Ontology type: schema:ScholarlyArticle Open Access: True
2020-02-17
AUTHORSElena Crisà, Austin G. Kulasekararaj, Vera Adema, Esperanza Such, Julie Schanz, Detlef Haase, Katayoon Shirneshan, Steven Best, Syed A Mian, Aytug Kizilors, José Cervera, Nicholas Lea, Dario Ferrero, Ulrich Germing, Barbara Hildebrandt, Ana Belén Valencia Martínez, Valeria Santini, Guillermo F. Sanz, Francesc Solé, Ghulam J. Mufti
ABSTRACTMonosomy 7 [−7] and/or partial loss of chromosome 7 [del(7q)] are associated with poor and intermediate prognosis, respectively, in myelodysplastic syndromes (MDS), but somatic mutations may also play a key complementary role. We analyzed the impact on the outcomes of deep targeted mutational screening in 280 MDS patients with −7/del(7q) as isolated cytogenetic abnormality (86 with del(7q) and 194 with −7). Patients with del(7q) or −7 had similar demographic and disease-related characteristics. Somatic mutations were detected in 79% (93/117) of patients (82% in −7 and 73% in del(7q) group). Median number of mutations per patient was 2 (range 0–8). There was no difference in mutation frequency between the two groups. Patients harbouring ≥2 mutations had a worse outcome than patients with <2 or no mutations (leukaemic transformation at 24 months, 38% and 20%, respectively, p = 0.044). Untreated patients with del(7q) had better overall survival (OS) compared with −7 (median OS, 34 vs 17 months, p = 0.034). In multivariable analysis, blast count, TP53 mutations and number of mutations were independent predictors of OS, whereas the cytogenetic subgroups did not retain prognostic relevance. This study highlights the importance of mutational analysis in terms of prognosis in MDS patients with isolated −7 or del(7q). More... »
PAGES2441-2450
http://scigraph.springernature.com/pub.10.1038/s41375-020-0728-x
DOIhttp://dx.doi.org/10.1038/s41375-020-0728-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1124913393
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/32066866
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Combined Chemotherapy Protocols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosome Deletion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosomes, Human, Pair 7",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myelodysplastic Syndromes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Analysis",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Fondazione Italiana Sindromi Mielodisplastiche (FISiM), Bologna, Italy",
"id": "http://www.grid.ac/institutes/grid.488236.3",
"name": [
"Department of Haematological Medicine, King\u2019s College Hospital, NHS Foundation Trust, London, UK",
"Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy",
"Fondazione Italiana Sindromi Mielodisplastiche (FISiM), Bologna, Italy"
],
"type": "Organization"
},
"familyName": "Cris\u00e0",
"givenName": "Elena",
"id": "sg:person.01346075445.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346075445.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Haematological Medicine, King\u2019s College Hospital, NHS Foundation Trust, London, UK",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Haematological Medicine, King\u2019s College Hospital, NHS Foundation Trust, London, UK"
],
"type": "Organization"
},
"familyName": "Kulasekararaj",
"givenName": "Austin G.",
"id": "sg:person.0756612713.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756612713.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA",
"id": "http://www.grid.ac/institutes/grid.239578.2",
"name": [
"Institut de Recerca Contra la Leuc\u00e8mia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain",
"Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"
],
"type": "Organization"
},
"familyName": "Adema",
"givenName": "Vera",
"id": "sg:person.01275363446.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275363446.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain",
"id": "http://www.grid.ac/institutes/grid.510933.d",
"name": [
"Department of Hematology, Hospital Universitario La Fe, Valencia, Spain",
"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain"
],
"type": "Organization"
},
"familyName": "Such",
"givenName": "Esperanza",
"id": "sg:person.01051446527.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051446527.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology and Medical Oncology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany",
"id": "http://www.grid.ac/institutes/grid.411984.1",
"name": [
"Department of Hematology and Medical Oncology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"
],
"type": "Organization"
},
"familyName": "Schanz",
"givenName": "Julie",
"id": "sg:person.01252562364.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252562364.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology and Medical Oncology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany",
"id": "http://www.grid.ac/institutes/grid.411984.1",
"name": [
"Department of Hematology and Medical Oncology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"
],
"type": "Organization"
},
"familyName": "Haase",
"givenName": "Detlef",
"id": "sg:person.0754465332.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754465332.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology and Medical Oncology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany",
"id": "http://www.grid.ac/institutes/grid.411984.1",
"name": [
"Department of Hematology and Medical Oncology, University Medical Center of G\u00f6ttingen, G\u00f6ttingen, Germany"
],
"type": "Organization"
},
"familyName": "Shirneshan",
"givenName": "Katayoon",
"id": "sg:person.0630023161.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630023161.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory for Molecular Haemato-Oncology, King\u2019s College Hospital, NHS Foundation Trust, London, UK",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Laboratory for Molecular Haemato-Oncology, King\u2019s College Hospital, NHS Foundation Trust, London, UK"
],
"type": "Organization"
},
"familyName": "Best",
"givenName": "Steven",
"id": "sg:person.01161245403.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161245403.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK",
"id": "http://www.grid.ac/institutes/grid.451388.3",
"name": [
"Department of Haematological Medicine, King\u2019s College Hospital, NHS Foundation Trust, London, UK",
"Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK"
],
"type": "Organization"
},
"familyName": "Mian",
"givenName": "Syed A",
"id": "sg:person.01323516313.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323516313.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory for Molecular Haemato-Oncology, King\u2019s College Hospital, NHS Foundation Trust, London, UK",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Laboratory for Molecular Haemato-Oncology, King\u2019s College Hospital, NHS Foundation Trust, London, UK"
],
"type": "Organization"
},
"familyName": "Kizilors",
"givenName": "Aytug",
"id": "sg:person.0673500240.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673500240.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Genetics Unit, Hospital Universitario La Fe, Valencia, Spain",
"id": "http://www.grid.ac/institutes/grid.84393.35",
"name": [
"Genetics Unit, Hospital Universitario La Fe, Valencia, Spain"
],
"type": "Organization"
},
"familyName": "Cervera",
"givenName": "Jos\u00e9",
"id": "sg:person.0662403264.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662403264.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory for Molecular Haemato-Oncology, King\u2019s College Hospital, NHS Foundation Trust, London, UK",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Laboratory for Molecular Haemato-Oncology, King\u2019s College Hospital, NHS Foundation Trust, London, UK"
],
"type": "Organization"
},
"familyName": "Lea",
"givenName": "Nicholas",
"id": "sg:person.01115351541.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115351541.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Hematology, University of Torino, AOU Citt\u00e0 della Salute e della Scienza, Torino, Italy",
"id": "http://www.grid.ac/institutes/grid.7605.4",
"name": [
"Fondazione Italiana Sindromi Mielodisplastiche (FISiM), Bologna, Italy",
"Division of Hematology, University of Torino, AOU Citt\u00e0 della Salute e della Scienza, Torino, Italy"
],
"type": "Organization"
},
"familyName": "Ferrero",
"givenName": "Dario",
"id": "sg:person.01167656223.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167656223.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University D\u00fcsseldorf, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Germing",
"givenName": "Ulrich",
"id": "sg:person.01362464041.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Human Genetics, Heinrich-Heine-University D\u00fcsseldorf, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Institute of Human Genetics, Heinrich-Heine-University D\u00fcsseldorf, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Hildebrandt",
"givenName": "Barbara",
"id": "sg:person.01320675564.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320675564.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MDS UNIT, AOU Careggi, University of Florence, Firenze, Italy",
"id": "http://www.grid.ac/institutes/grid.24704.35",
"name": [
"MDS UNIT, AOU Careggi, University of Florence, Firenze, Italy"
],
"type": "Organization"
},
"familyName": "Mart\u00ednez",
"givenName": "Ana Bel\u00e9n Valencia",
"id": "sg:person.01353231341.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353231341.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MDS UNIT, AOU Careggi, University of Florence, Firenze, Italy",
"id": "http://www.grid.ac/institutes/grid.24704.35",
"name": [
"Fondazione Italiana Sindromi Mielodisplastiche (FISiM), Bologna, Italy",
"MDS UNIT, AOU Careggi, University of Florence, Firenze, Italy"
],
"type": "Organization"
},
"familyName": "Santini",
"givenName": "Valeria",
"id": "sg:person.0750150340.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750150340.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medicine, University of Valencia, Valencia, Spain",
"id": "http://www.grid.ac/institutes/grid.5338.d",
"name": [
"Department of Hematology, Hospital Universitario La Fe, Valencia, Spain",
"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain",
"Department of Medicine, University of Valencia, Valencia, Spain"
],
"type": "Organization"
},
"familyName": "Sanz",
"givenName": "Guillermo F.",
"id": "sg:person.013151467432.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151467432.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut de Recerca Contra la Leuc\u00e8mia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain",
"id": "http://www.grid.ac/institutes/grid.7080.f",
"name": [
"Institut de Recerca Contra la Leuc\u00e8mia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"
],
"type": "Organization"
},
"familyName": "Sol\u00e9",
"givenName": "Francesc",
"id": "sg:person.01050536234.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050536234.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Haematological Medicine, King\u2019s College Hospital, NHS Foundation Trust, London, UK",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Haematological Medicine, King\u2019s College Hospital, NHS Foundation Trust, London, UK"
],
"type": "Organization"
},
"familyName": "Mufti",
"givenName": "Ghulam J.",
"id": "sg:person.01222427147.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222427147.32"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/ng.620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026607201",
"https://doi.org/10.1038/ng.620"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2014.25",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037658009",
"https://doi.org/10.1038/leu.2014.25"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41375-019-0457-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1113174185",
"https://doi.org/10.1038/s41375-019-0457-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2010.167",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037627473",
"https://doi.org/10.1038/leu.2010.167"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2013.336",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013726992",
"https://doi.org/10.1038/leu.2013.336"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.621",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045969373",
"https://doi.org/10.1038/ng.621"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/mo:22:2:169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014435385",
"https://doi.org/10.1385/mo:22:2:169"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00295602",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007785898",
"https://doi.org/10.1007/bf00295602"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2405076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011056830",
"https://doi.org/10.1038/sj.leu.2405076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048677204",
"https://doi.org/10.1038/sj.leu.2403806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.3733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012926250",
"https://doi.org/10.1038/nm.3733"
],
"type": "CreativeWork"
}
],
"datePublished": "2020-02-17",
"datePublishedReg": "2020-02-17",
"description": "Monosomy 7 [\u22127] and/or partial loss of chromosome 7 [del(7q)] are associated with poor and intermediate prognosis, respectively, in myelodysplastic syndromes (MDS), but somatic mutations may also play a key complementary role. We analyzed the impact on the outcomes of deep targeted mutational screening in 280 MDS patients with \u22127/del(7q) as isolated cytogenetic abnormality (86 with del(7q) and 194 with \u22127). Patients with del(7q) or \u22127 had similar demographic and disease-related characteristics. Somatic mutations were detected in 79% (93/117) of patients (82% in \u22127 and 73% in del(7q) group). Median number of mutations per patient was 2 (range 0\u20138). There was no difference in mutation frequency between the two groups. Patients harbouring \u22652 mutations had a worse outcome than patients with <2 or no mutations (leukaemic transformation at 24 months, 38% and 20%, respectively, p\u2009=\u20090.044). Untreated patients with del(7q) had better overall survival (OS) compared with \u22127 (median OS, 34 vs 17 months, p\u2009=\u20090.034). In multivariable analysis, blast count, TP53 mutations and number of mutations were independent predictors of OS, whereas the cytogenetic subgroups did not retain prognostic relevance. This study highlights the importance of mutational analysis in terms of prognosis in MDS patients with isolated \u22127 or del(7q).",
"genre": "article",
"id": "sg:pub.10.1038/s41375-020-0728-x",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.8099002",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1097065",
"issn": [
"0887-6924",
"1476-5551"
],
"name": "Leukemia",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "34"
}
],
"keywords": [
"overall survival",
"myelodysplastic syndrome",
"somatic mutations",
"better overall survival",
"terms of prognosis",
"disease-related characteristics",
"untreated patients",
"intermediate prognosis",
"blast count",
"independent predictors",
"myelodysplastic patients",
"multivariable analysis",
"MDS patients",
"prognostic relevance",
"worse outcomes",
"monosomy 7",
"median number",
"patients",
"TP53 mutations",
"cytogenetic abnormalities",
"cytogenetic subgroups",
"mutational screening",
"key complementary role",
"prognosis",
"chromosome 7",
"number of mutations",
"outcomes",
"mutation frequency",
"mutations",
"partial loss",
"complementary role",
"syndrome",
"abnormalities",
"survival",
"subgroups",
"predictors",
"mutational analysis",
"screening",
"count",
"loss",
"group",
"total loss",
"differences",
"study",
"number",
"role",
"impact",
"relevance",
"analysis",
"frequency",
"importance",
"characteristics",
"terms"
],
"name": "Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7",
"pagination": "2441-2450",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1124913393"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41375-020-0728-x"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"32066866"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41375-020-0728-x",
"https://app.dimensions.ai/details/publication/pub.1124913393"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:09",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_844.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41375-020-0728-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-020-0728-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-020-0728-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-020-0728-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-020-0728-x'
This table displays all metadata directly associated to this object as RDF triples.
399 TRIPLES
21 PREDICATES
104 URIs
85 LITERALS
22 BLANK NODES