-Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrimidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Radich", 
        "givenName": "Jerald P.", 
        "id": "sg:person.011362420057.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011362420057.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Abteilung H\u00e4matologie/Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany", 
          "id": "http://www.grid.ac/institutes/grid.275559.9", 
          "name": [
            "Abteilung H\u00e4matologie/Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hochhaus", 
        "givenName": "Andreas", 
        "id": "sg:person.01064615503.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064615503.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Semmelweis University, Budapest, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.11804.3c", 
          "name": [
            "Semmelweis University, Budapest, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masszi", 
        "givenName": "Tam\u00e1s", 
        "id": "sg:person.0751651512.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751651512.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Gda\u0144sk, Gda\u0144sk, Poland", 
          "id": "http://www.grid.ac/institutes/grid.11451.30", 
          "name": [
            "Medical University of Gda\u0144sk, Gda\u0144sk, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hellmann", 
        "givenName": "Andrzej", 
        "id": "sg:person.01154416326.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154416326.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University Hospital, Aarhus, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Aarhus University Hospital, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stentoft", 
        "givenName": "Jesper", 
        "id": "sg:person.016036621425.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036621425.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario de Gran Canaria Dr Negr\u00edn, Las Palmas de Gran Canaria, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411250.3", 
          "name": [
            "Hospital Universitario de Gran Canaria Dr Negr\u00edn, Las Palmas de Gran Canaria, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casares", 
        "givenName": "Mar\u00eda Teresa G\u00f3mez", 
        "id": "sg:person.013411572177.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013411572177.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411347.4", 
          "name": [
            "Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Guti\u00e9rrez", 
        "givenName": "J. Valent\u00edn", 
        "id": "sg:person.01203162637.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203162637.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St James\u2019s Hospital, Dublin, Ireland", 
          "id": "http://www.grid.ac/institutes/grid.416409.e", 
          "name": [
            "St James\u2019s Hospital, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conneally", 
        "givenName": "Eibhlin", 
        "id": "sg:person.01132647406.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647406.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany", 
          "id": "http://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "le Coutre", 
        "givenName": "Philipp D.", 
        "id": "sg:person.01344447222.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344447222.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.14778.3d", 
          "name": [
            "Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gattermann", 
        "givenName": "Norbert", 
        "id": "sg:person.01273447501.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy", 
          "id": "http://www.grid.ac/institutes/grid.414504.0", 
          "name": [
            "Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martino", 
        "givenName": "Bruno", 
        "id": "sg:person.01105522434.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105522434.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "III. Med. Klinik, Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg, Mannheim, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "III. Med. Klinik, Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg, Mannheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saussele", 
        "givenName": "Susanne", 
        "id": "sg:person.0611020122.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611020122.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Developmental Therapeutics Consortium, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Developmental Therapeutics Consortium, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giles", 
        "givenName": "Francis J.", 
        "id": "sg:person.011165370517.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011165370517.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Haematology, SA Pathology, Royal Adelaide Hospital, Adelaide, Australia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Haematology, SA Pathology, Royal Adelaide Hospital, Adelaide, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ross", 
        "givenName": "David M.", 
        "id": "sg:person.01110323637.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110323637.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis Pharma AG, Basel, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Pharma AG, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aimone", 
        "givenName": "Paola", 
        "id": "sg:person.01156721025.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156721025.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis Pharma AG, Basel, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Pharma AG, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Sai", 
        "id": "sg:person.013222113051.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013222113051.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis Pharmaceuticals Corporation, Moscow, Russian Federation", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Novartis Pharmaceuticals Corporation, Moscow, Russian Federation"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Titorenko", 
        "givenName": "Ksenia", 
        "id": "sg:person.011367550003.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367550003.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin, Orbassano, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "University of Turin, Orbassano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saglio", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01334477453.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334477453.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00432-018-2604-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101145018", 
          "https://doi.org/10.1007/s00432-018-2604-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2017.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083850241", 
          "https://doi.org/10.1038/leu.2017.63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2016.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047140338", 
          "https://doi.org/10.1038/leu.2016.104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41375-020-0776-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1125320161", 
          "https://doi.org/10.1038/s41375-020-0776-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41375-020-01111-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1134383975", 
          "https://doi.org/10.1038/s41375-020-01111-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2016.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041273297", 
          "https://doi.org/10.1038/leu.2016.5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2016.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022073613", 
          "https://doi.org/10.1038/leu.2016.115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2017.253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091207323", 
          "https://doi.org/10.1038/leu.2017.253"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-03-11", 
    "datePublishedReg": "2021-03-11", 
    "description": "The ENESTfreedom trial assessed the feasibility of treatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase (CML-CP) following frontline nilotinib treatment. Results for long-term outcomes after a 5-year follow-up are presented herein. Patients who had received \u22652 years of frontline nilotinib therapy and achieved MR4.5 underwent a 1-year nilotinib treatment consolidation phase before attempting TFR. At the 5-year data cut-off, 81/190 patients entering the TFR phase (42.6%) were still in TFR, with 76 (40.0%) in MR4.5. Patients who lost major molecular response (MMR) entered a treatment re-initiation phase; 90/91 patients entering this phase (98.9%) regained MMR and 84/91 patients (92.3%) regained MR4.5. The Kaplan\u2013Meier estimated treatment-free survival rate at 5 years was 48.2%. No disease progression or CML-related deaths were reported. Whereas the incidence of adverse events (AEs) declined from 96 weeks following the start of TFR, an increase in AE frequency was observed for patients in the treatment re-initiation phase. Low Sokal risk score, BCR-ABL1IS levels at 48 weeks of TFR and stable MR4.5 response for the first year of TFR were associated with higher TFR rates. Overall, these results support the efficacy and safety of attempting TFR following upfront nilotinib therapy of >3 years in patients with CML-CP.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41375-021-01205-5", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "treatment-free remission", 
      "major molecular response", 
      "chronic myeloid leukemia", 
      "adverse events", 
      "nilotinib therapy", 
      "myeloid leukemia", 
      "chronic phase chronic myeloid leukemia", 
      "treatment-free survival rate", 
      "phase chronic myeloid leukemia", 
      "CML-related deaths", 
      "Sokal risk score", 
      "higher TFR rates", 
      "long-term outcomes", 
      "TFR phase", 
      "TFR rate", 
      "frontline nilotinib", 
      "CML-CP", 
      "nilotinib treatment", 
      "chronic phase", 
      "Kaplan-Meier", 
      "disease progression", 
      "risk score", 
      "patients", 
      "survival rate", 
      "data cut", 
      "MR4.5", 
      "remission", 
      "therapy", 
      "leukemia", 
      "AE frequency", 
      "first year", 
      "trials", 
      "consolidation phase", 
      "weeks", 
      "molecular response", 
      "years", 
      "nilotinib", 
      "incidence", 
      "progression", 
      "response", 
      "death", 
      "efficacy", 
      "outcomes", 
      "treatment", 
      "scores", 
      "rate", 
      "safety", 
      "levels", 
      "start", 
      "update", 
      "events", 
      "increase", 
      "results", 
      "frequency", 
      "feasibility", 
      "phase", 
      "cut"
    ], 
    "name": "Treatment-free remission following frontline nilotinib in patients with chronic phase chronic myeloid leukemia: 5-year update of the ENESTfreedom trial", 
    "pagination": "1344-1355", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1136297746"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41375-021-01205-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33707652"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41375-021-01205-5", 
      "https://app.dimensions.ai/details/publication/pub.1136297746"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_900.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41375-021-01205-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-021-01205-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-021-01205-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-021-01205-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-021-01205-5'


 

This table displays all metadata directly associated to this object as RDF triples.

359 TRIPLES      21 PREDICATES      101 URIs      85 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41375-021-01205-5 schema:about N09c6a4f4bac54a34b50edbbce97e50a5
2 N0c6eff5b961743528dfbfcae67b2a569
3 N1d21cfa5ea394fe8942435fab9248aac
4 N65c15a19bcdf4b228e5cf78287987f48
5 N6906bf0c533a43c888d3805f59609a53
6 N9ce4be8b44c54222bc91d3effa1bc0af
7 Nad2a516a09414d4c81ad2b4c0cb20699
8 Nc5ee8ee0be104920abf3ddc9fcb8cc33
9 Nd0b76abc28ca43b1ae9e0d5901f0b244
10 Nd6b5d65bf0dc448881aa1449bf6a8774
11 Ndcf7c18a080a41c894f654a9a5db8fe6
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N38ff91bd71d348c4920e8f6bbc4795a5
15 schema:citation sg:pub.10.1007/s00432-018-2604-x
16 sg:pub.10.1038/leu.2016.104
17 sg:pub.10.1038/leu.2016.115
18 sg:pub.10.1038/leu.2016.5
19 sg:pub.10.1038/leu.2017.253
20 sg:pub.10.1038/leu.2017.63
21 sg:pub.10.1038/s41375-020-01111-2
22 sg:pub.10.1038/s41375-020-0776-2
23 schema:datePublished 2021-03-11
24 schema:datePublishedReg 2021-03-11
25 schema:description The ENESTfreedom trial assessed the feasibility of treatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase (CML-CP) following frontline nilotinib treatment. Results for long-term outcomes after a 5-year follow-up are presented herein. Patients who had received ≥2 years of frontline nilotinib therapy and achieved MR4.5 underwent a 1-year nilotinib treatment consolidation phase before attempting TFR. At the 5-year data cut-off, 81/190 patients entering the TFR phase (42.6%) were still in TFR, with 76 (40.0%) in MR4.5. Patients who lost major molecular response (MMR) entered a treatment re-initiation phase; 90/91 patients entering this phase (98.9%) regained MMR and 84/91 patients (92.3%) regained MR4.5. The Kaplan–Meier estimated treatment-free survival rate at 5 years was 48.2%. No disease progression or CML-related deaths were reported. Whereas the incidence of adverse events (AEs) declined from 96 weeks following the start of TFR, an increase in AE frequency was observed for patients in the treatment re-initiation phase. Low Sokal risk score, BCR-ABL1IS levels at 48 weeks of TFR and stable MR4.5 response for the first year of TFR were associated with higher TFR rates. Overall, these results support the efficacy and safety of attempting TFR following upfront nilotinib therapy of >3 years in patients with CML-CP.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N55f004d019ee4328925ab007b8dc0399
29 Nda326d3d1b694aa1afab256000fa68e8
30 sg:journal.1097065
31 schema:keywords AE frequency
32 CML-CP
33 CML-related deaths
34 Kaplan-Meier
35 MR4.5
36 Sokal risk score
37 TFR phase
38 TFR rate
39 adverse events
40 chronic myeloid leukemia
41 chronic phase
42 chronic phase chronic myeloid leukemia
43 consolidation phase
44 cut
45 data cut
46 death
47 disease progression
48 efficacy
49 events
50 feasibility
51 first year
52 frequency
53 frontline nilotinib
54 higher TFR rates
55 incidence
56 increase
57 leukemia
58 levels
59 long-term outcomes
60 major molecular response
61 molecular response
62 myeloid leukemia
63 nilotinib
64 nilotinib therapy
65 nilotinib treatment
66 outcomes
67 patients
68 phase
69 phase chronic myeloid leukemia
70 progression
71 rate
72 remission
73 response
74 results
75 risk score
76 safety
77 scores
78 start
79 survival rate
80 therapy
81 treatment
82 treatment-free remission
83 treatment-free survival rate
84 trials
85 update
86 weeks
87 years
88 schema:name Treatment-free remission following frontline nilotinib in patients with chronic phase chronic myeloid leukemia: 5-year update of the ENESTfreedom trial
89 schema:pagination 1344-1355
90 schema:productId Nd08962777ab043c1ba1c9be26a46ec6a
91 Nefe73f3ae3d244788939f5f2f63d7da5
92 Nf12783d7b9fa48019071dffe942cde39
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1136297746
94 https://doi.org/10.1038/s41375-021-01205-5
95 schema:sdDatePublished 2022-08-04T17:11
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N692cca8aecb54a2b844d8ad86b88b1ed
98 schema:url https://doi.org/10.1038/s41375-021-01205-5
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N09c6a4f4bac54a34b50edbbce97e50a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Adolescent
104 rdf:type schema:DefinedTerm
105 N09f63e1387354b26a58d078e24cf6fe6 rdf:first sg:person.01132647406.49
106 rdf:rest N2ec22513c5854bd8a65db6959122592e
107 N0bbb841cb18e427ea492bf4a8f7445b9 rdf:first sg:person.011165370517.24
108 rdf:rest N93b167e82bf74165b4e5139e334334cd
109 N0c6eff5b961743528dfbfcae67b2a569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Leukemia, Myeloid, Chronic-Phase
111 rdf:type schema:DefinedTerm
112 N0ee6f2046e7c4136917db813da4ea127 rdf:first sg:person.01203162637.37
113 rdf:rest N09f63e1387354b26a58d078e24cf6fe6
114 N1c0b58925d234adb8118d254600c340f rdf:first sg:person.01273447501.34
115 rdf:rest N9ece88b6bc6845f4889c39f5d7c36a68
116 N1d21cfa5ea394fe8942435fab9248aac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Leukemia, Myelogenous, Chronic, BCR-ABL Positive
118 rdf:type schema:DefinedTerm
119 N21b661c8509f4b78a9b5ebf23d6ad07b rdf:first sg:person.013411572177.22
120 rdf:rest N0ee6f2046e7c4136917db813da4ea127
121 N2ec22513c5854bd8a65db6959122592e rdf:first sg:person.01344447222.75
122 rdf:rest N1c0b58925d234adb8118d254600c340f
123 N38ff91bd71d348c4920e8f6bbc4795a5 rdf:first sg:person.011362420057.85
124 rdf:rest N87878b65d01a4df3ad3a5d539a72749f
125 N46b7b8659dd848dea277e32059af670d rdf:first sg:person.01156721025.39
126 rdf:rest Nd10b7e054a58441ca270f6973d1cd142
127 N55f004d019ee4328925ab007b8dc0399 schema:volumeNumber 35
128 rdf:type schema:PublicationVolume
129 N58fda04432ca4a9b8b4f27016b983d9b rdf:first sg:person.0751651512.21
130 rdf:rest N7e8826c1cb1e4e1e82c4d6d47dc6a7dc
131 N65c15a19bcdf4b228e5cf78287987f48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 N6906bf0c533a43c888d3805f59609a53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Protein Kinase Inhibitors
136 rdf:type schema:DefinedTerm
137 N692cca8aecb54a2b844d8ad86b88b1ed schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N7e8826c1cb1e4e1e82c4d6d47dc6a7dc rdf:first sg:person.01154416326.31
140 rdf:rest Nfab5ce4e6ed94098adf5e6079769be7e
141 N87878b65d01a4df3ad3a5d539a72749f rdf:first sg:person.01064615503.48
142 rdf:rest N58fda04432ca4a9b8b4f27016b983d9b
143 N93b167e82bf74165b4e5139e334334cd rdf:first sg:person.01110323637.14
144 rdf:rest N46b7b8659dd848dea277e32059af670d
145 N9ce4be8b44c54222bc91d3effa1bc0af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Survival Rate
147 rdf:type schema:DefinedTerm
148 N9d6f86db68494dcdbc37bbb0b2d618ad rdf:first sg:person.0611020122.69
149 rdf:rest N0bbb841cb18e427ea492bf4a8f7445b9
150 N9ece88b6bc6845f4889c39f5d7c36a68 rdf:first sg:person.01105522434.09
151 rdf:rest N9d6f86db68494dcdbc37bbb0b2d618ad
152 Nad2a516a09414d4c81ad2b4c0cb20699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Female
154 rdf:type schema:DefinedTerm
155 Nc29ce8f9cb864035bde909bd1c87d534 rdf:first sg:person.01334477453.06
156 rdf:rest rdf:nil
157 Nc5ee8ee0be104920abf3ddc9fcb8cc33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Treatment Outcome
159 rdf:type schema:DefinedTerm
160 Nd08962777ab043c1ba1c9be26a46ec6a schema:name doi
161 schema:value 10.1038/s41375-021-01205-5
162 rdf:type schema:PropertyValue
163 Nd0b76abc28ca43b1ae9e0d5901f0b244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Kaplan-Meier Estimate
165 rdf:type schema:DefinedTerm
166 Nd10b7e054a58441ca270f6973d1cd142 rdf:first sg:person.013222113051.10
167 rdf:rest Nfe75e762c42e44e59c9aa0154181160b
168 Nd6b5d65bf0dc448881aa1449bf6a8774 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Male
170 rdf:type schema:DefinedTerm
171 Nda326d3d1b694aa1afab256000fa68e8 schema:issueNumber 5
172 rdf:type schema:PublicationIssue
173 Ndcf7c18a080a41c894f654a9a5db8fe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Pyrimidines
175 rdf:type schema:DefinedTerm
176 Nefe73f3ae3d244788939f5f2f63d7da5 schema:name dimensions_id
177 schema:value pub.1136297746
178 rdf:type schema:PropertyValue
179 Nf12783d7b9fa48019071dffe942cde39 schema:name pubmed_id
180 schema:value 33707652
181 rdf:type schema:PropertyValue
182 Nfab5ce4e6ed94098adf5e6079769be7e rdf:first sg:person.016036621425.38
183 rdf:rest N21b661c8509f4b78a9b5ebf23d6ad07b
184 Nfe75e762c42e44e59c9aa0154181160b rdf:first sg:person.011367550003.65
185 rdf:rest Nc29ce8f9cb864035bde909bd1c87d534
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
190 schema:name Clinical Sciences
191 rdf:type schema:DefinedTerm
192 sg:journal.1097065 schema:issn 0887-6924
193 1476-5551
194 schema:name Leukemia
195 schema:publisher Springer Nature
196 rdf:type schema:Periodical
197 sg:person.01064615503.48 schema:affiliation grid-institutes:grid.275559.9
198 schema:familyName Hochhaus
199 schema:givenName Andreas
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064615503.48
201 rdf:type schema:Person
202 sg:person.01105522434.09 schema:affiliation grid-institutes:grid.414504.0
203 schema:familyName Martino
204 schema:givenName Bruno
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105522434.09
206 rdf:type schema:Person
207 sg:person.01110323637.14 schema:affiliation grid-institutes:None
208 schema:familyName Ross
209 schema:givenName David M.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110323637.14
211 rdf:type schema:Person
212 sg:person.011165370517.24 schema:affiliation grid-institutes:None
213 schema:familyName Giles
214 schema:givenName Francis J.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011165370517.24
216 rdf:type schema:Person
217 sg:person.01132647406.49 schema:affiliation grid-institutes:grid.416409.e
218 schema:familyName Conneally
219 schema:givenName Eibhlin
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132647406.49
221 rdf:type schema:Person
222 sg:person.011362420057.85 schema:affiliation grid-institutes:grid.270240.3
223 schema:familyName Radich
224 schema:givenName Jerald P.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011362420057.85
226 rdf:type schema:Person
227 sg:person.011367550003.65 schema:affiliation grid-institutes:None
228 schema:familyName Titorenko
229 schema:givenName Ksenia
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367550003.65
231 rdf:type schema:Person
232 sg:person.01154416326.31 schema:affiliation grid-institutes:grid.11451.30
233 schema:familyName Hellmann
234 schema:givenName Andrzej
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154416326.31
236 rdf:type schema:Person
237 sg:person.01156721025.39 schema:affiliation grid-institutes:grid.419481.1
238 schema:familyName Aimone
239 schema:givenName Paola
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156721025.39
241 rdf:type schema:Person
242 sg:person.01203162637.37 schema:affiliation grid-institutes:grid.411347.4
243 schema:familyName García-Gutiérrez
244 schema:givenName J. Valentín
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203162637.37
246 rdf:type schema:Person
247 sg:person.01273447501.34 schema:affiliation grid-institutes:grid.14778.3d
248 schema:familyName Gattermann
249 schema:givenName Norbert
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34
251 rdf:type schema:Person
252 sg:person.013222113051.10 schema:affiliation grid-institutes:grid.419481.1
253 schema:familyName Li
254 schema:givenName Sai
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013222113051.10
256 rdf:type schema:Person
257 sg:person.01334477453.06 schema:affiliation grid-institutes:grid.7605.4
258 schema:familyName Saglio
259 schema:givenName Giuseppe
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334477453.06
261 rdf:type schema:Person
262 sg:person.013411572177.22 schema:affiliation grid-institutes:grid.411250.3
263 schema:familyName Casares
264 schema:givenName María Teresa Gómez
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013411572177.22
266 rdf:type schema:Person
267 sg:person.01344447222.75 schema:affiliation grid-institutes:grid.6363.0
268 schema:familyName le Coutre
269 schema:givenName Philipp D.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344447222.75
271 rdf:type schema:Person
272 sg:person.016036621425.38 schema:affiliation grid-institutes:grid.154185.c
273 schema:familyName Stentoft
274 schema:givenName Jesper
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036621425.38
276 rdf:type schema:Person
277 sg:person.0611020122.69 schema:affiliation grid-institutes:grid.7700.0
278 schema:familyName Saussele
279 schema:givenName Susanne
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611020122.69
281 rdf:type schema:Person
282 sg:person.0751651512.21 schema:affiliation grid-institutes:grid.11804.3c
283 schema:familyName Masszi
284 schema:givenName Tamás
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751651512.21
286 rdf:type schema:Person
287 sg:pub.10.1007/s00432-018-2604-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1101145018
288 https://doi.org/10.1007/s00432-018-2604-x
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/leu.2016.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047140338
291 https://doi.org/10.1038/leu.2016.104
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/leu.2016.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022073613
294 https://doi.org/10.1038/leu.2016.115
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/leu.2016.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041273297
297 https://doi.org/10.1038/leu.2016.5
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/leu.2017.253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091207323
300 https://doi.org/10.1038/leu.2017.253
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/leu.2017.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083850241
303 https://doi.org/10.1038/leu.2017.63
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/s41375-020-01111-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1134383975
306 https://doi.org/10.1038/s41375-020-01111-2
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/s41375-020-0776-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125320161
309 https://doi.org/10.1038/s41375-020-0776-2
310 rdf:type schema:CreativeWork
311 grid-institutes:None schema:alternateName Developmental Therapeutics Consortium, Chicago, IL, USA
312 Division of Haematology, SA Pathology, Royal Adelaide Hospital, Adelaide, Australia
313 Novartis Pharmaceuticals Corporation, Moscow, Russian Federation
314 schema:name Developmental Therapeutics Consortium, Chicago, IL, USA
315 Division of Haematology, SA Pathology, Royal Adelaide Hospital, Adelaide, Australia
316 Novartis Pharmaceuticals Corporation, Moscow, Russian Federation
317 rdf:type schema:Organization
318 grid-institutes:grid.11451.30 schema:alternateName Medical University of Gdańsk, Gdańsk, Poland
319 schema:name Medical University of Gdańsk, Gdańsk, Poland
320 rdf:type schema:Organization
321 grid-institutes:grid.11804.3c schema:alternateName Semmelweis University, Budapest, Hungary
322 schema:name Semmelweis University, Budapest, Hungary
323 rdf:type schema:Organization
324 grid-institutes:grid.14778.3d schema:alternateName Universitätsklinikum Düsseldorf, Düsseldorf, Germany
325 schema:name Universitätsklinikum Düsseldorf, Düsseldorf, Germany
326 rdf:type schema:Organization
327 grid-institutes:grid.154185.c schema:alternateName Aarhus University Hospital, Aarhus, Denmark
328 schema:name Aarhus University Hospital, Aarhus, Denmark
329 rdf:type schema:Organization
330 grid-institutes:grid.270240.3 schema:alternateName Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
331 schema:name Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
332 rdf:type schema:Organization
333 grid-institutes:grid.275559.9 schema:alternateName Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
334 schema:name Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
335 rdf:type schema:Organization
336 grid-institutes:grid.411250.3 schema:alternateName Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain
337 schema:name Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain
338 rdf:type schema:Organization
339 grid-institutes:grid.411347.4 schema:alternateName Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
340 schema:name Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
341 rdf:type schema:Organization
342 grid-institutes:grid.414504.0 schema:alternateName Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
343 schema:name Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio Calabria, Italy
344 rdf:type schema:Organization
345 grid-institutes:grid.416409.e schema:alternateName St James’s Hospital, Dublin, Ireland
346 schema:name St James’s Hospital, Dublin, Ireland
347 rdf:type schema:Organization
348 grid-institutes:grid.419481.1 schema:alternateName Novartis Pharma AG, Basel, Switzerland
349 schema:name Novartis Pharma AG, Basel, Switzerland
350 rdf:type schema:Organization
351 grid-institutes:grid.6363.0 schema:alternateName Charité-Universitätsmedizin Berlin, Berlin, Germany
352 schema:name Charité-Universitätsmedizin Berlin, Berlin, Germany
353 rdf:type schema:Organization
354 grid-institutes:grid.7605.4 schema:alternateName University of Turin, Orbassano, Italy
355 schema:name University of Turin, Orbassano, Italy
356 rdf:type schema:Organization
357 grid-institutes:grid.7700.0 schema:alternateName III. Med. Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
358 schema:name III. Med. Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany
359 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...