Prognostic index for patients with relapsed or refractory acute myeloid leukemia who underwent hematopoietic cell transplantation: a KSGCT multicenter analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05-30

AUTHORS

Takayoshi Tachibana, Junya Kanda, Takuma Ishizaki, Yuho Najima, Masatsugu Tanaka, Noriko Doki, Shin-ichiro Fujiwara, Shun-ichi Kimura, Makoto Onizuka, Satoshi Takahashi, Takeshi Saito, Takehiko Mori, Shin Fujisawa, Emiko Sakaida, Kenji Matsumoto, Nobuyuki Aotsuka, Moritaka Goto, Reiko Watanabe, Katsuhiro Shono, Kensuke Usuki, Nobuhiro Tsukada, Heiwa Kanamori, Yoshinobu Kanda, Shinichiro Okamoto

ABSTRACT

A multicenter retrospective study was performed to explore a prognostic scoring index in order to identify a population who are least likely to benefit from allogeneic hematopoietic cell transplantation (HCT) in patients with relapsed or refractory acute myeloid leukemia (AML). The cohort included 519 patients with AML, who received HCT between 2005 and 2015 at a status of relapse or primary induction failure. Multivariate analysis demonstrated five independent predictors for OS, including C-reactive protein ≥ 1 mg/dL, peripheral blood blast fraction ≥ 20%, poor-risk karyotype, performance status ≥ 2, and bone marrow unrelated donor as a stem cell source. A prognostic scoring index was explored based on these predictors, and successfully separated the cohort into four groups. At 2 years, OS was 47%, 24%, 8%, and 0% for Good (Score 0, 1: n = 118), Intermediate-1 (Score 2: n = 75), Intermediate-2 (Score 3: n = 39), and Poor (Score 4: n = 24), respectively (P < 0.001). The predicting value of the index was confirmed in a validation cohort. Although a further validation study is warranted, the scoring index may be useful to predict survival and to identify the population with the lowest survival prior to HCT in patients with relapsed or refractory AML. More... »

PAGES

2610-2618

References to SciGraph publications

  • 2017-06-27. HLA-DPB1 mismatch induces a graft-versus-leukemia effect without severe acute GVHD after single-unit umbilical cord blood transplantation in LEUKEMIA
  • 2018-01-12. Impact of pretransplant leukemic blast% in bone marrow and peripheral blood on transplantation outcomes of patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation in non-CR in BONE MARROW TRANSPLANTATION
  • 2002-09-26. Long-term outcome after allogeneic bone marrow transplantation for hematological malignancies with non-remission status in ANNALS OF HEMATOLOGY
  • 2000-12-01. Long-term outcome after allogeneic hematopoietic stem cell transplantation for advanced stage acute myeloblastic leukemia: a retrospective study of 379 patients reported to the Société Française de Greffe de Moelle (SFGM) in BONE MARROW TRANSPLANTATION
  • 2013-08-09. Feasibility of clofarabine cytoreduction followed by haploidentical hematopoietic stem cell transplantation in patients with relapsed or refractory advanced acute leukemia in ANNALS OF HEMATOLOGY
  • 2004-09-13. Outcome of allogeneic bone marrow transplantation for children with advanced acute myeloid leukemia in BONE MARROW TRANSPLANTATION
  • 2016-01-20. Prognostic value of pretransplant serum C-reactive protein in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2000-04-26. Poor outcome in children with refractory/relapsed leukemia undergoing bone marrow transplantation with mismatched family member donors in BONE MARROW TRANSPLANTATION
  • 2005-10-31. Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up in BONE MARROW TRANSPLANTATION
  • 2013-04-08. Recent decrease in non-relapse mortality due to GVHD and infection after allogeneic hematopoietic cell transplantation in non-remission acute leukemia in BONE MARROW TRANSPLANTATION
  • 1998-03-25. Leukemia-free survival and mortality in patients with refractory or relapsed acute leukemia given marrow transplants from sibling and unrelated donors in BONE MARROW TRANSPLANTATION
  • Journal

    TITLE

    Leukemia

    ISSUE

    11

    VOLUME

    33

    Author Affiliations

  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
  • Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
  • Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
  • Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
  • Department of Hematology, Chiba University Hospital, Chiba, Japan
  • Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
  • Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
  • First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
  • Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
  • Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan
  • Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41375-019-0494-9

    DOI

    http://dx.doi.org/10.1038/s41375-019-0494-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1116051862

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31147621


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Graft vs Host Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multivariate Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation Conditioning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tachibana", 
            "givenName": "Takayoshi", 
            "id": "sg:person.01074653417.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074653417.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan", 
                "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Junya", 
            "id": "sg:person.01100640630.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishizaki", 
            "givenName": "Takuma", 
            "id": "sg:person.01122167503.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122167503.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Najima", 
            "givenName": "Yuho", 
            "id": "sg:person.01214267464.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Masatsugu", 
            "id": "sg:person.01171141246.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doki", 
            "givenName": "Noriko", 
            "id": "sg:person.01240752436.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujiwara", 
            "givenName": "Shin-ichiro", 
            "id": "sg:person.01073536015.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416093.9", 
              "name": [
                "Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kimura", 
            "givenName": "Shun-ichi", 
            "id": "sg:person.0600361031.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600361031.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265061.6", 
              "name": [
                "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onizuka", 
            "givenName": "Makoto", 
            "id": "sg:person.01046262603.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Satoshi", 
            "id": "sg:person.0721047700.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Takeshi", 
            "id": "sg:person.015754574322.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mori", 
            "givenName": "Takehiko", 
            "id": "sg:person.015512754302.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413045.7", 
              "name": [
                "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujisawa", 
            "givenName": "Shin", 
            "id": "sg:person.01145377314.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Chiba University Hospital, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411321.4", 
              "name": [
                "Department of Hematology, Chiba University Hospital, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakaida", 
            "givenName": "Emiko", 
            "id": "sg:person.0775302360.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775302360.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.268441.d", 
              "name": [
                "Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsumoto", 
            "givenName": "Kenji", 
            "id": "sg:person.0731726365.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731726365.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459661.9", 
              "name": [
                "Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aotsuka", 
            "givenName": "Nobuyuki", 
            "id": "sg:person.0577376767.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577376767.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410793.8", 
              "name": [
                "First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goto", 
            "givenName": "Moritaka", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Reiko", 
            "id": "sg:person.012637131732.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637131732.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459433.c", 
              "name": [
                "Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shono", 
            "givenName": "Katsuhiro", 
            "id": "sg:person.01225510655.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225510655.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414992.3", 
              "name": [
                "Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Usuki", 
            "givenName": "Kensuke", 
            "id": "sg:person.0724116206.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414929.3", 
              "name": [
                "Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsukada", 
            "givenName": "Nobuhiro", 
            "id": "sg:person.0766244401.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766244401.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanamori", 
            "givenName": "Heiwa", 
            "id": "sg:person.01060176576.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan", 
                "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Yoshinobu", 
            "id": "sg:person.0617055140.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okamoto", 
            "givenName": "Shinichiro", 
            "id": "sg:person.0715264147.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00277-013-1862-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021611826", 
              "https://doi.org/10.1007/s00277-013-1862-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2017.202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086386336", 
              "https://doi.org/10.1038/leu.2017.202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-002-0506-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007999028", 
              "https://doi.org/10.1007/s00277-002-0506-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2013.42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052715288", 
              "https://doi.org/10.1038/bmt.2013.42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1701152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018024009", 
              "https://doi.org/10.1038/sj.bmt.1701152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1702373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038683413", 
              "https://doi.org/10.1038/sj.bmt.1702373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-016-1941-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044949634", 
              "https://doi.org/10.1007/s12185-016-1941-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41409-017-0028-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100248956", 
              "https://doi.org/10.1038/s41409-017-0028-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026148482", 
              "https://doi.org/10.1038/sj.bmt.1705207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1704689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025993882", 
              "https://doi.org/10.1038/sj.bmt.1704689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1702690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032432312", 
              "https://doi.org/10.1038/sj.bmt.1702690"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-05-30", 
        "datePublishedReg": "2019-05-30", 
        "description": "A multicenter retrospective study was performed to explore a prognostic scoring index in order to identify a population who are least likely to benefit from allogeneic hematopoietic cell transplantation (HCT) in patients with relapsed or refractory acute myeloid leukemia (AML). The cohort included 519 patients with AML, who received HCT between 2005 and 2015 at a status of relapse or primary induction failure. Multivariate analysis demonstrated five independent predictors for OS, including C-reactive protein\u2009\u2265\u20091\u2009mg/dL, peripheral blood blast fraction\u2009\u2265\u200920%, poor-risk karyotype, performance status\u2009\u2265\u20092, and bone marrow unrelated donor as a stem cell source. A prognostic scoring index was explored based on these predictors, and successfully separated the cohort into four groups. At 2 years, OS was 47%, 24%, 8%, and 0% for Good (Score 0, 1: n\u2009=\u2009118), Intermediate-1 (Score 2: n\u2009=\u200975), Intermediate-2 (Score 3: n\u2009=\u200939), and Poor (Score 4: n\u2009=\u200924), respectively (P\u2009<\u20090.001). The predicting value of the index was confirmed in a validation cohort. Although a further validation study is warranted, the scoring index may be useful to predict survival and to identify the population with the lowest survival prior to HCT in patients with relapsed or refractory AML.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41375-019-0494-9", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097065", 
            "issn": [
              "0887-6924", 
              "1476-5551"
            ], 
            "name": "Leukemia", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "33"
          }
        ], 
        "keywords": [
          "refractory acute myeloid leukemia", 
          "hematopoietic cell transplantation", 
          "acute myeloid leukemia", 
          "prognostic scoring index", 
          "cell transplantation", 
          "myeloid leukemia", 
          "Scoring Index", 
          "allogeneic hematopoietic cell transplantation", 
          "primary induction failure", 
          "poor-risk karyotype", 
          "multicenter retrospective study", 
          "C-reactive protein", 
          "stem cell source", 
          "induction failure", 
          "performance status", 
          "independent predictors", 
          "unrelated donors", 
          "further validation studies", 
          "multicenter analysis", 
          "prognostic index", 
          "retrospective study", 
          "validation cohort", 
          "patients", 
          "multivariate analysis", 
          "cohort", 
          "cell source", 
          "transplantation", 
          "leukemia", 
          "lower survival", 
          "validation study", 
          "survival", 
          "intermediate-1", 
          "predictors", 
          "status", 
          "index", 
          "OS", 
          "relapse", 
          "population", 
          "dl", 
          "study", 
          "failure", 
          "group", 
          "years", 
          "karyotype", 
          "donors", 
          "protein", 
          "intermediate 2", 
          "analysis", 
          "fraction", 
          "values", 
          "poor", 
          "source", 
          "order"
        ], 
        "name": "Prognostic index for patients with relapsed or refractory acute myeloid leukemia who underwent hematopoietic cell transplantation: a KSGCT multicenter analysis", 
        "pagination": "2610-2618", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1116051862"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41375-019-0494-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31147621"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41375-019-0494-9", 
          "https://app.dimensions.ai/details/publication/pub.1116051862"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_802.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41375-019-0494-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0494-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0494-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0494-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41375-019-0494-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    451 TRIPLES      22 PREDICATES      109 URIs      89 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41375-019-0494-9 schema:about N04f344732eba438d93341423c2feb0bc
    2 N2708c1ba66ba461eb5c80483d10c255c
    3 N318a5c15b966444ead1b2f6bced31d94
    4 N33289365df0c48789fd17bf7fb8154be
    5 N5c0671dd35d144c5a24487b9c55f5511
    6 N81af9d52c3de4b87b187696ee161d805
    7 Na2ffa3fb6d6a447fba02bd7d8425708d
    8 Na561492d5a8d4fc9b38d7dab13fdcfe6
    9 Nb216058c026f4a529efbe0bc7c3a69dc
    10 Nbbff57bed37f4300a1c19019f8853fc2
    11 Nc573c55ebd7943818054f50a20512de7
    12 Nc92832be29d440d7b305a832a639d3bc
    13 Nca5ecf0144744936bdf082b08377c0e0
    14 Nced65843c6b24212b66750321e34c3e2
    15 Nd3eeaefbc1834a97a357073a5a5a8ff3
    16 Nd651a2f71e334c8482ba2b223a9ae225
    17 Nd67f4fb8dbce404fb786e5bc0b629c36
    18 Nefaa153b03f346f8b82f85d4d87dfdd4
    19 anzsrc-for:11
    20 anzsrc-for:1102
    21 schema:author Nd973c3007c5542c3842edcbd2c97313d
    22 schema:citation sg:pub.10.1007/s00277-002-0506-z
    23 sg:pub.10.1007/s00277-013-1862-6
    24 sg:pub.10.1007/s12185-016-1941-2
    25 sg:pub.10.1038/bmt.2012.244
    26 sg:pub.10.1038/bmt.2013.42
    27 sg:pub.10.1038/leu.2017.202
    28 sg:pub.10.1038/s41409-017-0028-x
    29 sg:pub.10.1038/sj.bmt.1701152
    30 sg:pub.10.1038/sj.bmt.1702373
    31 sg:pub.10.1038/sj.bmt.1702690
    32 sg:pub.10.1038/sj.bmt.1704689
    33 sg:pub.10.1038/sj.bmt.1705207
    34 schema:datePublished 2019-05-30
    35 schema:datePublishedReg 2019-05-30
    36 schema:description A multicenter retrospective study was performed to explore a prognostic scoring index in order to identify a population who are least likely to benefit from allogeneic hematopoietic cell transplantation (HCT) in patients with relapsed or refractory acute myeloid leukemia (AML). The cohort included 519 patients with AML, who received HCT between 2005 and 2015 at a status of relapse or primary induction failure. Multivariate analysis demonstrated five independent predictors for OS, including C-reactive protein ≥ 1 mg/dL, peripheral blood blast fraction ≥ 20%, poor-risk karyotype, performance status ≥ 2, and bone marrow unrelated donor as a stem cell source. A prognostic scoring index was explored based on these predictors, and successfully separated the cohort into four groups. At 2 years, OS was 47%, 24%, 8%, and 0% for Good (Score 0, 1: n = 118), Intermediate-1 (Score 2: n = 75), Intermediate-2 (Score 3: n = 39), and Poor (Score 4: n = 24), respectively (P < 0.001). The predicting value of the index was confirmed in a validation cohort. Although a further validation study is warranted, the scoring index may be useful to predict survival and to identify the population with the lowest survival prior to HCT in patients with relapsed or refractory AML.
    37 schema:genre article
    38 schema:inLanguage en
    39 schema:isAccessibleForFree false
    40 schema:isPartOf N1e764644af8540ffa8aa165f3bf75aa9
    41 Nde799172d35540cf8b6167da501b5016
    42 sg:journal.1097065
    43 schema:keywords C-reactive protein
    44 OS
    45 Scoring Index
    46 acute myeloid leukemia
    47 allogeneic hematopoietic cell transplantation
    48 analysis
    49 cell source
    50 cell transplantation
    51 cohort
    52 dl
    53 donors
    54 failure
    55 fraction
    56 further validation studies
    57 group
    58 hematopoietic cell transplantation
    59 independent predictors
    60 index
    61 induction failure
    62 intermediate 2
    63 intermediate-1
    64 karyotype
    65 leukemia
    66 lower survival
    67 multicenter analysis
    68 multicenter retrospective study
    69 multivariate analysis
    70 myeloid leukemia
    71 order
    72 patients
    73 performance status
    74 poor
    75 poor-risk karyotype
    76 population
    77 predictors
    78 primary induction failure
    79 prognostic index
    80 prognostic scoring index
    81 protein
    82 refractory acute myeloid leukemia
    83 relapse
    84 retrospective study
    85 source
    86 status
    87 stem cell source
    88 study
    89 survival
    90 transplantation
    91 unrelated donors
    92 validation cohort
    93 validation study
    94 values
    95 years
    96 schema:name Prognostic index for patients with relapsed or refractory acute myeloid leukemia who underwent hematopoietic cell transplantation: a KSGCT multicenter analysis
    97 schema:pagination 2610-2618
    98 schema:productId N15fce243ae974d2cb1e92b50f0ce8326
    99 N17a6f30e9be94a6887ebad6aa1fdebb3
    100 N85950b0c1380486ea504fcf2897c64bd
    101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1116051862
    102 https://doi.org/10.1038/s41375-019-0494-9
    103 schema:sdDatePublished 2022-05-20T07:35
    104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    105 schema:sdPublisher Na5f0e27bf89145f1837769273e5b5bda
    106 schema:url https://doi.org/10.1038/s41375-019-0494-9
    107 sgo:license sg:explorer/license/
    108 sgo:sdDataset articles
    109 rdf:type schema:ScholarlyArticle
    110 N03ef3f9a576e4a2dbd89f1d4048c83e7 rdf:first sg:person.01122167503.96
    111 rdf:rest N49a60045116746fd97d3a40fd4cd7378
    112 N04c01dc1c2fe42cd8df95be8f40eba82 rdf:first sg:person.0766244401.31
    113 rdf:rest N0cb397416a2a4ed2a6849a187bf3908a
    114 N04f344732eba438d93341423c2feb0bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Hematopoietic Stem Cell Transplantation
    116 rdf:type schema:DefinedTerm
    117 N0cb397416a2a4ed2a6849a187bf3908a rdf:first sg:person.01060176576.11
    118 rdf:rest N859eec1ca6c24be38c800244f855c23c
    119 N15fce243ae974d2cb1e92b50f0ce8326 schema:name doi
    120 schema:value 10.1038/s41375-019-0494-9
    121 rdf:type schema:PropertyValue
    122 N17a6f30e9be94a6887ebad6aa1fdebb3 schema:name pubmed_id
    123 schema:value 31147621
    124 rdf:type schema:PropertyValue
    125 N1cbfef83a2fe41cb962ee68e2a62069b rdf:first sg:person.01145377314.06
    126 rdf:rest N979f23af158f4238a3f8b2c71373e0de
    127 N1e764644af8540ffa8aa165f3bf75aa9 schema:issueNumber 11
    128 rdf:type schema:PublicationIssue
    129 N1f6aa1e35bc74ea580ce4c31b397a7d7 rdf:first sg:person.015754574322.05
    130 rdf:rest Nab0ea82e559943568264d181e2a39c5b
    131 N2511d7c5e4834f019e4d861a493c8ee6 rdf:first sg:person.0715264147.87
    132 rdf:rest rdf:nil
    133 N2708c1ba66ba461eb5c80483d10c255c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Transplantation Conditioning
    135 rdf:type schema:DefinedTerm
    136 N291f4392d98141e1bc54b43b50dc5bf1 rdf:first sg:person.012637131732.19
    137 rdf:rest N59c4081dace54799af4b48169f1fde9d
    138 N2b2808d1698e497f9cc0a162136792e9 rdf:first sg:person.0577376767.42
    139 rdf:rest Nd98944668d1e4a939395907325bf6675
    140 N2e7281c6336c476b8b0e7e25edbcd2aa rdf:first sg:person.01046262603.08
    141 rdf:rest Na4626556b2f747f4bf4841b49f7f536b
    142 N318a5c15b966444ead1b2f6bced31d94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Humans
    144 rdf:type schema:DefinedTerm
    145 N33289365df0c48789fd17bf7fb8154be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Leukemia, Myeloid, Acute
    147 rdf:type schema:DefinedTerm
    148 N3bf48939878d42e2b0fac779613dd472 rdf:first sg:person.01240752436.35
    149 rdf:rest N97c7d71b85a14c33ab6771ccef071623
    150 N49a60045116746fd97d3a40fd4cd7378 rdf:first sg:person.01214267464.19
    151 rdf:rest N66f3956ef48547a9a66becff843d6b75
    152 N59c4081dace54799af4b48169f1fde9d rdf:first sg:person.01225510655.03
    153 rdf:rest Ne40ee66fef1d4826a75ed56a924c3c9b
    154 N5c0671dd35d144c5a24487b9c55f5511 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Graft vs Host Disease
    156 rdf:type schema:DefinedTerm
    157 N66f3956ef48547a9a66becff843d6b75 rdf:first sg:person.01171141246.33
    158 rdf:rest N3bf48939878d42e2b0fac779613dd472
    159 N68386699b7704366bbabb89b1f23b775 schema:affiliation grid-institutes:grid.410793.8
    160 schema:familyName Goto
    161 schema:givenName Moritaka
    162 rdf:type schema:Person
    163 N81af9d52c3de4b87b187696ee161d805 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Neoplasm Recurrence, Local
    165 rdf:type schema:DefinedTerm
    166 N85950b0c1380486ea504fcf2897c64bd schema:name dimensions_id
    167 schema:value pub.1116051862
    168 rdf:type schema:PropertyValue
    169 N859eec1ca6c24be38c800244f855c23c rdf:first sg:person.0617055140.49
    170 rdf:rest N2511d7c5e4834f019e4d861a493c8ee6
    171 N979f23af158f4238a3f8b2c71373e0de rdf:first sg:person.0775302360.96
    172 rdf:rest Nf34101b97f4b4c52ab24c8f6ad0cd888
    173 N97c7d71b85a14c33ab6771ccef071623 rdf:first sg:person.01073536015.79
    174 rdf:rest Nffed80f79659400cb3615bf5650971f2
    175 Na2ffa3fb6d6a447fba02bd7d8425708d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Aged
    177 rdf:type schema:DefinedTerm
    178 Na4626556b2f747f4bf4841b49f7f536b rdf:first sg:person.0721047700.17
    179 rdf:rest N1f6aa1e35bc74ea580ce4c31b397a7d7
    180 Na561492d5a8d4fc9b38d7dab13fdcfe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Female
    182 rdf:type schema:DefinedTerm
    183 Na5f0e27bf89145f1837769273e5b5bda schema:name Springer Nature - SN SciGraph project
    184 rdf:type schema:Organization
    185 Nab0ea82e559943568264d181e2a39c5b rdf:first sg:person.015512754302.32
    186 rdf:rest N1cbfef83a2fe41cb962ee68e2a62069b
    187 Nb216058c026f4a529efbe0bc7c3a69dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Treatment Outcome
    189 rdf:type schema:DefinedTerm
    190 Nb953926ee21148208dfaf03520cd1913 rdf:first sg:person.01100640630.10
    191 rdf:rest N03ef3f9a576e4a2dbd89f1d4048c83e7
    192 Nbbff57bed37f4300a1c19019f8853fc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Middle Aged
    194 rdf:type schema:DefinedTerm
    195 Nc573c55ebd7943818054f50a20512de7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Remission Induction
    197 rdf:type schema:DefinedTerm
    198 Nc92832be29d440d7b305a832a639d3bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Male
    200 rdf:type schema:DefinedTerm
    201 Nca5ecf0144744936bdf082b08377c0e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Retrospective Studies
    203 rdf:type schema:DefinedTerm
    204 Nced65843c6b24212b66750321e34c3e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Adult
    206 rdf:type schema:DefinedTerm
    207 Nd3eeaefbc1834a97a357073a5a5a8ff3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Young Adult
    209 rdf:type schema:DefinedTerm
    210 Nd651a2f71e334c8482ba2b223a9ae225 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Prognosis
    212 rdf:type schema:DefinedTerm
    213 Nd67f4fb8dbce404fb786e5bc0b629c36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Adolescent
    215 rdf:type schema:DefinedTerm
    216 Nd973c3007c5542c3842edcbd2c97313d rdf:first sg:person.01074653417.74
    217 rdf:rest Nb953926ee21148208dfaf03520cd1913
    218 Nd98944668d1e4a939395907325bf6675 rdf:first N68386699b7704366bbabb89b1f23b775
    219 rdf:rest N291f4392d98141e1bc54b43b50dc5bf1
    220 Nde799172d35540cf8b6167da501b5016 schema:volumeNumber 33
    221 rdf:type schema:PublicationVolume
    222 Ne40ee66fef1d4826a75ed56a924c3c9b rdf:first sg:person.0724116206.23
    223 rdf:rest N04c01dc1c2fe42cd8df95be8f40eba82
    224 Nefaa153b03f346f8b82f85d4d87dfdd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Multivariate Analysis
    226 rdf:type schema:DefinedTerm
    227 Nf34101b97f4b4c52ab24c8f6ad0cd888 rdf:first sg:person.0731726365.30
    228 rdf:rest N2b2808d1698e497f9cc0a162136792e9
    229 Nffed80f79659400cb3615bf5650971f2 rdf:first sg:person.0600361031.85
    230 rdf:rest N2e7281c6336c476b8b0e7e25edbcd2aa
    231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Medical and Health Sciences
    233 rdf:type schema:DefinedTerm
    234 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    235 schema:name Cardiorespiratory Medicine and Haematology
    236 rdf:type schema:DefinedTerm
    237 sg:journal.1097065 schema:issn 0887-6924
    238 1476-5551
    239 schema:name Leukemia
    240 schema:publisher Springer Nature
    241 rdf:type schema:Periodical
    242 sg:person.01046262603.08 schema:affiliation grid-institutes:grid.265061.6
    243 schema:familyName Onizuka
    244 schema:givenName Makoto
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08
    246 rdf:type schema:Person
    247 sg:person.01060176576.11 schema:affiliation grid-institutes:grid.414944.8
    248 schema:familyName Kanamori
    249 schema:givenName Heiwa
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11
    251 rdf:type schema:Person
    252 sg:person.01073536015.79 schema:affiliation grid-institutes:grid.410804.9
    253 schema:familyName Fujiwara
    254 schema:givenName Shin-ichiro
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79
    256 rdf:type schema:Person
    257 sg:person.01074653417.74 schema:affiliation grid-institutes:grid.414944.8
    258 schema:familyName Tachibana
    259 schema:givenName Takayoshi
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074653417.74
    261 rdf:type schema:Person
    262 sg:person.01100640630.10 schema:affiliation grid-institutes:grid.258799.8
    263 schema:familyName Kanda
    264 schema:givenName Junya
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10
    266 rdf:type schema:Person
    267 sg:person.01122167503.96 schema:affiliation grid-institutes:grid.256642.1
    268 schema:familyName Ishizaki
    269 schema:givenName Takuma
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122167503.96
    271 rdf:type schema:Person
    272 sg:person.01145377314.06 schema:affiliation grid-institutes:grid.413045.7
    273 schema:familyName Fujisawa
    274 schema:givenName Shin
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06
    276 rdf:type schema:Person
    277 sg:person.01171141246.33 schema:affiliation grid-institutes:grid.414944.8
    278 schema:familyName Tanaka
    279 schema:givenName Masatsugu
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33
    281 rdf:type schema:Person
    282 sg:person.01214267464.19 schema:affiliation grid-institutes:grid.415479.a
    283 schema:familyName Najima
    284 schema:givenName Yuho
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19
    286 rdf:type schema:Person
    287 sg:person.01225510655.03 schema:affiliation grid-institutes:grid.459433.c
    288 schema:familyName Shono
    289 schema:givenName Katsuhiro
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225510655.03
    291 rdf:type schema:Person
    292 sg:person.01240752436.35 schema:affiliation grid-institutes:grid.415479.a
    293 schema:familyName Doki
    294 schema:givenName Noriko
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35
    296 rdf:type schema:Person
    297 sg:person.012637131732.19 schema:affiliation grid-institutes:None
    298 schema:familyName Watanabe
    299 schema:givenName Reiko
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637131732.19
    301 rdf:type schema:Person
    302 sg:person.015512754302.32 schema:affiliation grid-institutes:grid.26091.3c
    303 schema:familyName Mori
    304 schema:givenName Takehiko
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32
    306 rdf:type schema:Person
    307 sg:person.015754574322.05 schema:affiliation grid-institutes:grid.411898.d
    308 schema:familyName Saito
    309 schema:givenName Takeshi
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05
    311 rdf:type schema:Person
    312 sg:person.0577376767.42 schema:affiliation grid-institutes:grid.459661.9
    313 schema:familyName Aotsuka
    314 schema:givenName Nobuyuki
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577376767.42
    316 rdf:type schema:Person
    317 sg:person.0600361031.85 schema:affiliation grid-institutes:grid.416093.9
    318 schema:familyName Kimura
    319 schema:givenName Shun-ichi
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600361031.85
    321 rdf:type schema:Person
    322 sg:person.0617055140.49 schema:affiliation grid-institutes:grid.410804.9
    323 schema:familyName Kanda
    324 schema:givenName Yoshinobu
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49
    326 rdf:type schema:Person
    327 sg:person.0715264147.87 schema:affiliation grid-institutes:grid.26091.3c
    328 schema:familyName Okamoto
    329 schema:givenName Shinichiro
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87
    331 rdf:type schema:Person
    332 sg:person.0721047700.17 schema:affiliation grid-institutes:grid.26999.3d
    333 schema:familyName Takahashi
    334 schema:givenName Satoshi
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17
    336 rdf:type schema:Person
    337 sg:person.0724116206.23 schema:affiliation grid-institutes:grid.414992.3
    338 schema:familyName Usuki
    339 schema:givenName Kensuke
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724116206.23
    341 rdf:type schema:Person
    342 sg:person.0731726365.30 schema:affiliation grid-institutes:grid.268441.d
    343 schema:familyName Matsumoto
    344 schema:givenName Kenji
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731726365.30
    346 rdf:type schema:Person
    347 sg:person.0766244401.31 schema:affiliation grid-institutes:grid.414929.3
    348 schema:familyName Tsukada
    349 schema:givenName Nobuhiro
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766244401.31
    351 rdf:type schema:Person
    352 sg:person.0775302360.96 schema:affiliation grid-institutes:grid.411321.4
    353 schema:familyName Sakaida
    354 schema:givenName Emiko
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775302360.96
    356 rdf:type schema:Person
    357 sg:pub.10.1007/s00277-002-0506-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007999028
    358 https://doi.org/10.1007/s00277-002-0506-z
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1007/s00277-013-1862-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021611826
    361 https://doi.org/10.1007/s00277-013-1862-6
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1007/s12185-016-1941-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044949634
    364 https://doi.org/10.1007/s12185-016-1941-2
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    367 https://doi.org/10.1038/bmt.2012.244
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/bmt.2013.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052715288
    370 https://doi.org/10.1038/bmt.2013.42
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/leu.2017.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086386336
    373 https://doi.org/10.1038/leu.2017.202
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/s41409-017-0028-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1100248956
    376 https://doi.org/10.1038/s41409-017-0028-x
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/sj.bmt.1701152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018024009
    379 https://doi.org/10.1038/sj.bmt.1701152
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/sj.bmt.1702373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038683413
    382 https://doi.org/10.1038/sj.bmt.1702373
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/sj.bmt.1702690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032432312
    385 https://doi.org/10.1038/sj.bmt.1702690
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/sj.bmt.1704689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025993882
    388 https://doi.org/10.1038/sj.bmt.1704689
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/sj.bmt.1705207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026148482
    391 https://doi.org/10.1038/sj.bmt.1705207
    392 rdf:type schema:CreativeWork
    393 grid-institutes:None schema:alternateName Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    394 schema:name Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    395 rdf:type schema:Organization
    396 grid-institutes:grid.256642.1 schema:alternateName Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    397 schema:name Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    398 rdf:type schema:Organization
    399 grid-institutes:grid.258799.8 schema:alternateName Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    400 schema:name Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    401 Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    402 rdf:type schema:Organization
    403 grid-institutes:grid.26091.3c schema:alternateName Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    404 schema:name Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    405 rdf:type schema:Organization
    406 grid-institutes:grid.265061.6 schema:alternateName Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
    407 schema:name Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
    408 rdf:type schema:Organization
    409 grid-institutes:grid.268441.d schema:alternateName Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
    410 schema:name Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
    411 rdf:type schema:Organization
    412 grid-institutes:grid.26999.3d schema:alternateName Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    413 schema:name Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    414 rdf:type schema:Organization
    415 grid-institutes:grid.410793.8 schema:alternateName First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    416 schema:name First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    417 rdf:type schema:Organization
    418 grid-institutes:grid.410804.9 schema:alternateName Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    419 schema:name Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    420 Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    421 rdf:type schema:Organization
    422 grid-institutes:grid.411321.4 schema:alternateName Department of Hematology, Chiba University Hospital, Chiba, Japan
    423 schema:name Department of Hematology, Chiba University Hospital, Chiba, Japan
    424 rdf:type schema:Organization
    425 grid-institutes:grid.411898.d schema:alternateName Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    426 schema:name Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    427 rdf:type schema:Organization
    428 grid-institutes:grid.413045.7 schema:alternateName Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    429 schema:name Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    430 rdf:type schema:Organization
    431 grid-institutes:grid.414929.3 schema:alternateName Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
    432 schema:name Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
    433 rdf:type schema:Organization
    434 grid-institutes:grid.414944.8 schema:alternateName Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
    435 schema:name Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
    436 rdf:type schema:Organization
    437 grid-institutes:grid.414992.3 schema:alternateName Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
    438 schema:name Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
    439 rdf:type schema:Organization
    440 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    441 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    442 rdf:type schema:Organization
    443 grid-institutes:grid.416093.9 schema:alternateName Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    444 schema:name Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    445 rdf:type schema:Organization
    446 grid-institutes:grid.459433.c schema:alternateName Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan
    447 schema:name Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan
    448 rdf:type schema:Organization
    449 grid-institutes:grid.459661.9 schema:alternateName Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
    450 schema:name Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
    451 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...